Quantitative MRI reveals the elderly ischemic brain is susceptible to increased early blood-brain barrier permeability...
Quantitative MRI reveals the elderly ischemic brain is susceptible to increased early blood-brain barrier permeability ... following tissue plasminogen activator related to claudin 5 and occludin disassembly ... alteplase; claudin 5; gadolinium pentetate; occludin; age distribution; aged; aging; animal experiment; animal model; article; ... Blood-brain barrier permeability for Gd-DTPA (K Gd) was substantial following reperfusion in all animal groups and was ...http://nparc.nrc-cnrc.gc.ca/eng/view/object/?id=ae12c4a7-5885-474d-9f42-8acdfa74a406
P-glycoprotein regulates blood-testis barrier dynamics via its effects on the occludin/zonula occludens 1 (ZO-1) protein...
P-glycoprotein regulates blood-testis barrier dynamics via its effects on the occludin/zonula occludens 1 (ZO-1) protein ... The blood-testis barrier (BTB), one of the tightest blood-tissue barriers in the mammalian body, creates an immune-privileged ... barrier "leaky." This effect was mediated by changes in the protein phosphorylation status of occludin via the action of FAK, ... creating the occludin/ZO-1/FAK/P-glycoprotein regulatory complex. Interestingly, a knockdown of P-glycoprotein by RNAi was ...http://www.popcouncil.org/research/p-glycoprotein-regulates-blood-testis-barrier-dynamics-via-its-effects-on-t
Redistribution of Tight Junction Proteins During EPEC Infection In Vivo | Springer for Research & Development
enteropathogenic E. coli tight junction claudins occludin barrier function This is a preview of subscription content, log in to ... Tight junctions and the modulation of barrier function in disease. Histochemistry and Cell Biology 130: 55-70.PubMedCrossRef ... Permeability in Crohn's disease: altered barrier functions in healthy relatives? Gastroenterology 104: 1848-1851.PubMedGoogle ... Intestinal barrier function: molecular regulation and disease pathogenesis. The Journal of Allergy and Clinical Immunology 124 ...https://rd.springer.com/article/10.1007/s10753-010-9285-1
Frontiers | Myosin Light Chain Kinase: A Potential Target for Treatment of Inflammatory Diseases | Pharmacology
The influence of MLCK in inflammatory diseases starts with endothelial barrier dysfunction. The effectiveness of anti-MLCK ... The influence of MLCK in inflammatory diseases starts with endothelial barrier dysfunction. The effectiveness of anti-MLCK ... The signaling pathways involved in MLCK activation and triggering of endothelial barrier dysfunction are discussed in this ... The signaling pathways involved in MLCK activation and triggering of endothelial barrier dysfunction are discussed in this ...https://www.frontiersin.org/articles/10.3389/fphar.2017.00292/full
JCI - Egress of sperm autoantigen from seminiferous tubules maintains systemic tolerance
E) FITC (green) exclusion by the occludin+ Sertoli cell barrier (red) of seminiferous tubules in an OVA-Hi mouse testis (left) ... The Sertoli cell barrier is not an endothelial barrier, and circulating Abs readily enter the testicular interstitial space (19 ... outside the occludin+ Sertoli cell barrier (red) in adult WT mouse testes (n = 7) surrounding approximately 18% of seminiferous ... are detected outside the occludin+ Sertoli cell barrier (red) and (G) inside interstitial MHC class II+ macrophages (green, ...https://jci.org/articles/view/89927
KAKEN - Researchers | MAEDA Naoyuki (00273623)
Expression of occludin and epithelial barrier function in the corneal epithelium. *. Principal Investigator. WATANABE Hitoshi ... Occludin / 調節痙攣 / Ischemic Optic Neuropathy / 核白内障 / レクチン / Nuclear Cataract / ZO-1 / MISI gene / High Myopia / Macular ...https://nrid.nii.ac.jp/nrid/1000000273623/
Efficacy of Intravitreal Injections of Triamcinolone Acetonide in a Rodent Model of Nonarteritic Anterior Ischemic Optic...
