*  Bladder Infection following Prostatectomy...
Hi DanMc,. I got a UTI following my stay in hospital for the operation. Symptoms were burning around the penis, including some loss of skin. I was given the antibiotic Norfloxacin, and after about 6 weeks, it cleared up - took a lot longer than the doctor thought to disappear. The test showed I had picked up Citrobacter which is a hospital acquired bug that is resistant to some antibiotics. In addition to the Citrobacter, I requested a skin test for yeast infection, and it turns out I also had Candida Albicans. I applied Canesten over the penis and scrotum, and this seemed to help - I still use it a couple of times a week.. One thing I found helpful when I had the UTI was to drink more water. This seemed to dilute the buring effect of the urine, even though it meant more pad usage. Berb ...
  http://www.healingwell.com/community/default.aspx?f=35&m=818185
*  ILCS - What does ILCS stand for? The Free Dictionary
Looking for online definition of ILCS or what ILCS stands for? ILCS is listed in the World's largest and most authoritative dictionary database of abbreviations and acronyms
  https://acronyms.thefreedictionary.com/ILCS
*  Longfonds Research
The field of type 2 immunity has broadened significantly over the past decade with the addition of new players such as the type 2 innate lymphoid cell (ILC2) and developments in understanding host-microbiota interactions. The conference featured an exceptional group of cross-disciplinary speakers each of whom are experts in different aspects within a defined set of diseases involving type 2 imm.... Keyword: type 2 immunity Airway dendritic cells ...
  http://research.longfonds.nl/database-zoeken?page=6
*  Suspicion of respiratory tract infection with multidrug-resistant Enterobacteriaceae: epidemiology and risk factors from a...
In this study we analysed the spectrum of Enterobacteriaceae in tracheal aspirates of intubated PICU patients from 2005 to 2014. The spectrum of Enterobacteriaceae in lower respiratory tract material revealed Enterobacter spp., E.coli and Klebsiella spp. as the most common isolates (86%). Comparable data of matching study settings are scarce in the current literature. Wilson et al. [5] collected daily tracheal aspirates from intubated children. Consistent with our findings, the most common Gram-negative organisms isolated were Klebsiella spp. and E.coli, followed by Citrobacter freundii and Enterobacter cloacae. Lee et al. [34] described the microbiological spectrum and susceptibility pattern of clinical isolates from a PICU and found a rate of 20% ESBL-positive Klebsiella in 2005. Our study displayed a lower rate with only 6.5% of Klebsiella spp. isolates being ESBL-positive. However, more than half of E.coli isolates (55%), about a quarter of all ...
  https://bmcinfectdis.biomedcentral.com/articles/10.1186/s12879-017-2251-x
*  Molecular genetic analysis of cephalosporinase production and its role in beta-lactam resistance in clinical isolates of...
Two strains of Enterobacter cloacae were isolated from a patient before (strain MHN1) and during (strain MHN2) treatment with moxalactam and gentamicin. Strain MHN1 exhibited inducible ampC cephalosporinase production. In contrast, strain MHN2 expressed the enzyme constitutively at a 3,000-fold higher level. With the Escherichia coli ampC gene as a hybridization probe it was shown that the genomic arrangement of the ampC region was the same in both strains. To gain more insight into regulatory phenomena, the ampC genes were cloned, and their expression was studied in E. coli K-12. The ampC gene from MHN1 behaved normally and conferred inducible beta-lactam resistance. A regulatory region of at least 800 base pairs involved in controlling repression-induction was located immediately upstream of ampC. Surprisingly, when present in E. coli the ampC gene from MHN2 no longer overproduced the cephalosporinase, and inducible expression was observed. This indicates that in MHN2 stable cephalosporinase ...
  https://infoscience.epfl.ch/record/151362
*  KEGG PATHWAY: Terpenoid backbone biosynthesis - Citrobacter koseri
Terpenoids, also known as isoprenoids, are a large class of natural products consisting of isoprene (C5) units. There are two biosynthetic pathways, the mevalonate pathway [MD:M00095] and the non-mevalonate pathway or the MEP/DOXP pathway [MD:M00096], for the terpenoid building blocks: isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). The action of prenyltransferases then generates higher-order building blocks: geranyl diphosphate (GPP), farsenyl diphosphate (FPP), and geranylgeranyl diphosphate (GGPP), which are the precursors of monoterpenoids (C10), sesquiterpenoids (C15), and diterpenoids (C20), respectively. Condensation of these building blocks gives rise to the precursors of sterols (C30) and carotenoids (C40). The MEP/DOXP pathway is absent in higher animals and fungi, but in green plants the MEP/DOXP and mevalonate pathways co-exist in separate cellular compartments. The MEP/DOXP pathway, operating in the plastids, is responsible for the formation of essential oil ...
