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*  Autoimmunity - wikidoc
Genetic Factors. Certain individuals are genetically susceptible to developing autoimmune diseases. This susceptibility is ... The most notable and consistent is the association between HLA B27 and ankylosing spondylitis. Correlations may exist between ... and central to the development of immunological tolerance to self-antigens. The latter concept has been termed natural ... any antibody produced against this antigen (which mimics the self-antigens) can also, in theory, bind to the host antigens, and ...
  http://wikidoc.org/index.php/Auto-immune_disorders
*  Autoimmunity - Wikipedia
Genetic factors[edit]. Certain individuals are genetically susceptible to developing autoimmune diseases. This susceptibility ... The most notable and consistent is the association between HLA B27 and spondyloarthropathies like ankylosing spondylitis and ... normally prevented from causing disease by the phenomenon of immunological tolerance to self-antigens.[citation needed] ... any antibody produced against this antigen (which mimics the self-antigens) can also, in theory, bind to the host antigens, and ...
  https://en.wikipedia.org/wiki/Autoimmune
*  HIV Medicine 2007 | Acute HIV-1 Infection
... including HLA-B27 and -B57 (O'Brien 2001, Kaslow 1996). Recent studies demonstrated that individuals expressing HLA-B57 ... Immunological and virological events during acute HIV-1 infection. During acute HIV-1 infection, the virus replicates ... In contrast, detection of p24 antigen has a sensitivity of only 79 % with a specificity of 99.5 - 99.96 %. The diagnosis of ... Positive selection of HIV-1 cytotoxic T lymphocyte escape variants during primary infection. Proc Natl Acad Sci U S A 1997,94: ...
  http://www.hivmedicine.com/textbook/acuteinf.htm
*  Autoimmune Disorders | SpringerLink
Such a contention is supported by the observation of an increased prevalence of many autoimmune... ... Many diseases with autoaggressive immune components appear to have predisposing genetic factors. ... Genetic modulation of antigen presentation by HLA-B27 molecules. J. Exp. Med. 175:361-369.PubMedCrossRefGoogle Scholar ... Genetic predispositions for immunological features in chronic liver diseases other than autoimmune hepatitis. J. Hepatol. 24:52 ...
  https://link.springer.com/chapter/10.1007%2F978-0-585-31180-7_5
*  B-Raf specific antibody responses in melanoma patients
... whereas the immunological attack of the tumor cell is independent of the function of the antigen [17]. To date, many TAA used ... T-cells in melanoma patients reactive against an HLA B27 restricted B-Raf V599E epitope encompassing the mutation identified ... Mutations of the BRAF gene are the most common genetic alteration in melanoma. Moreover, BRAF mutations are already present in ... including autoimmune diseases or neoplastic diseases of different origin. Furthermore, as the control group has been sampled in ...
  http://pubmedcentralcanada.ca/pmcc/articles/PMC518968/?lang=en-ca
*  Horror Autoinflammaticus: The Molecular Pathophysiology of Autoinflammatory Disease
The inability to explain the association of HLA-B27 with AS on the basis of antigen presentation and models of adaptive ... Classification of nonbacterial osteitis: retrospective study of clinical, immunological and genetic aspects in 89 patients. ... Common variants in NLRP2 and NLRP3 genes are strong prognostic factors for the outcome of HLA-identical sibling allogeneic stem ... the spectrum of self-reactive immunological disease represents a continuum between autoimmune disorders based primarily on ...
  http://pubmedcentralcanada.ca/pmcc/articles/PMC2996236/
*  Human leukocyte antigen - Wikipedia
In this system, antigens were eventually assigned letters and numbers (e.g., HLA-B27 or, shortened, B27). A parallel system ... People with certain HLA antigens are more likely to develop certain autoimmune diseases, such as type I diabetes, ankylosing ... The large extent of variability in HLA genes poses significant challenges in investigating the role of HLA genetic variations ... Because gene typing is based on SSP-PCR, it is possible that new variants, in particular in the class I and DRB1 loci, may be ...
  https://en.wikipedia.org/wiki/Human_leucocyte_antigen
*  4. Breaking Tolerance: Autoimmunity & Dysregulation
Table 3. Association of autoimmune diseases and MHC. MHC-I association. Ankylosing spondylitis (HLA-B27). ... Systemic autoimmune diseases. Sjögren's syndrome. Salivary and lacrimal glands. Nuclear antigens (SSA, SSB). Dry eyes, dry ... Genetic associations outside the MHC locus include the autoinflammatory disorders (e.g. genes for FcγR have a moderate ... sequence variants of NOD2/CARD15) predisposing to defective innate signalling pathways and thus inadequate immunity ...