Glucocorticoid induction of occludin expression and endothelial barrier requires transcription factor p54 NonO. Invest ... Triamcinolone treatment has also been reported to stabilize the blood-retinal barrier and prevent osmotic swelling of Müller ... A novel mechanism for glucocorticoid-induced tightening of endothelial barriers. Invest Ophthalmol Vis Sci. 2013; 54: 4016. ... Glucocorticoids induce transactivation of tight junction genes occludin and claudin-5 in retinal endothelial cells via a novel ...https://iovs.arvojournals.org/article.aspx?articleid=2515093
Jiang R[au] - PubMed - NCBI
Effect of electroacupuncture at ST36 on the intestinal mucosal mechanical barrier and expression of occludin in a rat model of ... Mechanical and barrier properties of corn distarch phosphate-zein bilayer films by thermocompression. ...https://www.ncbi.nlm.nih.gov/pubmed?cmd=search&term=Jiang+R%5Bau%5D&dispmax=50
Estrogen Enhances Esophageal Barrier Function by Potentiating Occludin Expression.. *Authors:. *Junya Honda, ...https://www.pubfacts.com/author/Tooru+Shimosegawa
Cell Junctions | Boundless Anatomy and Physiology
Occludins, which maintain the barrier between adjacent cells.. *Claudins, which form the backbone of tight junction strands. ... Occludin: Model of the protein structure of the coiled-coil domain of human occludin. ... The occludins and claudins are the major components of tight junction strands. When fully formed, a tight junction is not one, ... blood-brain barrier: A structure in the central nervous system (CNS) that keeps various substances found in the bloodstream out ...https://courses.lumenlearning.com/boundless-ap/chapter/cell-junctions/
Protein Kinase Cβ Phosphorylates Occludin Regulating Tight Junction Trafficking in Vascular Endothelial Growth Factor-Induced...
Occludin S408 phosphorylation regulates tight junction protein interactions and barrier function. J Cell Biol 2011;193:565-582 ... occludin fragments. B: Occludin immunoblot with polyclonal occludin antibody. ... PKCβ-mediated occludin reduction by VEGF. A: VEGF-induced loss of occludin content in retinas was prevented by PKCβ inhibitors ... PKCβ-mediated occludin modifications in rat retinas. A: Occludin IP and phospho-Ser 490 or ubiquitin blot demonstrate time ...http://diabetes.diabetesjournals.org/content/61/6/1573
JCI - Cigarette smoke and HIV synergistically affect lung pathology in cynomolgus macaques
Occludin S408 phosphorylation regulates tight junction protein interactions and barrier function. J Cell Biol. 2011;193(3):565- ... Junctional adhesion molecule A promotes epithelial tight junction assembly to augment lung barrier function. Am J Pathol. 2015; ... compromised the airway epithelial barrier that is dependent on the interaction of tight junction proteins such as occludin ( ... In addition, changes in the epithelial barrier and upper airway structures underscore the inference that the lung undergoes ...https://www.jci.org/articles/view/121935
Impact of Kefir Derived Lactobacillus kefiri on the Mucosal Immune Response and Gut Microbiota
... epithelial barrier and IgA related genes were zo-1, occludin, and pIgR; mucin genes were muc1, muc2, muc3, muc4, muc6, and ... C. L. Ohland and W. K. MacNaughton, "Probiotic bacteria and intestinal epithelial barrier function," The American Journal of ... M. Rescigno, "The intestinal epithelial barrier in the control of homeostasis and immunity," Trends in Immunology, vol. 32, no ... The expression of cytokines, chemokines, mucins, and epithelial barrier genes as well as IgA related genes was studied by qRT- ...https://www.hindawi.com/journals/jir/2015/361604/
Protocols and Video Articles Authored by Milena Z. Adzemovic (Translated to Hebrew)
Increased intrathecal production of CCL11 in congenic rats was accompanied by a tighter blood brain barrier, reflected by more ... occludin(+) blood vessels. In addition, the congenic strain showed a reduced antigen specific response and a predominant anti- ... Imatinib Ameliorates Neuroinflammation in a Rat Model of Multiple Sclerosis by Enhancing Blood-brain Barrier Integrity and by ... Neurodegeneration in ALS mouse models occurs together with signs of disrupted blood-spinal cord barrier (BSCB) and regressed ...https://www.jove.com/author/Milena+Z._Adzemovic?language=Hebrew
Genome-wide transcriptome analysis using RNA-Seq reveals a large number of differentially expressed genes in a transient MCAO...
