*  Incidence of Lewy Body Dementias in a General Population | Lewy Body Dementia Association
24 of those (77.4 percent) had autopsy-confirmed Lewy body pathology. The clinical and pathological diagnosis agreement in ... Incidence of Lewy Body Dementias in a General Population. The prevalence of a disease identifies how many people are affected ... A new study examines for the first time in North America the incidence of Lewy body dementias and its distribution by age and ... The combined incidence of Lewy body dementias in this study was 5.9 cases per 100,000 person-years, with a higher incidence in ...
  https://www.lbda.org/content/incidence-lewy-body-dementias-general-population
*  KAKEN - Research Projects | Study of the establishment of animal model with Alzheimer's disease to control thepathological...
Publications] Horiuchi M. et al.: 'An autopsy case of diffuse Lewy body disease.'St.Marianna Med.J.. 27. 739-744 (1999). *. ... Publications] Horiuchi M. et al: 'An Autopay Case of Diffuse Lewy Body Disease.'St. Marianna Med. J.. 27. 739-744 (1999). *. ... Publications] Horiuchi M. et al: 'An Autopay Case of Diffuse Lewy Body Disease'St. Marianna Med. J.. 27. 739-744 (1999). *. ... Publications] Horiuchi M. et al: 'Pure Progressive Autonomic Failure with Postprandial and Orthostatic Hypotension: An Autopsy ...
  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-10670921/
*  Publications | Center for Neurodegenerative Disease Research | Perelman School of Medicine at the University of Pennsylvania
CSF tau and amyloid-beta predict cerebral synucleinopathy in autopsied Lewy body disorders.. Neurology. 2018 Feb 21; Authors: ... Lewy body-like alpha-synuclein inclusions trigger reactive microgliosis prior to nigral degeneration.. J Neuroinflammation. ... Analysis of C9orf72 repeat expansions in a large international cohort of dementia with Lewy bodies.. Neurobiol Aging. 2016 Sep ... Investigating the genetic architecture of dementia with Lewy bodies: a two-stage genome-wide association study.. Lancet Neurol ...
  http://www.med.upenn.edu/cndr/publications.html
*  Plus it
Neuropathological correlates of volumetric MRI in autopsy-confirmed Lewy body dementia. Neurobiol Aging 2012;33:1228-36. ... dementia with Lewy bodies. HD. Huntington disease. MSA. multiple-system atrophy. PSP. progressive supranuclear palsy. ... Dementia with Lewy Bodies.. DLB accounts for a small fraction of presenile-onset dementia syndromes, constituting only ... Brain tissue damage in dementia with Lewy bodies: an in vivo diffusion tensor MRI study. Brain 2005;128:1595-604. ...
  http://www.ajnr.org/content/35/3/418
*  Publications - Mayo Clinic
Rapid eye movement sleep behavior disorder and subtypes in autopsy-confirmed dementia with Lewy bodies. Mov Disord. 2012 Jan; ... Incidental Lewy body disease: do some cases represent a preclinical stage of dementia with Lewy bodies? Neurobiol Aging. 2011 ... Plasma sphingolipid changes with autopsy-confirmed Lewy Body or Alzheimer's pathology. Alzheimers Dement (Amst). 2016; 3:43-50 ... Pattern of brain atrophy rates in autopsy-confirmed dementia with Lewy bodies. Neurobiol Aging. 2015 Jan; 36: (1)452-61. View ...
  http://www.mayo.edu/research/searchpublications/publications?authid=11207922
*  Clinical Diagnostic Criteria for Dementia with Lewy Bodies | SpringerLink
Clinical diagnostic concepts and methods for the dementias associated with Lewy body disease have evolved over the last three ... Cognitive profiles differ across disease course in autopsy-proven dementia with Lewy bodies and Alzheimer's disease. Neurobiol ... Kosaka K. Lewy body disease and dementia with Lewy bodies. Proc Jpn Acad Series B Phys Biol Sci. 2014;90(8):301-6.CrossRef ... Senile dementia of Lewy body type. A clinically and neuropathologically distinct form of Lewy body dementia in the elderly. J ...
