Alphabody - Wikipedia
Alphabody CMPX-1023 has been successfully developed to target the p19 subunit of Interleukin 23 (IL-23) and has entered ... as potential new pharmaceutical drugs against cancer and autoimmune disease. In 2012, a collaboration agreement was signed with ... which work by targeting the p40 subunit. However, the p40 subunit is also present in Interleukin 12 (IL-12) and causes serious ... In brief, IL-23 is a pro-inflammatory cytokine that has been implicated in autoimmune inflammatory diseases like psoriasis, ...https://en.wikipedia.org/wiki/Alphabody
Interleukin 23 subunit alpha - Wikipedia
Knockout mice deficient in either p40 or p19, or in either subunit of the IL-23 receptor (IL-23R and IL12R-β1) develop less ... therapeutic targets for autoimmune inflammation". Current Opinion in Immunology. 18 (6): 670-5. doi:10.1016/j.coi.2006.09.008. ... Experimental work revealed that p19 formed a heterodimer by binding to p40, a subunit of IL-12. This new heterodimer was named ... alpha subunit p19". Parham C, Chirica M, Timans J, Vaisberg E, Travis M, Cheung J, et al. (June 2002). "A receptor for the ...https://en.wikipedia.org/wiki/Interleukin_23_subunit_alpha
Chris Garcia | Stanford Medicine Profiles
Binding of p19 to p40 is mediated primarily by an arginine residue on helix D of p19 that forms an extensive charge and ... Interleukin-4 and Interleukin-13 are cytokines critical to the development of T cell-mediated humoral immune responses, which ... Structure of an autoimmune T cell receptor complexed with class II peptide-MHC: Insights into MHC bias and antigen specificity ... The earliest events in TCR signaling must involve the transfer of information from the antigen binding TCR subunit to the CD3 ...https://med.stanford.edu/profiles/chris-garcia?tab=teaching
Deleterious Effect of the IL-23/IL-17A Axis and γδT Cells on Left Ventricular Remodeling After Myocardial Infarction.
... comprising an IL-12/IL-23p40 subunit and a p19 subunit, interacts with its receptor IL-23R (composed of IL-23R and IL12R-β1) to ... Liao YH,Xia N,Zhou SF,Tang TT,Yan XX,Lv BJ,Nie SF,Wang J,Iwakura Y,Xiao H,Yuan J,Jevallee H,Wei F,Shi GP,Cheng X. Interleukin- ... 17 autoimmune diseases,14,15,18-20 and allograft transplantation.21 Recent reports also implicated IL-17A has having a key role ... Baldeviano GC,Barin JG,Talor MV,Srinivasan S,Bedja D,Zheng D,Gabrielson K,Iwakura Y,Rose NR,Cihakova D. Interleukin-17A is ...http://www.biomedsearch.com/nih/Deleterious-Effect-IL-17A-Axis/23316306.html
Correlations between Psoriasis and Inflammatory Bowel Diseases
... the subunit α (p19) is encoded by the IL-23 gene in humans while subunit (p40) is shared with the IL-12; . ... F. Capon, P. di Meglio, J. Szaub et al., "Sequence variants in the genes for the interleukin-23 receptor (IL23R) and its ligand ... Th17 cells have an important role in many autoimmune diseases and infections (those involving Propionibacterium acnes, ... Locus 6p22 (SNP: rs6908425) is located in the fifth intron of the CDKAL1 gene (CDK5 regulatory subunit-associated protein 1- ...https://www.hindawi.com/journals/bmri/2013/983902/
Interleukin 23 - Wikipedia
Becher B, Durell BG, Noelle RJ (Aug 2002). "Experimental autoimmune encephalitis and inflammation in the absence of interleukin ... subunit (that is shared with IL12) and the IL23A (IL-23p19) subunit. A functional receptor for IL-23 (the IL-23 receptor) has ... "Novel p19 protein engages IL-12p40 to form a cytokine, IL-23, with biological activities similar as well as distinct from IL-12 ... "Prevention of experimental autoimmune encephalomyelitis by antibodies against interleukin 12". Journal of Experimental Medicine ...https://en.wikipedia.org/wiki/Interleukin_23
Either a Th17 or a Th1 effector response can drive autoimmunity: conditions of disease induction affect dominant effector...
