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*  A novel microtubule-modulating agent EM011 inhibits angiogenesis by repressing the HIF-1α axis and disrupting cell polarity and...
Thus, microtubule-disrupting agents that perturb the HIF-1α axis and neovascularization cascade are attractive anticancer drug ... Thus, microtubule-disrupting agents that perturb the HIF-1α axis and neovascularization cascade are attractive anticancer drug ... which are critical for cell migration. These events were associated with a drug-mediated decrease in activation of Rho GTPases ... inhibits a spectrum of angiogenic events by interfering with endothelial cell invasion, migration and proliferation. Employing ...
  http://oxfordindex.oup.com/view/10.1093/carcin/bgs200
*  Regulation of Cdc42 polarization by the Rsr1 GTPase and Rga1, a Cdc42 GTPase-activating protein, in budding yeast | Journal of...
Despite a large number of studies on cell polarization, how the axis of cell polarity is determined in the proper orientation ... despite cell-to-cell variation. Taken together, these results suggest that even in cells that bud in a random pattern, the axis ... Although wild-type cells exhibit changes of the polarity axis around the bud-neck region during T1, we found that rsr1Δ or bud2 ... 2013). Establishment of a robust single axis of cell polarity by coupling multiple positive feedback loops. Nat. Commun. 4, ...
  http://jcs.biologists.org/content/128/11/2106
*  Genetic analysis of Wnt/PCP genes in neural tube defects | Springer for Research & Development
Background Mouse homozygous mutants in Wnt/planar cell polarity (PCP) pathway genes have been shown to cause neural tube ... Nishimura T, Honda H, Takeichi M. Planar cell polarity links axes of spatial dynamics in neural-tube closure. Cell. 2012;149(5 ... Cells were seeded onto 20 mm Glass Bottom Cell Culture Dish and transfected with Celsr2-GFP, Dvl3-Flag. Cells were washed in ... regulates planar cell polarity under the control of frizzled. Cell. 1999;98(5):585-95.CrossRefPubMedGoogle Scholar ...
  https://rd.springer.com/article/10.1186/s12920-018-0355-9
*  Polarity - Biology-Online Dictionary
polarity of cells in a developing embryo (during embryogenesis). *polarity of cells in axis formation ... Examples of polarity manifested in a cell or group of cells are as follows: *polarity inside a dividing cell (during cell ... Biology) Polarity is also an essential and common feature in organisms, particularly at the cell level. ... Chemistry) Polarity confers molecules and compounds distinctive features in terms of structure and chemical interaction with ...
  https://www.biology-online.org/dictionary/Polarity
*  William Nelson | Stanford Medicine Profiles
In contrast, migratory mesenchymal cells have a front-rear axis of polarity. During development, mesenchymal cells convert to ... or after development of cell polarity. At low cell density, Rac1V12 cells had a flattened morphology and intact cell-cell ... Modulation of epithelial morphogenesis and cell fate by cell-to-cell signals and regulated cell adhesion. Seminars in cell ... Cadherins form trans-interactions on opposing cell surfaces which result in weak cell-cell adhesion. Stronger cell-cell ...
  https://med.stanford.edu/profiles/w-james-nelson
*  Microtubules provide directional information for core PCP function - Semantic Scholar
... contribute to polarization of individual cells. How polarity is globally coordinated with tissue axes is unresolved. Consistent ... signaling controls the polarization of cells within the plane of an epithelium. Two molecular modules composed of Fat(Ft)/ ... Cell biology in development The cell biology of planar cell polarity. *Danelle Devenport ... Cell Flow Reorients the Axis of Planar Polarity in the Wing Epithelium of Drosophila. *Benoît Aigouy, Reza Farhadifar, +4 ...
  https://www.semanticscholar.org/paper/Microtubules-provide-directional-information-for-Matis-Russler-Germain/b444f20c65ffdf1edf56ea5a20b2622d7ec64f32
*  Interactive Fly, Drosophila
Activation of Discs large by aPKC aligns the mitotic spindle to the polarity axis during asymmetric cell division. Elife 6. ... and Dsh may serve as a bridge to connect cell signaling and polarity (Liu, 2016). Developmental signaling and cell polarity ... independent of its role in cell polarity. It is believed that other cell polarity determinants may similarly participate in ... Epithelial cell polarity is controlled by components of the Scribble polarity module, and its regulation is critical for tissue ...
