*  Bordetella adenylate cyclase toxin: the role of cell interaction in toxin functio - Joshua Eby
AC toxin) is necessary for disease caused by Bordetella pertussis, which has reemerged in the United States over the last two ... family of pore-forming bacterial protein toxins. AC toxin intoxicates host cells by binding to the cell membrane and ... Bordetella adenylate cyclase toxin: the role of cell interaction in toxin functio Eby, Joshua Clark University of Virginia, ... The toxin molecule is a unique hybrid of an adenylate cyclase enzyme and a binding domain homologous to the repeats-in-toxin ( ...
  http://grantome.com/grant/NIH/K08-AI081900-05
*  ASMscience | The Evolution of Bacteri
The prevailing paradigm of bacterial evolution is clonal descent with periodic modification, punctuated with discrete ... Adenylate Cyclase Toxin. 0.5277453. Bacterial Proteins. 0.52708477. 0.5277453. Highlighted Text: Show , Hide ... The STa family of toxins. Citation: Stine O, Nataro J. 2006. The Evolution of Bacterial Toxins, p 167-188. In Seifert H, DiRita ... Hewlett, E. L.,, L. Gray,, M. Allietta,, I. Ehrmann,, V. M. Gordon, and, M. C. Gray. 1991. Adenylate cyclase toxin from ...
  http://www.asmscience.org/content/book/10.1128/9781555815622.ch10
*  Protein Lounge: Glutathione Metabolism in B. pertussis
It produces a complex array of adhesins, aggressins and toxins that are presumed to be important in the colonisation of its ... including Pertussis Toxin, Adenylate Cyclase Toxin, Dermonecrotic Toxin and Tracheal Cytotoxin (Ref.1, 2 & 3).. Glutathione in ... important functions within the bacterial cell. This tripeptide is specifically a thiol compound, present in the highest [...]. ... It produces a complex array of adhesins, aggressins and toxins that are presumed to be important in the colonisation of its ...
  http://www.proteinlounge.com/Pathway/Glutathione%20Metabolism%20in%20B.%20pertussis
*  ASMscience | Toxins as Vaccines and A
This represents the first vaccine produced by genetic inactivation of a bacterial toxin. Several methods have been described ... representing approximately 2,300 and 1,800-2,000 Lf/mg of protein nitrogen for tetanus and diphtheria, respectively, by ... As for the other toxins, to be included in vaccines, PT needs to be detoxified. The most powerful mucosal immunogens and ... This chapter describes those toxins classically used to prevent disease and the approaches for their future use. Today, it is ...
  http://www.asmscience.org/content/book/10.1128/9781555817893.chap22
*  Mechanisms of Bacterial Pathogenicity
Toxins With Short-Range Effects Related to Invasion Bacterial protein toxins which have adenylate cyclase activity, are thought ... botulinum toxin, diphtheria toxin, anthrax toxin, tetanus toxin, pertussis toxin, cholera enterotoxin, adenylate cyclase, staph ... proteins that are noted for their contribution to bacterial invasion of tissues. TABLE 3. SOME EXTRACELLULAR BACTERIAL PROTEINS ... One component of the anthrax toxin (EF or Edema Factor) is an adenylate cyclase that acts on nearby cells to cause increased ...
  http://textbookofbacteriology.net/pathogenesis_4.html
*  Antibodies | Free Full-Text | Diving through Membranes: Molecular Cunning to Enforce the Endosomal Escape of Antibody-Targeted...
Thus, enforcing the endosomal escape of anti-tumor toxins without affecting the integrity of other cellular membranes is of ... membrane barrier including the use of molecular ferries such as cell penetrating peptides or viral membrane fusion proteins, ... been developed in the last decades to overcome endosomal accumulation and subsequent lysosomal degradation of targeted protein- ... and calmodulin-dependent adenylate cyclase that increases cAMP levels, thus interfering with cellular water homeostasis and ...
