*  Protocols and Video Articles Authored by Lixin Liu
... cardiac alpha-myosin heavy chain, and troponin I. GFP-positive cells in myocardium sectioned from MI hearts confirmed the ... but the function of this gene remains unclear. In this study, a real-time polymerase chain reaction-based assay was developed ... The eukaryotic expression plasmid pcDNA 3.1 (+)/r-Caspase-3 was constructed by rearrangement of the large subunit and small ... The combination of unique hemodynamic patterns and specific structural and functional features of the vessels and endothelium ...
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*  Faculty
Regulation of B cell fate commitment and immunoglobulin heavy-chain gene rearrangements by Ikaros. Nature Immunology, 9(8), 927 ... Fukunaga R, Yokoyama S, "Structural insights into the first step of RNA-dependent cysteine biosynthesis in archaea. Structural ... Molecular pathways and mechanisms regulating the recombination of immunoglobulin genes during B-lymphocyte development. Adv Exp ... toxicity in well-defined animal model systems and in patient samples by a multi-disciplinary team comprised of both basic ...
  http://biolchem.bs.jhmi.edu/Pages/Faculty.aspx?ra=2
*  Basic concepts in immunity and inflammation
The first re-arrangement entails the joining of the D segment to the J segment of the immunoglobulin heavy chain gene (IgH). ... T-lymphocyte ontogeny:. T-cell development occurs in the thymus. T-cell precursors, however, arrive at the thymus from the bone ... These contain an N-terminal extracellular domain with structural homology to calcium-dependent lectins, followed by a domain ... two heavy chains (H chains) of identical molecular weight up to 53,000 Daltons (D) and two light chains (L chains) having a ...
  http://periobasics.com/basic-concepts-in-immunity-and-inflammation.html
*  Bertil Glader | Stanford Medicine Profiles
... and the immunoglobulin gene rearrangement studies showed rearranged heavy chain genes with germ line light chain genes. ... In addition, the SUP-HD1 cell line, produced IFN-gamma, a T-lymphocyte-associated lymphokine. Based on these data, the SUP-HD1 ... Rather, this condition is thought to be due to a structural membrane defect which is manifested by imbalanced cation leaks (K ... Cell lines cultured in vitro possessed the same basic immunophenotype and biochemical enzyme activity as the patients' original ...
  https://med.stanford.edu/profiles/bertil-glader
*  MONOCLONAL ANTIBODIES AGAINST HEPATITIS C VIRUS CORE PROTEIN - Patent application
For example, the technology for expression of both heavy and light chain genes in E. coli is the subject of the PCT patent ... The amount of basic solution added to the sample depends on the concentration of the basic solution. Based on the concentration ... HCV structural genes (core and envelope) are encoded near the 5'-end of the genome, followed by the proteases and helicase, the ... Briefly, to produce a human-human hybridoma, a human lymphocyte donor is selected. A donor who is known as infected with HCV ( ...
  http://www.patentsencyclopedia.com/app/20120009196
*  Antibody - wikidoc
They are made of a few basic structural units called chains; each antibody has two large heavy chains H and two small light ... "Evidence for somatic rearrangement of immunoglobulin genes coding for variable and constant regions". Proc. Natl. Acad. Sci. U. ... Goding J. "Allotypes of IgM and IgD receptors in the mouse: a probe for lymphocyte differentiation". Contemp Top Immunobiol. 8 ... Heavy chain. For more details on this topic, see heavy chain.. There are five types of mammalian Ig heavy chain denoted by the ...
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*  Download Precalculus Functions And Graphs Eleventh Edition With Cengagenow Printed Access Card
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*  Protocols and Video Articles Authored by Patrick Collins
... which either transcribe the Ifng gene and silence the Il4 gene or transcribe the Il4 gene and silence the Ifng gene, ... Structural treatments, such as permethrin can be used to support a fumigation strategy in storages made of galvanised steel. ... In mixed lymphocyte cultures using tumour cells as antigenic stimulators, addition of recombinant galectin-1 dose-dependently ... That is, in the presence of an active Lgt4, GlcNAc is preferentially added to the (1-->4) chain of the growing oligosaccharide ...