  http://www.sdbonline.org/sites/fly/newgene/disclrg1.htm
*  Abl - Tyrosine-protein kinase Abl - Drosophila melanogaster (Fruit fly) - Abl gene & protein
... critical for embryonic epithelial morphogenesis regulating cell shape changes and cell migration. Plays a critical role in ... planar cell polarity pathway involved in axis elongation Source: FlyBase ,p>Inferred from Mutant Phenotype,/p> ,p>Describes ... cell-cell junction Source: FlyBase ,p>Inferred from Direct Assay,/p> ,p>Used to indicate a direct assay for the function, ... regulation of cell proliferation Source: GO_Central. *regulation of cell shape Source: FlyBase ,p>Inferred from Mutant ...
  http://www.uniprot.org/uniprot/P00522
*  KAKEN - Researchers | NISHIMURA Tamako (40415261)
... planar polarity,planar cell polarity,WAVE2,DAAM1,AJ,神経上皮細胞, # of Research Projects ... Cell biology, Keywords:F-アクチン,神経管,ミオシン,neural tube, ... Journal Article] Planar cell polarity links axes of spatial dynamics in neural-tube closure2012. *. Author(s). Nishimura, T. ... Journal Article] Planar cell polarity links axes of spatial dynamics in neural tube closure2012. *. Author(s). Tamako Nishimura ...
  https://nrid.nii.ac.jp/nrid/1000040415261/
*  WNT Signaling | www.antibodies-online.com
During early development, Wnt signaling plays a major role in axon guidance, cell polarity, and body axis specification. ... Wnt signaling can also prompt morphological changes to cellular structure e.g., the non-canonical planar cell polarity pathway ... Cell motility, adhesion, cytokinesis, and other functions of the cell cortex are mediated by reorganization of the actin ... In mammalian cells, the enzyme is composed of four different chains: alpha, beta, gamma, and delta. The product of this gene is ...
  https://www.antibodies-online.com/wnt-signaling-pathway-10/
*  PRICKLE1 - Wikipedia
"Prickle and Strabismus form a functional complex to generate a correct axis during planar cell polarity signaling". EMBO J. 22 ... Prickle planar cell polarity protein 1 is a protein that in humans is encoded by the PRICKLE1 gene. This gene encodes a nuclear ... Prickle planar cell polarity protein 1". Retrieved 2017-08-08. Katoh M, Katoh M (2003). "Identification and characterization of ... Cell. Biol. 23 (24): 9025-31. PMC 309669 . PMID 14645515. Kim SM, Yang JW, Park MJ, Lee JK, Kim SU, Lee YS, Lee MA (2006). " ...
  https://en.wikipedia.org/wiki/PRICKLE1
*  An Option Space for Neural Evolution | Philosophical Transactions of the Royal Society B: Biological Sciences
This is ensured by the planar polarity of the cells, which controls the axis of beating [17]. In ciliated larvae, Wnt ... 2010 Coupling between hydrodynamic forces and planar cell polarity orients mammalian motile cilia. Nat. Cell Biol. 12, 341-350 ... 2012 A conserved function for Strabismus in establishing planar cell polarity in the ciliated ectoderm during cnidarian larval ... New kinds of cell-to-cell interactions became important and nervous systems arose, on this view, to coordinate the micro- ...
  http://rstb.royalsocietypublishing.org/content/370/1684/20150181
*  Genetic analysis of Wnt/PCP genes in neural tube defects | BMC Medical Genomics | Full Text
Mouse homozygous mutants in Wnt/planar cell polarity (PCP) pathway genes have been shown to cause neural tube defects (NTDs) ... Nishimura T, Honda H, Takeichi M. Planar cell polarity links axes of spatial dynamics in neural-tube closure. Cell. 2012;149(5 ... Cells were seeded onto 20 mm Glass Bottom Cell Culture Dish and transfected with Celsr2-GFP, Dvl3-Flag. Cells were washed in ... regulates planar cell polarity under the control of frizzled. Cell. 1999;98(5):585-95.View ArticlePubMedGoogle Scholar. ...
  https://bmcmedgenomics.biomedcentral.com/articles/10.1186/s12920-018-0355-9
*  Eya1 controls cell polarity, spindle orientation, cell fate and Notch signaling in distal embryonic lung epithelium |...
