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*  Endocardial Cushion Defects: Background, Pathophysiology, Epidemiology
... more commonly known as atrioventricular (AV) canal or septal defects, include a range of defects characterized by involvement ... These defects can be classified by several methods. ... The failure of the endocardial cushions to fuse results in an ... Endocardial cushion defects, more commonly known as atrioventricular (AV) canal or septal defects, include a range of defects ... Anatomy of the endocardial cushion defect (ie, complete form); note the common atrioventricular valve straddling the atrial ...
  https://emedicine.medscape.com/article/154823-overview
*  Atrioventricular canal - Wikipedia
There are other names for these heart abnormalities such as endocardial cushion defects or atrioventricular septal defect In a ... This defect is developed because of the improper formation of the endocardial cushions, and their job is to separate the ... Atrioventricular septal defect Atrioventricular septum "Orphanet: Complete atrioventricular canal". www.orpha.net. Retrieved ... www.mayoclinic.com/health/atrioventricular-canal-defect/DS00745 Cincinnati Children's Hospital "Atrioventricular Septal Defect ...
  https://en.wikipedia.org/wiki/Atrioventricular_canal
*  The Development of the Atrioventricular Junction in the Human Heart | Circulation Research
van Mierop LHS, Alley RD, Kausel HW, Stranahan A. The anatomy and embryology of endocardial cushion defects. J Thorac ... atrioventricular cushions on the endocardial side (Fig 2d⇓). A small area of the internal relief of the atrioventricular canal ... cells within the tissue of the atrioventricular sulcus, endocardial cells, and cells within the atrioventricular cushions. RA ... The role of atrioventricular endocardial cushions in the septation of the heart. Int J Cardiol. 1985;8:25-44. ...
  http://circres.ahajournals.org/content/78/1/110
*  Differential function of genes regulated by VEGF-NFATc1 signaling pathway in migration of pulmonary valve endothelial cells
CYR61 deficient mice show severe atrioventricular septal defects (AVSD) accompanying endocardial cushion defects (17). HB-EGF ... The primordial heart valve cushions are swellings in the atrioventricular (AV) junction and outflow tract at ED 9.5 in mice. ... Induction of endocardial cushion tissue in the avian heart is regulated, in part, by TGFbeta-3-mediated autocrine signaling. ... The cushion is made up of extracellular matrix components initially, but as endocardial endothelial cells are stimulated to ...
  http://pubmedcentralcanada.ca/pmcc/articles/PMC2810463/
*  OU CARDIAC Flashcards - Cram.com
Atrioventricular (endocardial cushion) defect. Large ventricular septal defect. Double-outlet right ventricle. Ebstein's ... cgi/content/full/88/4/395The mitral valve is formed from endocardial cushions that originate both at the atrioventricular ... ATRIOVENTRICULAR (ENDOCARDIAL CUSHION) DEFECT, large ventricular septal defect, double-outlet right ventricle….coarctation. ... ATRIOVENTRICULAR (ENDOCARDIAL CUSHION) DEFECT, large ventricular septal defect, double-outlet right ventricle….coarctation. ...
  http://www.cram.com/flashcards/ou-cardiac-1429748
*  Atrioventricular septal defect - Wikipedia
... "common atrioventricular canal" (CAVC) or "endocardial cushion defect", is characterized by a deficiency of the atrioventricular ... It is caused by an abnormal or inadequate fusion of the superior and inferior endocardial cushions with the mid portion of the ... Atrioventricular Canal Defect - Stanford Children's Health Atrioventricular Septal Defect information from Seattle Children's ... Atrioventricular septal defect (AVSD) or atrioventricular canal defect (AVCD), previously known as " ...
  https://en.wikipedia.org/wiki/Atrioventricular_septal_defect
*  Protocols and Video Articles Authored by Yuji Mishina (Translated to Hindi)
Alk3 CKO embryos also displayed defects in atrioventricular canal (AVC) endocardial cushion formation in the heart. ... Aug, 2005 , Pubmed ID: 16037571 Endocardial cushions are precursors of mature atrioventricular (AV) valves. Their formation is ... Endocardial Cushion and Myocardial Defects After Cardiac Myocyte-specific Conditional Deletion of the Bone Morphogenetic ... identifying defects in outflow tract wall and cushion morphology that preceded a spectrum of septation defects from double ...
