*  Frontiers | The role of EGFR and ErbB family related proteins in the oligodendrocyte specification in germinal niches of the...
Regulation of myelin genes implicated in psychiatric disorders by functional activity in axons. Front. Neuroanat. 3:4. doi: ... P0 or MPZ) in Schwann cells (Chen et al., 2006). Neuroregulin 1 (NRG-1) induces heterodimerization between ErbB2 and ErbB3 ... Figure 5. Biological effects reported in ErbB family proteins. The homo or heterodimerization of the ErbB proteins may generate ... Golli myelin basic proteins stimulate oligodendrocyte progenitor cell proliferation and differentiation in remyelinating adult ...
  https://www.frontiersin.org/articles/10.3389/fncel.2013.00258/full
*  Structure & Function Flashcards by Deesha Sarma | Brainscape
4) Transmembrane protein in myelin sheath: PLP in CNS, P0 in PNS ... Schwann cells- wraps myelin around the axon/nerve fiber, also ... motor axons- travel along permissive pathway, deviate at decision points. sensory axons- travel along motor axon routes, ... if muscle protein synthesis (actin and myosin are protein) > muscle protein breakdown --> hypertrophy ... 2) oligodendrocytes produce myelin sheath by sending out processes to wrap axons spirally (as opposed to schwann cells which ...
  https://www.brainscape.com/flashcards/structure-amp-function-4272832/packs/6115391
*  Metabolic regulator LKB1 is crucial for Schwann cell-mediated axon maintenance. - PubMed - NCBI
Protein-Serine-Threonine Kinases/metabolism*. *Schwann Cells/physiology*. Substances. *Luminescent Proteins. *Myelin P0 Protein ... The degeneration of axons in LKB1 mutants was most dramatic in unmyelinated small sensory fibers, whereas motor axons were ... The latter acts in a compensatory manner to support distressed axons. LKB1 signaling is essential for SC-mediated axon support ... of sciatic nerve lysates probed with the indicated antibodies for detection of structural myelin proteins. For uncropped ...
  https://www.ncbi.nlm.nih.gov/pubmed/25195104
*  Plus it
... and myelin proteins (MAG and P0). β-Actin serves as a loading control. B, The polarity protein Par-3 (red) is asymmetrically ... The polarity protein Par-3 is asymmetrically localized in SCs at the SC-SC and SC-axon interface (Fig. 1B). We hypothesize that ... the myelin-specific proteins, MBP and P0, were analyzed and compared between the mice. Although the expression of MBP and P0 ... 4D). Concomitantly, the expression of the myelin-specific proteins, MBP and P0, from sciatic nerves, were analyzed and compared ...
  http://www.jneurosci.org/content/31/8/3032
*  Plus it
MAG, P0, and MBP are myelin-related proteins, the expression of which was enhanced when primary rat Schwann cells were treated ... 6G). To evaluate myelin formation, we calculated the number of myelinated axons per area. Figure 6J shows 1.5-fold more myelin- ... Here, we demonstrate that in cultured Schwann cells, neuregulin and PDGF suppressed the expression of myelin-associated protein ... Protein Zero (P0), and suppressed cAMP-inducible POU (SCIP) and reducing immature Schwann cell markers such as GFAP and neural ...
  http://www.jneurosci.org/content/24/30/6724
*  Charcot-Marie-Tooth Disease Fact Sheet | National Institute of Neurological Disorders and Stroke
... making up a single segment of the myelin sheath. This protein may be involved in Schwann cell communication with the axon. ... To date, scientists have identified more than 120 different point mutations in the P0 gene. As a result of abnormalities in P0 ... Myelin twists around the axon like a jelly-roll cake and prevents the loss of electrical signals. Without an intact axon and ... CMT2 results from abnormalities in the axon of the peripheral nerve cell rather than the myelin sheath. It is less common than ...
  https://www.ninds.nih.gov/Disorders/Patient-Caregiver-Education/Fact-Sheets/Charcot-Marie-Tooth-Disease-Fact-Sheet
*  Dismutase-competent SOD1 mutant accumulation in myelinating Schwann cells is not detrimental to normal or transgenic ALS model...
