*  Endonuclease 8-like 1 (Q96FI4) | InterPro | EMBL-EBI
InterPro provides functional analysis of proteins by classifying them into families and predicting domains and important sites ... GO:0003684 damaged DNA binding GO:0003906 DNA-(apurinic or apyrimidinic site) lyase activity GO:0008270 zinc ion binding GO: ... GO:0006284 base-excision repair GO:0006289 nucleotide-excision repair Molecular Function. GO:0003676 nucleic acid binding ... Some features on this website won't work properly (Click here to enable JavaScript). ...
  http://www.ebi.ac.uk/interpro/protein/Q96FI4
*  APEX1 - Wikipedia
DNA-(apurinic or apyrimidinic site) lyase is an enzyme that in humans is encoded by the APEX1 gene. Apurinic/apyrimidinic (AP) ... Mol CD, Hosfield DJ, Tainer JA (2000). "Abasic site recognition by two apurinic/apyrimidinic endonuclease families in DNA base ... by DNA damaging agents or by DNA glycosylases that remove specific abnormal bases. AP sites are pre-mutagenic lesions that can ... Robson CN, Hickson ID (1991). "Isolation of cDNA clones encoding a human apurinic/apyrimidinic endonuclease that corrects DNA ...
  https://en.wikipedia.org/wiki/APEX1
*  FPG IleRS zinc finger - Wikipedia
... apurinic/apyrimidinic) lyase activity introduces nicks in the DNA strand, cleaving the DNA backbone by beta-delta elimination ... to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates. Fpg is a monomer composed of ... DNA glycosylase/AP lyase enzymes are involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. These ... phosphodiester bonds of the resulting apurinic/apyrimidinic site (AP lyase activity; EC). Fpg has a preference for oxidised ...
  https://en.wikipedia.org/wiki/FPG_IleRS_zinc_finger
*  APEX1 purified MaxPab rabbit polyclonal antibody (D02P) - (H00000328-D02P) - Products - Abnova
DNA-(apurinic or apyrimidinic site) lyase,OTTHUMP00000163988,apurinic/apyrimidinic (abasic) endonuclease,apurinic/apyrimidinic ... by DNA damaging agents or by DNA glycosylases that remove specific abnormal bases. AP sites are pre-mutagenic lesions that can ... Apurinic/apyrimidinic (AP) sites occur frequently in DNA molecules by spontaneous hydrolysis, ... prevent normal DNA replication so the cell contains systems to identify and repair such sites. Class II AP endonucleases cleave ...
  http://www.abnova.com/products/products_detail.asp?Catalog_id=H00000328-D02P&SL=
*  APEX1 Pre-design Chimera RNAi - (H00000328-R03) - Products - Abnova
... multifunctional DNA repair enzyme) 1 (APEX1), transcript variant 3, mRNA. (H00000328-R03) - Products - Abnova ... DNA-(apurinic or apyrimidinic site) lyase,OTTHUMP00000163988,apurinic/apyrimidinic (abasic) endonuclease,apurinic/apyrimidinic ... by DNA damaging agents or by DNA glycosylases that remove specific abnormal bases. AP sites are pre-mutagenic lesions that can ... Apurinic/apyrimidinic (AP) sites occur frequently in DNA molecules by spontaneous hydrolysis, ...
  http://www.abnova.com/products/products_detail.asp?catalog_id=H00000328-R03
*  Biomolecules | Free Full-Text | Functional Aspects of PARP1 in DNA Repair and Transcription | HTML
Inhibiting its enzyme activity with small molecules thus achieves synthetic lethality by preventing unwanted DNA repair in the ... we shall discuss how transcription and DNA repair are so intricately linked that disturbance by PARP1 enzymatic inhibition, ... is an ADP-ribosylating enzyme essential for initiating various forms of DNA repair. ... Apurinic/apyrimidinic (AP) site recognition by the 5'-dRP/AP lyase in poly(ADP-ribose) polymerase-1 (PARP-1). Proc. Natl. Acad ...
