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*  norpA - 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase - Drosophila melanogaster (Fruit fly) - norpA gene & protein
The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes (By similarity). Essential component of the phototransduction pathway (PubMed:2457447). Essential downstream component of a hh-signaling pathway which regulates the Duox-dependent gut immune response to bacterial uracil; required for the activation of Cad99C and consequently Cad99C-dependent endosome formation, which is essential for the Duox-dependent production of reactive oxygen species (ROS) in response to intestinal bacterial infection (PubMed:25639794).
  http://www.uniprot.org/uniprot/P13217
*  Secretory IgA: coordinating the capture and sampling of enteric pathogens (161.20) | The Journal of Immunology
Secretory IgA (SIgA) antibodies directed against the O-antigen (O-Ag) component of lipopolysaccharide are the primary determinants of mucosal immunity to enteric bacterial pathogens, such as Shigella flexneri and Salmonella enteric serovar Typhimurium. In this report, we demonstrate that monoclonal IgA Abs against the O-Ag are effective inhibitors of the bacterial type 3 secretion systems (T3SS) required for bacterial entry into intestinal epithelial cells. While these Abs did not affect bacterial viability, they did transiently de-energize both S. flexneri and S. Typhimurium, possibly accounting for the "paralysis" that has been observed in the case of S. Typhimurium, following Ab treatment. O-Ag specific IgA Abs also elicited long lasting ultrastructural changes in the bacterial outer membranes, suggesting that S. flexneri and S. Typhimurium made undergo specific adaptations in response to SIgA. These findings may have ...
  http://www.jimmunol.org/content/186/1_Supplement/161.20
*  UniProt: A8AL20 CITK8
ID A8AL20_CITK8 Unreviewed; 327 AA. AC A8AL20; DT 23-OCT-2007, integrated into UniProtKB/TrEMBL. DT 23-OCT-2007, sequence version 1. DT 27-SEP-2017, entry version 56. DE RecName: Full=2-keto-3-deoxygluconate permease {ECO:0000256,HAMAP-Rule:MF_00070}; DE Short=KDG permease {ECO:0000256,HAMAP-Rule:MF_00070}; GN Name=kdgT {ECO:0000256,HAMAP-Rule:MF_00070}; GN OrderedLocusNames=CKO_03092 {ECO:0000313,EMBL:ABV14183.1}; OS Citrobacter koseri (strain ATCC BAA-895 / CDC 4225-83 / SGSC4696). OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales; OC Enterobacteriaceae; Citrobacter. OX NCBI_TaxID=290338 {ECO:0000313,EMBL:ABV14183.1, ECO:0000313,Proteomes:UP000008148}; RN [1] {ECO:0000313,EMBL:ABV14183.1, ECO:0000313,Proteomes:UP000008148} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=ATCC BAA-895 / CDC 4225-83 / SGSC4696 RC {ECO:0000313,Proteomes:UP000008148}; RG The ...
  http://www.genome.jp/dbget-bin/www_bget?uniprot:A8AL20_CITK8
*  Dynamic Regulation of Epithelial Cell Survival by Enteropathogenic E. coli - V...
Enteropathogenic E. coli (EPEC), an intestinal pathogen that causes diarrhea, is responsible for significant morbidity and mortality, especially among children...
  http://grantome.com/grant/NIH/R01-AI081742-02
*  Bladder Infection following Prostatectomy...
Hi DanMc,. I got a UTI following my stay in hospital for the operation. Symptoms were burning around the penis, including some loss of skin. I was given the antibiotic Norfloxacin, and after about 6 weeks, it cleared up - took a lot longer than the doctor thought to disappear. The test showed I had picked up Citrobacter which is a hospital acquired bug that is resistant to some antibiotics. In addition to the Citrobacter, I requested a skin test for yeast infection, and it turns out I also had Candida Albicans. I applied Canesten over the penis and scrotum, and this seemed to help - I still use it a couple of times a week.. One thing I found helpful when I had the UTI was to drink more water. This seemed to dilute the buring effect of the urine, even though it meant more pad usage. Berb ...
