*  N-(p-amylcinnamoyl)anthranilic acid - Wikipedia
Some have provided evidence that these channels are present in human atrial cells, while others have failed to find similar ... Escande D, Coulombe A, Faivre JF, Deroubaix E, Coraboeuf E. "Two types of transient outward currents in adult human atrial ... "4-Aminopyridine and the early outward current of sheep cardiac Purkinje fibers". J Gen Physiol 1979;73:139-157. Zygmunt AC, ... Li GR, Feng J, Wang Z, Fermini B, Nattel S. "Comparative mechanisms of 4-aminopyridine-resistant Ito in human and rabbit atrial ...
  https://en.wikipedia.org/wiki/N-(p-amylcinnamoyl)anthranilic_acid
*  4-Aminopyridine - Wikipedia
... and atrial fibrillation. The drug was originally intended, by Acorda Therapeutics, to have the brand name Amaya, however the ... "Aminopyridines for symptomatic treatment in multiple sclerosis". Cochrane Database Syst Rev (4): CD001330. doi:10.1002/14651858 ... Octopus Envenomations at eMedicine.com Wu, ZZ; Li, DP; Chen, SR; Pan, HL (2009). "Aminopyridines Potentiate Synaptic and ... The use of 4-aminopyridine in bird control has been criticized by the Humane Society of the United States. Fampridine has been ...
  https://en.wikipedia.org/wiki/4-Aminopyridine
*  Atrial Fibrillation Begets Atrial Fibrillation | Circulation
Shortening of Atrial Refractoriness by Atrial Fibrillation In the present study we found no changes in atrial conduction ... Mechanisms of Chronic Atrial Fibrillation Burst pacing between two closely spaced atrial electrodes induces atrial fibrillation ... Intra-atrial conduction and atrial fibrillation. In: Olsson SB, Allessie MA, Campbell RWF, eds. Atrial Fibrillation: Mechanisms ... A single unipolar atrial electrogram recorded from theleft atrial appendage during different stages of atrial fibrillation (AF ...
  http://circ.ahajournals.org/content/92/7/1954
*  Short-Term Effects of Rapid Pacing on mRNA Level of Voltage-Dependent K+ Channels in Rat Atrium | Circulation
Rapid Atrial Pacing Model of the Rat. Figure 1⇓ shows ECG lead II, the atrial electrogram, and right atrial pressure obtained ... Atrial fibrillation begets atrial fibrillation: a study in awake chronically instrumented goats. Circulation. 1995;92:1954-1968 ... Right atrial rapid pacing was performed through the electrode catheter introduced from cervical vein. ECG lead II, atrial ... Daoud EG, Bogun F, Goyal R, Harvey M, Man C, Strickberger SA, Morady F. Effect of atrial fibrillation on atrial refractoriness ...
  http://circ.ahajournals.org/content/101/16/2007
*  endocardium - oi
Ticagrelor, but not clopidogrel active metabolite, displays antithrombotic properties in the left atrial endocardium ... Electrophysiological responses of canine atrial endocardium and epicardium to acetylcholine and 4-aminopyridine ...
  http://oxfordindex.oup.com/view/10.1093/oi/authority.20110803095751857
*  A Novel Anionic Inward Rectifier in Native Cardiac Myocytes | Circulation Research
A, Carboxylic acid derivative 9-AC blocked ICl.ir in mouse atrial myocytes. A-a, Mean I-V curves of ICl.ir obtained from 4 ... We also examined the Cl− dependence of the current in guinea pig atrial myocytes using different [Cl−]i. As shown in Figure 6A⇓ ... Total RNA from atrial (20 μg) and ventricular (20 μg) tissue was hybridized with a 32P-labeled mouse ClC-2 probe (420 bp) as ... As shown in Figure 4B⇓, 1⇑ mmol/L SITS failed to affect the current in mouse atrial cells. The changes in current densities ...
  http://circres.ahajournals.org/content/86/4/e63
*  Faculty Profile - Jacobs School of Medicine and Biomedical Sciences - University at Buffalo
Murphey CR, Clark JW, Giles WR, Rasmusson RL, Halter JA, Hicks K, Hoyt B. Conduction in bullfrog atrial strands: simulations of ... Activation and inactivation kinetics of an E-4031-sensitive current from singleferret atrial myocytes. Biophys J. 1996; 70(6). ... 2006; 340(4).. *Wang S, Ponoran TA, Rasmusson RL, Ragsdale DS, Peterson BZ. Amino acid substitutions in the pore of the CaV1.2 ... 1999; 113(4).. *Rasmusson R, Morales MJ, Wang S, Liu S, Campbell DL, Brahmajothi MV, Strauss H. Inactivation of voltage-gated ...
  http://medicine.buffalo.edu/content/medicine/faculty/profile.html?ubit=rr32
*  Plus it
2000) β(2)-Adrenergic and several other G protein-coupled receptors in human atrial membranes activate both G(s) and G(i). Circ ... 2004) Mechanisms of β3-adrenoceptor-induced eNOS activation in right atrial and left ventricular human myocardium. Br J ... 4, B and C). Pretreatment with 100 μM NOR induced a significant decrease in the maximal response (Emax of 115 ± 38%; n = 4; P ... 9 and 10). Both β1 and β2-AR mRNA (n = 6) and protein expression (n = 4) were significantly reduced, following NOR treatment, ...
  http://jpet.aspetjournals.org/content/316/1/392
*  Pathophysiological basis and clinical application of T-wave alternans | JACC: Journal of the American College of Cardiology
Atrial fibrillation and other frequent arrhythmias, such as frequent atrial and/or ventricular premature beats, limit the use ... frequent atrial or ventricular ectopy or atrial arrhythmias. However, the indeterminate rate of TWA testing may be reduced by ... It does not appear to matter whether the threshold heart rate required to induce TWA is achieved by exercise or atrial pacing. ... 1997) T-wave alternans during exercise and atrial pacing in humans. J Cardiovasc Electrophysiol 8:987-993. ...
