*  International Journal of Pharmaceutical Sciences and Drug Research 2014; 6(4): 253-262
Hutchinson-Gilford progeria syndrome: report of a Libyan family and evidence of autosomal recessive inheritance. Clin Genet. ... Kieras FJ, Brown WT, Houck GE, Zebrower M. Elevation of urinary hyaluronic acid in Werner syndrome and progeria. Biochem Med ... IJPSPP Hutchinson-Gilford Progeria Syndrome: A Prematurely Aging Disorder Ahsas Goyal*, Neetu Agrawal, Bhupesh C. Semwal, ... Majority of affected patients show an autosomal dominant inheritance, although some cases of autosomal recessive inheritance ...
  http://spotidoc.com/doc/318324/international-journal-of-pharmaceutical-sciences-and-drug...
*  Progeroid syndromes - Wikipedia
Main article: Werner syndrome. Werner syndrome (WS) is a rare autosomal recessive disorder.[9][10] It has a global incidence ... Werner syndrome[edit]. Werner syndrome is inherited in an autosomal recessive manner, which means both parents must contribute ... Bloom syndrome[edit]. Main article: Bloom syndrome. Bloom syndrome (BS) is a very rare autosomal recessive disorder.[21] ... Rothmund-Thomson syndrome[edit]. autosomal recessive. Cancer[edit]. Some segmental progeroid syndromes, such as Werner syndrome ...
  https://en.wikipedia.org/wiki/Accelerated_aging_disease
*  WRN monoclonal antibody (M09), clone 3C11 - (H00007486-M09) - Products - Abnova
Defects in this gene are the cause of Werner syndrome, an autosomal recessive disorder characterized by premature aging. [ ...
  http://www.abnova.com/products/products_detail.asp?catalog_id=H00007486-M09
*  Pregnancy sub-cluster 61
Werner's syndrome (WS) is a rare autosomal recessive disorder, characterised by skin changes prematurely during adolescence. An ... Dermatosparaxis Ehlers-Danlos syndrome (or EDS VIIC), a rare autosomal recessive connective tissue disorder, is characterized ... Carney complex is a rare, autosomal-dominant, multisystem disorder characterized by endocrine overactivity, spotty skin ... Carney Complex: A Rare Cause of Cushing Syndrome in Pregnancy. Spaniol Lt Alison LA Departments of Obstetrics and Gynecology, ...
  http://www.biomedsearch.com/cluster/69/Pregnancy/sub-61.html
*  WRNIP1 - Wikipedia
Werner's syndrome is a rare autosomal recessive disorder characterized by premature aging. The protein encoded by this gene ... WRNIP1 has been shown to interact with Werner syndrome ATP-dependent helicase. GRCh38: Ensembl release 89: ENSG00000124535 - ... "A novel protein interacts with the Werner's syndrome gene product physically and functionally". J Biol Chem. 276 (23): 20364-9 ... "Entrez Gene: WRNIP1 Werner helicase interacting protein 1". Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to ...
  https://en.wikipedia.org/wiki/WRNIP1
*  Identify Werner protein molecular partners in S phase alt cell :: University of Southern California Dissertations and Theses
... in this gene are the causal factor for the outset of an autosomal recessive progerid disorder known as Werner Syndrome. WRN has ... IDENTIFY WERNER PROTEIN MOLECULAR PARTNERS IN S PHASE ALT CELL by Fangjin Huang A Thesis Presented to the FACULTY OF THE USC ... IDENTIFY WERNER PROTEIN MOLECULAR PARTNERS IN S PHASE ALT CELL by Fangjin Huang A Thesis Presented to the FACULTY OF THE USC ... The Werner protein (WRN) is encoded by the WRN gene. Mutations ... Identify Werner protein molecular partners in S phase alt cell ...
