*  Autoimmune Aquaporin-4 Channelopathy Presented with Psychiatric Symptoms: A Case Report
... , Anjiao Peng, Jiangwen Cai, Wanlin Lai ... Autoimmune Aquaporin-4 Channelopathy Presented with Psychiatric Symptoms: A Case Report. Anjiao Peng1, Jiangwen Cai2 Wanlin Lai ... proposed that the term "autoimmune aquaporin-4 channelopathy" should be used, with "NMOSD" considered as a part [1]. This is ... Neuromyelitis optica and the evolving spectrum of autoimmune aquaporin-4 channelopathies: A decade later. Ann. N. Y. Acad. Sci ...
  http://www.jneuropsychiatry.org/peer-review/autoimmune-aquaporin4-channelopathy-presented-with-psychiatric-symptoms-a-case-report-12520.html
*  Publications - Mayo Clinic
Asymptomatic myelitis in neuromyelitis optica and autoimmune aquaporin-4 channelopathy. Neurol Clin Pract. 2015 Apr; 5: (2)175- ... Autoimmune myelopathies. Handb Clin Neurol. 2016; 133:327-51 View PubMed. * Flanagan EP, Drubach DA, Boeve BF. Autoimmune ... Autoimmune myelopathies. Continuum.2011 Aug;17:(4):776-99. * Flanagan EP, McKeon A, Lennon VA, Kearns J, Weinshenker BG, Krecke ... Trident sign trumps Aquaporin-4-IgG ELISA in diagnostic value in a case of longitudinally extensive transverse myelitis. Mult ...
  https://www.mayo.edu/research/searchpublications/publications?authid=14854830
*  Neuromyelitis optica - Wikipedia
Some authors propose to use the name "autoimmune aquaporin-4 channelopathy" for these diseases, while others prefer a more ... AQP4+ NMO is currently considered an autoimmune disease (autoimmune astrocytopathy, or autoimmune astrocytic channelopathy) in ... Pittock, Sean J.; Lucchinetti, Claudia F. (June 2015). "Neuromyelitis optica and the evolving spectrum of autoimmune aquaporin- ... is an autoimmune aquaporin-4 channelopathy, due to these specific autoantibodies. In these cases, astrocytes are the victims of ...
  https://en.wikipedia.org/wiki/Neuromyelitis_optica
*  Inflammatory demyelinating diseases of the central nervous system - Wikipedia
Matsushita T, Isobe N, Matsuoka T, Shi N, Kawano Y, Wu XM, Yoshiura T, Nakao Y, Ishizu T, Kira JI (2009). "Aquaporin-4 ... autoimmune syndrome and anti-aquaporin-4 antibody-negative opticospinal multiple sclerosis in Japanese". Mult. Scler. 15 (7): ... Anti-MOG associated spectrum, often clinically presented as an anti-MOG autoimmune encephalomyelitis, but can also appear as ... Vojdani A, Mukherjee PS, Berookhim J, Kharrazian D (2015). "Detection of antibodies against human and plant aquaporins in ...
  https://en.wikipedia.org/wiki/Inflammatory_demyelinating_diseases_of_the_central_nervous_system
*  Aquaporin - Wikipedia
Autoimmune reactions against aquaporin 4 in humans produce Devic's disease. If aquaporin could be manipulated, that could ... The gating of an aquaporin is carried out by an interaction between a gating mechanism and the aquaporin, which causes a 3D ... It was not until 1992 that the first aquaporin, 'aquaporin-1' (originally known as CHIP 28), was reported by Peter Agre, of ... There have been two clear examples of diseases identified as resulting from mutations in aquaporins: Mutations in the aquaporin ...
  https://en.wikipedia.org/wiki/Aquaporin
*  Aquaporin 4 - Wikipedia
Aquaporin-4's overall function is to provide fast water transportation as well as maintain homeostatic balance within the ... The expression of aquaporin 4 is reliant on the disease stage of TBI. In an acute stage of TBI, the lack of aquaporin 4 causes ... Aquaporin-4, also known as AQP4, is a water channel protein encoded by the AQP4 gene in humans. AQP4 belongs to the aquaporin ... Aquaporin-4 is highly expressed in the human body primarily at the end-feet of astrocytes. Additionally, AQP4 can also be ...
  https://en.wikipedia.org/wiki/Aquaporin_4
*  KAKEN - Researchers | MIYAMOTO Katsuichi (50388526)
Journal Article] Keratan sulfate exacerbates experimental autoimmune encephalomyelitis.2015. *. Author(s). Ueno R, Miyamoto K, ... Journal Article] Upregulation of water channel aquaporin-4 in experimental autoimmune encephalomyeritis2009. *. Author(s). ... Journal Article] Roles of complex gangliosides in the development of experimental autoimmune encephalomyelitis2008. *. Author(s ... Journal Article] Roles of complex gangliosides in the development of experimental autoimmune encephalomyelitis2008. *. Author(s ...
  https://nrid.nii.ac.jp/nrid/1000050388526/
*  Complement-independent retinal pathology produced by intravitreal injection of neuromyelitis optica immunoglobulin G | Journal...