  http://mdpi.com/2073-4468/2/2/209/htm
*  Pertussis | Rudolph's Pediatrics, 23e | AccessPediatrics | McGraw-Hill Medical
Adenylate cyclase toxin invades phagocytes and induces high levels of cyclic adenosine monophosphate (AMP), which impairs ... Pertussis toxin, necessary but not sufficient to cause clinical pertussis, is secreted by the bacteria and affects G-protein ... B pertussis produces numerous virulence factors, including toxins and attachment agents, many of which are antigenic and ... are involved in bacterial attachment to ciliated respiratory epithelium. Pertactin-deficient B pertussis strains have been ...
  http://accesspediatrics.mhmedical.com/content.aspx?bookid=2126§ionid=166915937
*  Anthrax toxin - Wikipedia
EF acts as a Ca2+ and calmodulin dependent adenylate cyclase that greatly increases the level of cAMP in the cell. This ... The PA requirement observed in animal-model experiments demonstrates a common paradigm for bacterial toxins, called the A / B ... the tripartite protein toxin, called anthrax toxin. Anthrax toxin is a mixture of three protein components: (i) protective ... The toxin was first discovered by Harry Smith in 1954. Anthrax toxin is composed of a cell-binding protein, known as protective ...
  https://en.wikipedia.org/wiki/Anthrax_toxin
*  Toxin B of Clostridium difficile activates human VIP submucosal neurons, in part via an IL-1β-dependent pathway |...
Just I, Hofmann F, Genth H, and Gerhard R. Bacterial protein toxins inhibiting low-molecular-mass GTP-binding proteins. Int J ... Fuchs M, Adermann K, Raab HR, Forssmann WG, and Kuhn M. Pituitary adenylate cyclase-activating polypeptide: a potent activator ... Just I, Selzer J, Hofmann F, and Aktories K. Clostridium difficile toxin B as a probe for Rho GTPases. In: Bacterial Toxins- ... Toxin B induced a rapid rise in IL-1β mRNA level and a sixfold increase in IL-1β protein in supernatant after 3 h of incubation ...
  http://ajpgi.physiology.org/content/285/5/G1049
*  EXAM #1: BACTERIAL INFECTIONS OF THE GI TRACT Flashcards by Jonathan Kallevang | Brainscape
BACTERIAL INFECTIONS OF THE GI TRACT flashcards from Jonathan Kallevang ... AB subunit protein - B-binds to receptors on microvilli - A-activates adenylate cyclase (increases cAMP) ... ETEC toxin is similar to the cholera toxin and causes a WATERY DIARRHEA ... Shiga-Like Toxins 1 and 2 i.e. "SLT-I and SLT-II" ... What is the MOA of the ETEC toxin? What symptom does this toxin ...
  https://www.brainscape.com/flashcards/exam-1-bacterial-infections-of-the-gi-tra-4224846/packs/6311361
*  RTX toxin - Wikipedia
... a membrane fusion protein), and CyaE (an outer membrane protein). The CyaA protein contains an adenylate cyclase domain (AC ... The RTX-toxin family (TC# 1.C.11) (subfamily of RTX-toxin superfamily) is a large family of multidomain Gram-negative bacterial ... another class of RTX proteins. RTX toxins have been found in numerous strains of Pathogenic E. coli. The prototypical RTX toxin ... The cyaA operon encodes the five proteins CyaA (RTX toxin), CyaC (CyaA activation protein), and the three T1SS proteins: CyaB ( ...
  https://en.wikipedia.org/wiki/RTX_toxin
*  2005, November - Journal of Young Investigators
Adenylate cyclase is activated by cholera toxin. The cholera toxin A1 fragment catalyzes the attachment of ADP-Ribose (ADPR) to ... Like toxins, there are many types of adhesins [Hultgren et al. 1993]. Because of the necessity to be on the bacterial surface ... Petrussis Toxin. The petrussis toxin modifies heterotrimeric G proteins. The pertussis toxin, PTx, is a protein that mediates ... Normal regulation of adenylate cyclase activity in mammalian cells (Adenylate cyclase (AC)) is activated normally by a ...
  https://www.jyi.org/2005-november
*  Mechanism of action of choleragen and E. coli heat-labile enterotoxin: activation of adenylate cyclase by ADP-ribosylation |...