Experimental autoimmune uveitis (EAU) represents autoimmune uveitis in humans. We examined the role of the interleukin (IL)-23- ... Novel p19 protein engages IL-12p40 to form a cytokine, IL-23, with biological activities similar as well as distinct from IL-12 ... Both cytokines share a common p40 subunit, but IL-23 has a unique p19 subunit whereas IL-12 uses a p35 subunit (1). IL-12 and ... Interleukin 12 protects from a T helper type 1-mediated autoimmune disease, experimental autoimmune uveitis, through a ...http://jem.rupress.org/content/205/4/799
Mouse IL-23 - Premium and research grade - Cytokines and growth factors - MACS Cell Culture and Stimulation - Products -...
IL-23 stands for interleukin 23. Mouse IL-23 is a recombinant protein optimized for use in cell culture, differentiation ... Its effects are mediated by a receptor composed of IL-12 receptor subunit β1 and an IL-23 specific subunit. IL-12 and IL-23 ... under reducing conditions (R). Units p40 and p19 are fused by a flexible linker region resulting in a single-chain polypeptide ... under reducing conditions (R). Units p40 and p19 are fused by a flexible linker region resulting in a single-chain polypeptide ...https://www.miltenyibiotec.com/BE-en/products/macs-cell-culture-and-stimulation/cytokines-and-growth-factors/premium-and-research-grade/mouse-il-23.html
IL23A Gene - GeneCards | IL23A Protein | IL23A Antibody
Interleukin 23 Subunit Alpha, including: function, proteins, disorders, pathways, orthologs, and expression. GeneCards - The ... alpha subunit p19' [90-027]. *'interleukin 23, alpha subunit p19' [90-028] ... This gene encodes a subunit of the heterodimeric cytokine interleukin 23 (IL23). IL23 is composed of this protein and the p40 ... subunit of interleukin 12 (IL12B). The receptor of IL23 is formed by the beta 1 subunit of IL12 (IL12RB1) and an IL23 specific ...http://www.genecards.org/cgi-bin/carddisp.pl?id_type=entrezgene&id=51561
COMPOSITIONS AND METHODS OF USE FOR THERAPEUTIC ANTIBODIES - Patent application
... protein subunits in IL12 and p19/p40 protein subunits in IL23. The IL12 p40 subunit of either cytokine binds to the ... interleukin-1 ("IL1"), interleukin-2 ("IL2"), interleukin-6 (IL6''), granulocyte macrophage colony stimulating factor ("GM-CSF ... Specific auto-immune diseases for which antibodies of the invention may be employed include autoimmune haematological disorders ... 26. The method of claim 25, wherein the disorder is an autoimmune or inflammatory disorder. 27. The method of claim 26, wherein ...http://www.patentsencyclopedia.com/app/20120034231
Sergio A. Lira - Wikipedia
2003). "Interleukin-23 rather than interleukin-12 is the critical cytokine for autoimmune inflammation of the brain". Nature. ... a cytokine that affects development of inflammatory and autoimmune conditions. Max Planck Gesellschaft (Germany) - Student ... "Interleukin-23 rather than interleukin-12 is the critical cytokine for autoimmune inflammation of the brain". Nature. 421 (6924 ... 10 (5): 514-23. doi:10.1038/ni.1716. PMID 19305396. CS1 maint: Multiple names: authors list (link) "Wiley::Chemokine Receptors ...https://en.wikipedia.org/wiki/Sergio_A._Lira
Therapeutic application of isolated naturally-occuring soluble truncated forms of IL-23 receptor - Patent application
... autoimmune disease to be clarified, when the p19 and p35 subunits were targeted in gene knockout studies. IL-23p19, but not IL- ... A functional interleukin 12 receptor complex is composed of two beta-type cytokine receptor subunits. Proc Natl Acad Sci USA. ... It is composed of two disulfide-linked subunits, p19 and p40. p40 is also a component, with p35, of IL-12, a cytokine in this ... Mice lacking p19 exhibit a decreased pro-inflammatory response to experimental autoimmune encephalomyelitis, inflammatory bowel ...http://www.patentsencyclopedia.com/app/20120071422
MP 196 - AdisInsight
... a novel monoclonal antibody that selectively targets interleukin-23 (IL-23), for the treatment of autoimmune ... 03 Mar 2016 Effimune has patent protection for antibodies directed against p19 subunit of human IL-23 in Europe (Effimune ... Preclinical Autoimmune disorders Most Recent Events * 31 May 2016 Effimune has merged with OSE Pharma to form OSE ... Mechanism of Action Interleukin 23 inhibitors * Orphan Drug Status Orphan designation is assigned by a regulatory body to ...http://adisinsight.springer.com/drugs/800044826?error=cookies_not_supported&code=6809e556-9f3a-4a88-b340-30fbfa684711