  http://www.healingwell.com/community/default.aspx?f=35&m=818185
*  ILCS - What does ILCS stand for? The Free Dictionary
Looking for online definition of ILCS or what ILCS stands for? ILCS is listed in the World's largest and most authoritative dictionary database of abbreviations and acronyms
  https://acronyms.thefreedictionary.com/ILCS
*  Maternal retinoids control type 3 innate lymphoid cells and set the offspring immunity. | Sigma-Aldrich
Sigma-Aldrich offers abstracts and full-text articles by [Serge A van de Pavert, Manuela Ferreira, Rita G Domingues, Hélder Ribeiro, Rosalie Molenaar, Lara Moreira-Santos, Francisca F Almeida, Sales Ibiza, Inês Barbosa, Gera Goverse, Carlos Labão-Almeida, Cristina Godinho-Silva, Tanja Konijn, Dennis Schooneman, Tom O'Toole, Mark R Mizee, Yasmin Habani, Esther Haak, Fabio R Santori, Dan R Littman, Stefan Schulte-Merker, Elaine Dzierzak, J Pedro Simas, Reina E Mebius, Henrique Veiga-Fernandes].
  https://www.sigmaaldrich.com/catalog/papers/24670648
*  Longfonds Research
The field of type 2 immunity has broadened significantly over the past decade with the addition of new players such as the type 2 innate lymphoid cell (ILC2) and developments in understanding host-microbiota interactions. The conference featured an exceptional group of cross-disciplinary speakers each of whom are experts in different aspects within a defined set of diseases involving type 2 imm.... Keyword: type 2 immunity Airway dendritic cells ...
  http://research.longfonds.nl/database-zoeken?page=6
*  Suspicion of respiratory tract infection with multidrug-resistant Enterobacteriaceae: epidemiology and risk factors from a...
In this study we analysed the spectrum of Enterobacteriaceae in tracheal aspirates of intubated PICU patients from 2005 to 2014. The spectrum of Enterobacteriaceae in lower respiratory tract material revealed Enterobacter spp., E.coli and Klebsiella spp. as the most common isolates (86%). Comparable data of matching study settings are scarce in the current literature. Wilson et al. [5] collected daily tracheal aspirates from intubated children. Consistent with our findings, the most common Gram-negative organisms isolated were Klebsiella spp. and E.coli, followed by Citrobacter freundii and Enterobacter cloacae. Lee et al. [34] described the microbiological spectrum and susceptibility pattern of clinical isolates from a PICU and found a rate of 20% ESBL-positive Klebsiella in 2005. Our study displayed a lower rate with only 6.5% of Klebsiella spp. isolates being ESBL-positive. However, more than half of E.coli isolates (55%), about a quarter of all ...
  https://bmcinfectdis.biomedcentral.com/articles/10.1186/s12879-017-2251-x
*  Items where School is "School of Applied Sciences | Biomolecular Sciences Research Centre" - University of Huddersfield...
van den Thillart, Guido, Dufour, Sylvie and Rankin, J. Cliff, eds. (2008) Spawning Migration of the European Eel. Fish & Fisheries Series, 30 . Springer Netherlands, London, UK. ISBN 978-1-4020-9095-0 (Online) Ababou, Abdessamad, Gautel, Mathias and Pfuhl, Mark (2007) Disecting the N-terminal myosin binding site of human cardiac myosin binding protein C : Structure and myosin binding of domain C2. Journal of Biological Chemistry, 282 (12). pp. 9204-9215. ISSN 00219258 Ahmed, Naveed, Tsang, Wing Y. and Page, Michael I. (2004) Acyl vs Sulfonyl Transfer in N-Acyl β-Sultams and 3-Oxo-β sultams. Organic Letters, 6 (2). pp. 201-203. ISSN 15237060 Akbar, Sirwan, Rout, Simon and Humphreys, Paul (2015) Draft Genome Sequences of Pseudomonas aeruginosa Strain PS3 and Citrobacter freundii Strain SA79 Obtained from a Wound DressingAssociated Biofilm. Genome Announcements, 3 (3). ISSN 2169-8287 Al-Nuaimi, Yusur, Hardman, Jonathan A., Bíró, Tamás, Haslam, Iain S., Philpott, Michael P., Tóth, Balázs I., ...
  http://eprints.hud.ac.uk/view/depts/bmsrc.default.html
*  Coliform bacteria - Wikipedia
Coliform bacteria are defined as rod-shaped Gram-negative non-spore forming and motile or non-motile bacteria which can ferment lactose with the production of acid and gas when incubated at 35-37°C. They are a commonly used indicator of sanitary quality of foods and water. Coliforms can be found in the aquatic environment, in soil and on vegetation; they are universally present in large numbers in the feces of warm-blooded animals. While coliforms themselves are not normally causes of serious illness, they are easy to culture, and their presence is used to indicate that other pathogenic organisms of fecal origin may be present. Such pathogens include disease-causing bacteria, viruses, or protozoa and many multicellular parasites. Coliform procedures are performed in aerobic respiration,aerobic or anaerobic conditions. Typical genera include: Citrobacter Enterobacter Hafnia Klebsiella Escherichia Escherichia coli (E. coli), a rod-shaped ...
  https://en.wikipedia.org/wiki/Coliform_bacteria
*  Molecular genetic analysis of cephalosporinase production and its role in beta-lactam resistance in clinical isolates of...