... the axis of polarity that will determine the orientation of the apical-basal cell division plane is defined by the cell fate ... cell polarity/geometry. Orientation of mitotic spindle and cell division axis can impact normal physiological processes, ... 2009). Numb regulates cell-cell adhesion and polarity in response to tyrosine kinase signalling. EMBO J. 28, 2360-2373. ... Each line represents the spindle axis of a single late mitotic cell. (N,O) Examples of distal epithelial mitotic cells that ...
  http://dev.biologists.org/content/138/7/1395
*  "Regulator of G protein signaling 3 modulates Wnt5b calcium dynamics an" by Christina M. Freisinger
Wnt signaling network plays a key role in a vast array of cellular processes including body axis patterning and cell polarity. ... In chapter 2, I describe endogenous Ca2+ dynamics from the very first cell divisions through early somitogenesis in zebrafish ... The process of vertebrate development requires communication among many cells of the embryo in order to define the body axis ( ... Wnt signaling network plays a key role in a vast array of cellular processes including body axis patterning and cell polarity. ...
  http://ir.uiowa.edu/etd/667/
*  CYTOO Launches 2D+ Solutions at HCA | SelectScience
CYTOO's 2D+ Solutions open fresh perspectives for cell based assay development in drug discovery. ... CYTOO, a life science systems & tools company providing disruptive solutions for cell-based assays and High Content Screening ( ... This approach results in control of cell contractility, cell polarity, organelle positioning, and cell division axis. This ... CYTOO's 2D+ Cell Culture Platform is based on standard and custom adhesive micropatterns in 96-well plates to guide cell ...
  http://www.selectscience.net/product-news/CYTOO-Inc/CYTOO-Launches-2D+-Solutions-at-HCA/?techID=122&artID=27150
*  Frontiers | Robustness and Accuracy in Sea Urchin Developmental Gene Regulatory Networks | Genetics
I propose that this direct activation of a set of regulatory genes enables a uniform regulatory response and a clear cut cell ... Interestingly, in the sea urchin in both cases, the signaling pathway that defines the axis controls directly the expression of ... I propose that this direct activation of a set of regulatory genes enables a uniform regulatory response and a clear cut cell ... I propose that the use of compound positive feedback circuitry provides the endodermal cells enough time to turn off mesodermal ...
  https://www.frontiersin.org/articles/10.3389/fgene.2016.00016/full
*  Role of membrane traffic in the generation of epithelial cell asymmetry.
Epithelial cells have an apical-basolateral axis of polarity, which is required for epithelial functions including barrier ... Epithelial cells have an apical-basolateral axis of polarity, which is required for epithelial functions including barrier ... Cell Membrane / metabolism*. Cell Polarity / genetics, physiology. Epithelial Cells / cytology*, metabolism*. Humans. Mice. ... Title: Nature cell biology Volume: 14 ISSN: 1476-4679 ISO Abbreviation: Nat. Cell Biol. Publication Date: 2012 Dec ...
  http://www.biomedsearch.com/nih/Role-membrane-traffic-in-generation/23196841.html
*  Cilia in left-right asymmetry | Philosophical Transactions of the Royal Society B: Biological Sciences
2010 Planar cell polarity enables posterior localization of nodal cilia and left-right axis determination during mouse and ... 2010 Planar polarization of node cells determines the rotational axis of node cilia. Nat. Cell Biol. 12, 170-176. (doi:10.1038/ ... to the posterior pole of the cell [23]. Genetic studies indicate planar cell polarity (PCP) proteins are involved in the ... 2010 Planar cell polarity breaks bilateral symmetry by controlling ciliary positioning. Nature 466, 378-382. (doi:10.1038/ ...
