*  Molecules | Free Full-Text | Role of O-Acetylation in the Immunogenicity of Bacterial Polysaccharide Vaccines
While these groups are often considered important for the structural identity of the polysaccharides, they play a major role in ... The structures of the bacterial capsular polysaccharide (CPS) antigens, extracted and purified from microbial cultures and ... has been dramatically reduced over the last 25 years through the use of glycoconjugate vaccines. ... the functional immune response to some vaccines such as meningococcal serogroup A and Salmonella typhi Vi, but do not seem to ...
  http://www.mdpi.com/1420-3049/23/6/1340
*  Selective Antibody Deficiency - The Clinical Advisor
"Evaluating children with respiratory tract infections: the role of immunization with bacterial polysaccharide vaccine". Pediatr ... Bacterial cell wall polysaccharides are classified as T independent antigens, meaning they can stimulate B cells directly and ... Because the B cell defect is limited to polysaccharide antigens, immunization with conjugated vaccines such as H flu vaccine ... By conjugating polysaccharide antigens with proteins, as in the heptavalent and 13-valent pneumococcal polysaccharide vaccines ...
  http://www.clinicaladvisor.com/pediatrics/selective-antibody-deficiency/article/623992/
*  George Siber bibliography - Wikipedia
... diphtheria toxoid conjugate vaccine given with or without bacterial polysaccharide immune globulin (BPIG) in Navajo infants. ... Ambrosino, DM; Siber GR; Chilmonczyk BA; Jernberg JA; Finberg RW (Sep 1987). "Impaired immune response to polysaccharides". The ... "Comparison of pneumococcal conjugate polysaccharide and free polysaccharide vaccines in elderly adults: conjugate vaccine ... diphtheria toxoid conjugate vaccine given with or without Bacterial Polysaccharide Immune Globulin (BPIG). Interscience ...
  https://en.wikipedia.org/wiki/George_Siber_bibliography
*  What Is and What Should Always Have Been: Long-Lived Plasma Cells Induced by T Cell-Independent Antigens | The Journal of...
1A). As a consequence, few polysaccharide vaccines consisting of bacterial capsule Ags are currently available. One noteworthy ... For responses to polysaccharides, classically referred to as type 2 T cell-independent Ags, Taillardet et al. (38) demonstrated ... Indeed, whereas vaccines to T cell-dependent Ags are more likely to be long-lasting, those against certain T cell-independent ... Duration of humoral immunity to common viral and vaccine antigens. N. Engl. J. Med. 357: 1903-1915. ...
  http://www.jimmunol.org/content/190/12/5913
*  Pathogenic Bacterial Sensors Based on Carbohydrates as Sensing Elements | Springer for Research & Development
Lee CJ (1987) Bacterial Capsular Polysaccharides - Biochemistry, Immunity and Vaccine. Mol Immunol 24:1005-1019Google Scholar ... Sood RK, Fattom A, Pavliak V and Naso RB (1996) Capsular polysaccharide-protein conjugate vaccines. Drug Discov Today 1:381-387 ... Moxon ER and Kroll JS (1990) The Role of Bacterial Polysaccharide Capsules as Virulence Factors. Curr Top Microbiol Immunol 150 ... Weintraub A (2003) Immunology of bacterial polysaccharide antigens. Carbohydr Res 338:2539-2547Google Scholar ...
  https://rd.springer.com/chapter/10.1007/978-0-387-75113-9_24
*  Pneumococcal Polysaccharide Vaccine (23-Valent) (Professional Patient Advice) - Drugs.com
Professional guide for Pneumococcal Polysaccharide Vaccine (23-Valent). Includes: pharmacology, pharmacokinetics, ... Drug class: bacterial vaccines. Consumer resources. *Pneumococcal polysaccharides vaccine (PPSV), 23-valent ... Vaccine, Inactivated (Bacterial). Pharmacology. Pneumococcal polysaccharide polyvalent is an inactive bacterial vaccine that ... Pneumococcal vaccine-naive or vaccination status unknown: Administer PCV13 followed by pneumococcal polysaccharide vaccine ( ...