... driven by the myelin protein zero (P0) promoter. In this model, mutant SOD1 accumulation in Schwann cells was comparable to ... Here, we examine the potential contribution of peripheral axon ensheathing Schwann cells to ALS by constructing transgenic mice ... Increasing mutant SOD1 synthesis in Schwann cells by cross-breeding transgenic P0-SOD1(G93A) and SOD1(G93A) mice did not affect ... Growth, locomotion and survival of these P0-SOD1(G93A) mice were indistinguishable from normal animals. There was no evidence ...
  https://www.ndcn.ox.ac.uk/publications/106543
*  Charcot-Marie-Tooth Disease (+ 5 Ways to Help Symptoms) | Health Garden
... while CMT1B is caused by mutations in the gene that carries the instructions for manufacturing the myelin protein zero (P0). ... Even though the myelin sheath might not be damaged due to this type, the axons still cannot work properly. ... CMT1A is caused by changes in the way that peripheral myelin protein-22 (PMP-22) is made, ... Axons cannot work properly when the myelin is damaged or destroyed.. *Charcot-Marie-Tooth disease type 2 (CMT3) - This type is ...
  https://www.adelsimpsonhealth.com/charcot-marie-tooth-disease-5-ways-to-help-symptoms/
*  Plus it
1993) Expression of the protein zero myelin gene in axon-related Schwann cells is linked to basal lamina formation. Development ... or P0 (I, J) or processed forin situ hybridization using CNP (C,D), MAG (G, H), or P0 RNA probes (K, L) to detect myelin- ... CD prevents expression of myelin-specific proteins and mRNAs. Expression of myelin-specific proteins was assessed by ... 1995) Crucial role for the myelin-associated glycoprotein in the maintenance of axon-myelin integrity. Eur J Neurosci 7:511-515 ...
  http://www.jneurosci.org/content/17/1/241
*  Myosin II has distinct functions in PNS and CNS myelin sheath formation | JCB
The reduction in myelin formation was corroborated by significantly decreased amounts of myelin proteins (MBP, P0, and myelin- ... SC associate with but fail to completely ensheath axons. Similarly, expression of myelin-specific proteins and transcription ... 2 A). Western blotting also confirmed a decrease in the amount of myelin proteins (MBP and P0) expressed in knockdown cultures ... right) Western blots of myelinating cocultures showing a marked reduction in the total amount of myelin proteins (P0 and MBP) ...
  http://jcb.rupress.org/content/182/6/1171.long
*  Schwann cell - Wikipedia
Unexpectedly, P0- mice also showed degeneration of both axons and their surround myelin sheaths, suggesting that P0 plays a ... of the total protein in the sheath. P0 has been shown to be essential for the formation of compact myelin, as P0 null mutant ( ... Myelin protein zero (P0) is a cell adhesion molecule belonging to the immunoglobulin superfamily and is the major component of ... Although myelination of large caliber axons was initiated in P0- mice, the resulting myelin layers were very thin and poorly ...
  https://en.wikipedia.org/wiki/Schwann_cell
*  2008 - Leukodystrophieforschung im LEUKONET
"P0 protein is required for and can induce formation of schmidt-lantermann incisures in myelin internodes." J Neurosci 28(28): ... Nave, K. A. and B. D. Trapp (2008). "Axon-glial signaling and the glial support of axon function." Annu Rev Neurosci 31: 535-61 ... "Absence of 2-hydroxylated sphingolipids is compatible with normal neural development but causes late-onset axon and myelin ... Nave, K. A. (2008). "Neuroscience: An ageing view of myelin repair." Nature 455(7212): 478-9 www.ncbi.nlm.nih.gov/entrez/query. ...
  http://www.leukonet.de/68/?L=nvguxjsfxqzpu
*  Perineurial glia regulate morphology of the Drosophila nervous system - UBC Library Open Collections
A sub-population of neural crest cells already expresses P0, a myelin protein restricted to the Schwann cell lineage (Jessen ... Sherman, D.L., and Brophy, P.J. (2005). Mechanisms of axon ensheathment and myelin growth. Nat Rev Neurosci 6, 683--‐690. Singh ... LeBlanc, S.E., Jang, S.W., Ward, R.M., Wrabetz, L., and Svaren, J. (2006). Direct regulation of myelin protein zero expression ... Jessen and Mirsky, 2005). Axons growing out of the ventral part of the neural tube express the transmembrane protein neuregulin ...