  https://link.springer.com/chapter/10.1007%2F978-4-431-55948-1_5
*  Similar articles for PubMed (Select 20235484) - PubMed - NCBI
An autopsy case of dementia with Lewy bodies who showed the typical parkinsonism in the initial five years]. ... An autopsy case of multiple system atrophy with many Lewy bodies--striatonigral degeneration, olivo-ponto-cerebellar atrophy ... Association of Lewy bodies and glial cytoplasmic inclusions in the brain of Parkinson's disease. ... The new mutation, E46K, of alpha-synuclein causes Parkinson and Lewy body dementia. ...
  https://www.ncbi.nlm.nih.gov/pubmed?linkname=pubmed_pubmed&from_uid=20235484
*  REM sleep behavior disorder was associated with Parkinson's disease: a community-based study | Springer for Research &...
Rapid eye movement sleep behavior disorder and subtypes in autopsy-confirmed dementia with Lewy bodies. Mov Disord. 2012;27:72- ... DLB, lewy body dementia; MSA, multiple system atrophy; MSQ, mayo sleep questionnaire; NPV, negative predictive value; PD, ... Lewy Body Dementia) [3, 4, 5, 6]. Reliable, accurate methods for identifying RBD may offer a window for early intervention. ... and vigorous or elaborate body movements including punching, kicking, sitting up, and even falling out of bed [2]. Recent ...
  https://rd.springer.com/article/10.1186/s12883-016-0640-1
*  Parkinson's disease: clinical features and diagnosis | Journal of Neurology, Neurosurgery & Psychiatry
Historically, pathological confirmation of the hallmark Lewy body on autopsy has been considered the criterion standard for ... The relevance of the Lewy body to the pathogenesis of idiopathic Parkinson's disease. J Neurol Neurosurg Psychiatry 1988;51:745 ... Improved accuracy of clinical diagnosis of Lewy body Parkinson's disease. Neurology 2001;57:1497-9. ... Based on autopsy data, imaging studies, response to levodopa and atypical clinical features, only 8.1% of patients did not meet ...
  http://jnnp.bmj.com/content/79/4/368
*  Study confirms imaging compound identifies amyloid-beta in human brain
The autopsy confirmed the diagnosis of dementia with Lewy bodies and had several findings characteristic of Alzheimer's disease ... His eventual diagnosis was dementia with Lewy bodies, a condition that can exist along with Alzheimer's. He also enrolled in a ... But since a definitive Alzheimer's diagnosis can be made only on autopsy, there had been no confirmation that PiB in human ... "The distribution of amyloid seen at autopsy matched the overall distribution seen in the PiB imaging study; levels were higher ...
  http://www.innovations-report.com/hrml/reports/studies/report-80713.html
*  Executive dysfunction - Wikipedia
Spatial deficits predict rate of cognitive decline in autopsy-verified dementia with lewy bodies. Neuropsychology. 22(6); 729- ...
  https://en.wikipedia.org/wiki/Executive_dysfunction
*  Alpha-synuclein and Cognitive Decline in Parkinson s Disease | Parkinson's Disease
... autopsy-confirmed Lewy body disease, including patients diagnosed with PD, PDD and DLB (Parkinson s UK brain bank, Oxford ... Dementia with Lewy bodies (DLB, typically described as Diffuse Lewy body Disease (DLBD) post-mortem) and to a lesser extent ... In the brain autopsy series we have begun to systematically quantify alpha‐synuclein immunoreactivity by genotype/haplotype, ...