The initial event appears to be the binding of the B subunit of the toxin to ganglioside GM1on the cell surface,... ... Choleragen exerts its effects on cells through the activation of adenylate cyclase. ... In: The Specificity and Action of Animal, Bacterial and Plant Toxins. Receptors and Recognition (Cuatrecasas, P., ed.). Series ... This protein appears to be the GTP-binding component (or G/F factor) of the adenylate cyclase system and is cruical to the ...
  https://link.springer.com/article/10.1007/BF02354931
*  Tick-Borne Flaviviruses Antagonize Both IRF-1 and Type I IFN Signaling To Inhibit Dendritic Cell Function | The Journal of...
... adenylate cyclase toxin (CyaA) of Bordetella pertussis suppresses LPS/IFN-γ-induced expression of IRF-1 and IRF-8 mRNA ... Factor H-IgG Chimeric Proteins as a Therapeutic Approach against the Gram-Positive Bacterial Pathogen Streptococcus pyogenes ... The work with TBEV was conducted in compliance with regulation 42 CFR 73 under the Division of Select Agents and Toxins ( ... Adenylate cycalse toxin of Bordetella pertussis inhibits TLR-induced IRF-1 and IRF-8 activation and IL-12 production and ...
  http://www.jimmunol.org/content/192/6/2744?ijkey=443d0fc6d3902ebe6bc9cae2298135f98e2227f0&keytype2=tf_ipsecsha
*  AB5 toxin - Wikipedia
In doing so, the downstream effects of the G protein signal transduction pathway is disrupted by activating adenylate cyclase. ... In addition to some of these AB5 toxins being used to create vaccines to prevent bacterial infection, they are also being ... Cholera toxin, shiga toxin, and SubAB toxin all have B subunits that are made up of five identical protein components, meaning ... Carbonetti, N. H. (2010). "Pertussis toxin and adenylate cyclase toxin: Key virulence factors of Bordetella pertussis and cell ...
  https://en.wikipedia.org/wiki/AB5_toxin
*  IMMUNOGENIC COMPOSITION - Patent application
... pertussis toxin or derivatives thereof, filamenteous hemagglutinin, adenylate cyclase, fimbriae), B. parapertussis and B. ... proteins thereof, such as HA, NP, NA, or M proteins, or combinations thereof), or derived from bacterial pathogens such as ... for example botulinum toxin and derivative thereof), C. difficile (for example Clostridium toxins A or B and derivatives ... for example a Yop protein), V. pestis, Y. pseudotuberculosis; Campylobacter spp, including C. jejuni (for example toxins, ...
  http://www.patentsencyclopedia.com/app/20110171261
*  Cell entry and cAMP imaging of anthrax edema toxin | The EMBO Journal
Gordon VM, Young Jr WW, Lechler SM, Gray MC, Leppla SH, Hewlett EL (1989) Adenylate cyclase toxins from Bacillus anthracis and ... Baldari T, Tonello F, Rossi‐Paccani S, Montecucco C (2006) Anthrax toxins: a paradigm of bacterial immune suppression. Trends ... Scobie HM, Rainey GJ, Bradley KA, Young JA (2003) Human capillary morphogenesis protein 2 functions as an anthrax toxin ... Adenylate cyclase toxin from Bordetella pertussis: current concepts and problems in the study of toxin functions. Int J Med ...
  http://emboj.embopress.org/content/25/22/5405
*  Application # 2011/0281347. Multivalent vaccines comprising recombinant viral vectors - Patents.com
... and the pertussis toxin S1 subunit. Other examples are the adenylate cyclase-hemolysins such as the cyaA genes of Bordetella ... Examples include, but are not limited to, viral proteins, bacterial proteins, parasite proteins, cytokines, chemokines, ... 0065] Although ADP-ribosylating toxins are potent adjuvants, the adjuvant encoded by the viral vectors in the invention may ... K02679). Alternatively, any bacterial toxin that is a member of the family of bacterial adenosine diphosphate-ribosylating ...
  http://patents.com/us-20110281347.html
*  Differential Response of Cortical Plate and Ventricular Zone Cells to GABA as a Migration Stimulus | Journal of Neuroscience
... pertussis toxin: a probe for functions of the inhibitory guanine nucleotide regulatory component of adenylate cyclase. Trends ... 1990) Bacterial toxins as probe for receptor-Gi coupling. Adv Second Messenger Phosphoprotein Res 24:63-69. ... Pertussis toxin (PTX) blocked GABA-induced migration, indicating that chemotropic signals involve G-protein activation. ... In mature neurons, GABAB receptors couple to Gi- or Go-proteins (Kerr and Ong, 1992; Bowery, 1993). R-baclofen, a GABAB ...