  https://www.drugs.com/ppa/pneumococcal-polysaccharide-vaccine-23-valent.html
*  Preventing Pneumococcal Disease Among Infants and Young Children
PNEUMOCOCCAL CONJUGATE VACCINE Advantages of Pneumococcal Conjugate Vaccine: Immunologic Theory Bacterial polysaccharides, ... conjugate vaccine followed, ,2 months later, by 23-valent polysaccharide vaccine. Conjugate vaccine has not been studied ... In February 2000, a 7-valent pneumococcal polysaccharide-protein conjugate vaccine (Prevnar, marketed by Wyeth Lederle Vaccines ... Vaccine Composition The 7-valent pneumococcal conjugate vaccine (Prevnar) includes seven purified capsular polysaccharides of S ...
  https://www.cdc.gov/MMWR/preview/MMWRhtml/rr4909a1.htm
*  Microparticles with adsorbed polypeptide-containing molecules - Patent # 7501134 - PatentGenius
Preferred polypeptide containing molecules are bacterial and viral antigens (including HIV antigens, meningitis B antigens, ... Constantino et al., "Size fractionation of bacterial capsular polysaccharides for their use in conjugate vaccines," Vaccine, ... The microparticle composition of claim 7, wherein the antigen comprises a polysaccharide conjugated to a polypeptide.. 17. A ... 1992) Vaccine 10:691-698 (Ref. 12); Costantino et al. (1999) Vaccine 17:1251-1263 (Ref. 13); Watson (2000)Padiatr Infect Dis J ...
  http://www.patentgenius.com/patent/7501134.html
*  Production of glycoprotein vaccines in Escherichia coli | Microbial Cell Factories | Full Text
Robbins JB, Schneerson R, Szu SC, Pozsgay V: Bacterial polysaccharide-protein conjugate vaccines. Pure Appl Chem. 1999, 71 (5 ... In contrast to isolated bacterial polysaccharides, conjugate vaccines induce a long-lasting T-lymphocyte dependent ... Conjugate vaccines in which polysaccharide antigens are covalently linked to carrier proteins belong to the most effective and ... Lockhart S: Conjugate vaccines. Expert Rev Vaccines. 2003, 2 (5): 633-648. 10.1586/14760584.2.5.633.View ArticleGoogle Scholar ...
  https://microbialcellfactories.biomedcentral.com/articles/10.1186/1475-2859-9-61
*  2005, November - Journal of Young Investigators
To overcome these inherent limitations of polysaccharide antigens, new vaccine formulations have coupled bacterial ... An important example of this occurs with bacterial polysaccharides, which are repetitive carbohydrate determinants on the ... The vaccines which we are going to consider here are non-genetic vaccines, or in simple terms, the components of these vaccines ... whereby a bacterial surface molecule binds tightly to a receptor. The bacterial molecule is expressed over the entire bacterial ...
  https://www.jyi.org/2005-november
*  Does larch arabinogalactan enhance immune function? A review of mechanistic and clinical trials | Nutrition & Metabolism | Full...
... as the vaccine is made of bacterial sugars from 23 pneumococcal types. Vaccines produced from bacterial polysaccharides are ... suggesting that this polysaccharide confers a benefit in preparing the immune system to manage infection with bacterial ... Larch arabinogalactanCommon cold infectionsImmune systemVaccineSCFAPolysaccharidesDietary fibersResistAid® Larix ... Polysaccharides from Larch Biomass. In: Karunaratne DDN, editor. The Complex World of Polysaccharides. InTech; 2012.Google ...