  https://www.immunopaedia.org.za/immunology/advanced/4-breaking-tolerance-autoimmunity-dysregulation/
*  Human leukocyte antigen - Wikipedia
In this system, antigens were eventually assigned letters and numbers (e.g., HLA-B27 or, shortened, B27). A parallel system ... People with certain HLA antigens are more likely to develop certain autoimmune diseases, such as type I diabetes, ankylosing ... describes a novel sequence feature variant type (SFVT) approach for HLA genetic analysis that categorizes HLA proteins into ... Because gene typing is based on SSP-PCR, it is possible that new variants, in particular in the class I and DRB1 loci, may be ...
  https://en.wikipedia.org/wiki/Human_leukocyte_antigen
*  Professor Ellie (Eleanor) Barnes - Nuffield Department of Medicine
UNLABELLED: Human leukocyte antigen B27 (HLA-B27) is associated with protection in human immunodeficiency virus (HIV) and ... and causal genetic variants have yet to be clearly defined. Locating these causal variants, mapping in detail the IFNλ3 ... has been proposed as an antigen triggering autoimmune pancreatitis (AIP), the pancreatic manifestation of IgG4-related disease ... We then ranked these ChAd vectors by immunological potency and found up to a thousandfold variation in potency for CD8+ T cell ...
  https://www.ndm.ox.ac.uk/principal-investigators/researcher/ellie-eleanor-barnes
*  Laboratory Primate Newsletter, Volume 35, Number 3
One of the animals had a major histocompatibility class I allele with some sequence similarity to HLA-B27. This allele is ... Pasteur, 25 rue du Dr Roux, 75724 Paris Cedex 15, France). Journal of Immunological Methods, 1995, 179, 1-12. . . . A technique ... autoimmune liver diseases and hepatitis * gastric ulcer disease and Helicobacter pylori * parasitic diseases which have an ... Flow cytometry detection of surface antigens on fresh, unfixed red blood cells infected by Plasmodium falciparum. Jouin, H., de ...
  http://www.brown.edu/Research/Primate/lpn35-3.html
*  Condition Related References - Kashi Clinical Laboratories
Susceptibility and resistance alleles of human leukocyte antigen (HLA) DQA1 and HLA DQB1 are shared in endocrine autoimmune ... Integration of genetic and immunological insights into a model of celiac disease pathogenesis. Annu. Rev. Immunol. 2011; 29:493 ... Interaction between ERAP1 and HLA-B27 in ankylosing spondylitis implicates peptide handling in the mechanism for HLA-B27 in ... Mapping of multiple susceptibility variants within the MHC region for 7 immune-mediated diseases. Proc Natl Acad Sci U S A. ...
  https://kashilab.com/condition-related-references/
*  Ankylosing Spondylitis and Axial Spondyloarthritis - PDF
44 Role of HLA-B27 HLA-B27, a class I surface antigen encoded by the B locus in the major histocompatibility complex (MHC), is ... ENDOPLASMIC RETICULUM NUCLEUS NATURAL KILLER CELL OR CD4+ T CELL HLA-B27 misfolding KIR3DL2 ER stress Genetic influences ... The Most Common Autoimmune Disease: Rheumatoid Arthritis. Bonita S. Libman, M.D. The Most Common Autoimmune Disease: Rheumatoid ... on the functional significance of the ERAP1 variants associated with ankylosing spondylitis and their interaction with HLA-B ...
  http://docplayer.net/33447291-Ankylosing-spondylitis-and-axial-spondyloarthritis.html
*  Ghent University Academic Bibliography
Onset of autoimmune lymphoproliferative syndrome (ALPS) in humans as a consequence of genetic defect accumulation Aude Magerus- ... Dendritic cells from spondylarthritis-prone HLA-B27-transgenic rats display altered cytoskeletal dynamics, class II major ... Common variants in FOXP1 are associated with generalized vitiligo Ying Jin, Stanca A Birlea, Pamela R Fain, Christina M ... Aflatoxin B1 interferes with the antigen-presenting capacity of porcine dendritic cells Jalil Mehrzad, Bert Devriendt UGent, ...
  https://biblio.ugent.be/publication?q=keyword+exact+%22T-CELLS%22&limit=250
*  Gary Peltz | Stanford Medicine Profiles
... yet only a handful of contributing genetic variants have been identified. Computational genetic mapping and quantitative trait ... exhibited HLA-DR-restricted cytotoxic activity against antigen-presenting cells pulsed with Borrelia antigen. In response to ... Analysis of pathogen-reactive T cell clones (CD3+4+8-TCR alpha beta +), isolated from the synovial fluid of 2 HLA-B27-positive ... this information could increase our understanding of the genetic factors affecting susceptibility to autoimmune and ...
  https://med.stanford.edu/profiles/gary-peltz
*  Frontiers | Genetic and Functional Associations with Decreased Anti-inflammatory Tumor Necrosis Factor Alpha Induced Protein 3...