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*  Philosophical Transactions of the Royal Society B: Biological Sciences
First, inferring rearrangements in heavy and light chain genes is difficult. The number of heavy chain variable genes on each ... 2011 Naive antibody gene-segment frequencies are heritable and unaltered by chronic lymphocyte ablation. Proc. Natl Acad. Sci. ... 2013 Multidonor analysis reveals structural elements, genetic determinants, and maturation pathway for HIV-1 neutralization by ... and is consistent with basic principles of population growth. However, the subdominance of anti-stalk antibodies in influenza ...
  http://rstb.royalsocietypublishing.org/content/370/1676/20140235.full?ijkey=7EY4oLE9ccz4Xf8&keytype=ref
*  RegenerativeMedicine.net - Article Archives
STEP study Structural basis of actin filament nucleation by tandem W domains Ectopic activation of germline and placental genes ... gene is expressed by human liver and other tumor types and has oncogenic activity in mice Targeting genomic rearrangements in ... Polymeric nanoparticles for nonviral gene therapy extend brain tumor survival in vivo Tumor-specific cytotoxic T lymphocyte ... dolichol chain lengths as biomarkers for retinitis pigmentosa caused by impaired dolichol biosynthesis The housekeeping gene ...
  http://regenerativemedicine.net/NewsletterArchives.asp?qEmpID=24856&qCat=RMJ
*  Protocols and Video Articles Authored by Maher Albitar
... polymerase chain reaction (PCR) for immunoglobulin heavy chain (IGHV) in BM, and cCD52 and cCD20 levels (blood and BM) at ... Although abnormalities in the neurofibromatosis 1 (NF1) gene, which is a gene involved in the ras pathway, have been observed ... A three-dimensional structural model of the 35INS ABL kinase domain complexed with imatinib was built using homology modeling, ... Patients who had no TA had slightly lower beta2M and lower lymphocyte counts (P = 0.5 and 0.04, respectively) as compared with ...
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*  Interactive Fly, Drosophila
Furthermore, mutations of zipper, the gene encoding the nonmuscle myosin heavy chain, exhibit mutant phenotypes in most of the ... Class I genes code for structural proteins that effect changes in epidermal cell shape and motility, including zipper, coracle ... the cytoskeletal rearrangement that is modulated by Rac1 upstream of JNK could be important in the LR asymmetric rearrangement ... Thus, although the basic logic of increased ROS in myeloid progenitors is conserved between flies and mice, the exact function ...
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*  TRB@ | Cancer Genetics Web
Because polymerase chain reaction amplification showed monoclonal rearrangement of the T-cell receptor β chain gene, this ... genes to characterize the basic properties of TILs in ovarian carcinoma. Due to somatic rearrangement during T-cell development ... In this chapter we describe an integrated approach to assess clonality via analysis of Ig heavy chain (IGH), Ig kappa (IGK), ... The transcription factor E2A is essential for lymphocyte development. In this study, we describe a recurrent E2A gene deletion ...
  http://www.cancerindex.org/geneweb/TRB.htm
*  Protocols and Video Articles Authored by Gabriella Sozzi
These data provide preliminary evidence of the inactivation of UQCRH gene in cancer either by structural rearrangements or ... Annual or Biennial CT Screening Versus Observation in Heavy Smokers: 5-year Results of the MILD Trial European Journal of ... We investigated by RT-polymerase chain reaction (PCR) and real-time quantitative PCR the prevalence and functional implications ... lymphocyte infiltration. The levels of B2M and HLA-I proteins correlated with those of PD-L1. Finally, a deficiency in HLA-I ...
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*  Protocols and Video Articles Authored by Thomas O. Metz
Human orthologues of genes in the mouse QTL are implicated in gastrointestinal cancer. Additionally, genes located in mouse QTL ... We utilized heavy-labeled precursors of F-Asn to monitor its formation in the intestine, in the presence or absence of ... Diacyltransferase Activity and Chain Length Specificity of Mycobacterium Tuberculosis PapA5 in the Synthesis of Alkyl β-Diol ... Initial data-dependent LC-MS/MS analyses of human plasma, erythrocyte, and lymphocyte lipids were performed in order to ...
