The pathophysiology of chronic graft-versus-host disease | SpringerLink
... still remains the most significant complication after allogeneic hematopoietic stem cell transplantation. The disease usually ... Late effects Chronic graft-versus-host disease Autoimmunity Stem cell transplantation Immune tolerance ... Tolerance and autoimmunity. N Engl J Med. 2001;344:655-664.CrossRefPubMedGoogle Scholar ... Autoimmunity after allogeneic bone marrow transplantation: a study of 53 long-term-surviving patients. Transplantation. 1988;46 ...https://link.springer.com/article/10.1532/IJH97.04015
Midterm 2 Review Flashcards by Kiana Hagerty | Brainscape
breakdown of self-tolerance results in autoimmunity. - Therapeutic potential: inducing tolerance can help prevent graft ... and maybe stem cell transplantation ... If tolerance fails, either bc of wrong environment (viral ... Central tolerance = self-reactive lymphocytes are deleted by negative selection. - Peripheral tolerance = leakage of self- ... Estrogens stimulate B cell autoimmunity such as MS, SLE, coeiliac disease, etc.. Falling estrogens support T cell autoimmunity ...https://www.brainscape.com/flashcards/midterm-2-review-6819563/packs/10832084
Biomedical Science - BSc (Hons) - Canterbury - The University of Kent
Transplantation immunology - Basis of tolerance and graft rejection; clinical applications of transplantation; general and ... Cell communication, and the regulation of immunity by T cell . Immunopathology, including autoimmunity, allergy and transplant ... Autoimmune disease - Organ-specific autoimmune diseases; systemic autoimmune diseases; induction of autoimmunity; treatment of ...https://www.kent.ac.uk/courses/undergraduate/263/biomedical-science
The roles of Synoviolin in immune tolerance and autoimmunity - Deyu Fang
Impaired T cell tolerance is the cause of all types of autoimmune diseases, which suffers more than 23 million Americans. Since ... inflammatory diseases and to achieve an optimal immune suppression to prolong the graft survival in organ transplantation. ... The roles of Synoviolin in immune tolerance and autoimmunity Fang, Deyu Northwestern University at Chicago, Chicago, IL, United ... The roles of Synoviolin in immune tolerance and autoimmunity. Fang, Deyu / Northwestern University at Chicago. $379,464. ...http://grantome.com/grant/NIH/R01-AI108634-01A1
Nonmyeloablative allogeneic hematopoietic stem cell transplantation for autoimmune disease - Pavletic - 2004 - Arthritis &...
Graft vs autoimmunity following allogeneic non-myeloablative blood stem cell transplantation in a patient with chronic ... There are at least 3 theoretical advantages of mixed chimerism over full chimerism as an approach to transplantation tolerance ... therapeutic capacity of allogeneic transplantation as applied to autoimmunity may lie in the putative graft-versus-autoimmunity ... Graft-versus-leukemia reactions after bone marrow transplantation. Blood 1990; 75: 555-62.. *PubMed , ...http://onlinelibrary.wiley.com/doi/10.1002/art.20452/full
Immunologic Tolerance as Taught by Allografts | SpringerLink
Tolerance, or the remarkable ability of the immune system to recognize and destroy invading pathogens, while refraining from ... of tolerance to noninherited maternal antigens on the occurrence of graft-versus-host disease after bone marrow transplantation ... 2003). Correlation of bronchiolitis obliterans syndrome (BOS) with autoimmunity to collagen (V). Am. J. Transplantation 3, 152( ... 1997). Tolerance induced in Rhesus monkeys by anti-CD3 immunotoxin. Transplantation 63, 1.PubMedCrossRefGoogle Scholar ...https://link.springer.com/chapter/10.1007/978-1-4419-8999-4_21
Improving the outcome of kidney transplantation by ameliorating renal ischemia reperfusion injury: lost in translation? |...