  https://nutritionandmetabolism.biomedcentral.com/articles/10.1186/s12986-016-0086-x
*  NmVac4-A/C/Y/W-135 - Wikipedia
The vaccine is made from bacterial capsular polysaccharides through fermentation of each individual serogroup of Neisseria ... meningococcal polysaccharide-diphtheria conjugate vaccine versus quadrivalent polysaccharide vaccine in two- to ten-year-old ... The vaccine contains 50 mcg of polysaccharide for each of the serogroup's (A, C, Y and W135) purified polysaccharide in a ... Vaccines have been prepared from the capsular polysaccharides of Neisseria meningitidis (groups A, C, W-135, and Y). These and ...
  https://en.wikipedia.org/wiki/NmVac4-A/C/Y/W-135
*  Polysaccharide encapsulated bacteria - Wikipedia
Lee CJ, Lee LH, Koizumi K. (2002) Polysaccharide Vaccines for Prevention of Encapsulated Pseudomonas Aueroginosa Bacterial ... Young children do not have the ability to make antibodies to polysaccharides and are, therefore, more susceptible to ... Wong W, Powars D, Chan L, Hiti A, Johnson C, Overturf G (1992). "Polysaccharide encapsulated bacterial infection in sickle cell ... a bacterial capsule, made of polysaccharide. Hemophilus influenzae type b (Hib) Streptococcus pneumoniae (pneumococcus) ...
  https://en.wikipedia.org/wiki/Polysaccharide_encapsulated_bacteria
*  Conjugate vaccine - Wikipedia
"Polysaccharide Vaccines for Prevention of Encapsulated Bacterial Infections: Part 1". Infect Med. 19: 127-133. Vaccines, ... By conjugating the polysaccharide to a protein carrier, a T cell response can be induced. Normally, polysaccharides by ... B cell Haemophilus influenzae type b (Hib) Hib vaccine Immunogenicity Meningococcal vaccine Pneumococcal vaccines Rappuoli, ... "Use of carrier protein for development of protein/polysaccharide conjugate vaccines and protein/protein conjugate vaccines". ...
  https://en.wikipedia.org/wiki/Conjugate_vaccine
*  Neisseria meningitidis - Wikipedia
Some of the vaccines cover serogroup B, while others cover A, C, W, and Y. A meningococcal polysaccharide vaccine (MPSV4) has ... 2009). Bacterial Polysaccharides: Current Innovations and Future Trends. Caister Academic. ISBN 978-1-904455-45-5. Hall, DJ; ... The first conjugate vaccine was licensed in 2005, the second in 2010. Conjugate vaccines are the preferred vaccine for people 2 ... DNA uptake sequence DNA taken up by Neisseria NmVac4-A/C/Y/W-135 polysaccharide vaccine Sara Branham Matthews microbiologist ...
  https://en.wikipedia.org/wiki/Neisseria_meningitidis
*  Polysaccharide - Wikipedia
Cell-surface polysaccharides play diverse roles in bacterial ecology and physiology. They serve as a barrier between the cell ... Mixtures of capsular polysaccharides, either conjugated or native are used as vaccines. Bacteria and many other microbes, ... Polysaccharide Structure Applications and commercial sources of polysaccharides European Polysaccharide Network of Excellence. ... Examples include storage polysaccharides such as starch and glycogen, and structural polysaccharides such as cellulose and ...
  https://en.wikipedia.org/wiki/Polysaccharide
*  Bacterial capsule - Wikipedia
... polysaccharides are not highly antigenic, especially in children, so many capsular vaccines contain polysaccharides conjugated ... It is a polysaccharide layer that lies outside the cell envelope, and is thus deemed part of the outer envelope of a bacterial ... These serotypes are the basis for the pneumococcal vaccines. Streptococcus agalactiae produces a polysaccharide capsule of nine ... When viewed, bacterial cells as well as the surface they are on, are stained dark, while the capsule remains pale or colorless ...
  https://en.wikipedia.org/wiki/Bacterial_capsule
*  Pathogenic Escherichia coli - Wikipedia
In March 2006, a vaccine eliciting an immune response against the E. coli O157:H7 O-specific polysaccharide conjugated to ... Sela S, Nestel D, Pinto R, Nemny-Lavy E, Bar-Joseph M (2005). "Mediterranean fruit fly as a potential vector of bacterial ... capsular polysaccharides, while the latter (II), associated with extraintestinal diseases, are under 50 kDa in size. Group I K ... The acidic capsular polysaccharide (CPS) is a thick, mucous-like, layer of polysaccharide that surrounds some pathogen E. coli ...