  http://digitallibrary.usc.edu/cdm/compoundobject/collection/p15799coll3/id/21674/rec/7
*  Progeroid syndromes - Wikipedia
Werner syndrome (WS) is a rare autosomal recessive disorder. It has a global incidence rate of less than 1 in 100,000 live ... autosomal recessive Some segmental progeroid syndromes, such as Werner syndrome (WS), Bloom syndrome (BS), Rothmund-Thomson ... Hutchinson-Gilford progeria syndrome, Werner syndrome, and Cockayne syndrome are the three genetic disorders in which patients ... Wiedemann-Rautenstrauch (WR) syndrome, also known as neonatal progeroid syndrome, is an autosomal recessive progeroid syndrome ...
  https://en.wikipedia.org/wiki/Progeroid_syndromes
*  POLD1 - Wikipedia
The WRN gene is mutated in Werner syndrome (an autosomal recessive disorder) leading to accelerated aging and increased genetic ... MDPL/MDP, AWS and Werner's syndrome all present with progeria. A first example of germline transmission was observed in a ... Kamath-Loeb AS, Shen JC, Schmitt MW, Loeb LA (April 2012). "The Werner syndrome exonuclease facilitates DNA degradation and ... Oshima J, Sidorova JM, Monnat RJ (March 2016). "Werner syndrome: Clinical features, pathogenesis and potential therapeutic ...
  https://en.wikipedia.org/wiki/POLD1
*  Ageing Research Reviews
Abstract Werner syndrome (WS) is a heritable autosomal recessive human disorder characterized by the premature onset of several ... Werner syndrome (WRN) gene variants and their association with altered function and age-associated diseases.. ... However, despite being the most prevalent neurodegenerative disorder, the number one communication disorder, and one of the top ... B, Valdiglesias V Abstract Frailty is an emerging geriatric syndrome characterized by higher vulnerability to stressors, with ...
  https://medworm.com/journal/ageing-research-reviews/
*  CP-91149 | High-Throughput Screen for the Chemical Inhibitors
Germline mutations in the WRN gene cause an autosomal recessive disorder Werner syndrome (WS). WS is usually characterized by ... We record that the manifestation of Werner proteins facilitates the changeover in human being cells of ALT type I love ... role from the SV40 source of replication and the consequences of Werner proteins and telomerase on telomere framework and ... Werner protein also colocalizes with telomeres in human ALT cells [13]. cells that lack functional telomerase undergo telomere ...
  http://acancerjourney.info/index.php/tag/cp-91149/
*  Joseph Paruta - Wikipedia
It is suspected that Joseph suffered from Werner syndrome, a rare autosomal recessive disorder that is characterized by the ... By middle age he started to lose his telltale white hair as the Werner's syndrome worsened. He had a hoarse voice and his skin ... It is also suspected that he suffered from impulse control disorders such as antisocial personality disorder. Gravano would ... By 1959, at the age of thirty Joseph had the telltale condition of the syndrome by having a "birdlike" facial appearance. This ...
  https://en.wikipedia.org/wiki/Joseph_Paruta
*  'werner syndrome' Protocols and Video...
... werner syndrome' include 'A Fluorescence-based Exonuclease Assay to Characterize DmWRNexo, Orthologue of Human Progeroid WRN ... Werner Syndrome: An autosomal recessive disorder that causes premature aging in adults, characterized by sclerodermal skin ...
  https://www.jove.com/keyword/werner+syndrome
*  Werner Syndrome
a rare autosomal recessive disorder of considerable biomedical interest because patients exhibit an accelerated development of ... Werner, syndrome de. ORPHA.net. [French]. Le syndrome de Werner est un syndrome de vieillissement précoce ... risques majeurs ... Werner Syndrome. NCBI Genes and Disease. Werner Syndrome is a premature aging disease that begins in adolescence or early ... Autosomal recessive ... The features of Werner syndrome are scleroderma - like skin changes, especially in the extremities, ...