Oxidative stress increases blood-brain barrier permeability and induces alterations in occludin during hypoxia-reoxygenation. J ... Matrix metalloproteinases and TIMPs are associated with blood-brain barrier opening after reperfusion in rat brain. Stroke. ... Polymerase delta-interacting protein 2 deficiency protects against blood-brain barrier permeability in the ischemic brain. J ... disturbance of the blood-brain barrier, accumulation of excess oxygen radicals and activation of apoptosis [10, 18, 37-39]. ...https://bmcgenomics.biomedcentral.com/articles/10.1186/s12864-018-5039-5
The Dual Role of Zonula Occludens (ZO) Proteins
Eph4 cells lacking ZO-1 show a retarded recruitment of claudins and occludin to TJs, and delayed barrier establishment . ... In addition, delayed arrival of ZO-1, occludin and E-cadherin at newly formed junctions following C. -switch was observed. ... J. Xu, F. Anuar, S. M. Ali, Y. N. Mei, D. C. Y. Phua, and W. Hunziker, "Zona occludens-2 is critical for blood-testis barrier ... embryos . A critical role of ZO-2 for the blood-testis barrier was demonstrated recently by Xu et al. showing that a lack ...https://www.hindawi.com/journals/bmri/2010/402593/
Spontaneous Bacterial Keratitis in CD36 Knockout Mice | IOVS | ARVO Journals
Chen Y Merzdorf C Paul DL Goodenough DA . COOH terminus of occludin is required for tight junction barrier function in early ... Furthermore, CD36 has been shown to play a critical role in both maintaining the epidermal barrier and restoring the barrier ... these barriers effectively prevent infection. However, a disruption of these barriers due to injury or disease significantly ... The epithelial barrier function in the corneas of CD36−/− mice. (A) Rose Bengal staining was performed on WT-C57BL/6 mice and ...https://iovs.arvojournals.org/article.aspx?articleid=2126531
Intranet - IMP/IMBA - Publications
2001). Perturbation of the tight junction permeability barrier by occludin loop peptides activates beta-catenin/TCF/LEF- ...http://cores.imp.ac.at/biooptics/publications/?xhtml=1%2F%5C%5C%5C%5C%5C%5C%5C%5C%5C%5C%5C%5C%5C%5C%5C%5C%5C%5C%5C%5C%5C%5C%5C%5C%5C%5C%5C%5C%5C%5C%5C%27From%2FRK%3D0%2FRS%3DUhWihNMQI1LWDV3V.sJxktWcMkU-
Frontiers | The Role of Substance P in Secondary Pathophysiology after Traumatic Brain Injury | Neurology
The improvements in these parameters occurred in association with an improvement in blood brain barrier integrity to serum ... The improvements in these parameters occurred in association with an improvement in blood brain barrier integrity to serum ... increased blood brain barrier permeability and edema formation. Edema formation is associated with the development of increased ... increased blood brain barrier permeability and edema formation. Edema formation is associated with the development of increased ...https://www.frontiersin.org/articles/10.3389/fneur.2017.00304/full
ZO-3, a Novel Member of the MAGUK Protein Family Found at the Tight Junction, Interacts with ZO-1 and Occludin | JCB
Data clearly indicate that occludin has a role in the paracellular permeability barrier (6, 31, 45), as expected from a ... Data from several laboratories indicate that occludin functions as part of the paracellular permeability barrier (6, 31, 45) ... 1994) Direct association of occludin with ZO-1 and its possible involvement in the localization of occludin at tight junctions ... A synthetic peptide corresponding to the extracellular domain of occludin perturbs the tight junction permeability barrier. J ...http://jcb.rupress.org/content/141/1/199
Epithelial Barrier Modulation by a Channel Forming Peptide, The Journal of Membrane Biology | 10.1007/s00232-008-9099-3 |...