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*  Immune System Boosters - Karel's Nutrition Blog
This process is known as isotype switching and is the consequence of DNA rearrangements in the genes encoding for the C (but ... regions of the heavy chains (Stavnezer, 1996). Isotype switching results in differing classes of antibodies with differing ... The basic mechanisms of immune response to dietary antigen Last Updated on Tue, 12 Apr 2016 , Nutrition Guide ... The gain in thymic weight is due to significant increases in the lymphocyte content of the thymic glands. In healthy humans, ...
  https://www.karelsavry.us/immune-system.html
*  JoVE | Peer Reviewed Scientific Video Journal - Methods and Protocols
T-Lymphocyte, Gene Transfer Techniques, Transduction, Genetic, Transfection, Adenovirus, gene transfer, microRNA, ... in SJL mice and cardiac myosin heavy chain-α (Myhc) 334-352-induced experimental autoimmune myocarditis (EAM) in A/J mice. Two ... Random rearrangement of the T cell receptor (TCR) α and β loci generates a T cell repertoire with vast diversity in antigen ... A basic necessity for researchers studying adaptive immunity with in vivo experimental models is an ability to identify T cells ...
  https://www.jove.com/visualize/abstract/19488401/phenotypic-characterization-autoreactive-b-cells-checkpoints-b-cell
*  Abnormalities of B cell phenotype, immunoglobulin gene expression and the emergence of autoimmunity in Sjögren's syndrome |...
Hansen A, Jacobi AM, Burmester GR, Lipsky PE, Dörner T: Comparison of heavy chain rearrangements in the blood and parotid gland ... suggesting that the basic process of IgV gene recombination is largely normal in patients with these autoimmune diseases. This ... Of potential importance is the fact that enhanced levels of B lymphocyte stimulator (BLyS; also known as B cell activating ... indicating intact selective mechanisms with selection against R mutations in the frame work regions that might cause structural ...
  https://arthritis-research.biomedcentral.com/articles/10.1186/ar603
*  Fundamentals of Feto-Neonatal Immunology and Its Clinical Relevance | Springer for Research & Development
Bauer K, Zemlin M, Hummel M et al (2002) Diversification of Ig heavy chain genes in human preterm neonates prematurely exposed ... Collins AM, Sewell WA, Edwards MR (2003) Immunoglobulin gene rearrangement, repertoire diversity, and the allergic response. ... Liu CC, Young LH, Young JD (1996) Lymphocyte-mediated cytolysis and disease. N Engl J Med 335: 1651-1659PubMedCrossRefGoogle ... Teyton L, Apostolopoulos V, Cantu C 3rd et al (2000) Function and dysfunction of T cell receptor: Structural studies. Immunol ...
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*  Document 7319
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*  Faculty
Regulation of B cell fate commitment and immunoglobulin heavy-chain gene rearrangements by Ikaros. Nature Immunology, 9(8), 927 ... Fukunaga R, Yokoyama S, "Structural insights into the first step of RNA-dependent cysteine biosynthesis in archaea. Structural ... Molecular pathways and mechanisms regulating the recombination of immunoglobulin genes during B-lymphocyte development. Adv Exp ... 2) What molecular and cellular events underlie Ephexin5-mediated excitatory synapse restriction important for basic wiring of ...
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*  Mark Nicolls | Stanford Medicine Profiles
We study the clonal structure of the B cell repertoire in SSc-PAH using immunoglobulin heavy chain (IGH) sequencing before and ... Gene microarray study corroborates proteomic findings in rodent islet cells JOURNAL OF PROTEOME RESEARCH Cardozo, A. K., ... Nicolls has a special interest in how the immune system contributes to vascular disease and has a basic science laboratory ... Pulmonary vascular structural changes frequently increase pulmonary vascular resistance, causing PH and right heart failure. ...
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