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*  Frontiers | The role of EGFR and ErbB family related proteins in the oligodendrocyte specification in germinal niches of the...
Regulation of myelin genes implicated in psychiatric disorders by functional activity in axons. Front. Neuroanat. 3:4. doi: ... P0 or MPZ) in Schwann cells (Chen et al., 2006). Neuroregulin 1 (NRG-1) induces heterodimerization between ErbB2 and ErbB3 ... Figure 5. Biological effects reported in ErbB family proteins. The homo or heterodimerization of the ErbB proteins may generate ... Golli myelin basic proteins stimulate oligodendrocyte progenitor cell proliferation and differentiation in remyelinating adult ...
  https://www.frontiersin.org/articles/10.3389/fncel.2013.00258/full
*  Structure & Function Flashcards by Deesha Sarma | Brainscape
4) Transmembrane protein in myelin sheath: PLP in CNS, P0 in PNS ... Schwann cells- wraps myelin around the axon/nerve fiber, also ... motor axons- travel along permissive pathway, deviate at decision points. sensory axons- travel along motor axon routes, ... if muscle protein synthesis (actin and myosin are protein) > muscle protein breakdown --> hypertrophy ... 2) oligodendrocytes produce myelin sheath by sending out processes to wrap axons spirally (as opposed to schwann cells which ...
  https://www.brainscape.com/flashcards/structure-amp-function-4272832/packs/6115391
*  Aging-associated changes in motor axon voltage-gated Na(+) channel function in mice. | Sigma-Aldrich
In mice deficient of myelin protein P0, severe peripheral nervous system myelin damage is associated with ectopic expression of ... The aim of the present study was to investigate the effect of regular aging on motor axon function with particular emphasis on ... Aging-associated changes in motor axon voltage-gated Na(+) channel function in mice.. [Mihai Moldovan, Mette Romer Rosberg, ... Our data suggest that alteration in voltage-gated Na(+) channel isoform expression contributes to changes in motor axon ...
  https://www.sigmaaldrich.com/catalog/papers/26923409
*  Metabolic regulator LKB1 is crucial for Schwann cell-mediated axon maintenance. - PubMed - NCBI
Protein-Serine-Threonine Kinases/metabolism*. *Schwann Cells/physiology*. Substances. *Luminescent Proteins. *Myelin P0 Protein ... The degeneration of axons in LKB1 mutants was most dramatic in unmyelinated small sensory fibers, whereas motor axons were ... The latter acts in a compensatory manner to support distressed axons. LKB1 signaling is essential for SC-mediated axon support ... of sciatic nerve lysates probed with the indicated antibodies for detection of structural myelin proteins. For uncropped ...
  https://www.ncbi.nlm.nih.gov/pubmed/25195104
*  Plus it
... and myelin proteins (MAG and P0). β-Actin serves as a loading control. B, The polarity protein Par-3 (red) is asymmetrically ... The polarity protein Par-3 is asymmetrically localized in SCs at the SC-SC and SC-axon interface (Fig. 1B). We hypothesize that ... the myelin-specific proteins, MBP and P0, were analyzed and compared between the mice. Although the expression of MBP and P0 ... 4D). Concomitantly, the expression of the myelin-specific proteins, MBP and P0, from sciatic nerves, were analyzed and compared ...
  http://www.jneurosci.org/content/31/8/3032
*  Polysaccharide-modified scaffolds for controlled lentivirus delivery in vitro and after spinal cord injury. - PubMed - NCBI
Neurofilament-160 (blue), myelin basic protein/MBP (red), and p0 (green) staining of bridges that delivered (a-d) Sonic ... Transgene expression persisted for weeks after implantation, and was able to enhance axon growth and myelination. These studies ... White arrowheads indicate oligodendrocyte-derived myelin fibers (MBP+/p0−) present in the bridges. Green arrowheads indicate ... Axon growth and myelination in heparin-modified bridges after 8 weeks implantation. ...