  http://mdpi.com/2218-273X/2/4/524/htm
*  DNA-(apurinic or apyrimidinic site) lyase - Wikipedia
In E. coli, DNA AP lyase (endonuclease III) helps repair oxidative damage to DNA bases by catalyzing the excision of the ... In enzymology, DNA-(apurinic or apyrimidinic site) lyase, also referred to as DNA-(apurinic or apyrimidinic site) 5'- ... "Homo sapiens GO:0003906 - DNA-(apurinic or apyrimidinic site) lyase activity". HumanCyc. SRI International. Retrieved March 9, ... Several names for DNA AP lyase include: AP lyase; AP endonuclease class I; endodeoxyribonuclease (apurinic or apyrimidinic); ...
  https://en.wikipedia.org/wiki/DNA-(apurinic_or_apyrimidinic_site)_lyase
*  mutM - Formamidopyrimidine-DNA glycosylase - Erwinia tasmaniensis (strain DSM 17950 / CIP 109463 / Et1/99) - mutM gene & protein
... apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta ... elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates. ... Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8 ... Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. ...
  http://www.uniprot.org/uniprot/B2VF70
*  mutM - Formamidopyrimidine-DNA glycosylase - Nitrosomonas eutropha (strain C91) - mutM gene & protein
... apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta ... elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates. ... Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8 ... Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. ...
  http://www.uniprot.org/uniprot/Q0AD66
*  mutM - Formamidopyrimidine-DNA glycosylase - Acinetobacter baylyi (strain ATCC 33305 / BD413 / ADP1) - mutM gene & protein
... apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta ... elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates. ... Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8 ... Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. ...
  http://www.uniprot.org/uniprot/Q6FE90
*  H2TH domain - Wikipedia
... apurinic/apyrimidinic) lyase activity introduces nicks in the DNA strand, cleaving the DNA backbone by beta-delta elimination ... to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates. Fpg is a monomer composed of ... is a DNA-binding domain found in DNA glycosylase/AP lyase enzymes, which are involved in base excision repair of DNA damaged by ... phosphodiester bonds of the resulting apurinic/apyrimidinic site (AP lyase activity;EC 4.2.99.18). Fpg has a preference for ...
  https://en.wikipedia.org/wiki/H2TH_domain
*  The Rate of hOGG1-mediated 8-oxoG Removal from Nucleosomal DNA
... including the removal and replacement of damaged DNA bases via base excision repair (BER). This pathway invo ... Organisms have evolved to repair DNA damage through several pathways, ... DNA damage can lead to mutagenesis and carcinogenesis. ... the damage site is treated by an apurinic/apyrimidinic lyase, ... including the removal and replacement of damaged DNA bases via base excision repair (BER). This pathway involves an enzymatic ...
  http://www.jbsdonline.com/the-rate-hogg1-mediated-8-oxog-removal-nucleosomal-dna-p18596.html
*  UniProt: Q4QLW2
... lyase activity; IEA:UniProtKB-EC. DR GO; GO:0140080; F:class III/IV DNA-(apurinic or apyrimidinic site) lyase activity; IEA: ... Cleaves the DNA backbone by beta-delta elimination CC to generate a single-strand break at the site of the removed base CC with ... DNA-(apurinic or apyrimidinic site) lyase MutM {ECO:0000255,HAMAP-Rule:MF_00103}; DE Short=AP lyase MutM {ECO:0000255,HAMAP- ... DNA_glyclase/AP_lyase_DNA-bd. DR InterPro; IPR015887; DNA_glyclase_Znf_dom_DNA_BS. DR InterPro; IPR020629; Formamido-pyr_DNA_ ...