  https://www.jove.com/author/Yuji_Mishina?language=Hindi
*  Elevated glucose inhibits VEGF-A-mediated endocardial cushion formation | JCB
Defects resulting from aberrant endocardial cushion (EC)* formation, such as atrioventricular (AV) septal defects, are strongly ... by matrix metalloproteinases is an important step in the epithelial-mesenchymal transformation of the endocardial cushions. Dev ... Atrioventricular (AV) septal defects resulting from aberrant endocardial cushion (EC) formation are observed at increased rates ... A novel role for VEGF in endocardial cushion formation and its potential contribution to congenital heart defects. Development. ...
  http://jcb.rupress.org/content/160/4/605?ijkey=cd7b9fd7160d1eecba70646d6476c34cf3d194ec&keytype2=tf_ipsecsha
*  Atrioventricular Septal (AV Canal) Defects in Children
Atrioventricular Septal Defect / AV Canal forms, signs, symptoms, diagnosis, treatment and outcomes information provided in the ... Also known as atrioventricular canal defects or endocardial cushion defects, they account for about 5 percent of all congenital ... complete atrioventricular septal defect is one in which there are defects in all structures formed by the endocardial cushions ... Atrioventricular Septal Defect − AV Canal Atrioventricular septal defects (AVSD) are a relatively common family of congenital ...
  https://www.cincinnatichildrens.org/patients/child/encyclopedia/defects/avsd
*  Atrioventricular septum - Wikipedia
Incomplete formation of the endocardial cushions can lead to atrioventricular septal defects, such as an ostium primum defect ... It is formed by the union of the dorsal AV cushion and ventral AV cushion. This septum divides the atrioventricular canal. In ... left atrial isomerism in the defect of partial atrioventricular septum". Rev Bras Cir Cardiovasc. 22 (1): 125-6. PMID 17992316 ... The atrioventricular septum is a septum of the heart between the right atrium (RA) and the left ventricle (LV). Although the ...
  https://en.wikipedia.org/wiki/Atrioventricular_septum
*  Endocardial cushions - Wikipedia
A problem in endocardial cushion development or remodeling is thought to be associated with atrioventricular septal defect. The ... called the endocardial cushions seen in the heart tube. Upon sectioning of the heart the atrioventricular endocardial cushions ... Endocardial cushions, or atrioventricular cushions, refer to a subset of cells in the development of the heart that play a ... The endocardial cushions are a subset of cells found in the developing heart tube that will give rise to the heart's valves and ...
  https://en.wikipedia.org/wiki/Endocardial_cushions
*  Protein signalling in heart development - Wikipedia
Defects in producing the AV septum produces atrioventricular septal defects, including a persistent AV canal and tricuspid ... which grows towards the endocardial cushions within the atrial canal. Right before the septum primum fuses with the endocardial ... The endocardial cushion serves as a makeshift valve until then. The primitive atrium is divided in two by joining of several ... The IV septum grows upward towards the endocardial cushion. As it grows, a foramen appears, the interventricular foramen, which ...
  https://en.wikipedia.org/wiki/Protein_signalling_in_heart_development
*  GATA4 - Wikipedia
Endocardial cells undergo epithelial to mesenchymal transitions (EMT) into the AV cushions during development. Their ... for human medicine by suggesting that mutations with the GATA4 transcription factor could be responsible for AV cushion defects ... GATA4 expression during cardiac development has been shown to be essential to proper atrioventricular (AV) formation and ... Mutations in this gene have been associated with cardiac septal defects as well as reproductive defects. GATA4 is a critical ...
  https://en.wikipedia.org/wiki/GATA4
*  Notch signaling pathway - Wikipedia
Wang J, Sridurongrit S, Dudas M, Thomas P, Nagy A, Schneider MD, Epstein JA, Kaartinen V (Oct 2005). "Atrioventricular cushion ... ventricular development by its expression in the interventricular septum and the endocardial cells of the cardiac cushions. ... Studies have revealed that both loss- and gain-of-function of the Notch pathway results in defects in AV canal development. In ... After the AV canal boundary formation, a subset of endocardial cells lining the AV canal are activated by signals emanating ...
  https://en.wikipedia.org/wiki/Notch_signaling_pathway