Nominal pQTL associations with genetic variants outside TNFAIP3 were identified. Conclusions: Our results suggest both immune ... A further aim was to determine the immune signaling and genetic variation regulating TNFAIP3 expression in individual subjects ... A further aim was to determine the immune signaling and genetic variation regulating TNFAIP3 expression in individual subjects ... Further, subjects with specific groups of variants within TNFAIP3 displayed differences in TNFAIP3 (p=0.03-0.004). ...
  https://www.frontiersin.org/articles/10.3389/fimmu.2017.00860/full
*  Frontiers | Molecular Recognition of Paired Receptors in the Immune System | Microbiology
2008). CD94-NKG2A recognition of human leukocyte antigen (HLA)-E bound to an HLA class I leader sequence. J. Exp. Med. 205, 725 ... Leukocyte receptor complex-encoded immunomodulatory receptors show differing specificity for alternative HLA-B27 structures. J ... 2008). Dcir deficiency causes development of autoimmune diseases in mice due to excess expansion of dendritic cells. Nat. Med. ... Especially, we believe that future accumulating information relating the genetic, molecular, and structural bases for paired ...
  https://www.frontiersin.org/articles/10.3389/fmicb.2012.00429/full
*  Application # 2017/0143726. ADENOSINE RECEPTOR AGONISTS AND ANTAGONISTS TO MODULATE T CELL RESPONSES - Patents.com
... confusion over the HLA-B27 marker. [0234] Sjogren's syndrome, is an autoimmune disorder in which immune cells attack and ... 0147] Alternatively, the antigen can be an autoimmune disease-specific antigen. In a T cell mediated autoimmune disease, a T ... An essential prerequisite for the pathogenesis of autoimmune diseases is indeed the breakage of immunological tolerance, which ... fragments or variants thereof. BRIEF DESCRIPTION OF THE DRAWINGS [0048] FIG. 1A-1D are graphs showing A.sub.2a receptor ...
  http://patents.com/us-20170143726.html
*  Adenovirus vectors
... which finds that participants with HLA gene variants known to be associated with slow progression (HLA B27, B57 & B5801) had ... Background: The genetic diversity of HIV antigens represents a paramount challenge in the development of vaccines. Here, we ... It contrast, the immunological role of retrovirus-specific CD4+ T cells remains unclear, particularly in the setting of elite ... The antibody, canakinumab, is FDA-approved for the treatment of certain autoimmune conditions and is being tested as a therapy ...
  http://tagbasicscienceproject.typepad.com/tags_basic_science_vaccin/adenovirus-vectors/
*  Translation of HLA-HIV Associations to the Cellular Level: HIV Adapts To Inflate CD8 T Cell Responses against Nef and HLA...
A Novel Pkhd1 Mutation Interacts with the Nonobese Diabetic Genetic Background To Cause Autoimmune Cholangitis ... Overall, we were able to provide immunological support for 190 HLA-associated polymorphisms in subtype B HIV-1 as being sites ... Clustered mutations in HIV-1 gag are consistently required for escape from HLA-B27-restricted cytotoxic T lymphocyte responses. ... and minor variants of known epitopes and presuming that the ex vivo peptide presentation was mediated by the predicted HLA ...
  http://www.jimmunol.org/content/187/5/2502
*  RegenerativeMedicine.net - Article Archives
Genetic sharing and heritability of paediatric age of onset autoimmune diseases Kidins220/ARMS binds to the B cell antigen ... Interaction between ERAP1 and HLA-B27 in ankylosing spondylitis implicates peptide handling in the mechanism for HLA-B27 in ... genetic variants near APOA1, and the risk of infantile hypertrophic pyloric stenosis MC1R is a potent regulator of PTEN after ... designed controlled release systems for periodontal disease that promote immunological homeostasis New reservoirs of HLA ...
  http://regenerativemedicine.net/NewsletterArchives.asp?qEmpID=25275&qCat=RMJ