  http://www.genome.jp/kegg-bin/show_pathway?cko00900
*  Colistin - For All Medical Treatment Options Explained, Visit CureCrowd
Colistin (polymyxin E) is a polymyxin antibiotic produced by certain strains of Bacillus polymyxa var. colistinus. Colistin is a mixture of cyclic polypeptides colistin A and B. Colistin is effective against most Gram-negative bacilli and is used as a polypeptide antibiotic. It is one of the last-resort antibiotics for multidrug-resistant Pseudomonas aeruginosa, and Acinetobacter.New Delhi metallo-β-Lactamase multidrug-resistant Enterobacteriaceae have also shown susceptibility to Colistin. ...
  https://www.curecrowd.com/treatments/colistin
*  Prevalence and characterisation of CTX-M beta-lactamases amongst Escherichia coli isolates from healthy food animals in China |...
The impact of extended-spectrum beta-lactamase (ESBL)-producing Enterobacteriaceae of food animal origins on human health has caught considerable attention worldwide. Intestinal Escherichia coli obtained from healthy food animals (pigs, cattle and poultry) in China were tested for the presence of ESBL genes. CTX-M-producing isolates were further characterised by pulsed-field gel electrophoresis (PFGE), phylogenetic grouping, genetic environment analysis, conjugation and plasmid replicon typing. A total of 127 of the 896 E. coli isolates showed reduced susceptibility to cefotaxime (minimal inhibitory concentration ,= 2 mu g/mL). bla(CTX-M) genes were detected in 111 of the 127 isolates. The most common CTX-M types were CTX-M-14 (n = 40), CTX-M-55 (n = 29) and CTX-M-65 (n = 22), followed by CTX-M-27, -15, -98, -24, -3, -102 and -104. CMY-2 was detected in two isolates. High clonal diversity was found amongst CTX-M-producing isolates. Insertion sequence ISEcp1 was observed 42 bp upstream of the ...
  http://ira.lib.polyu.edu.hk/handle/10397/19735
*  Surface display of ACC deaminase on endophytic Enterobacteriaceae strains to increase saline resistance of host rice sprouts by...
Ethylene is a gaseous plant growth hormone produced endogenously by almost all plants. Besides being a plant growth regulator, ethylene has also been established as a stress hormone [13]. Under a stress condition (e.g., salinity, drought, waterlogging, heavy metals, and pathogenicity), the endogenous production of ethylene is accelerated substantially, which adversely affects the root growth and consequently the plant growth as a whole [14]. Some soil microbes that produce the ACC deaminase promote plant growth by sequestering and cleaving plant produced ACC, and thereby reducing the plant ethylene level and allowing the plant to be more resistant to a wide variety of environmental stresses [10]. Genetically engineered plants expressing ACC deaminase activity are less subject to the deleterious effects of stress conditions on plant growth than non-transgenic plants [14, 15]. However, improvement of ACC deaminase traits in bacteria has not been well studied [14], probably attributable to that ...
  https://microbialcellfactories.biomedcentral.com/articles/10.1186/s12934-017-0831-5
*  Resistance mechanisms to third generation cephalosporins in bacteria Enterobacter spp. - Faculty of Science Repository
Strains of Enterobacter spp. are important causes of nosocomial infections. Resistance to antibiotics, especially to third generation cephalosporins, is constantly increasing. Resistance can be mediated through production of inducible β-lactamases, derepressed chromosomal β-lactamases, extended spectrum β-lactamases (ESBL) or through combination of these mechanisms. The purpose of this research was to clarify the resistance mechanisms to antibiotics in question. Disk-diffusion method showed the rise of bacterial resistance to third generation cephalosporins, which was confirmed by MIC method. Cephoxitinecephotaxime antagonistic test showed that none of the isolates produced inducible chromosomal AmpC β-lactamases. Double disk-synergy test showed that all the isolates were ESBL positive, which was confirmed by CLSI test. All the isolates showed chromosomal AmpC β-lactamase hyperproduction, which was detected by boronic acid test. Modified Hodge test showed that two bacterial ...
  http://digre.pmf.unizg.hr/552/
*  Phenotypic and genotypic comparison of ESBL production by Vaginal Escherichia coli isolates from pregnant and non-pregnant...