Two strains of Enterobacter cloacae were isolated from a patient before (strain MHN1) and during (strain MHN2) treatment with moxalactam and gentamicin. Strain MHN1 exhibited inducible ampC cephalosporinase production. In contrast, strain MHN2 expressed the enzyme constitutively at a 3,000-fold higher level. With the Escherichia coli ampC gene as a hybridization probe it was shown that the genomic arrangement of the ampC region was the same in both strains. To gain more insight into regulatory phenomena, the ampC genes were cloned, and their expression was studied in E. coli K-12. The ampC gene from MHN1 behaved normally and conferred inducible beta-lactam resistance. A regulatory region of at least 800 base pairs involved in controlling repression-induction was located immediately upstream of ampC. Surprisingly, when present in E. coli the ampC gene from MHN2 no longer overproduced the cephalosporinase, and inducible expression was observed. This indicates that in MHN2 stable cephalosporinase ...
  https://infoscience.epfl.ch/record/151362
*  triphenylmethane dye
... definition, any of a great number of dyes, as gentian violet, fuchsin, and rosaniline, produced from triphenylmethane by replacement of the ring hydrogen atoms with hydroxy, amino, sulfo, or other atoms or groups. See more.
  http://www.dictionary.com/browse/triphenylmethane-dye
*  Nosocomial acquisition of methicillin-resistant **Staphyloccocus aureus** (MRSA) and extended-spectrum beta-lactamase (ESBL) *...
Background: The risk of acquisition of antibiotic resistant-bacteria during or shortly after antibiotic therapy is still unclear and it is often confounded by scarce data on antibiotic usage. Primary objective of the study is to compare rates of acquisition of methicillin-resistant Staphylococcus aureus and extended spectrum beta-lactamase-producing Enterobacteriaceae in hospitalised patients, after starting antibiotic therapy. Methods/Design: The study, running in three European hospitals, is a multicenter, prospective, longitudinal, observational cohort study funded from the European Community's Seventh Framework Programme [FP7/2007-2013] within the project 'Impact of Specific Antibiotic Therapies on the prevalence of hUman host ResistaNt bacteria' (acronym SATURN). Nasal and rectal screening for methicillin-resistant Staphylococcus aureus and extended spectrum beta-lactamase-producing Enterobacteriaceae will be obtained at hospital ...
  https://repository.uantwerpen.be/link/irua/98290
*  Ichthyophthirius multifiliis as a potential vector of Edwardsiella ictaluri in channel catfish - Xu - 2012 - FEMS Microbiology...
Previous studies by our group and others have demonstrated that parasitism enhances mortality in fish coinfected with bacteria regardless of the order of infection (i.e. parasitism followed by bacterial exposure or vice versa). Our hypothesis in this study was that Ich, a ciliated protozoan parasite, could vector E. ictaluri, a bacterial pathogen, into channel catfish. Our results using fluorescent E. ictaluri demonstrated that the bacteria attached to the Ich reproductive and infective stages (tomonts and theronts). Confocal microscopy further demonstrated a close association of E. ictaluri with the surface of Ich and that the bacteria were not internalized. In a previous study, we demonstrated using lectins that surface carbohydrates are present on Ich theronts (Xu et al., 2001). Soybean agglutinin and lentil agglutinin were the most effective at binding Ich theronts, suggesting that the sugar molecules present were ...