These grafts are associated with an increased sensitivity to IRI and decreased graft outcome due to prolonged ischemia and ... delayed graft function and acute and chronic rejection. Kidneys from living donors show a superior short- and long-term graft ... During kidney transplantation ischemia reperfusion injury (IRI) occurs, which is a risk factor for acute kidney injury, ... Therefore, preventing or ameliorating IRI may improve graft survival. Animal experiments focus on understanding the mechanism ...https://translational-medicine.biomedcentral.com/articles/10.1186/s12967-016-0767-2
Graft-versus-host disease - Wikipedia
"Transplantation tolerance and autoimmunity after xenogeneic thymus transplantation". Journal of Immunology. 166 (3): 1843-54. ... After bone marrow transplantation, T cells present in the graft, either as contaminants or intentionally introduced into the ... 2009). "Elafin is a Biomarker of Graft Versus Host Disease of the Skin". Biology of Blood and Marrow Transplantation. 15 (2): ... A great deal of current research on allogeneic bone marrow transplantation involves attempts to separate the undesirable graft- ...https://en.wikipedia.org/wiki/Graft-versus-host_disease
Intestinal microbiota sustains inflammation and autoimmunity induced by hypomorphic RAG defects | JEM
... suppression of the gut microbiome prevents acute graft-versus-host disease following allogeneic bone marrow transplantation. ... indicating that a break in immune tolerance contributes to the development of autoimmunity in OS. The symptoms are very similar ... Oral tolerance is impaired in Rag2R229Q mice. We found that Foxp3+GITR+ T reg cells were abundantly present in the inflamed ... Oral tolerance is impaired in Rag2R229Q mice, and transfer of WT T reg cells attenuates gut inflammation. (A) EAE model of oral ...http://jem.rupress.org/content/early/2016/02/23/jem.20151116
Reduced Intensity Conditioning With Clofarabine, Antithymocyte Globulin (ATG), Total Lymphoid Irradiation (TLI) Followed by...
... models and clinical trials.TLI has been shown to promote immune tolerance resulting in a decrease in the incidence of graft ... graft versus host disease which remains a major source of morbidity and mortality following reduced intensity transplantation. ... of T lymphocytes that demonstrate an immunosuppressive phenotype and play an important role in the prevention of autoimmunity ... There has been increasing interest in evaluating the role of regulatory T cells as a means of inhibiting graft versus host ...https://clinicaltrials.gov/ct2/show/study/NCT00697684?show_desc=Y
PAR-14-065: Research Using Biosamples From Selected Type 1 Diabetes Clinical Studies (DP3)
"Autoimmunity-Blocking Antibody for Tolerance in Recently Diagnosed Type 1 Diabetes". In this Phase II protocol, two courses of ... prevention of graft rejection following kidney, liver, and pancreatic islet transplantation. The ITN develops and conducts ... 6. The Immune Tolerance Network (ITN) is an international consortium dedicated to advancement of tolerance-inducing therapies ... "Islet Transplantation in Type I Diabetic Patients using the Edmonton Protocol of Steroid-Free Immunosuppression". This was a ...https://grants.nih.gov/grants/guide/pa-files/PAR-14-065.html
The model used single-donor islet transplantation with induction of operational tolerance. The term "operational tolerance" is ... Matzinger P, Anderson CC: Immunity or tolerance: Opposite outcomes of microchimerism from skin grafts. Nat Med 7:80-87, 2001. ... xenograft resistance to autoimmunity might have favored durable functional islet mass in xenogeneic IPIT, as suggested from ... Manipulation of cytokine networks in transplantation: false hope or realistic opportunity for tolerance? Transplantation 63:489 ...http://diabetes.diabetesjournals.org/content/50/6/1227
Testicular Immune Privilege Promotes Transplantation Tolerance by Altering the Balance between Memory and Regulatory T Cells |...