This study was designed to detect and compare ESBLs' distribution among vaginal E. coli isolates from pregnant and non-pregnant women. Most of this study-included isolates were resistant to CTX and more than half of them were resistant to CAZ. All of CAZ resistant isolates were also resistant to CTX. The members of Enterobacteriaceae possess many mechanisms of resistance to β-lactam antibiotics, however, β-lactamases are the most common and clinically significant mechanism of resistance to β-lactam antibiotics among this bacterial group [7]. Four types of ESBLs were detected in this study, namely: TEM-, SHV-, CTX-M-, and OXA-type. Of this study-included isolates, 65.5% (40/61) were ESBL producers by PCR technique. In Iraq, previous researchers [17, 18] reported ESBL production by 100% of enteropathogenic E. coli (EPEC) isolates from infants, most of them were suffering from watery diarrhea for more than 10 days, for that they were hospitalized. The important reason for this ...
  https://ann-clinmicrob.biomedcentral.com/articles/10.1186/1476-0711-12-7
*  Antibiotics
There has been increasing concern on the emergence of multidrug-resistant foodborne pathogens from foods of animal origin, including poultry. The current study aimed to evaluate antibiotic-resistant Enterobacteriaceae from raw retail chicken/turkey parts (thigh, wings, breast, and ground) and beef meat (ground and chunks) in Middle Tennessee. Resistance of the collected Enterobacteriaceae to a panel of antibiotics was determined by the Kirby-Bauer disk diffusion test. Retail meats were also assayed for the presence of Salmonella spp. and Escherichia coli O157:H7. Two hundred thirty-seven samples representing 95.2% of the total of 249 samples tested were positive for Enterobacteriaceae. The level of contamination with Enterobacteriaceae in raw meats ranged from 3.26 log cfu/g to 4.94 log cfu/g with significant differences in counts among meat types (P , 0.05). Contamination was significantly greater (P , 0.05) in ground beef, beef chucks, ...
  http://antibioticinformation.blogspot.com
*  Hexokinase and glucose-phosphoenolpyruvate phosphotransferase synthesis in Klebsiella aerogenes strains growing in continuous...
Considerable differences in steady-state hexokinase specific activity were found in 16 N.C.I.B. strains of Klebsiella aerogenes grown in identical conditions in glucose-limited chemostats. Strains of N.C.I.B. 8258 had no detectable activity, but its glucose-phosphoenolpyruvate phosphotransferase specific activity and that of the other strains were closely similar, and it is concluded that this phosphotransferase activity regulates the overall utilization of glucose, in which hexokinase plays no essential role. The hexokinase activity was subject to regulation by the availability of phosphorus, but this did not affect the glucose phosphotransferase activity. tlactose-grown organisms (including strain N.C.I.B. 8258) had no glucose phosphotransferase activity, but more than adequate hexokinase activity to phosphorylate the intracellularly liberated glucose. ...
  http://www.biochemj.org/content/166/3/643
*  Klebsiella - Wikipedia
Klebsiella is a genus of nonmotile, Gram-negative, oxidase-negative, rod-shaped bacteria with a prominent polysaccharide-based capsule.. Klebsiella species are found everywhere in nature. This is thought to be due to distinct sublineages developing specific niche adaptations, with associated biochemical adaptations which make them better suited to a particular environment. They can be found in water, soil, plants, insects, animals, and humans. Klebsiella is named after German-Swiss microbiologist Edwin Klebs (1834-1913). Carl Friedlander described Klebsiella bacillus which is why it was termed Friedlander bacillus for many years. The members of the genus Klebsiella are a part of the human and animal's normal flora in the nose, mouth and intestines. The species of Klebsiella are all gram-negative and non-motile. They tend to be shorter and thicker when compared to others in the Enterobacteriaceae family. The cells are rods in shape and generally measures 0.3 to 1.5 µm wide by ...
  https://en.wikipedia.org/wiki/Klebsiella
*  Spreading and mechanisms of antimicrobial resistance of microorganisms, producing beta-lactamases.phenotyping of potential ampc...
Abstract: Susceptibility of nosocomial potential AmpC-beta-lactamases producers strains (n=128), isolated from patients admitted to 30 medical centers of 15 various regions of Russia has been investigated. The susceptibility testing was performed by the broth microdilution method. The most active antibacterial agents acting to the investigated strains remained carbapenems (imipenem and meropenem). PCR-based detection of beta-lactamase genes (TEM, SHV, CTX) was investigated in 51 E. cloacae strains. Alone or in various combinations TEM type beta-lactamases have been found in 31 (60,8%) isolates, SHV - in 22 (43,1%), and CTX - in 22 (43,1%). There were negative results of TEM, SHV, CTX beta-lactamases genotyping in 13 (25,5%) E. cloacae suspect strains ...
  http://pbmc.ibmc.msk.ru/index.php/en/article/PBMC-2009-55-1-50-en
*  trpc | Application of Computational Methods for the Design of BACE-1 Inhibitors
Among 177 carbapenemase-producing Gram-negative bacilli (108 KPC 32 NDM 11 IMP 8 OXA-48 4 OXA-181 2 OXA-232 5 IMI 4 VIM and 3 SME producers) aztreonam-avibactam was energetic against all isolates except two NDM producers with elevated MICs of 8/4 and 16/4 mg/liter; ceftazidime-avibactam was active against all KPC- IMI- SME- and most OXA-48 group-producing isolates (93%) but not metallo-β-lactamase makers. and certain class D β-lactamases by covalent acylation of the β-lactamase active site serine residue. It restores susceptibility of harboring extended-spectrum β-lactamases (ESBLs) AmpC cephalosporinases and class A carbapenemases to ceftazidime or ceftaroline (1). studies of avibactam in combination with aztreonam have also proven activity against harboring NDM (a class B metallo-β-lactamase); however you will find scant data for the additional less commonly experienced carbapenemases (2 -4). The aim of this study was to examine the activities of ceftazidime and aztreonam with and without ...