  https://en.wikipedia.org/wiki/Pathogenic_Escherichia_coli
*  Reverse vaccinology - Wikipedia
A Streptococcus and B Streptococcus vaccines were two of the first Reverse Vaccines created. Because those bacterial strains ... This bacterium's polysaccharide shell is identical to that of a human self-antigen, but its surface proteins vary greatly; and ... Whereas, conventional vaccinology approaches can find other biomolecular targets such as polysaccharides. Though using ... Since then, it has been used on several other bacterial vaccines. The basic idea behind reverse vaccinology is that an entire ...
  https://en.wikipedia.org/wiki/Reverse_vaccinology
*  Rachel Schneerson - Wikipedia
"Recent Contributions in Vaccine Development for the landmark development of a polysaccharide-protein conjugate vaccine for ... Using polysaccharides also eliminated many of the severe side effects of killed-bacteria vaccines. Scientists supported by the ... She is best known for her development of the vaccine against bacterial meningitis (Haemophilus influenzae type B (Hib)) with ... In fact, many scientists believed that a polysaccharide-based vaccine would never work because immature defenses of the infant ...
  https://en.wikipedia.org/wiki/Rachel_Schneerson
*  SUPPRESSION OF BLOOD GROUP AGGLUTINABILITY OF HUMAN ERYTHROCYTES BY CERTAIN BACTERIAL POLYSACCHARIDES | JEM
Erythrocytes coated with bacterial capsular polysaccharides, notably the Vi antigen, were no longer agglutinated by antibodies directed against the various antigens native to the red cell surface. These effects could not be attributed to prevention of antibody uptake even though in some systems the uptake of antibody was diminished. In fact, agglutination by Rh-incomplete antibody was brought back to the original titer only after the sensitized Vi-coated cells had been subjected to ten alternating exposures to globulin and antiglobulin. Hemagglutination by Newcastle, mumps, and influenza viruses was also suppressed. Erythrocytes coated with Vi polysaccharide assumed the distinctive physicochemical attributes of this acidic polymer which results in a stabilization of the erythrocyte suspension as manifested by increased electrophoretic mobility and a striking decrease in the rate of sedimentation. Among the possible models for explaining the ...
  http://jem.rupress.org/content/117/3/321
*  SYNTHESIS OF FRAGMENTS OF SALMONELLA TYPHI CAPSULAR POLYSACCHARIDE AND THEIR ZWITTERIONIC ANALOGUES | Archivio Istituzionale...
Polysaccharide antigens are T cell-independent antigens, and do not induce immune B cell memory. Consequently, vaccines based on polysaccharides have limited clinical usefulness and induce short-lasting antibody responses in adults. Their immunogenicity can be enhanced by conjugation to an immunogenic carrier protein, generating T cell-dependent glycoconjugate antigens able to induce immunological memory. However, these glycoconjugates suffer from some problems. Recent investigations have found a group of structurally distinct bacterial polysaccharides able to activate T cells in vivo and in vitro. They present a zwitterionic charge motif distributed along the chain and, for this reason, they are called zwitterionic polysaccharides (ZPSs). This zwitterionic charge motif is believed to be responsible for their particular immunological behavior. The integrity of the zwitterionic motif is ...
  https://air.unimi.it/handle/2434/243479
*  Biology-Online • View topic - Bacterial Polysaccharides Cellular Localization
I used a tool called pSORTb which predicts the cellular localization of proteins. In the results I get, many enzymes which are known to break polysaccharides are predicted to be intracellular. Because polysaccharides have an enormous molecular weight they cannot enter the cell and so that leads to the conclusion that they are not only degraded but also synthesized by the bacteria. However, based on my biological background, I cannot think of any known *intracellular* polysaccharide synthesized by bacteria, except starch ...
  http://www.biology-online.org/biology-forum/about23729.html?hilit=Localization
*  Reglemers™ - Symbiotix Biotherapies, Inc.