They suppress autoimmunity and prevent graft rejection in many animal models (26, 31, 32, 33, 34, 35, 46, 47). However, it is ... Primary graft function was defined as blood glucose under 200 mg/dl for 24 h after transplantation. Graft rejection was defined ... They were essential for maintaining transplantation tolerance as depletion of CD25+ Treg cells in vivo broke the tolerance (Fig ... costimulatory blockade and intratesticular islet transplantation to induce tolerance indicates that transplantation tolerance ...http://www.jimmunol.org/content/174/10/6161
Frontiers | Differential Sensitivity of Regulatory and Effector T Cells to Cell Death: A Prerequisite for Transplant Tolerance ...
Thus, the development of graft-specific, non toxic innovative therapeutic strategies has become a major challenge, the goal ... Thus, the development of graft-specific, non toxic innovative therapeutic strategies has become a major challenge, the goal ... to promote operational tolerance. Various approaches, notably the one based on monoclonal antibodies or fusion proteins ... to promote operational tolerance. Various approaches, notably the one based on monoclonal antibodies or fusion proteins ...https://www.frontiersin.org/articles/10.3389/fimmu.2015.00242/full
A possible role of low regulatory T cells in anti-acetylcholine receptor antibody positive myasthenia gravis after bone marrow...
... appears several months following allogenic hematopoietic stem cell transplantation (HSCT) and is clinically analogous to ... Wing K, Sakaguchi S. Regulatory T cells exert checks and balances on self tolerance and autoimmunity. Nat Immunol. 2010;11(1):7 ... Chronic graft-versus-host disease (GVHD) appears several months following allogenic hematopoietic stem cell transplantation ( ... Myasthenia gravis after allogeneic bone marrow transplantation: relationship to chronic graft-versus-host disease. Neurology. ...https://bmcneurol.biomedcentral.com/articles/10.1186/s12883-017-0881-7
STAT4-associated natural killer cell tolerance following liver transplantation | Gut
Genetic variants of STAT-4 affect the development of graft fibrosis after liver transplantation for HCV-induced liver disease. ... inducing an NK cell tolerant phenotype may be beneficial in suppressing autoimmunity. ... This could have a beneficial effect in relation to graft tolerance, and a detrimental effect on susceptibility to pathogens, ... Alloreactivity of natural killer cells in allogeneic liver transplantation. Transplantation 2001;72:116-22. doi:10.1097/ ...https://gut.bmj.com/content/66/2/352
Murine Pancreatic Islets Transplantation under the Kidney ...
Islet transplantation in preclinical animal models can be performed in different sites such the kidney capsule, spleen, bone ... Pancreatic islet transplantation is a valid therapeutic approach to restore insulin loss and to promote adequate glycemic ... Pancreatic islet transplantation in mice is an optimal preclinical model to identify new therapeutic strategies aiming at ... This protocol describes murine islet transplantation under the kidney capsule. This is a widely accepted procedure for research ...https://bio-protocol.org/e2743
Infant immunization by breastfeeding | Philosophical Transactions of the Royal Society B: Biological Sciences
Data generated by others in the field of autoimmunity in transplantation reach a similar conclusion (see here below). ... 3. Systemic tolerance or priming is related to age at which antigen is first encountered. Pediatr. Res. 18, 588-594. (doi: ... There is also evidence in humans that renal graft survival is improved when the donor expresses NIMA . ... 2010 Oral tolerance in neonates: from basics to potential prevention of allergic disease. Mucosal Immunol. 3, 326-333. (doi: ...http://rstb.royalsocietypublishing.org/content/370/1671/20140139
Graft vs. Host Disease (GVHD). *Transplantation Tolerance Induction. *Mechanisms and Prevention of Graft Rejection ... Translational Research on Human Immune Responses in Disease, including Autoimmunity, Inflammation, Infection, Allergy, and ... Therapeutic Modulation of Tolerance and Autoimmune Disease in Animal Models. *Development of Therapies for Human Autoimmune ...http://www.immunology2018.org/abstracts/topic-categories/