... alpha subunit p19. Background. Interleukin-23 (IL-23) is a heterodimeric cytokine consisting of two subunits, one called p40, ... the encoded protein has been shown to be an endogenous pyrogen capable of inducing fever in people with autoimmune diseases or ... Knockout mice deficient in either p40 or p19, or in either subunit of the IL-23 receptor (IL-23R and IL12R-β1) develop less ... Hybrid heterodimers consisting of murine p35 and human p40 subunits retain bioactivity on murine cells; however, the ...http://invivosaglik.com/nanobodies_63_en.html
Engineered Anti-IL-23p19 Antibodies - Patent application
The p19 subunit is structurally related to IL-6, granulocyte-colony stimulating factor (G-CSF), and the p35 subunit of IL-12. ... 0003] Interleukin-12 (IL-12) is a heterodimeric molecule composed of p35 and p40 subunits. Studies have indicated that IL-12 ... the treatment of autoimmune diseases or diseases that are most likely of autoimmune origin (e.g. rheumatoid arthritis, ... When expressed in a cell, the p19 subunit first form a complex with the p40 subunit, which it shares with IL-12. As noted above ...http://www.patentsencyclopedia.com/app/20110142853
人IL-23 ELISA试剂盒(Interleukin-23) | Abcam中国官方网站
Interleukin-23) ELISA试剂盒datasheet (ab64708).Abcam抗体、ELISA、激动剂拮抗剂、表观遗传试剂、蛋白多肽 ... Combination use of immune complexes and a Ca2(+) channel blocker azelnidipine enhances interleukin-12 p40 secretion without T ... Interleukin-23) Human in vitro ELISA (Enzyme-Linked Immunosorbent Assay) kit is designed for the quantitative measurement of IL ... Interleukin-23). 参阅全部 IL23 试剂盒. ... inflammation and thus mayhttp://www.abcam.cn/human-il-23-elisa-kit-interleukin-23-ab64708.html
IL-10 Modulates Th17 Pathogenicity during Autoimmune Diseases | Open Access Journals
... however dysregulated immune response may lead to inflammatory or autoimmune diseases. Elevate.. ... The interleukin-17/interleukin-22 innate axis in the gut as a new drug target in allergic-inflammatory and autoimmune diseases ... subunits, which have homologies to IL-12p35 and p40 respectively. It belongs to IL-12 cytokine family, which also includes IL- ... p19/p40) and IL-35 (p35/Ebi3) [116-120]. IL-27R deficient mice develop severe immunopathology in several infection and ...https://www.omicsonline.org/open-access/il10-modulates-th17-pathogenicity-during-autoimmune-diseases-2155-9899-1000400.php?aid=69646
Dexamethasone restrains ongoing expression of interleukin-23p19 in peripheral blood-derived human macrophages | Springer for...
... interleukin-23 has been shown to be involved in the pathogenesis of autoimmune diseases favoring the development of a T cell ... of its unique p19 subunit - by human Mφ. Moreover, since NF-κB and p38 MAPK are involved in the regulation of IL-23p19 ... Although autoimmune diseases have long been considered being T cell-mediated, the pleiotropic role of Mφ in immunity has lately ... DEX-dependent inhibition of expression of the interleukin subunits IL-23p19, IL-12/IL-23p40 and IL-12p35, respectively. Real ...https://rd.springer.com/article/10.1186/1471-2210-11-8
Cytokines and Transcription Factors That Regulate T Helper Cell Differentiation: New Players and New Insights | SpringerLink
Devergne O, Birkenbach M, Kieff E: Epstein-Barr virus-induced gene 3 and the p35 subunit of interleukin 12 form a novel ... Becher B, Durell BG, Noelle RJ: Experimental autoimmune encephalitis and inflammation in the absence of interleukin-12. J Clin ... Oppmann B, Lesley R, Blom B, et al.: Novel p19 protein engages IL-12p40 to form a cytokine, IL-23, with biological activities ... Szabo SJ, Dighe AS, Gubler U, Murphy KM: Regulation of the interleukin (IL)-12R beta 2 subunit expression in developing T ...https://link.springer.com/article/10.1023%2FA%3A1023381027062
Immune Modulatory Treatment of Trinitrobenzene Sulfonic Acid Colitis with Calcitriol Is Associated with a Change of a T Helper ...