  http://www.genome.jp/dbget-bin/www_bget?uniprot:Q4QLW2
*  OGG1 - N-glycosylase/DNA lyase - Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) - OGG1 gene & protein
Has a beta-lyase activity that nicks DNA 3' to the lesion. ... DNA repair enzyme that incises DNA at 8-oxoG residues. Excises ... 7,8-dihydro-8-oxoguanine and 2,6-diamino-4-hydroxy-5-N-methylformamidopyrimidine (FAPY) from damaged DNA. ... apurinic or apyrimidinic site) lyase activity Source: UniProtKB-EC. *class III/IV DNA-(apurinic or apyrimidinic site) lyase ... site' target='_top'>More...,/a>,/p>Active sitei. 241. Schiff-base intermediate with DNA. 1. ...
  http://www.uniprot.org/uniprot/P53397
*  APEX1 antibody | pab50070 | Covalab - Covalab Biotechnology
... apurinic or apyrimidinic site) lyase (APE-1) antibody , P27695 , APEX nuclease (APEN), Apurinic-apyrimidinic endonuclease 1 (AP ... Functions as a apurinic/apyrimidinic (AP) endodeoxyribonuclease in the DNA base excision repair (BER) pathway of DNA lesions ... DNA-(apurinic or apyrimidinic site) lyase (APE-1) antibody. APEX nuclease (APEN). Apurinic-apyrimidinic endonuclease 1 (AP ... Affinity purified human Apurinic/Apyrimidinic Endonuclease (APE/ref-1) fusion protein. Target Specificity Reacts with human ~37 ...
  https://www.covalab.com/dna-apurinic-or-apyrimidinic-site-lyase-ape-1-antibody-2.html
*  Recombinant Human NEIL1 protein (ab123204) | Abcam
DNA glycosylase/AP lyase Neil1. *DNA-(apurinic or apyrimidinic site) lyase Neil1 ... Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both ... Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. ... Epigenetics and Nuclear Signaling DNA / RNA DNA Damage & Repair Base Excision Repair ...
  http://www.abcam.com/recombinant-human-neil1-protein-ab123204.html
*  AP site - Wikipedia
... apurinic/apyrimidinic site), also known as an abasic site, is a location in DNA (also in RNA but much less likely) that has ... a DNA glycosylase recognizes a damaged base and cleaves the N-glycosidic bond to release the base, leaving an AP site. A ... see DNA structure). In alternative fashion, bifunctional glycosylase-lyases can cleave the AP site, leaving a 5' phosphate ... It has been estimated that under physiological conditions 10,000 apurinic sites and 500 apyrimidinic may be generated in a cell ...
  https://en.wikipedia.org/wiki/AP_site
*  MUTYH - Wikipedia
The excision of the bases causes the formation of an apurinic/ apyrimidinic (AP site) gap. These gap sites are mutagenic in ... namely polymerase and dRP lyase. DNA ligase is used to seal the fragments after dRP excision causes the formation of 5'PO4 that ... the result of base pair transversion. The enzyme excises adenine bases from the DNA backbone at sites where adenine is ... MUTYH (mutY DNA glycosylase, earlier mutY Homolog (E. coli)) is a human gene that encodes a DNA glycosylase, MUTYH glycosylase ...
  https://en.wikipedia.org/wiki/MUTYH
*  DNA-binding protein RFX8 | definition of DNA-binding protein RFX8 by Medical dictionary
What is DNA-binding protein RFX8? Meaning of DNA-binding protein RFX8 medical term. What does DNA-binding protein RFX8 mean? ... Looking for online definition of DNA-binding protein RFX8 in the Medical Dictionary? DNA-binding protein RFX8 explanation free ... DNA-apurinic or apyrimidinic site lyase 2. *DNA-based Immunomodulatory Sequence. *DNA-Binding Domain Protein ... DNA-(apurinic or apyrimidinic site) lyase. *DNA-(apurinic or apyrimidinic site) lyase 2 ...
  https://medical-dictionary.thefreedictionary.com/DNA-binding+protein+RFX8
*  Endonuclease III homolog 2 (Q08214) | InterPro | EMBL-EBI
InterPro provides functional analysis of proteins by classifying them into families and predicting domains and important sites ... GO:0003906 DNA-(apurinic or apyrimidinic site) lyase activity GO:0019104 DNA N-glycosylase activity GO:0051539 4 iron, 4 sulfur ... GO:0006281 DNA repair GO:0006284 base-excision repair GO:0006285 base-excision repair, AP site formation ... Some features on this website won't work properly (Click here to enable JavaScript). ...