"Autoimmune Diabetes and Transplantation Tolerance Induced by Costimula" by Julie Lambert
... diabetes and have been used to investigate tolerance induction protocols for islet transplantation in a setting of autoimmunity ... However, some Idd loci impaired the induction of transplantation tolerance. These data suggest that Idd loci can facilitate or ... impair induction of transplantation tolerance by costimulation blockade, and that Idd3 (IL-2) is critical component in this ... Costimulation blockade-based tolerance protocols that induce prolonged skin and permanent islet allograft survival in non- ...https://escholarship.umassmed.edu/gsbs_diss/344/
The costimulatory immunogen LPS induces the B-Cell clones that infiltrate transplanted human kidneys | PNAS
2010) The yin and yang of B cells in graft rejection and tolerance. Transplant Rev (Orlando) 24:67-78. ... transplantation. Kidney transplantation is considered to be the treatment of choice for patients with end stage renal disease. ... 2010) Antihuman leukocyte antigen antibody-induced autoimmunity: role in chronic rejection. Curr Opin Organ Transplant 15:16-20 ... 2008) Characterization of intra-graft B cells during renal allograft rejection. Kidney Int 74:664-673. ...http://www.pnas.org/content/109/16/6036
Double-Negative T Cells, Activated by Xenoantigen, Lyse Autologous B and T Cells Using a Perforin/Granzyme-Dependent, Fas-Fas...
Donor-lymphocyte infusion induces transplantation tolerance by activating systemic and graft-infiltrating double-negative ... an important role in the regulation of immune responses to self or allogeneic Ags in numerous in vivo models of autoimmunity, ... rat skin graft on the late thoracic wall and then the graft will be secured with bandage. Skin graft was monitor daily after ... Four DNT cells and LF-cotreated mice received rat skin graft transplantation after last time DNT cell transfer. b, The ...http://www.jimmunol.org/content/177/10/6920
Patent US8076096 - Alteration of cell membrane with FasL - Google Patents
Graft-versus-host-disease (GvHD) is another possible adverse consequence of bone marrow transplantation. Donor T cells in the ... Its dysregulation leads to autoimmunity and tumors. The immune system also serves as a barrier to the transplantation of ... induce tolerance to autoimmune antigens and foreign grafts. BMT is, therefore, perceived as a natural way of performing gene ... Host-versus-graft reactions and GvHD therefore limit the clinical use of bone marrow transplantation, which might otherwise be ...http://www.google.com/patents/US8076096?dq=U.S.+Patent+
CD4+CD25highCD127low Regulatory T Cells in Peripheral Blood Are Not an Independent Factor for Chronic Graft-versus-Host Disease...
T regulatory cells suppress autoimmunity while establishing transplantation tolerance," Journal of Immunology, vol. 176, no. 12 ... and to maintain self-tolerance [2-4]. Treg are believed to maintain tolerance after solid organ transplantation and after HSCT ... S. J. Lee, G. Vogelsang, and M. E. D. Flowers, "Chronic graft-versus-host disease," Biology of Blood and Marrow Transplantation ... P. T. Walsh, D. K. Taylor, and L. A. Turka, "Tregs and transplantation tolerance," Journal of Clinical Investigation, vol. 114 ...https://www.hindawi.com/journals/tswj/2012/606839/
Immunobiology - NCBI Bookshelf
... graft rejection, and immunity to tumors, are treated as variations on this basic protective function. In these cases the nature ... Other aspects of immunology, such as allergy, autoimmunity, ... Autoimmunity and Transplantation*Autoimmune responses are ... Self-tolerance and its loss*13-25. Many autoantigens are not so abundantly expressed that they induce clonal deletion or anergy ... Antibodies reacting with endothelium cause hyperacute graft rejection. *13-21. The converse of graft rejection is graft-versus- ...https://www.ncbi.nlm.nih.gov/books/NBK10757/?depth=2