  https://open.library.ubc.ca/cIRcle/collections/ubctheses/24/items/1.0300655
*  Plus it
Numerous swollen axons with thin myelin sheets (arrowheads) and axon degeneration (arrows) were observed in both lines when ... The crucial role of neuronal KCC3 protein in regulating peripheral axon volume. The KCC3 cotransporter was proposed to act ... FlouroMyelin dye (Molecular Probes, 1:300) was used to label myelin. Immunohistochemistry was performed on fixed E17 or P0 of ... Although axon degeneration, hypomyelination, and axon swelling in the sciatic nerves and the CNS were previously described in ...
  http://www.jneurosci.org/content/32/11/3865
*  Plus it
... formed myelin (P0; purple) on host axons (NF, blue). Scale bar, 10 μm. ... This may be explained by higher expression of growth-associated proteins, such as GAP-43, and cytoskeletal proteins in axons ... we do not know the extent along the axons or whether the thickness of the myelin surrounding the axons approaches normal. Thus ... The BDA-labeled regenerated axons were found to be myelinated by SCs (Fig. 7A-C). However this myelin could come from either ...
  http://www.jneurosci.org/content/33/13/5655
*  Protocols and Video Articles Authored by Chi Wang Ip
Feb, 2009 , Pubmed ID: 19028581 Mice hetero- or homozygously deficient for myelin protein zero (P0+/-, P0-/- mice) are models ... proteolipid protein (PLP), leads to late-onset degeneration of myelin and pathological changes in axons. Based on the ... proteolipid protein, CD8+ T-lymphocytes mediate the primarily genetically caused myelin and axon damage. In the present study, ... We detected myelin basic protein (MBP)-specific CD8â º T cells in peripheral lymphoid organs of CD8-depleted animals which, ...
  https://www.jove.com/author/Chi+Wang_Ip
*  Myelinogenesis - Wikipedia
... and P0. It is likely that axons from myelinated fibers are able to induce Schwann cell myelin protein synthesis throughout the ... Synthesis of detectable myelin-specific proteins did not occur in Schwann cells free of axons and thus proving that the axons ... A key part of the experiment was to indicate that Schwann cells don't synthesize myelin-proteins in the absence of axons. ... Myelin is an insulating material that forms the myelin sheath and wraps around the axon of the neuron to allow functioning in ...
  https://en.wikipedia.org/wiki/Myelinogenesis
*  SMART: IG domain annotation
Myelin protein P0 (P25189) (SMART). OMIM:159440: Charcot-Marie-Tooth neuropathy-1B. OMIM:118200: Dejerine-Sottas disease, ... Axon guidance. 5.50. map04662. B cell receptor signaling pathway. 4.79. map04650. Natural killer cell mediated cytotoxicity. ... Click on the protein counts, or double click on taxonomic names to display all proteins containing IG domain in the selected ... myelin P-zero-related. OMIM:145900: Hypomyelination, congenital. Myosin-binding protein C, cardiac-type (Q14896) (SMART). OMIM: ...
  http://smart.embl.de/smart/do_annotation.pl?DOMAIN=IG&START=94&END=176&E_VALUE=5.75e-4&TYPE=SMART&BLAST=GPATLIFEGDTLVLHCRAWQDWPLTQVIFYREGSALGPPGPKSEFSITMVQKSDGGHYHCSGIFRSPGPGSREAASPVAITVQ
*  Hitting "Reset" in Protein Synthesis Restores Myelination in Model of Charcot-Marie-Tooth Disease | www.bioquicknews.com
... which make myelin for nerves. Myelin is the crucial fatty material that wraps the axons of neurons and allows them to transmit ... Many CMT neuropathies are associated with mutations in a gene known as P0, which glues the wraps of myelin together. Dr. ... it is a disease of myelin and it results from misfolded proteins in cells that produce myelin. The new findings were published ... The cells commence protein synthesis again when a protein called Gadd34 becomes involved. "After cells have reacted to, and ...