Bacterioides fragilis is a gram-negative anaerobe and a prototypic gut commensal organism. B. fragilis is able to produce eight different capsular polysaccharides, which envelope the organism and form its protective capsule. Polysaccharide A (PSA) is one of these polysaccharides and, interestingly, has a unique zwitterionic motif that includes alternating positively and negatively charged sugar residues. PSA consists of a tetrasaccharide repeat unit that forms a polymer of between 30-300 repeats.. Such bacterial capsular polysaccharides are well known to industry, and are the basis of polysaccharide conjugate vaccines used successfully for decades in millions of people. The specific zwitterionic polysaccharide PSA was shown, in a series of landmark papers by our company's scientific founders that overturned established immunologic paradigms, to be processed ...
  http://symbiotix-bio.com/technology/reglemers/
*  Aggregate formation in soil. 1. Influence of some bacterial polysaccharides on the binding of soil particles | Biochemical...
Thank you for your interest in spreading the word about Biochemical Journal.. NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address.. ...
  http://www.biochemj.org/content/43/1/5
*  Polysaccharides - NCBES
Polysaccharides are also abundant in plant and marine sources and these are an as yet relatively untapped resource for these molecules. Isolated polysaccharides have been shown to have potent biological activities in a range of cell types and as such are a focus of identification of novel bioactive compounds for therapeutic use. Polysaccharides are under investigation for the modulation of the immune system that can be used to both reduce inflammation in certain diseases but also to potentiate inflammation which has been shown to be beneficial post-surgery. Using a range of high throughput strategies were are examining the biological roles of naturally derived polysaccharides, with a particular focus on seaweed-derived polysaccharides.. ...
  http://ncbes.nuigalway.ie/research/alimentary-glycoscience-research-cluster/polysaccharides/
*  Pneumococcal Polysaccharide Powder Type 1 (US Type 1) ATCC ® 164-X
Pneumococcal Polysaccharide Powder Type 1 (US Type 1) ATCC ® 164-X™ Designation: TypeStrain=False Application: Elisa standard polysaccharide type 1
  https://atcc.org/en/Products/Culture_Reagents/Polysaccharides/164-X.aspx?slp=1
*  Pneumococcal Polysaccharide Powder Type 2 (US Type 2) ATCC ® 16-X&
Pneumococcal Polysaccharide Powder Type 2 (US Type 2) ATCC ® 16-X™ Designation: TypeStrain=False Application: Elisa standard polysaccharide type 2
  https://www.atcc.org/en/Global/Products/8/6/6/B/16-X.aspx
*  Pneumococcal Polysaccharide Powder Type 2 (US Type 2) ATCC ® 168-X
Pneumococcal Polysaccharide Powder Type 2 (US Type 2) ATCC ® 168-X™ Designation: TypeStrain=False Application: Elisa standard polysaccharide type 2
  https://www.atcc.org/en/Global/Products/C/5/0/B/168-X.aspx?p=1&rel=%7B0%7D
*  Pneumococcal Polysaccharide Powder Type 2 (US Type 2) ATCC ® 165-X
Pneumococcal Polysaccharide Powder Type 2 (US Type 2) ATCC ® 165-X™ Designation: TypeStrain=False Application: Elisa standard polysaccharide type 2
  https://www.atcc.org/en/Products/Culture_Reagents/Polysaccharides/165-X.aspx?slp=1
*  Biosynthesis of heparin : Modulation of polysaccharide chain length in a cell-free system
The formation of heparin-precursor polysaccharide (N-acetylheparosan) was studied with a mouse mastocytoma microsomal fraction. Incubation of this fraction with UDP-[3H]GlcA and UDP-GlcNAc yielded labelled macromolecules that could be depolymerized, apparently to single polysaccharide chains, by alkali treatment, and thus were assumed to be proteoglycans. Label from UDP-[3H]GlcA (approx. 3 microM) is transiently incorporated into microsomal polysaccharide even in the absence of added UDP-GlcNAc, probably owing to the presence of endogenous sugar nucleotide. When the concentration of exogenous UDP-GlcNAc was increased to 25 microM the rate of incorporation of 3H increased and proteoglycans carrying polysaccharide chains with an Mr of approx. 110,000 were produced. Increasing the UDP-GlcNAc concentration to 5 mM led to an approx. 4-fold decrease in the rate of 3H incorporation and a decrease in the Mr of the resulting ...