  https://www.michaeljfox.org/foundation/grant-detail.php?grant_id=1314
*  Kenji Kosaka (psychiatrist) - Wikipedia
Two years later, he reported three autopsied cases of Dementia with Lewy bodies. The term Dementia with Lewy bodies was ... and Lewy-body changes". Acta Neuropathol. 36 (3): 221-233. doi:10.1007/bf00685366. PMID 188300. Kosaka K. (1978). "Lewy bodies ... He received the 2013 Asahi Prize for discovering Dementia with Lewy bodies. In 1976, Kosaka described the concept of Dementia ... レビー小体型認知症研究会 [Japanese Society for Dementia with Lewy bodies] (in Japanese). Retrieved February 3, 2014. ...
  https://en.wikipedia.org/wiki/Kenji_Kosaka_(psychiatrist)
*  MPTP - Wikipedia
Upon autopsy, Lewy bodies and destruction of dopaminergic neurons in the substantia nigra were discovered. In 1982, six people ...
  https://en.wikipedia.org/wiki/MPTP
*  Lewy Body Disease
The only way to diagnose Lewy body disease conclusively is through an autopsy. . But, a doctor can do tests to narrow the cause ... Lewy Body Disease. (Lewy Body Dementia; Dementia with Lewy Bodies). by Krisha McCoy, MS. ... Lewy body disease is caused by the build up of Lewy bodies. These are abnormal protein deposits inside brain cells that control ... It is not clear exactly what causes the build up of Lewy bodies in the brain. But, Lewy body disease is linked to: *Parkinson's ...
  http://www.empowher.com/media/reference/lewy-body-disease
*  Researchers identify tissue biomarker for dementia with lewy bodies and Parkinson's disease | EurekAlert! Science News
... dementia with Lewy bodies,' can be difficult in the early stages of both conditions. While brain biopsies can be more accurate ... Lewy-type α-synucleinopathy (LTS) is found in the brains of all Parkinson's disease patients when they are autopsied. For a ... 28 with dementia with Lewy bodies (DLB), nine with incidental Lewy-body disease, 33 with Alzheimer's disease with Lewy bodies, ... step will be to do biopsies of the submandibular gland in living people with dementia with Lewy bodies to confirm these autopsy ...
  https://www.eurekalert.org/pub_releases/2016-04/ip-rit041116.php
*  Imaging of Dementia | Springer for Research & Development
Alzheimer's disease versus dementia with Lewy bodies: cerebral metabolic distinction with autopsy confirmation. Ann Neurol 50: ... Mild Cognitive Impairment Alzheimer Disease Dementia With Lewy Body Frontotemporal Dementia Acetylcholinesterase Activity These ... 18F-fluorodopa PET study of striatal dopamine uptake in the diagnosis of dementia with lewy bodies. Neurology 55:1575-1577 ... Sensitivity and specificity of dopamine transporter imaging with 123I-FP-CIT SPECT in dementia with Lewy bodies: a phase III, ...
  https://rd.springer.com/chapter/10.1007/978-88-470-0840-3_33
*  Colonic Tissue Obtained during Colonoscopy or Flexible Sigmoidoscopy May Be Used to Predict Parkinson's Disease - Healthcanal...
These protein aggregates form Lewy bodies, a characteristic structure seen in Parkinson's disease brains at autopsy. ... 2017 Genetics and Birth Defects Children's Hospital Oakland Scientists Conduct First-Ever Gene Editing Inside a Human Body ...
  https://www.healthcanal.com/cancers/29387-colonic-tissue-obtained-during-colonoscopy-or-flexible-sigmoidoscopy-may-be-used-to-predict-parkinsons-disease.html
*  Rehabilitation Medicine | Mount Sinai - New York
But the autopsies found an increased risk for Lewy bodies (abnormal aggregates of protein) in TBI with LOC less than an hour ... Neuropathological findings at autopsy revealed an increased risk for Lewy bodies (abnormal aggregates of protein) in traumatic ... Neuropathological findings at autopsy (1,652 autopsy cases) showed no association between TBI with LOC and beta amyloid plaques ... autopsies, and in that group researchers evaluated the relationship between TBI and neuropathological findings. Neuropathology ...