  http://www.ibis-birthdefects.org/start/werner.htm
*  Werner's syndrome protein (WRN) migrates Holliday junctions and co‐localizes with RPA upon replication arrest | EMBO Reports
Individuals affected by the autosomal recessive disorder Werner's syndrome (WS) develop many of the symptoms characteristic of ... Fry, M. and Loeb, L.A. (1999) Human Werner syndrome DNA helicase unwinds tetrahelical structures of the fragile X syndrome ... Yamagata, K., Kato, J., Shimamoto, A., Goto, M., Furuichi, Y. and Ikeda, H. (1998) Bloom's and Werner's syndrome genes suppress ... Kamath‐Loeb, A.S., Shen, J.C., Loeb, L.A. and Fry, M. (1998) Werner syndrome protein: II. Characterization of the integral 3′-5 ...
  http://embor.embopress.org/content/1/1/80
*  Lipodystrophy, including Lipoatrophy
Psychiatry healthcare professionals gain a thorough knowledge base of psychiatric disorder information to offer the best ... Werner syndrome: Autosomal recessive disorder, prematurely aged appearance, cataract, diabetes mellitus, hypogonadism, ... Leprachaunism (Donohue syndrome): Rare autosomal recessive disorder, mutations in the insulin receptor gene, intrauterine and ... Cockayne syndrome: Rare auotosomal recessive disorder characterized by growth failure, onset during second year of life, ...
  http://www.psychiatryadvisor.com/dermatology/lipodystrophy-including-lipoatrophy/article/589225/
*  Werner syndrome
... is a rare autosomal recessive disorder, caused by mutations in the WRN gene. Clinical findings include: senile ... Werner syndrome (WS) is an autosomal recessive genetic instability and progeroid ('premature aging') syndrome which is ... Unfortunately there is no cure for Werner syndrome at this time. If you or a loved one has been diagnosed with Werner syndrome ... "Werner syndrome" (open studies are recruiting volunteers) and 1 "Werner syndrome" studies with "all" status. Visit ...
  http://www.diseaseinfosearch.org/result/7471
*  WRNIP1 - PrimePCR Assay and Template | Life Science | Bio-Rad
Werner's syndrome is a rare autosomal recessive disorder characterized by premature aging. The protein encoded by this ... Werner helicase interacting protein 1 Assay Type: SYBR® Green Assay Design: Exonic Application: Gene Expression Unique Assay ID ... Werner helicase interacting protein 1 Assay Type: SYBR® Green Assay Design: exonic Application: Gene Expression Unique Assay ID ... Werner helicase interacting protein 1 Assay Type: Probe Assay Design: exonic Application: Gene Expression Unique Assay ID: ...
  http://www.bio-rad.com/en-us/prime-pcr-assays/gene/wrnip1-human
*  Werner syndrome - Wikipedia
Werner syndrome (WS), also known as "adult progeria", is a rare, autosomal recessive disorder which is characterized by the ... Werner syndrome is named after the German scientist Otto Werner. He identified the syndrome in four siblings observed with ... The mutation in the WRN gene that causes Werner syndrome is autosomal and recessive, meaning that sufferers must inherit a copy ... Otto Werner was the first to observe Werner syndrome in 1904 as a part of his dissertation research. As a German ...
  https://en.wikipedia.org/wiki/Werner_syndrome
*  Understanding the impact of 1q21.1 copy number variant | Orphanet Journal of Rare Diseases | Full Text
... an autosomal recessive disorder, associated with predisposition to cancer and premature aging, neither of which were noted in ... The Werner syndrome LBCs (WRN) were from a WRN syndrome patient homozygous for the p.Arg368X pathogenic mutation. A549 ... Franchitto A, Oshima J, Pichierri P: The G2-phase decatenation checkpoint is defective in Werner syndrome cells. Cancer ... Copy Number VariantAtaxia Telangiectasia MutateAMPK ActivityCopy Number ChangeWerner Syndrome ...
