A Bioinformatics Analysis of Bacterial Type-III Secretion System Genes and Proteins - eTheses Repository
A Bioinformatics Analysis of Bacterial Type-III Secretion System Genes and Proteins. ... T3SSs consist of multiple proteins which assemble to form an apparatus capable of exporting proteins through both membranes of ... Type-III secretion systems (T3SSs) are responsible for the biosynthesis of flagella, and the interaction of many animal and ... Proteins conserved amongst T3SSS can be used for analysis of these systems using computational homology searching. By using ...http://etheses.bham.ac.uk/1300/
NMR STUDIES OF BACTERIAL TYPE III SECRETION APPARATUS NEEDLE AND TIP PROTEINS AND THE NMR STRUCTURE OF THE HANTAVIRUS...
NMR STUDIES OF BACTERIAL TYPE III SECRETION APPARATUS NEEDLE AND TIP PROTEINS AND THE NMR STRUCTURE OF THE HANTAVIRUS ... The type III secretion apparatus (TTSA) functions like a syringe to inject proteins through an external needle and into a ... Many Gram-negative bacterial pathogens utilize type III secretion systems (TTSSs) for subverting the normal cellular functions ... The tip complex is assembled by SipD, the tip protein in Salmonella, and BipD, the tip protein in Burkholderia. We also ...https://kuscholarworks.ku.edu/handle/1808/5438
Graduate Thesis Or Dissertation | Creation of an efficient protein expression and secretion system in the gram-positive...
Creation of an efficient protein expression and secretion system in the gram-positive bacterial vector, Streptococcus gordonii ... This bacterial expression system takes advantage of the natural pathway of protein export and anchoring on the surface of the ... These proteins were tested for the ability to bind chitin beads and cleave between the target protein and the intein. Results ... In this case, the affinity tag would need to be removed from the target protein. In order to both purify a protein and remove ...https://ir.library.oregonstate.edu/concern/graduate_thesis_or_dissertations/cn69m634q
Protein secretion systems in bacterial-host associations, and their description in the Gene Ontology
... ... including the processes of bacterial secretion. Here we survey bacterial secretion systems known to modulate interactions with ... Protein secretion plays a central role in modulating the interactions of bacteria with their environments. This is particularly ... A number of secreted proteins are destined to enter the host cell (effectors and toxins), and thus several secretion systems ...https://vtechworks.lib.vt.edu/handle/10919/18926
Defining Assembly Pathways by Fluorescence Microscopy | SpringerLink
Bacterial secretion systems are among the largest protein complexes in prokaryotes and display remarkably complex architectures ... Bacterial secretion systems are among the largest protein complexes in prokaryotes and display remarkably complex architectures ... Tseng T-T, Tyler B, Setubal J (2009) Protein secretion systems in bacterial-host associations, and their description in the ... In: Journet L., Cascales E. (eds) Bacterial Protein Secretion Systems. Methods in Molecular Biology, vol 1615. Humana Press, ...https://link.springer.com/protocol/10.1007%2F978-1-4939-7033-9_23
Screening for Secretion of the Type VI Secretion System Protein Hcp by Enzyme-Linked Immunosorbent Assay and Colony Blot |...
The T6SS facilitates the secretion and injection of toxic effector proteins into host... ... The bacterial type VI secretion system (T6SS) is a secretory apparatus encoded by many Gram-negative bacteria. ... In: Journet L., Cascales E. (eds) Bacterial Protein Secretion Systems. Methods in Molecular Biology, vol 1615. Humana Press, ... Screening for Secretion of the Type VI Secretion System Protein Hcp by Enzyme-Linked Immunosorbent Assay and Colony Blot. ...https://link.springer.com/protocol/10.1007%2F978-1-4939-7033-9_32
Biopolymers, Volume 7, Polyamides and Complex Proteinaceous Materials I - Fillers
Cell Membranes: Protein Components and Functions (W. Wimley). Bacterial Protein Secretion and Targeting (A. Driessen, et al.). ... self-assembling proteins, cell membranes, feathers, elastic proteins, silk proteins, adhesive proteins, protein composites, ... Topics included are: poly(g-d-glutamate), cyanophycin, modifications of proteins, sweet-tasting proteins, motor proteins, ... Self-assembling Symmetric Protein Materials (J. Padilla & T. Yu). Self-assembly Protein Systems: Microbial S-layers (U. Sleytr ...http://www.chemtec.org/proddetail.php?prod=978-3-527-30222-2&cat=19
Infectious Diseases | Sackler Faculty of Medicine | Tel Aviv University
Bacterial Protein Secretion Systems and Toxins'. Dr. Dor Salomon, Ph.D. and his lab are identifying novel virulent and ... Host-Virus Interactions in Bacterial Systems'. Prof. Udi Qimron, Ph.D. studies basic aspects of bacteriophage growth with ... Fuad Iraqi, Ph.D. actively identifies and characterizes genes involves in the host response to a variety of bacterial and ... emphasis on the recently identified bacterial defense system, the CRISPR. Our ultimate objective is to identify novel ...https://en-med.tau.ac.il/InfectiousDiseases
Staff Profile - Institute for Cell and Molecular Biosciences - Newcastle University