  http://www.ebi.ac.uk/interpro/protein/Q08214
*  Simultaneous sensitive detection of multiple DNA glycosylases from lung cancer cells at the single-molecule level - Chemical...
hOGG1 may catalyze the removal of 8-oxoG from 8-oxoG/C base pairs to generate an apurinic/apyrimidinic (AP) site, and hAAG may ... The bi-functional hOGG1 enzyme is responsible for the excision of 8-oxoguanine (8-oxoG) with combined glycosylase/lyase ... Human 8-oxoguanine DNA glycosylase (hOGG1), human alkyladenine DNA glycosylase (hAAG), human apurinic/apyrimidinic endonuclease ... releasing the damaged base to form an AP site.15-17 The AP site is then cleaved by a Schiff base intermediate and APE1, leading ...
  http://pubs.rsc.org/en/content/articlehtml/2018/sc/c7sc04296e
*  Crystal structure of a repair enzyme of oxidatively damaged DNA, MutM (Fpg), from an extreme thermophile, Thermus thermophilus...
... phosphodiester bonds of the resulting apurinic/apyrimidinic site (AP lyase activity). The crystal structure of MutM from an ... DNA glycosylase activity, which excises various damaged bases from DNA to produce an aldehydic abasic site; (ii) an AP lyase ... A DNA glycosylase which excises imidazole ring‐opened purines and nicks DNA at apurinic/apyrimidinic sites. J Biol Chem, 265, ... DNA glycosylase of Escherichia coli and an activity nicking DNA at apurinic/apyrimidinic sites. Proc Natl Acad Sci USA, 86, ...
  http://emboj.embopress.org/content/19/15/3857
*  DNA glycosylase - Wikipedia
... creating an apurinic/apyrimidinic site, commonly referred to as an AP site. This is accomplished by flipping the damaged base ... "Role of the Arabidopsis DNA glycosylase/lyase ROS1 in active DNA demethylation". Proc. Natl. Acad. Sci. U.S.A. 103 (31): 11796- ... Base excision repair is the mechanism by which damaged bases in DNA are removed and replaced. DNA glycosylases catalyze the ... AlkA refers to 3-methyladenine DNA glycosylase II. DNA glycosylases involved in base excision repair (BER) may be associated ...
  https://en.wikipedia.org/wiki/DNA_glycosylase
*  Base Excision Repair, AP Endonucleases and DNA Glycosylases
Base excision repair is an important cellular mechanism that protects the integrity of DNA by repairing damage caused by ... Mol CD, Hosfield DJ and Tainer JA (2000) Abasic site recognition by two apurinic/apyrimidinic endonuclease families in DNA base ... 2000) The lyase activity of the DNA repair protein β‐polymerase protects from DNA‐damage‐induced cytotoxicity. Nature 405: 807- ... The altered DNA base, and in some cases a few nucleotides adjacent to the altered base, is removed by excision, and the DNA is ...
  http://www.els.net/WileyCDA/ElsArticle/refId-a0000563.html
*  AP endonuclease - Wikipedia
Apurinic/apyrimidinic (AP) endonuclease is an enzyme that is involved in the DNA base excision repair pathway (BER). Its main ... Class I AP endonucleases (EC 4.2.99.18) cleave 3' to AP sites by a β-lyase mechanism, leaving an unsaturated aldehyde, termed a ... which pack tightly with the hydrophobic side of the AP site, discriminating against sites that do have bases. The AP site is ... Levin, Joshua D; Demple, Bruce (1990). "Analysis of class II (hydrolytic) and class I (beta-lyase) apurinic/apyrimidinic ...
  https://en.wikipedia.org/wiki/AP_endonuclease