  http://rstb.royalsocietypublishing.org/content/371/1710/20150410
*  Most recent papers with the keyword Neuroblast | Read by QxMD
Activation of Discs large by aPKC aligns the mitotic spindle to the polarity axis during asymmetric cell division. ... greater cell body areas of Iba-1-positive cells, and higher numbers of hypertrophic Iba-1-positive cells (with a cell body area ... An intact actomyosin network is essential for anchoring polarity proteins to the cell cortex and maintaining cell size ... read/29185419/activation-of-discs-large-by-apkc-aligns-the-mitotic-spindle-to-the-polarity-axis-during-asymmetric-cell-division ...
  https://www.readbyqxmd.com/keyword/72584
*  NKT Cells in Tumor Immunity: Opposing Subsets Define a New Immunoregulatory Axis | The Journal of Immunology
T cell response. Within the CD4+ T cell family perhaps the best known polarity axis is between Th1 (IFN-γ-producing) and Th2 ( ... Treg cell. There is some evidence that Treg cells can suppress type I NKT cells (124), that type I NKT cells stimulated by ... T cells (61). Likewise, B cells or tumor cells pulsed with tumor peptides and αGalCer were effective, with help from NKT cells ... Subsets of NKT cells in tumor immunity; nested dichotomies determining function and a new immunoregulatory axis. NKT cells are ...
  http://www.jimmunol.org/content/180/6/3627
*  Protocols and Video Articles Authored by Leila Green (Translated to Dutch)
... conserved morphogenetic movement that drives axial lengthening of the primary body axis and depends on the planar cell polarity ... These data uncover a potential role for PKP2 upstream of β1 integrin and RhoA in integrating cell-cell and cell-substrate ... smaller than control cells. Focal adhesions in PKP2-deficient cells are ∼2 Ã- larger and more stable than in control cells, ... Platelet-biased Stem Cells Reside at the Apex of the Haematopoietic Stem-cell Hierarchy Nature. Aug, 2013 , Pubmed ID: 23934107 ...
  https://www.jove.com/author/Leila_Green?language=Dutch
*  Planar polarity from flies to vertebrates | Journal of Cell Science
Polarity is a fundamental property of many cells. Yeast cells can become polarized along the mother-daughter axis, epithelial ... A) Wing cells display only apical-basal polarity until the pupal stage. Planar polarity is first evident by the production of a ... This tissue polarity, or planar cell polarity (PCP), is a property shown by some epithelia to become polarized within the plane ... Mutations in PCP genes cause cells to lose their planar organization, yet maintaining their individual cell polarity. Loss of ...
  http://jcs.biologists.org/content/117/4/527.long
*  Duke Department of Biology
Croce, JC; McClay, DR, The canonical Wnt pathway in embryonic axis polarity., Seminars in Cell and Developmental Biology, vol. ... We then ask how this specification programs cells for their morphogenetic movements at gastrulation, and how the cells deploy ... We then ask how this specification programs cells for their morphogenetic movements at gastrulation, and how the cells deploy ... Cell and Molecular Biology. Developmental Biology. Research Categories: Developmental Biology Research Description: We ask how ...
  http://fds.duke.edu/db/aas/Biology/faculty/david.mcclay
*  Drosophila ATP6AP2/VhaPRR functions both as a novel planar cell polarity core protein and a regulator of endosomal trafficking ...
Cell flow reorients the axis of planar polarity in the wing epithelium of Drosophila. Cell 142: 773-786. ... planar cell polarity. Introduction. The planar cell polarity (PCP) pathway is a highly conserved pathway that polarizes cells ... Hexagonal packing of Drosophila wing epithelial cells by the planar cell polarity pathway. Dev Cell 9: 805-817. ... positive cells (green) and not to untransfected cells (asterisks) or Nhe2 expressing cells (B′, B′′). The non‐transfected cells ...
  http://emboj.embopress.org/content/32/2/245