2005) IL-33, an interleukin-1-like cytokine that signals via the IL-1 receptor-related protein ST2 and induces T helper type 2- ... The immunoregulatory properties of calcitriol have been demonstrated in different models of autoimmune diseases (systemic lupus ... Harrington LE, Hatton RD, Mangan PR, Turner H, Murphy TL, Murphy KM, and Weaver CT (2005) Interleukin 17-producing CD4+ ... Neurath MF, Fuss I, Kelsall BL, Stuber E, and Strober W (1995) Antibodies to interleukin 12 abrogate established experimental ...http://jpet.aspetjournals.org/content/324/1/23.long
Adoptive Immunotherapy of Experimental Autoimmune Encephalomyelitis Via T Cell Delivery of the IL-12 p40 Subunit | The Journal...
Interestingly, the IL-12 p40 subunit can also associate with a p19 subunit produced by dendritic cells to form the newly ... Regulation of the interleukin (IL)-12R β2 subunit expression in developing T helper 1 (Th1) and Th2 cells. J. Exp. Med. 185: ... Interleukin 12 administration induces T helper type 1 cells and accelerates autoimmune diabetes in NOD mice. J. Exp. Med. 181: ... An interleukin (IL)-10/IL-12 immunoregulatory circuit controls susceptibility to autoimmune disease. J. Exp. Med. 187: 537. ...http://www.jimmunol.org/content/167/4/2379.long
Frontiers | Regulatory effects of C5a on IL-17A, IL-17F, and IL-23 | Immunology
Using C5a, C5aR, or C5L2 deficiency or blockade, IL-17/IL-23 production and/or IL-17-dependent disease progression has been ... The contributions of C5a interaction with its receptors in the production of IL-17/IL-23 and promotion of IL-17-dependent ... Using C5a, C5aR, or C5L2 deficiency or blockade, IL-17/IL-23 production and/or IL-17-dependent disease progression has been ... The contributions of C5a interaction with its receptors in the production of IL-17/IL-23 and promotion of IL-17-dependent ...https://www.frontiersin.org/articles/10.3389/fimmu.2012.00387/full
Splenic suppressor of cytokine signaling 3 transgene expression affects T cell responses and prevents development of collagen...
A point mutation of Tyr-759 in interleukin 6 family cytokine receptor subunit gp130 causes autoimmune arthritis. J Exp Med 2002 ... Role of interleukin-4 and interleukin-10 in murine collagen-induced arthritis: protective effect of interleukin-4 and ... Activation of interleukin-6 gene expression through the NF-κB transcription factor. Mol Cell Biol 1990; 10: 2327-34.. *PubMed ... Serum levels of interleukin-6 followed a similar but not significant trend. Values are the mean and SEM. ∗ = P , 0.05 versus ...http://onlinelibrary.wiley.com/doi/10.1002/art.24072/full
COMPOSITIONS AND METHODS FOR MODULATING C-REL-DEPENDENT CYTOKINE PRODUCTION - Patent application
... autoimmune neuropathies, Guillain-Barre syndrome, autoimmune uveitis, autoimmune hemolytic anemia, pernicious anemia, ... In yet other aspects, IL-12 subunit p35 expression is inhibited, and/or the NFκB element of IL-12 subunit p35 promoter is ... 0004] Interleukin-12 (IL-12) is a di-sulfide linked heterodimeric cytokine (p70) composed of two independently regulated ... autoimmune neuropathies, Guillain-Barre syndrome, autoimmune uveitis, autoimmune hemolytic anemia, pernicious anemia, ...http://www.patentsencyclopedia.com/app/20120208203
Furthermore, mice with a deleted p19 subunit of IL-23 showed significantly reduced number of IL-17-producing T cells and were ... Type 1 diabetes (T1D) is an autoimmune disease which is characterized. 28 Feb 2018 ovarian ... Finally, several approaches are being explored for intervention to block interleukin- (IL-) 17 activity or suppress Th17 ... In contrast, p35 subunit of IL-12 deficient mice produced an increased number of IL-17-producing T cells and developed severe ...http://www.ovarian-cancersymptoms.com/category/epigenetics/