Neuromyelitis optica and the evolving spectrum of autoimmune aquaporin-4 channelopathies: a decade later. Ann N Y Acad Sci. ... Aquaporin 4 and neuromyelitis optica. Lancet Neurol. 2012;11:535-44. doi:10.1016/S1474-4422(12)70133-3.View ArticlePubMedPubMed ... Anti-aquaporin-4 monoclonal antibody blocker therapy for neuromyelitis optica. Ann Neurol. 2012;71:314-22. doi:10.1002/ana. ... Liu XQ, Kobayashi H, Jin ZB, Wada A, Nao-I N. Differential expression of Kir4.1 and aquaporin 4 in the retina from endotoxin- ...
  https://jneuroinflammation.biomedcentral.com/articles/10.1186/s12974-016-0746-9
*  Neuromyelitis optica study model based on chronic infusion of autoantibodies in rat cerebrospinal fluid | Journal of...
Aquaporin-4 autoimmunity. Neurol Neuroimmunol Neuroinflamm. 2015;2:e110.View ArticlePubMedPubMed CentralGoogle Scholar. ... Lucchinetti CF, Guo Y, Popescu BF, Fujihara K, Itoyama Y, Misu T. The pathology of an autoimmune astrocytopathy: lessons ... Intrathecal pathogenic anti-aquaporin-4 antibodies in early neuromyelitis optica. Ann Neurol. 2009;66:617-29.View ArticlePubMed ... Neuromyelitis opticaAquaporin-4AstrocyteGlutamateAnimal modelAutoantibodiesAutoimmune diseases. Background. Devic's ...
  https://jneuroinflammation.biomedcentral.com/articles/10.1186/s12974-016-0577-8
*  Classification, diagnosis, and differential diagnosis of multiple sclerosis | LiveWiseMS
Autoimmune aquaporin-4 myopathy in neuromyelitis optica spectrum. JAMA Neurol 2014; 71: 1025-1029. ... Neuromyelitis optica-IgG (aquaporin-4) autoantibodies in immune mediated optic neuritis. J Neurol Neurosurg Psychiatry 2010; 81 ... Short myelitis lesions in aquaporin-4-IgG-positive neuromyelitis optica spectrum disorders. JAMA Neurol 2015; 72:81-87. The ... Prognostic factors and disease course in aquaporin-4 antibody-positive patients with neuromyelitis optica spectrum disorder ...
  http://livewisems.org/resources/journal-articles/classification-diagnosis-and-differential-diagnosis-of-multiple-sclerosis
*  Sjögren syndrome and neuromyelitis optica spectrum disorder co-exist in a common autoimmune milieu.
Our Cases and others, as previously reported in literature, with similar heterogeneous autoimmune response to aquaporin-4, ... suggest that SS and NMO co-exist in a common autoimmune milieu which is not dependent on aquaporin-4 autoimmunity.. ... and negative in 4. Our Case 1 was seronegative for AQP4-IgG and had no non-organ-specific autoantibodies other than anti-SSB ...
  http://www.biomedsearch.com/nih/syndrome-neuromyelitis-optica-spectrum-disorder/25098478.html
*  Publications - Mayo Clinic
Autoimmune aquaporin-4 myopathy in neuromyelitis optica spectrum. JAMA Neurol. 2014 Aug; 71(8):1025-9. View PubMed ... Paraneoplastic autoimmune optic neuritis with retinitis defined by CRMP-5-IgG. Ann Neurol. 2003 Jul; 54 (1):38-50 View PubMed ... Diagnostic utility of aquaporin-4 in the analysis of active demyelinating lesions. Neurology. 2015 Jan 13; 84: (2)148-58. View ... Autoimmune dementia: clinical course and predictors of immunotherapy response. Mayo Clin Proc. 2010 Oct; 85: (10)881-97. View ...