  http://www.bioquicknews.com/node/1156
*  Molekulare Analyse der Nogo Expression und der Myelinisierung im Hippocampus während der Entwicklung und nach Läsion
Reappearing mature axons were found in the hippocampus following axonal sprouting. Various myelin-associated proteins, with ... Only a slight Nogo-C expression was found at P0 in the principal cell layers of the hippocampus. During adulthood, all Nogo ... lasting loss of myelin. Quantitative analysis of myelin and myelin breakdown products at different time points after lesion ... Nogo-C und myelin basic protein (MBP) mRNA, werden erst am P15 expremiert, zu einem Zeitpunkt also, an dem myelinisierte Fasern ...
  https://edoc.hu-berlin.de/handle/18452/16070
*  Regeneration in the Goldfish Visual System by Sam Nona - Webvision
... but contains two proteins IP1 and IP2 which are immunologically related to PNS myelin protein P0 (Jeserich et al., 1990). On ... Axons of retinal ganglion cells emerge from the back of the eye, acquire myelin sheath and become grouped into bundles, thus ... Antibodies to two fish-derived myelin proteins (central myelin 36K, and peripheral/central myelin 6D2; Jeserich and Waehneldt, ... this basis it may be argued that fish myelin proteins have similar properties to myelin proteins found in the PNS, which are ...
  http://webvision.med.utah.edu/book/part-x-primary-visual-cortex/regeneration-in-the-goldfish-visual-system/
*  Professor John Pollard - The University of Sydney
Yan, W., Pollard, J., Archelos,, J., Hartung, H. (2001). P0 protein is a target antigen in chronic inflammatory denyelinating ... Mathey, E., Pollard, J. (2016). Myelin Antigens in Guillain-Barre Syndrome: EAN, the Pied Piper of Myelin. In Hugh J Willison, ... Ng, K., Howells, J., Pollard, J., Burke, D. (2008). Up-regulation of slow K+ channels in peripheral motor axons: a ... Yan, W., Pollard, J., Archelos,, J., Hartung, H. (2001). P0 protein is a target antigen in chronic inflammatory denyelinating ...
  http://sydney.edu.au/medicine/people/academics/profiles/john.pollard.php
*  Gene Report for G00000652 - Genes2Cognition Neuroscience Research Programme
Loss of the structural proteins of compact peripheral nervous system (PNS) myelin, P0 protein, and myelin basic protein does ... Complementary interacting molecules on myelin and axons are required for long-term axon-myelin stability. Their disruption ... Western blots showed that the proteins of compact myelin, P0 glycoprotein, and myelin basic protein were not significantly ... myelin-associated glycoprotein, late myelin gene products are absent, including those for protein zero and myelin basic protein ...
  http://www.genes2cognition.org/db/gene/G00000652
*  Plus it
4E). The myelin sheath thickness (g-ratio; ratio of axon diameter to axon + myelin sheath diameter) was calculated for ... Residual Rac1 protein is attributed to axonal Rac1 because Rac1 protein is nearly absent in sciatic nerves after in vitro axon ... P0-P120) support a major role for Rac1 in SC myelination. We found that myelin sheaths do not form in the Rac1 mutant mice at ... Protein concentration was measured on a spectrophotometer using Bio-Rad DC Protein Assay Kit. Equal amounts of protein were ...
  http://www.jneurosci.org/content/32/48/17251
*  Gene expression analysis of nuclear factor I-A deficient mice indicates delayed brain maturation | Genome Biology | Full Text
... a phylogenetically conserved transcription/replication protein, plays a crucial role in mouse brain development. Previous ... myelin-associated glycoprotein; Mal, myelin and lymphocyte protein; Mobp, myelin oligodendrocyte basic protein; Mog, myelin ... whereas five encode proteins that function in axon repulsion (for example, Ephrin B2 and collapsin response mediator protein-1 ... mice died at P0 and about 10% survived to P16. In contrast, 0% of Nfia-/- mice survive past P0 in an inbred C57BL/6 background ...
  https://genomebiology.biomedcentral.com/articles/10.1186/gb-2007-8-5-r72