  http://uu.diva-portal.org/smash/record.jsf?pid=diva2:455588
*  Structural analysis of colanic acid from Escherichia coli by using methylation and base-catalysed fragmentation. Comparison...
Essentially the same methanolysis products were obtained after methylation of the slime and capsular polysaccharides from Escherichia coli K12 (S53 and S53C sub-strains) and the slime polysaccharides from E. coli K12 (S61), Aerobacter cloacae N.C.T.C. 5290 and Salmonella typhimurium SL1543. These were the methyl glycosides of 2-O-methyl-l-fucose, 2,3-di-O-methyl-l-fucose, 2,3-di-O-methyl-d-glucuronic acid methyl ester, 2,4,6-tri-O-methyl-d-glucose, 2,4,6-tri-O-methyl-d-galactose and the pyruvic acid ketal, 4,6-O-(1′-methoxycarbonylethylidene)-2,3-O-methyl-d-galactose. All were identified as crystalline derivatives from an E. coli polysaccharide. The structure of the ketal was proved by proton-magnetic-resonance and mass spectrometry, and by cleavage to pyruvic acid and 2,3-di-O-methyl-d-galactose. All these polysaccharides are therefore regarded as variants on the same fundamental structure for which the name colanic acid is adopted. ...
  http://www.biochemj.org/content/115/5/947
*  Probable polysaccharide biosynthesis protein elisa and antibody
Shop Probable polysaccharide biosynthesis protein ELISA Kit, Recombinant Protein and Probable polysaccharide biosynthesis protein Antibody at MyBioSource. Custom ELISA Kit, Recombinant Protein and Antibody are available.
  https://www.mybiosource.com/protein_family.php?root=probable-polysaccharide-biosynthesis-protein
*  SAUSA300 0162 - AureoWiki
Cell Wall and CapsuleCapsular and extracellular polysacchridesSerotype determining Capsular polysaccharide biosynthesis in Staphylococcus Capsular polysaccharide synthesis enzyme Cap5K ...
  http://aureowiki.med.uni-greifswald.de/SAUSA300_0162
*  Polysaccharide, Polysaccharide Suppliers and Manufacturers at Alibaba.com
Polysaccharide, Wholesale Various High Quality Polysaccharide Products from Global Polysaccharide Suppliers and Polysaccharide Factory,Importer,Exporter at Alibaba.com.
  http://www.alibaba.com/showroom/polysaccharide.html
*  MBOAT - Synthesis and Evaluation of Novel PI3K inhibitors
Bacterial capsular polysaccharides (CPS) are produced by a multi-protein membrane layer complicated, in which a particular type of tyrosine-autokinases named BY-kinases, control their move and polymerization. is certainly defective recommending that CpsD autophosphorylation interferes with these procedures therefore producing in cell constriction problems and cell elongation. We display that CpsD stocks structural homology with ParA-like … Read more Bacterial capsular polysaccharides (CPS) are produced by a multi-protein membrane layer. Read More ...