  https://ojrd.biomedcentral.com/articles/10.1186/1750-1172-6-54
*  Dyskeratosis Congenita Publications and Abstracts | PubFacts.com
Although it is well established that autosomal recessive mutations in the WRN gene is responsible for Werner syndrome, the ... but autosomal-dominant and X-linked recessive disorders also exist. The clinical features of patients with DNA repair syndromes ... Background: Werner syndrome is a progeroid disorder characterized by premature age-related phenotypes. ... Multiple inheritance patterns have been described in these disorders; many are transmitted in an autosomal recessive pattern, ...
  https://www.pubfacts.com/search/Dyskeratosis+Congenita
*  Cancer syndrome - Wikipedia
Both alleles of a gene must be mutated in autosomal recessive disorders for an individual to have a predisposition to cancer. A ... Rothmund-Thomson syndrome, Werner's syndrome and Xeroderma pigmentosum. Although cancer syndromes exhibit an increased risk of ... Examples of autosomal recessive cancer syndromes are ataxia telangiectasia, Bloom syndrome, Fanconi anemia, MUTYH-associated ... Examples of autosomal dominant cancer syndromes are autoimmune lymphoproliferative syndrome (Canale-Smith syndrome), Beckwith- ...
  https://en.wikipedia.org/wiki/Cancer_syndrome
*  Medical Advisor Journals, Kyle J. Norton Site, Health Tips for Better Living and Living Health: Antioxidants - The Theories of...
The syndrome does not develop until they reach puberty is caused by autosomal recessive disorder due to alter gene on ... Werner syndrome. It is Adult progeria, an disorder causes the appearance of premature aging. ... Hutchison-Gilford syndrome. It is an extremely rare genetic condition wherein symptoms resembling aspects of aging are ... The theory suggest that there are many of diseases and syndromes of which can contribute to faster track to aging. * ...
  https://kylejnorton.blogspot.ca/2013/11/antioxidants-theories-of-aging.html
*  Werner syndrome - Renal and Urology News
WS is a rare autosomal recessive disorder with a frequency ranging of approximately 1:59,000 in North Sardinia, 1:100,000 in ... Werner syndrome OMIM #277700. Are You Confident of the Diagnosis?. What you should be alert for in the history. Werner syndrome ... A detailed discussion of the molecular and genetic basis of the progeroid syndromes including Werner syndrome is presented to ... aging syndromes is presented with a detailed discussion of both Hutchinson-Gilford progeria syndrome and Werner syndrome, their ...
  https://www.renalandurologynews.com/dermatology/werner-syndrome/article/592160/
*  Jack (1996 film) - Wikipedia
Lin (Keone Young). According to them, as this very rare autosomal recessive disorder progresses, Jack will age at a rate four ... Williams plays the role of Jack Powell, a boy who ages four times faster than normal as a result of Werner syndrome, a form of ... because of his Werner syndrome, his internal clock is starting to run out. Realizing the dangers it might entail for his health ... and is diagnosed with an exaggerated form of Werner syndrome as stated by Dr. Benfante (Allan Rich) and Dr. ...
  https://en.wikipedia.org/wiki/Jack_(1996_film)
*  Severe Myocardial Fibrosis Caused by a Deletion of the 5' End of the Lamin A/C Gene | JACC: Journal of the American College of...
... cause autosomal recessive axonal neuropathy in human (Charcot-Marie-Tooth disorder type 2) and mouse. Am J Hum Genet 70:726-736 ... the Hutchinson-Gilford progeria syndrome (27,28); atypical Werner's syndrome (29); and lipoatrophy with diabetes, hepatic ... 2000) Different mutations in the LMNA gene cause autosomal dominant and autosomal recessive Emery-Dreifuss muscular dystrophy. ... Mutations in the lamin A/C gene have been reported in a variety of disorders, such as autosomal dominant and recessive Emery- ...
  http://www.onlinejacc.org/content/49/25/2430