  https://www.ncbi.nlm.nih.gov/pubmed/?term=23791981
*  Plus it
MAG, P0, and MBP are myelin-related proteins, the expression of which was enhanced when primary rat Schwann cells were treated ... 6G). To evaluate myelin formation, we calculated the number of myelinated axons per area. Figure 6J shows 1.5-fold more myelin- ... Here, we demonstrate that in cultured Schwann cells, neuregulin and PDGF suppressed the expression of myelin-associated protein ... Protein Zero (P0), and suppressed cAMP-inducible POU (SCIP) and reducing immature Schwann cell markers such as GFAP and neural ...
  http://www.jneurosci.org/content/24/30/6724
*  Nerve Regenerative Effects of GABA-B Ligands in a Model of Neuropathic Pain
P0 and PMP22. P0 is a glycoprotein accounting for over half of the total proteins in PNS myelin, while PMP22 represents 2-5% of ... B. B. Sun and S. Y. Chiu, "N-type calcium channels and their regulation by GABAB receptors in axons of neonatal rat optic nerve ... for glycoprotein P0 (P0) and peripheral myelin protein of 22 kDa (PMP22) and 50,000 CPM for 18S, and incubated at 45°C ... baclofen plus CGP56433 showed a partial but significant increase in the mRNA levels of both myelin proteins: P0 (. ; 95% CI: ...
  https://www.hindawi.com/journals/bmri/2014/368678/
*  Charcot-Marie-Tooth Disease Fact Sheet | National Institute of Neurological Disorders and Stroke
... making up a single segment of the myelin sheath. This protein may be involved in Schwann cell communication with the axon. ... To date, scientists have identified more than 120 different point mutations in the P0 gene. As a result of abnormalities in P0 ... Myelin twists around the axon like a jelly-roll cake and prevents the loss of electrical signals. Without an intact axon and ... CMT2 results from abnormalities in the axon of the peripheral nerve cell rather than the myelin sheath. It is less common than ...
  https://www.ninds.nih.gov/Disorders/Patient-Caregiver-Education/Fact-Sheets/Charcot-Marie-Tooth-Disease-Fact-Sheet
*  Dismutase-competent SOD1 mutant accumulation in myelinating Schwann cells is not detrimental to normal or transgenic ALS model...
... driven by the myelin protein zero (P0) promoter. In this model, mutant SOD1 accumulation in Schwann cells was comparable to ... Here, we examine the potential contribution of peripheral axon ensheathing Schwann cells to ALS by constructing transgenic mice ... Increasing mutant SOD1 synthesis in Schwann cells by cross-breeding transgenic P0-SOD1(G93A) and SOD1(G93A) mice did not affect ... Growth, locomotion and survival of these P0-SOD1(G93A) mice were indistinguishable from normal animals. There was no evidence ...
  https://www.ndcn.ox.ac.uk/publications/106543
*  Charcot-Marie-Tooth Disease (+ 5 Ways to Help Symptoms) | Health Garden
... while CMT1B is caused by mutations in the gene that carries the instructions for manufacturing the myelin protein zero (P0). ... Even though the myelin sheath might not be damaged due to this type, the axons still cannot work properly. ... CMT1A is caused by changes in the way that peripheral myelin protein-22 (PMP-22) is made, ... Axons cannot work properly when the myelin is damaged or destroyed.. *Charcot-Marie-Tooth disease type 2 (CMT3) - This type is ...
  https://www.adelsimpsonhealth.com/charcot-marie-tooth-disease-5-ways-to-help-symptoms/
*  Plus it
1993) Expression of the protein zero myelin gene in axon-related Schwann cells is linked to basal lamina formation. Development ... or P0 (I, J) or processed forin situ hybridization using CNP (C,D), MAG (G, H), or P0 RNA probes (K, L) to detect myelin- ... CD prevents expression of myelin-specific proteins and mRNAs. Expression of myelin-specific proteins was assessed by ... 1995) Crucial role for the myelin-associated glycoprotein in the maintenance of axon-myelin integrity. Eur J Neurosci 7:511-515 ...
  http://www.jneurosci.org/content/17/1/241
*  Myosin II has distinct functions in PNS and CNS myelin sheath formation | JCB
The reduction in myelin formation was corroborated by significantly decreased amounts of myelin proteins (MBP, P0, and myelin- ... SC associate with but fail to completely ensheath axons. Similarly, expression of myelin-specific proteins and transcription ... 2 A). Western blotting also confirmed a decrease in the amount of myelin proteins (MBP and P0) expressed in knockdown cultures ... right) Western blots of myelinating cocultures showing a marked reduction in the total amount of myelin proteins (P0 and MBP) ...