  http://medicalconsultingcenter.com/?cat=89
*  IJMS | Free Full-Text | Three-Dimensional Structural Aspects of Protein-Polysaccharide Interactions | Notes
Linear polysaccharides are typically composed of repeating mono- or disaccharide units and are ubiquitous among living organisms. Polysaccharide diversity arises from chain-length variation, branching, and additional modifications. Structural diversity is associated with various physiological functions, which are often regulated by cognate polysaccharide-binding proteins. Proteins that interact with linear polysaccharides have been identified or developed, such as galectins and polysaccharide-specific antibodies, respectively. Currently, data is accumulating on the three-dimensional structure of polysaccharide-binding proteins. These proteins are classified into two types: exo-type and endo-type. The former group specifically interacts with the terminal units of polysaccharides, whereas the latter with internal units. In this review, we describe the structural aspects of exo-type and ...
  http://www.mdpi.com/1422-0067/15/3/3768/notes
*  British Library EThOS: Molecular studies of the Escherichia coli K5 capsule gene cluster
Group II K antigens such as the K5 are associated with Escherichia coli causing serious extraintestinal infections. Genes for the production of group II capsules (kps) are organised into three functional regions 1, 2 and 3. The central region 2 encodes proteins involved in the biosynthesis of type specific polysaccharide. Proteins encoded by the flanking regions 1 and 3 are involved in the export of polysaccharide across the bacterial membranes unto the cell surface. Translocation of polysaccharide across the inner membrane is mediated by two region 3 encoded proteins, KpsM and KpsT which belong to the ATP-binding cassette (ABC) superfamily of transporters. Region 1 encodes six proteins, KpsF-E-D-U-C-S. The KpsE protein was shown to localise in the inner membrane and mutants lacking the encoded protein were unable to export polysaccharide to the cell surface. To understand the export role of the KpsE, its ...
  http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.674499
*  An alternative polysaccharide uptake mechanism of marine bacteria<...
TY - JOUR. T1 - An alternative polysaccharide uptake mechanism of marine bacteria. AU - Reintjes,Greta. AU - Arnosti,Carol. AU - Fuchs,Bernhard M.. AU - Amann,Rudolf. PY - 2017/7/1. Y1 - 2017/7/1. N2 - Heterotrophic microbial communities process much of the carbon fixed by phytoplankton in the ocean, thus having a critical role in the global carbon cycle. A major fraction of the phytoplankton-derived substrates are high-molecular-weight (HMW) polysaccharides. For bacterial uptake, these substrates must initially be hydrolysed to smaller sizes by extracellular enzymes. We investigated polysaccharide hydrolysis by microbial communities during a transect of the Atlantic Ocean, and serendipitously discovered - using super-resolution structured illumination microscopy - that up to 26% of total cells showed uptake of fluorescently labelled polysaccharides (FLA-PS). Fluorescence in situ hybridisation identified ...
  https://uncch.pure.elsevier.com/en/publications/an-alternative-polysaccharide-uptake-mechanism-of-marine-bacteria
*  "Characterization of the antibody response to type iii pneumococcal pol" by P J. Baker, B Prescott et al.
Baker, P J.; Prescott, B; Stashak, P W.; and Amsbaugh, D F., "Characterization of the antibody response to type iii pneumococcal polysaccharide at the cellular level. Iii. Studies on the average avidity of the antibody produced by specific plaque-forming cells." (1971). Subject Strain Bibliography 1971. 1026 ...
  https://mouseion.jax.org/ssbb1971/1026/
*  A Phase I Trial of Tecogalan Sodium (DS-4152) Administered as an Infusion Every 21 Days - Full Text View - ClinicalTrials.gov
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies. ...
  https://clinicaltrials.gov/show/NCT00002136?order=102
*  A Phase I Trial of Tecogalan Sodium ( DS-4152 ) Administered as an Infusion Weekly x 4 - Full Text View - ClinicalTrials.gov
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies. ...
  https://clinicaltrials.gov/show/NCT00002137?order=124
*  A Phase I Trial of Tecogalan Sodium (DS-4152) Administered as an Infusion Every 21 Days - Full Text View - ClinicalTrials.gov
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies. ...
  https://clinicaltrials.gov/show/NCT00002136?order=127