students on projects that exploit bacterial genetics to study bacterial protein secretion. ... My expertise utilise Bacterial genetics to study fundmental apsects of the bacterial life cycle. My laboratory uses, protein ... The bacterial flagellar protein export apparatus processively transports flagellar proteins even with extremely infrequent ATP ... The rate of protein secretion dictates the temporal dynamics of flagellar gene expression. Molecular Microbiology 2008, 70(4), ...http://www.ncl.ac.uk/camb/staff/profile/phillipaldridge.html
Type VI secretion requires a dynamic contractile phage tail-like structure
Type VI Secretion Systems (T6SS) are bacterial virulence-associated nanomachines composed of proteins that are evolutionarily ... Identification of a conserved bacterial protein secretion system in Vibrio cholerae using the Dictyostelium host model system. ... Type VI secretion system translocates a phage tail spike-like protein into target cells where it cross-links actin. Proc Natl ... T6SS+ bacterial effector cells are thought to kill target cells through delivery of toxic effector proteins in a cell-cell ...http://pubmedcentralcanada.ca/pmcc/articles/PMC3527127/?lang=en-ca
2003 May;185(9):2910-9. RN  RM PMID:16929299 RT Signal sequence directs localized secretion of bacterial surface proteins. ... RN  RM PMID: 12700270 RT The YSIRK-G/S motif of staphylococcal protein A and its role in efficiency of signal peptide ... There is a strong correlation between proteins carrying this region at the N-terminus and those carrying the Gram-positive ... Many surface proteins found in Streptococcus, Staphylococcus, and related lineages share apparently homologous signal sequences ...http://www.jcvi.org/cgi-bin/tigrfams/HmmReportPage.cgi?acc=TIGR01168
Frontiers | Modulation of Type III Secretion System in Pseudomonas aeruginosa: Involvement of the PA4857 Gene Product |...
... and bacterial motility,whereas chronic infectionsare often associated with biofilm formation and the type VI secretion system ( ... and bacterial motility,whereas chronic infectionsare often associated with biofilm formation and the type VI secretion system ( ... pathogen that causes serious acute or chronic infections in humans.Acute infections typically involve the type Ш secretion ... pathogen that causes serious acute or chronic infections in humans.Acute infections typically involve the type Ш secretion ...https://www.frontiersin.org/articles/10.3389/fmicb.2016.00007/full
Genome Update: Protein secretion systems in 225 bacterial genomes. Binnewies TT, Bendtsen JD, Hallin PF, Nielsen N, Wassenaar ... Genome opdate: Protein secretion systems in 225 bacterial genomes. Bennewies TT, Bendtsen JD, Hallin PF, Nielsen N, Wassenaar ... Genome update: Prediction of secreted proteins in 225 bacterial proteomes. Bendtsen JD, Binnewies TT, Hallin PF, Sicheritz- ... Functionality of System Components: Conservation of Protein Function in Protein Feature Space. Jensen LJ, Ussery DW, Brunak S. ...http://www.cbs.dtu.dk/publications/index.php?userid=517
Structures of the C-terminal CLTD subdomains of the Int | Open-i
The bacterial intimins and invasins: a large and novel family of secreted proteins. ... Furthermore, there is little understanding of the molecular events governing secretion of these proteins to the extracellular ... The bacterial intimins and invasins: a large and novel family of secreted proteins. ... Furthermore, there is little understanding of the molecular events governing secretion of these proteins to the extracellular ...https://openi.nlm.nih.gov/detailedresult.php?img=PMC3008723_pone.0014403.g007&req=4
Jorge E Galan, PhD, DVM > Microbial Pathogenesis | Yale School of...
American Society for Microbiology (1996 - Present) Colloquium: Type III Protein Secretion and Bacterial Pathogenesis, New ... Fallen Leaf Conferences (1998 - Present) Conference on Common Themes on Bacterial Transporters ...http://medicine.yale.edu/micropath/people/jorge_galan-1.profile
KEGG ENZYME: 188.8.131.52
Protein secretion by Gram-negative bacterial ABC exporters--a review.. Journal. Gene. 192 (1997) 7-11. ... Chemical substance (4) KEGG COMPOUND (4) Chemical reaction (2) KEGG REACTION (1) KEGG RCLASS (1) Protein sequence (492) UniProt ...http://www.genome.jp/dbget-bin/www_bget?ec:184.108.40.206
Bacteria use slime jets to get around | Physics Forums - The Fusion of Science and Community
... signal transduction or type III bacterial protein secretion'. Its interesting though. The bacteria are saying, 'look mom, no ... Bacterial Mobility and Chemotaxis: The Molecular Biology of a Behavioral System'. Dr. Robert Macnab of Yale University ... Actually, I didn't see the world 'jets' used in either of these articles but 'secretion of slime' to get around seemed to be a ... Bacterial Mobility and Chemotaxis: The Molecular Biology of a Behavioral System'. CRC Critical Reviews in Biochemistry, vol. 5 ...https://www.physicsforums.com/threads/bacteria-use-slime-jets-to-get-around.116288/
Microbiology Society Journals | Interactions of Burkholderia cenocepacia and other Burkholderia cepacia complex bacteria with...