  http://jcb.rupress.org/content/182/6/1171.long
*  Frontiers | mTORC1 Activation by Loss of Tsc1 in Myelinating Glia Causes Downregulation of Quaking and Neurofascin 155 Leading...
mRNA and protein expression analyses revealed strong reduction in the RNA-binding protein Quaking (Qk) and the 155 kDa glial ... of myelinating glial cells and proper organization of axonal domains and provide insights into TSC-associated myelinated axon ... mRNA and protein expression analyses revealed strong reduction in the RNA-binding protein Quaking (Qk) and the 155 kDa glial ... The mutant mice of either sex showed reduced myelination, disrupted paranodal domains in myelinated axons, and disorganized ...
  https://www.frontiersin.org/articles/10.3389/fncel.2018.00201/full
*  The Role of Non-pore-Forming β Subunits in Physiology and Pathophysiology of Voltage-Gated Sodium Channels | SpringerLink
Voltage-gated sodium channel β1 and β2 subunits were discovered as auxiliary proteins that co-purify with pore-forming α ... Filbin MT, Tennekoon GI (1993) Homophilic adhesion of the myelin P0 protein requires glycosylation of both molecules in the ... Rasband MN (2010) The axon initial segment and the maintenance of neuronal polarity. Nat Rev Neurosci 11(8):552-562PubMedGoogle ... Poliak S, Peles E (2003) The local differentiation of myelinated axons at nodes of Ranvier. Nat Rev Neurosci 4(12):968-980 ...
  https://link.springer.com/chapter/10.1007/978-3-642-41588-3_4
*  Schwann cell - Wikipedia
Unexpectedly, P0- mice also showed degeneration of both axons and their surround myelin sheaths, suggesting that P0 plays a ... of the total protein in the sheath. P0 has been shown to be essential for the formation of compact myelin, as P0 null mutant ( ... Myelin protein zero (P0) is a cell adhesion molecule belonging to the immunoglobulin superfamily and is the major component of ... Although myelination of large caliber axons was initiated in P0- mice, the resulting myelin layers were very thin and poorly ...
  https://en.wikipedia.org/wiki/Schwann_cell
*  2008 - Leukodystrophieforschung im LEUKONET
"P0 protein is required for and can induce formation of schmidt-lantermann incisures in myelin internodes." J Neurosci 28(28): ... Nave, K. A. and B. D. Trapp (2008). "Axon-glial signaling and the glial support of axon function." Annu Rev Neurosci 31: 535-61 ... "Absence of 2-hydroxylated sphingolipids is compatible with normal neural development but causes late-onset axon and myelin ... Nave, K. A. (2008). "Neuroscience: An ageing view of myelin repair." Nature 455(7212): 478-9 www.ncbi.nlm.nih.gov/entrez/query. ...
  http://www.leukonet.de/68/?L=nvguxjsfxqzpu
*  Plus it
Numerous swollen axons with thin myelin sheets (arrowheads) and axon degeneration (arrows) were observed in both lines when ... The crucial role of neuronal KCC3 protein in regulating peripheral axon volume. The KCC3 cotransporter was proposed to act ... FlouroMyelin dye (Molecular Probes, 1:300) was used to label myelin. Immunohistochemistry was performed on fixed E17 or P0 of ... Although axon degeneration, hypomyelination, and axon swelling in the sciatic nerves and the CNS were previously described in ...
  http://www.jneurosci.org/content/32/11/3865
*  Perineurial glia regulate morphology of the Drosophila nervous system - UBC Library Open Collections
A sub-population of neural crest cells already expresses P0, a myelin protein restricted to the Schwann cell lineage (Jessen ... Sherman, D.L., and Brophy, P.J. (2005). Mechanisms of axon ensheathment and myelin growth. Nat Rev Neurosci 6, 683--‐690. Singh ... LeBlanc, S.E., Jang, S.W., Ward, R.M., Wrabetz, L., and Svaren, J. (2006). Direct regulation of myelin protein zero expression ... Jessen and Mirsky, 2005). Axons growing out of the ventral part of the neural tube express the transmembrane protein neuregulin ...