  http://onlinelibrary.wiley.com/doi/10.1111/j.1574-6968.2012.02518.x/full
*  Citrobacter farmeri - Wikipedia
Citrobacter farmeri is a Gram-negative species of bacteria. Brenner, D. J.; Grimont, P. A. D.; Steigerwalt, A. G.; Fanning, G. R.; Ageron, E.; Riddle, C. F. (1993). "Classification of Citrobacteria by DNA Hybridization: Designation of Citrobacter farmeri sp. nov., Citrobacter youngae sp. nov., Citrobacter braakii sp. nov., Citrobacter werkmanii sp. nov., Citrobacter sedlakii sp. nov., and Three Unnamed Citrobacter Genomospecies". International Journal of Systematic Bacteriology. 43 (4): 645-658. doi:10.1099/00207713-43-4-645. ISSN 0020-7713. PMID 8240948. Tan, C. K.; Lai, C. C.; Lin, S. H.; Liao, C. H.; Huang, Y. T.; Hsueh, P. R. (2010). "Fatal Citrobacter farmeri Meningitis in a Patient with Nasopharyngeal Cancer". Journal of Clinical Microbiology. 48 (4): 1499-1500. doi:10.1128/JCM.00282-10. ISSN 0095-1137. PMC 2849549 . PMID 20181904. ...
  https://en.wikipedia.org/wiki/Citrobacter_farmeri
*  KEGG PATHWAY: Methane metabolism - Cronobacter sakazakii ATCC BAA-894
Methane is metabolized principally by methanotrophs and methanogens in the global carbon cycle. Methanotrophs consume methane as the only source of carbon, while methanogens produce methane as a metabolic byproduct. Methylotrophs, which are microorganisms that can obtain energy for growth by oxidizing one-carbon compounds, such as methanol and methane, are situated between methanotrophs and methanogens. Methanogens can obtain energy for growth by converting a limited number of substrates to methane under anaerobic conditions. Three types of methanogenic pathways are known: CO2 to methane [MD:M00567], methanol to methane [MD:M00356], and acetate to methane [MD:M00357]. Methanogens use 2-mercaptoethanesulfonate (CoM; coenzyme M) as the terminal methyl carrier in methanogenesis and have four enzymes for CoM biosynthesis [MD:M00358]. Coenzyme B-Coenzyme M heterodisulfide reductase (Hdr), requiring for the final reaction steps of methanogenic pathway, is divided into two types: cytoplasmic HdrABC in ...
  http://www.genome.jp/kegg-bin/show_pathway?esa00680+ESA_03811
*  International prospective study of **Klebsiella pneumoniae** bacteremia: implications of extended-spectrum ß-lactamase...
Background: Commonly encountered nosocomially acquired gram-negative bacteria, especially Klebsiella pneumoniae, produce extended-spectrum ß-lactamases (ESBLs) as an antibiotic resistance mechanism. Objective: To determine whether microbiology laboratories should report the presence of ESBLs and to establish the infection-control implications of ESBL-producing organisms. Design: Prospective observational study. Setting: 12 hospitals in South Africa, Taiwan, Australia, Argentina, the United States, Belgium, and Turkey. Patients: 440 patients with 455 consecutive episodes of K. pneumoniae bacteremia between 1 January 1996 and 31 December 1997; of these, 253 episodes were nosocomially acquired. Measurements: The K. pneumoniae isolates were examined for the presence of ESBLs. Pulsed-field gel electrophoresis was used to analyze the molecular epidemiology of nosocomial bacteremia with ESBL-producing K. pneumoniae. Results: Overall, 30.8% (78 of 253) episodes of nosocomial bacteremia and 43.5% (30 ...
  https://repository.uantwerpen.be/link/irua/72171
*  Characterization and Comparison of Extended-Spectrum beta-Lactamase (ESBL) Resistance Genotypes and Population Structure of...
We investigated the general level of antibiotic resistance with further analysis of extended-spectrum beta-lactamase (ESBL) prevalence, as well as the population structure of E. coli in fecal flora of humans and Franklin's gulls (Leucophaeus pipixcan) in central parts of Chile. We found a surprisingly high carriage rate of ESBL-producing E. coli among the gulls 112/372 (30.1%) as compared to the human population 6/49 (12.2%.) Several of the E. coli sequence types (STs) identified in birds have previously been reported as Multi Drug Resistant (MDR) human pathogens including the ability to produce ESBLs. This means that not only commensal flora is shared between birds and humans but also STs with pathogenic potential. Given the migratory behavior of Franklin's gulls, they and other migratory species, may be a part of ESBL dissemination in the environment and over great geographic distances. Apart from keeping the antibiotic use low, breaking the transmission chains between the environment and ...
  http://www.diva-portal.org/smash/record.jsf?pid=diva2:664352
*  Extended-spectrum beta-lactamase-producing Pseudomonas aeruginosa in camel in Egypt: potential human hazard | Annals of...