Identification of a conserved bacterial protein secretion system in Vibrio cholerae using the Dictyostelium host model system. ... Galán, J. E. & Wolf-Watz, H. ( 2006 ). Protein delivery into eukaryotic cells by type III secretion machines. Nature 444, 567- ... Backert, S. & Meyer, T. F. ( 2006 ). Type IV secretion systems and their effectors in bacterial pathogenesis. Curr Opin ... A virulence locus of Pseudomonas aeruginosa encodes a protein secretion apparatus. Science 312, 1526-1530.[CrossRef] [Google ...http://mic.microbiologyresearch.org/content/journal/micro/10.1099/mic.0.031344-0
Keystone Symposia | Scientific Conferences on Biomedical and Life Science Topics
Type III Secretion Machines: Bacterial Devices for Protein Delivery into Eukaryotic Cells. ... AAA+ protein machines catalyze basic biological processes: they degrade proteins, remodel protein complexes and nucleic acids, ... The ClpXP Protein-Unfolding Machine. Aaron L. Lucius, University of Alabama at Birmingham, USA Short Talk: Examination of E. ... p97 as a Protein Targeting Platform. Andreas Matouschek, University of Texas at Austin, USA A Second Component to the ...https://www.keystonesymposia.org/index.cfm?e=web.Meeting.Program&meetingid=1077
New research could provide new insights into tuberculosis and other diseases // News // Eck Institute for Global Health //...
Their method could also help in the identification of compounds that can inhibit bacterial protein secretion. ... enzymes or fluorescent markers to bacterial proteins to identify bacterial genes that are used to export bacterial proteins ... For bacterial pathogens such as TB, these systems transport bacterial proteins that promote interaction with host cells, ... of Notre Dame's Eck Institute for Global Health have developed a method to directly detect bacterial protein secretion, which ...http://globalhealth.nd.edu/news/new-research-could-provide-new-insights-into-tuberculosis-and-other-diseases/
Resistance to Bacterial Pathogens in Plants
Alfano JR and Collmer A (2004) Type III secretion system effector proteins: double agents in bacterial disease and plant ... Keywords: bacterial pathogens; disease resistance; effector proteins; type three secretion system; plants ... Hueck CJ (1998) Type III protein secretion systems in bacterial pathogens of animals and plants. Microbiology and Molecular ... Direct and indirect recognition of bacterial effectors: (a) The bacterial pathogen R. solanacearum injects the effector protein ...http://www.els.net/WileyCDA/ElsArticle/refId-a0020091.html
This Week in Science | Science
Mougous et al. (p. 1526) provide evidence for an unusual form of bacterial protein secretion in Pseudomonas aeruginosa that is ... The major protein exported by the secretion apparatus is Hcp1. The authors present the crystal structure of Hcp1, which forms a ... Transport of proteins across the mitochondrial inner membrane occurs through the Tim23 protein translocation channel. Transport ... Meinecke et al. (p. 1523) found that the protein Tim50 is crucial for maintaining membrane potential. When the Tim23 channel ...http://science.sciencemag.org/content/312/5779/twis
ANTIBACTERIAL PEPTIDES ACTIVE IN SYSTEMIC INFECTIONS - Patent application
Bacterial membrane protein secretion. New patent applications in this class:. Date. Title. ... The Chex1-Arg20 peptide reduced the bacterial counts in a dose- and time-dependent manner. While at 10 mg/kg, the bacterial ... is the C-terminal D-E helix of the 70 kDa bacterial heat shock protein DnaK (Otvos et al., 2005. J. Med. Chem. 48: 5349-5359; ... determining blood bacterial counts. Table 5 shows the effect of peptide Chex1-Arg20 on blood bacterial counts of mice ...http://www.patentsencyclopedia.com/app/20100323951
The Threat of Pierce's Disease to Midwest Wine and Table Grapes
Bacterial type two secretion system secreted proteins: double-edged swords for plant pathogens. Mol. Plant-Microbe Interact. 18 ... Bacterial cells attach to the xylem vessel and multiply, forming biofilm-like colonies that occlude the xylem, disrupting water ... Type I and Type II secretion systems for the export of exoenzymes involved in plant cell wall degradation and allow bacterial ... Pierce's disease bacterial strains currently are limited to the warmer climates in the United States. Climatic differences ...http://www.apsnet.org/publications/apsnetfeatures/Pages/Pierces.aspx
ASMscience | Postadhesion Events Indu
Type III protein secretion systems in bacterial pathogens of animals and plants. Microbiol. Mol. Biol. Rev. 62:379-433.. ... Type III secretion machines: bacterial devices for protein delivery into host cells. Science 284:1322-1328.. ... Type III Secretion System. 0.48637563. Mitogen-Activated Protein Kinase Pathway. 0.45375392. Type IV Secretion Systems. ... Role played by the fibronectin-binding protein SfbI (protein F1) of Streptococcus pyogenes in bacterial internalization by ...http://www.asmscience.org/content/book/10.1128/9781555817800.chap8