  http://www.mountsinai.org/about/newsroom/specialty-reports/2017/rehabilitation-medicine
*  Parkinson's Research Moves Beyond Dopamine
... are so-called Lewy bodies, which are sticky clumps comprised of alpha-synuclein that aggregate inside cells. Lewy bodies can ... Upon autopsy, synuclein pathology is seen in about 90 percent of people who have "sporadic," or non-genetic, forms of ... The hallmark pathological characteristics of Parkinson's, almost invariably seen in patients upon autopsy, ... heart rate and other automatic body functions, may account for many of the nondopaminergic symptoms increasingly recognized as ...
  https://www.dana.org/Publications/Brainwork/Details.aspx?id=43729
*  Thomas Montine | Stanford Medicine Profiles
... of data from 213 patients who had been followed up to autopsy and met inclusion criteria of Lewy body disorder with autopsy- ... any Lewy body in ACT: RR for TBI with LOC >1 hour, 2.64; 95% CI, 1.40-4.99; Lewy bodies in substantia nigra and/or locus ... and genetic and neuropathological data from a cohort of patients with Lewy body disorders with autopsy-confirmed α ... Human Striatal Dopaminergic and Regional Serotonergic Synaptic Degeneration with Lewy Body Disease and Inheritance of APOE e4. ...
  https://med.stanford.edu/profiles/thomas-montine?tab=bio
*  Publications - Mayo Clinic
Pattern of brain atrophy rates in autopsy-confirmed dementia with Lewy bodies. Neurobiol Aging. 2015 Jan; 36: (1)452-61. View ... 18F-FDG PET in Posterior Cortical Atrophy and Dementia with Lewy Bodies. J Nucl Med. 2017 Apr; 58 (4):632-638 Epub 2016 Sept 29 ... AV-1451 tau and beta-amyloid positron emission tomography imaging in dementia with Lewy bodies. Ann Neurol. 2017 Jan; 81: (1)58 ... AV-1451 tau and beta-amyloid positron emission tomography imaging in dementia with Lewy bodies Annals of Neurology. 2017 Jan; ...
  http://www.mayo.edu/research/searchpublications/publications?authid=14056721
*  Publications - Mayo Clinic
Pattern of brain atrophy rates in autopsy-confirmed dementia with Lewy bodies. Neurobiol Aging. 2015 Jan; 36: (1)452-61. View ... Risk factors for dementia with Lewy bodies: a case-control study. Neurology. 2013 Aug 27; 81: (9)833-40. View PubMed ... White matter integrity in dementia with Lewy bodies: a voxel-based analysis of diffusion tensor imaging. Neurobiol Aging. 2015 ... Mild cognitive impairment associated with limbic and neocortical Lewy body disease: a clinicopathological study. Brain. 2010 ...
  https://www.mayo.edu/research/searchpublications/publications?authid=12273562
*  DLB and PDD Diagnostic Criteria | Lewy Body Dementia Association
... for the presence of neocortical Lewy bodies (LBs) at autopsy, the current diagnostic gold standard. However, these criteria are ... Lewy body dementias include two clinical diagnoses, dementia with Lewy bodies (DLB) and Parkinson's disease dementia (PDD), ... Lewy Body Dementia Association, Inc.. 912 Killian Hill Road S.W., Lilburn, GA 30047 ... representing the Scientific Advisory Council of the Lewy Body Dementia Association. May, 2008 ...
  https://www.lbda.org/node/470
*  Lyme discovery: Borrelia bacteria hides inside parasitic worms, causing chronic brain diseases - Outbreak News Today
Finally, four specimens from patients who died from Lewy Body dementia, the same illness which afflicted comedian Robin ... The examination of autopsied brain tissues from patients who died of serious neurological conditions has revealed that many ... A tick bite delivers the nematode into the human body.. "Both the worms and the Borrelia pathogens can cause devastating brain ...
  http://outbreaknewstoday.com/lyme-discovery-borrelia-bacteria-hides-inside-parasitic-worms-causing-chronic-brain-diseases-13216/amp/