  http://www.mayo.edu/research/searchpublications/publications?authid=11207922
*  Neurologic Complications Associated with Sjögren's Disease: Case Reports and Modern Pathogenic Dilemma
A comparable autoimmune mechanism against both protein sequences of aquaporin-4 (antigen specific for NMO) and aquaporin-5 ( ... Antibodies targeting aquaporin-4 (NMO antibodies) were not tested for in the serum because the test was not available; anyway, ... L. M. Cardoso, L. C. Zacharias, and M. L. Monteiro, "Neuropatia òptica auto-immune: relato de caso," Arquivos Brasileiros de ... A 40-year-old woman referred to our Rheumatology Unit in January 2012, in the suspicion of an autoimmune disorder. Since 2006, ...
  https://www.hindawi.com/journals/crinm/2014/590292/
*  neuropathology blog: MOC Exam Topic: More on Aquaporin-4
autoimmune (8) * basic science (1) * Best of the Month series (118) * biomarkers (20) ... Genetic knock-out of the gene encoding the astroglial water channel aquaporin-4, which is importantly involved in paravascular ... Worth mentioning that [aquaporin-4] is the most well known target in Neuromyelitis Optica (NMO) and NMO spectrum disorders, ... My last post elicited two important comments on aquaporin-4. Since not all readers necessarily look at the comments, I am ...
  http://neuropathologyblog.blogspot.com/2016/11/moc-exam-topic-more-on-aquaporin-4.html
*  Autoimmune encephalitis: a review of diagnosis and treatment
Antibodies to aquaporin 4, myelin-oligodendrocyte glycoprotein, and the glycine receptor α1 subunit in patients with isolated ... Table 2 Diagnostic criteria for autoimmune encephalitis. Diagnostic criteria for possible autoimmune encephalitis (all three of ... Pathophysiology of autoimmune encephalitis: an overview. Autoimmune encephalitis presents an immune response against neuronal ... Table 1 Diagnostic criteria for definite autoimmune limbic encephalitis. Diagnosis can be made when all four of the following ...
  http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2018000100041&lng=en&nrm=iso&tlng=en
*  Induction of Paralysis and Visual System Injury in Mice by T Cells Specific for Neuromyelitis Optica Autoantigen Aquaporin-4 |...
... å indusere lammelse og opticospinal betennelse av overføring av aquaporin-4 (AQP4)-spesifikke... ... Lucchinetti, C. F., et al. The pathology of an autoimmune astrocytopathy: lessons learned from neuromyelitis optica. Brain ... Zeka, B., et al. Aquaporin 4-specific T cells and NMO-IgG cause primary retinal damage in experimental NMO/SD. Acta Neuropathol ... Bennett, J. L., et al. Intrathecal pathogenic anti-aquaporin-4 antibodies in early neuromyelitis optica. Ann Neurol. 66, (5), ...
  https://www.jove.com/video/56185/induksjon-av-lammelse-og-visuelle-systemet-skade-i-mus-ved-t-celler?language=Norwegian
*  Induction of Paralysis and Visual System Injury in Mice by T Cells Specific for Neuromyelitis Optica Autoantigen Aquaporin-4 |...
... en protokol for at fremkalde lammelser og opticospinal betændelse af overførsel af aquaporin-4 (AQP4)-specifikke... ... Lucchinetti, C. F., et al. The pathology of an autoimmune astrocytopathy: lessons learned from neuromyelitis optica. Brain ... Zeka, B., et al. Aquaporin 4-specific T cells and NMO-IgG cause primary retinal damage in experimental NMO/SD. Acta Neuropathol ... Bennett, J. L., et al. Intrathecal pathogenic anti-aquaporin-4 antibodies in early neuromyelitis optica. Ann Neurol. 66, (5), ...
  https://www.jove.com/video/56185/induktion-af-lammelse-og-visuelle-system-skade-i-mus-af-t-celler?language=Danish
*  Cerebrospinal fluid - Wikipedia
This creates osmotic pressure and draws water into the CSF, facilitated by aquaporins. Chloride, with a negative charge, moves ... and specific antibodies such as Aquaporin 4 may be tested for to assist in the diagnosis of autoimmune conditions. A lumbar ... 4 (147): 147ra111. doi:10.1126/scitranslmed.3003748. PMC 3551275 . PMID 22896675. Allan H. Ropper, Robert H. Brown Adams and ... 93 (4): 568-578. doi:10.1093/bja/aeh204. "Intrathecal Chemotherapy for Cancer Treatment , CTCA". CancerCenter.com. Retrieved 22 ...
  https://en.wikipedia.org/wiki/Cerebrospinal_fluid
*  Myelin Oligodendrocyte Glycoprotein (MOG35-55) Induced Experimental Autoimmune Encephalomyelitis (EAE) in C57BL/6 Mice |...