  http://www.jneurosci.org/content/18/16/6378.long
*  Bordetella - Wikipedia
One of the most important of the regulated toxins is adenylate cyclase toxin, which aids in the evasion of innate immunity. The ... Binding of this protein to the consensus sequence represents gene expression by reducing transcription. It is not known what ... Principles of Bacterial Pathogenesis. Academic Press. pp. 619-674. ISBN 0-12-304220-8. Mattoo S, Cherry J (2005). "Molecular ... Gray MC, Donato GM, Jones FR, Kim T, Hewlett EL (2004). "Newly secreted adenylate cyclase toxin is responsible for intoxication ...
  https://en.wikipedia.org/wiki/Bordetella
*  SELF-INJECTION DEVICE - Patent application
... pertussis toxin or derivatives thereof, filamenteous hemagglutinin, adenylate cyclase, fimbriae), B. parapertussis and B. ... proteins thereof, such as HA, NP, NA, or M proteins, or combinations thereof), or derived from bacterial pathogens such as ... for example Botulinum toxin and derivative thereof), C. difficile (for example clostridium toxins A or B and derivatives ... for example shiga toxin-like toxin or derivatives thereof); Vibrio spp, including V. cholera (for example cholera toxin or ...
  http://www.patentsencyclopedia.com/app/20120310173
*  Vaccine Comprising an Oil in Water Emulsion Adjuvant - Patent application
... pertussis toxin or derivatives thereof, filamenteous hemagglutinin, adenylate cyclase, fimbriae), B. parapertussis and B. ... or M proteins, or combinations thereof), or derived from bacterial pathogens such as Neisseria spp, including N. gonorrhea and ... for example botulinum toxin and derivative thereof), C. difficile (for example clostridium toxins A or B and derivatives ... preferably in the form of a Protein D-E6 or Protein D-E7 fusion protein or Protein D E6/E7 fusion protein. [0091]The vaccine of ...
  http://www.patentsencyclopedia.com/app/20100183667
*  Killer yeast - Wikipedia
It is an example of protein priming in DNA replication. MAK genes are not known. The toxin consists of three subunits, which ... 1989) to use toxins to differentiate between 58 bacterial cultures. Vaughan-Martini, Cardinali and Martini (1996) used 24 ... The mechanism of action appears to be the inhibition of adenylate cyclase in sensitive cells. Affected cells are arrested in G1 ... The methods were not effective at reducing toxin production in other yeast species. Many toxins are sensitive to pH levels; for ...
  https://en.wikipedia.org/wiki/Killer_yeast
*  Exotoxin - Wikipedia
For example, Cholera toxin ADP-ribosylates, thereby activating tissue adenylate cyclase to increase the concentration of cAMP, ... Some exotoxins act directly at the ribosome to inhibit protein synthesis. An example is Shiga toxin. Other toxins act at ... 2007). "Histone modifications induced by a family of bacterial toxins". Proc. Natl. Acad. Sci. U.S.A. 104 (33): 13467-72. doi: ... Toxins of this type include cholera toxin, pertussis toxin, Shiga toxin and heat-liable enterotoxin from E. coli. Once in the ...
  https://en.wikipedia.org/wiki/Exotoxin
*  Role of neurogenic inflammation in local communication in the visceral mucosa | SpringerLink
Jhang JF, Kuo HC (2016) Botulinum toxin A and lower urinary tract dysfunction: Pathophysiology and mechanisms of action. Toxins ... Calcitonin gene-related peptide activates the K+ channels of vascular smooth muscle cells via adenylate cyclase. Basic Res ... Mo L (2004) Ablation of the Tamm-Horsfall protein gene increases susceptibility of mice to bladder colonization by type 1 ... Khasriya R, Sathiananthamoorthy S, Ismail S, Kelsey M, Wilson M, Rohn JL, Malone-Lee J (2013) Spectrum of bacterial ...
  https://link.springer.com/article/10.1007/s00281-018-0674-0