  http://world-of-links.com/category/trpc/
*  Microbiota in Non-Infectious Disorders: Winter Lab - UT Southwestern, Dallas, Texas
A second focus of our research group is to understand what mechanisms contribute to microbiota changes in the inflamed intestine in the absence of a bacterial pathogen. During non-infectious inflammatory disorders affecting the intestinal mucosa such as IBD, an enrichment of commensal Proteobacteria (i.e. Enterobacteriaceae) by unknown mechanisms has been described.. Our central hypothesis (see central model) is that oxidized compounds, such as tetrathionate or nitrate, are generated as a byproduct of the inflammatory response. These terminal electron acceptors can be utilized by facultative anaerobic Proteobacteria (i.e. Enterobacteriaceae) in the gut to efficiently edge out bacteria that rely on fermentation to generate energy for growth.. To study the mechanisms driving this dysbiosis, we are using E. coli as a model organism in several animal models of non-infectious diarrhea. We were able to demonstrate ...
  http://www.utsouthwestern.edu/labs/winter-sebastian/research/interactions-among-the-host.html
*  Evaluation of a Multiplex PCR Assay To Rapidly Detect Enterobacteriaceae with a Broad Range of β-Lactamases Directly from...
PubMed Central Canada (PMC Canada) provides free access to a stable and permanent online digital archive of full-text, peer-reviewed health and life sciences research publications. It builds on PubMed Central (PMC), the U.S. National Institutes of Health (NIH) free digital archive of biomedical and life sciences journal literature and is a member of the broader PMC International (PMCI) network of e-repositories.
  http://pubmedcentralcanada.ca/pmcc/articles/PMC5075117/
*  Citrobacter - Wikipedia, entziklopedia askea.
Citrobacterek, Enterobacter, Klebsiella eta Escherichiarekin batera bakterio koliformeen multzoa osatzen du. Koliformeak hestean bizi diren bakterioak dira, ezaugarri biokimiko amankomunak dituztenak eta garrantzi handikoak ingurugiro-mikrobiologian, kutsadura fekalaren adierazleak baitira.. Citrobacter giza zein animalien hesteetan bizi da, baina egoera librean ere aurki daiteke (uretan, lur-zoruan...) Espezie batzuk oportunistak dira, gaixotasunak sortuz immunitate-sistema ahula dutenengan. Gaitzak eragiten dituenean gernu-infekzioak eta meningitis dira ohikoenak.. ...
  https://eu.wikipedia.org/wiki/Citrobacter
*  Enterobacter - Wikipedia, entziklopedia askea.
Enterobacter-ek, Citrobacter, Klebsiella eta Escherichiarekin batera bakterio koliformeen multzoa osatzen du. Koliformeak hestean bizi diren bakterioak dira, ezaugarri biokimiko amankomunak dituztenak eta garrantzi handikoak ingurugiro-mikrobiologian, kutsadura fekalaren adierazleak baitira.. Enterobacter giza zein animalien hesteetan bizi da, baina egoera librean ere aurki daiteke (uretan, lur-zoruan...) Espezie batzuk oportunistak dira, gaixotasunak sortuz immunitate-sistema ahula dutenengan; hori dela eta, infekzio nosokomial askoren jatorrian dago bakterio hau.. ...
  https://eu.wikipedia.org/wiki/Enterobacter
*  Contribution of novel frimbriae to Proteus mirabilis virulence - Pearson Melanie
Urinary tract infections are one of the most common bacterial infections in the U.S. Proteus mirabilis, a member of the Enterobacteriaceae, is a major cause of...
  http://grantome.com/grant/NIH/K22-AI083743-02
*  Providencia 2017: The Top 20 Providencia Apartment Rentals - Airbnb, Santiago Metropolitan Region, Chile
Sep 19, 2017 - Rent Apartments in Providencia, Chile from $20/night. Find unique places to stay with local hosts in 191 countries. Belong anywhere with Airbnb.
  https://www.airbnb.com/s/Providencia--Chile?type=apartment
*  CAZy - Bacteria
Lineage: cellular organisms; Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Klebsiella; Klebsiella ...
  http://www.cazy.org/b3857.html
*  CAZy - Bacteria
Lineage: cellular organisms; Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Klebsiella; Klebsiella ...
  http://www.cazy.org/b8406.html