Induction of Paralysis and Visual System Injury in Mice by T Cells Specific for Neuromyelitis Optica Autoantigen Aquaporin-4… ... Induction of Experimental Autoimmune Encephalomyelitis in Mice and Evaluation of the Disease-dependent Distribution of Immune ... Handel, A. E., Lincoln, M. R., Ramagopalan, S. V. Of mice and men: experimental autoimmune encephalitis and multiple sclerosis. ... Overcoming Unresponsiveness in Experimental Autoimmune Encephalomyelitis (EAE) Resistant Mouse Strains by Adoptive Transfer and ...
  https://www.jove.com/video/51275/mog?language=Chinese
*  NAVER Academic > Search...
Effects of age and sex on aquaporin-4 autoimmunity.. Amy M L Quek et al. ARCHIVES OF NEUROLOGY cited 16 times ... Autoimmune Diseases, pathology, physiopathology, Child, Child,... MEDLINE®/PubMed® ... Adolescent, Adult, Age Factors, Aged, Aged, 80 and over, Aquaporin 4, immunology, Autoantibodies, biosynthesis, ... 2012 Anhar Hassan et al. ARCHIVES OF NEUROLOGY cited 4 times Adult, Aged, Aged, 80 and over, Cohort Studies, Female, Follow-Up ...
  https://academic.naver.com/search.naver?field=3&query=ARCHIVES+OF+NEUROLOGY+69%EA%B6%8C+8%ED%98%B8
*  Stiff Person Syndrome: A Rare Neurological Disorder, Heterogeneous in Clinical Presentation and Not Easy to Treat
J. F. Baizabal-Carvallo and J. Jankovic, "Stiff-person syndrome: insights into a complex autoimmune disorder," Journal of ... and the presence of anti-aquaporin-4 antibodies in the serum. Its clinical spectrum has been recently expanded into NMO ... Furthermore, it is common that patients with classic SPS suffer from other autoimmune disorders such as type I insulin- ... Its underlying pathogenesis is probably autoimmune, as in most cases antibodies against glutamic acid decarboxylase (GAD) are ...
  https://www.hindawi.com/journals/crinm/2015/278065/
*  Protocols and Video Articles Authored by Andrés Cruz-Herranz
Induction of Paralysis and Visual System Injury in Mice by T Cells Specific for Neuromyelitis Optica Autoantigen Aquaporin-4' ... Induction of Paralysis and Visual System Injury in Mice by T Cells Specific for Neuromyelitis Optica Autoantigen Aquaporin-4 ... However, their pathogenic role in CNS autoimmune inflammatory disease is unclear. Although multiple AQP4 T-cell epitopes have ... Here, we describe the advances leading to development of an animal model for aquaporin-targeted CNS autoimmunity (ATCA). This ...
  https://www.jove.com/author/Andr%C3%A9s_Cruz-Herranz
*  Protocols and Video Articles Authored by Andrés Cruz-Herranz (Translated to Dutch)
... van verlamming en visuele systeem schade in muizen door T cellen specifiek voor Neuromyelitis Optica Autoantigen Aquaporin-4' ... Here, we describe the advances leading to development of an animal model for aquaporin-targeted CNS autoimmunity (ATCA). This ... However, their pathogenic role in CNS autoimmune inflammatory disease is unclear. Although multiple AQP4 T-cell epitopes have ... Dec, 2016 , Pubmed ID: 27940915 Aquaporin-4 (AQP4)-specific T cells are expanded in neuromyelitis optica (NMO) patients and ...
  https://www.jove.com/author/Andr%C3%A9s_Cruz-Herranz?language=Dutch
*  Balo's concentric sclerosis | Hydrobates
This disease is automimmune in nature and a specific target of autoimmune attacks has been identified, the protein aquaporin 4 ... This knowledge is useful in distinguishing NMO from typical MS by determining the concentration of antibodies against aquaporin ... 4 in the blood. For more details see this article in PloS Medicine. ...
  https://alanrendall.wordpress.com/2008/06/06/balos-concentric-sclerosis/
*  Antibody to aquaporin 4 in the diagnosis of neuromyelitis optica. - Nuffield Department of Clinical Neurosciences
... of putative autoimmune aetiology. Early discrimination between multiple sclerosis (MS) and NMO is important, as optimum ... The binding sites of this autoantibody were reported to colocalize with aquaporin 4 (AQP4) water channels. Thus we hypothesized ... and showed that the aquaporin 4 water channel is a target antigen in a majority of patients with NMO. The newly developed assay ... patients with systemic autoimmune diseases (n = 45; 0 positive), and healthy participants (n = 29; 0 positive). CONCLUSIONS: In ...
  https://www.ndcn.ox.ac.uk/publications/242101