  https://open.library.ubc.ca/cIRcle/collections/ubctheses/24/items/1.0300655
*  Plus it
... formed myelin (P0; purple) on host axons (NF, blue). Scale bar, 10 μm. ... This may be explained by higher expression of growth-associated proteins, such as GAP-43, and cytoskeletal proteins in axons ... we do not know the extent along the axons or whether the thickness of the myelin surrounding the axons approaches normal. Thus ... The BDA-labeled regenerated axons were found to be myelinated by SCs (Fig. 7A-C). However this myelin could come from either ...
  http://www.jneurosci.org/content/33/13/5655
*  PNS myelin - Schwann Cells - GUWS Medical
The specific galactolipids found in PNS myelin are largely the same as CNS myelin, although some glycolipids such as sulphated ... and the main ones that are special to PNS myelin are peripheral myelin protein zero (P0), peripheral myelin protein 22 (PMP22 ... As such, it serves the same function as PLP in CNS myelin. P0 knockout mice exhibit severe hypomyelination and axon ... The major CNS myelin proteins are also found in PNS myelin, ... peripheral nerve P2 protein, and periaxin.. P0 is a ...
  https://www.guwsmedical.info/schwann-cells/pns-myelin.html
*  Protocols and Video Articles Authored by Chi Wang Ip
Feb, 2009 , Pubmed ID: 19028581 Mice hetero- or homozygously deficient for myelin protein zero (P0+/-, P0-/- mice) are models ... proteolipid protein (PLP), leads to late-onset degeneration of myelin and pathological changes in axons. Based on the ... proteolipid protein, CD8+ T-lymphocytes mediate the primarily genetically caused myelin and axon damage. In the present study, ... We detected myelin basic protein (MBP)-specific CD8â º T cells in peripheral lymphoid organs of CD8-depleted animals which, ...
  https://www.jove.com/author/Chi+Wang_Ip
*  Myelinogenesis - Wikipedia
... and P0. It is likely that axons from myelinated fibers are able to induce Schwann cell myelin protein synthesis throughout the ... Synthesis of detectable myelin-specific proteins did not occur in Schwann cells free of axons and thus proving that the axons ... A key part of the experiment was to indicate that Schwann cells don't synthesize myelin-proteins in the absence of axons. ... Myelin is an insulating material that forms the myelin sheath and wraps around the axon of the neuron to allow functioning in ...
  https://en.wikipedia.org/wiki/Myelinogenesis
*  Faculty Profile - Jacobs School of Medicine and Biomedical Sciences - University at Buffalo
Proteolipid protein cannot replace P0 protein as the major structural protein of peripheral nervous system myelin.. Glia. 2015 ... Myelin is a multi-lamellar sheath that invests large axons and permits rapid conduction of nerve signals. Failure in myelin ... P0 (protein zero) mutation S34C underlies instability of internodal myelin in S63C mice.. J Biol Chem. 2010; 285(53). ... Taveggia C, Pizzagalli A, Feltri ML, Grinspan JB, Kamholz J, Wrabetz L. MEBA derepresses the proximal myelin basic protein ...
  https://medicine.buffalo.edu/content/medicine/faculty/profile.html?ubit=mlfeltri
*  Gene expression analysis of nuclear factor I-A deficient mice indicates delayed brain maturation | Genome Biology | Full Text
... a phylogenetically conserved transcription/replication protein, plays a crucial role in mouse brain development. Previous ... myelin-associated glycoprotein; Mal, myelin and lymphocyte protein; Mobp, myelin oligodendrocyte basic protein; Mog, myelin ... whereas five encode proteins that function in axon repulsion (for example, Ephrin B2 and collapsin response mediator protein-1 ... mice died at P0 and about 10% survived to P16. In contrast, 0% of Nfia-/- mice survive past P0 in an inbred C57BL/6 background ...
  https://genomebiology.biomedcentral.com/articles/10.1186/gb-2007-8-5-r72