"Epithelial Barrier Modulation by a Channel Forming Peptide, The Journal of Membrane Biology" on DeepDyve, the largest online ... A synthetic peptide corresponding to the extracellular domain of occludin perturbs the tight junction permeability barrier ... Epithelial Barrier Modulation by a Channel Forming Peptide. Epithelial Barrier Modulation by a Channel Forming Peptide ... Epithelial Barrier Modulation by a Channel Forming Peptide. Somasekharan, Suma; Brandt, Robert; Iwamoto, Takeo; Tomich, John; ...https://www.deepdyve.com/lp/springer_journal/epithelial-barrier-modulation-by-a-channel-forming-peptide-DgeaV507Z0
Polyamines are necessary for synthesis and stability of occludin protein in intestinal epithelial cells | Gastrointestinal and...
Chen Y, Merzdorf C, Paul DL, and Goodenough DA. COOH terminus of occludin is required for tight junction barrier function in ... Expression of occludin mRNAs and protein was measured by semiquantitative RT-PCR and Western blot analysis, whereas barrier ... 1 show that polyamine depletion dramatically decreased levels of occludin, ZO-1, and ZO-2 proteins, but the epithelial barrier ... Measurement of occludin protein synthesis.. Occludin protein synthesis was examined by using 35S-methionine-labeling technique ...http://ajpgi.physiology.org/content/288/6/G1159
Frontiers | Cerebral Microvascular Endothelial Cell Apoptosis after Ischemia: Role of Enolase-Phosphatase 1 Activation and Aci...
In this study, we investigated the role of ENOPH1 in blood brain barrier (BBB) injury under ischemic conditions. Focal cerebral ... In this study, we investigated the role of ENOPH1 in blood brain barrier (BBB) injury under ischemic conditions. Focal cerebral ... Normobaric hyperoxia attenuates early blood-brain barrier disruption by inhibiting MMP-9-mediated occludin degradation in focal ... mediated occludin degradation and caveolin-1-mediated claudin-5 redistribution contribute to blood-brain barrier damage in ...https://www.frontiersin.org/articles/10.3389/fnmol.2016.00079/full
... results in reversible ultrastructure and occludin tight junction protein expression changes in hippocampal blood-brain barrier ... Hypoxia-inducible factor-1α is involved in isoflurane-induced blood-brain barrier disruption in aged rats model of POCD.. ... Surgery-Induced Hippocampal Angiotensin II Elevation Causes Blood-Brain Barrier Disruption via MMP/TIMP in Aged Rats.. Authors: ...https://www.pubfacts.com/author/Cheng+Ni
DCU Faculties and Centres: School of Biotechnology - DORAS - DCU
Collins, Nora (2006) Hemodynamic regulation of occludin and ZO-1: effect on barrier function. PhD thesis, Dublin City ... Factors affecting microvascular endothelial tight junction assembly and barrier function in the blood-brain barrier. PhD thesis ... Walsh, Tony G. (2010) Hemodynamic regulation of blood-brain barrier phenotype: A cooperative effort linking adherens and tight ... Rochfort, Keith D. (2013) Characterisation of anti-inflammatory and pro-inflammatory influences on blood-brain barrier ...http://doras.dcu.ie/view/groups/groups4a.html