Extended-spectrum beta lactamase-producing bacteria are one of the fastest emerging resistance problems worldwide. ESBL-producing bacteria were observed in human medical practice, the observation of these bacteria in companion animals and the increase in livestock has initiated monitoring studies concentrating on livestock [13, 21].. Livestock may be an important vehicle for the community-wide dissemination of antimicrobial-resistant Enterobacteriaceae, also P. aeruginosa especially ESBL-producing type isolates have been found in increasing numbers in food-producing animals [9, 10, 22].. Accordingly to the hypothesis that animals might become infection sources or even natural persistent sources acting as risky reservoirs of infection leading to the spread of these bacteria specifically multidrug resistant types in community [23]. There are essential needs for monitoring or surveillance studies incorporating veterinary ...
  https://ann-clinmicrob.biomedcentral.com/articles/10.1186/s12941-017-0197-x
*  Peer Evaluation : In vitro Evaluation of Biofield Treatment on Enterobacter cloacae: Impact on Antimicrobial Susceptibility and...
Abstract : This research work investigated the influence of biofield treatment on Enterobacter cloacae (ATCC 13047) against antimicrobial susceptibility. Two sets of ATCC samples were taken in this experiment and denoted as A and B. ATCC A sample was revived and divided into two parts Gr. I (control) and Gr. II (revived); likewise, ATCC B was labeled as Gr. III (lyophilized). Group II and III were given with biofield treatment. The control and treatment groups of E. cloacae cells were tested with respect to antimicrobial susceptibility, biochemical reactions pattern and biotype number. The result showed significant decrease in the minimum inhibitory concentration (MIC) value of aztreonam and ceftazidime (≤ 8 μg/mL), as compared to control group (≥ 16 μg/mL). It was observed that 9% reaction was altered in the treated groups with respect to control out of the 33 biochemical reactions. Moreover, biotype number of this organism was substantially changed in group II (7731 7376) and group III ...
  http://peerevaluation.org/read/libraryID:30452
*  share via email
Extended-spectrum beta-lactamases (ESBLs), AmpC-type beta-lactamases (ACBLs) and carbapenemases are among the most important resistance mechanisms in Enterobacteriaceae. This study investigated the presence of these resistance mechanisms in consecutive non-replicate isolates of Escherichia coli (n = 2,352), Klebsiella pneumoniae (n = 697), and Proteus mirabilis (n = 275) from an Italian nationwide cross-sectional survey carried out in October 2013. Overall, 15.3% of isolates were non-susceptible to extended-spectrum cephalosporins but susceptible to carbapenems (ESCR-carbaS), while 4.3% were also non-susceptible to carbapenems (ESCR-carbaR). ESCR-carbaS isolates were contributed by all three species, with higher proportions among isolates from inpatients (20.3%) but remarkable proportions also among those from outpatients (11.1%). Most ESCR-carbaS isolates were ESBL-positive (90.5%), and most of them were contributed by E. coli carrying blaCTX-M group 1 genes. Acquired ACBLs were less common ...
  http://www.eurosurveillance.org/content/10.2807/1560-7917.ES.2017.22.31.30583
*  Conlan Group - National Human Genome Research Institute (NHGRI)
The Microbial Genomics Section (MGS) explores connections between microbes, microbial communities and human health. The MGS has an ambitious portfolio of projects focused on cataloging the bacterial and fungal diversity of human skin as it relates to both health and disease. Analysis of the relative abundance of bacterial and fungal marker genes has been used to generate both baseline characterizations of healthy individuals and testable hypotheses about the underlying causes of diseases like atopic dermatitis. Comprehensive studies employing metagenomic sequencing to capture pathway and abundance data across taxonomic kingdoms are now underway. In addition, a fruitful collaboration with the National Institutes of Health (NIH) Clinical Center's Department of Laboratory Medicine has been established to examine outbreaks of clinically relevant hospital pathogens, focusing on carbapenem-resistant Enterobacteriaceae, using high-resolution genome sequencing.. ...
  https://www.genome.gov/27566926/conlan-group/
*  Enterobacter gergoviae | definition of Enterobacter gergoviae by Medical dictionary
Looking for online definition of Enterobacter gergoviae in the Medical Dictionary? Enterobacter gergoviae explanation free. What is Enterobacter gergoviae? Meaning of Enterobacter gergoviae medical term. What does Enterobacter gergoviae mean?
  https://medical-dictionary.thefreedictionary.com/Enterobacter+gergoviae