  http://www.onlinejacc.org/content/40/2/207
*  Induction of Heat Shock Response Protects the Heart Against Atrial Fibrillation | Circulation Research
Atrial tachypacing without GGA reduced ERP in a statistically significant fashion at most atrial sites (Figure 7B). Atrial ... Atrial tachypacing in the absence of GGA produced the changes typical of atrial tachycardia remodeling, reducing atrial ERP and ... atrial tissue of GGA-treated atrial tachypaced (GGA+ATP) dogs, compared with nonpaced (NP) and non-GGA-treated 7-day atrial ... we compared atrial cell death and fibrous tissue content in atrial tissue samples taken after euthanasia of control, atrial ...
  http://circres.ahajournals.org/content/99/12/1394
*  Cloning and expression of a rat cardiac delayed rectifier pota...
RAK expressed in oocytes compares closely to the intrinsic adult rat atrial delayed-rectifier current measured by using whole- ... It is blocked by 4-aminopyridine greater than barium much greater than tetraethylammonium chloride, which is similar to the ...
  https://www.mysciencework.com/publication/show/cloning-and-expression-of-a-rat-cardiac-delayed-rectifier-potassium-channel
*  α-Adrenergic Control of Volume-Regulated Cl− Currents in Rabbit Atrial Myocytes | Circulation Research
IK1 in rabbit atrial and ventricular myocytes,10 11 and IKACh in rabbit atrial and ventricular cells.10 11 In guinea pig ... We have found that α1-adrenergic activation inhibits the volume-regulated Cl− currents ICl.b and ICl.swell in rabbit atrial ... Single atrial cells were obtained from rabbit hearts by using a previously described dissociation technique.21 37 Briefly, ... The response of ICl.b and ICl.swell in rabbit atrial myocytes to α-adrenergic and PKC stimulation that we observed is opposite ...
  http://circres.ahajournals.org/content/77/2/379
*  WikiGenes - Cordilox - 2-(3,4-dimethoxyphenyl)-5-[2-(3,4...
Treatment of multifocal atrial tachycardia with verapamil. Levine, J.H., Michael, J.R., Guarnieri, T. N. Engl. J. Med. (1985) [ ... Verapamil-induced atrial fibrillation. Falk, R.H., Knowlton, A.A., Manaker, S. N. Engl. J. Med. (1988) [Pubmed] ... Verapamil-induced atrial fibrillation [2].. *Hypotension after quinidine plus verapamil. Possible additive competition at alpha ... Involvement of P-glycoprotein in the transmembrane transport of interleukin-2 (IL-2), IL-4, and interferon-gamma in normal ...
  https://www.wikigenes.org/e/chem/e/2520.html
*  Frontiers | The Role of DPO-1 and XE991-Sensitive Potassium Channels in Perivascular Adipose Tissue-Mediated Regulation of...
2009). Novel KCNA5 loss-of-function mutations responsible for atrial fibrillation. J. Hum. Genet. 54, 277-283. doi: 10.1038/jhg ... 2006). Kv channels contribute to nitric oxide- and atrial natriuretic peptide-induced relaxation of a rat conduit artery. J. ... Among them adenosine and atrial natriuretic peptide (ANP) act via activation of the KCNQ (KV7) subfamily of KV channels ( ... The composition of 60 mM KCl (in mmol/L) was 63.7 NaCl, 60 KCl, 1.2 KH2PO4, 25 NaHCO3, 1.2 Mg2SO4, 11.1 glucose, and 1.6 CaCl2 ...
  https://www.frontiersin.org/articles/10.3389/fphys.2016.00335/full
*  Pharmacology Flashcards - Cram.com
Study Flashcards On Pharmacology at Cram.com. Quickly memorize the terms, phrases and much more. Cram.com makes it easy to get the grade you want!
  http://www.cram.com/flashcards/pharmacology-501238
*  KAKEN - Research Projects | Regional differences in the pacemaker activity of the heart (KAKENHI-PROJECT-07044244)
Publications] Muhammad Nikmaram: 'Variation in the effects of Cs^+,UL-SF 49 and ZD 7288 within the sino-atrial node' American ... Publications] Muhammad Nikmaram: 'Variation in the effects of Cs^+, UL-SF 49 and ZD 7288 within the sino-atrial node' American ... Publications] Muhammad Nikmaram: 'Variation in the effects of Cs^+,UL-SF 49 and ZD 7288 within the sino-atrial node' American ... Publications] Itsuo Kodama: 'Regional differences in the response of the isolated sino-atrial node of the rebbit to vagal ...
  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-07044244/
*  Patent US7732199 - Process for making transplantable cardiomyocytes from human embryonic stem cells - Google Patents
Atrial natriuretic factor (ANF), a hormone expressed in developing heart and fetal cardiomyocytes but down-regulated in adults ... Atrial natriuretic factor (ANF) was upregulated during cardiac differentiation of hES cells as detected by a semiquantitative ... Method of isolation, culture and proliferation of human atrial myocytes. US5733727. Jun 7, 1995. Mar 31, 1998. Indiana ... Koide et al., Atrial natriuretic peptide accelerates proliferation of chick embryonic cardiomyocytes in vitro, Differentiation ...
  http://www.google.com/patents/US7732199?dq=5958006
*  Two Components of Delayed Rectifier Current in Canine Atrium and Ventricle | Circulation Research
Two IK Components Are Present in Canine Atrial Myocytes The characteristics of IK in canine left atrial myocytes were assessed ... Two IK components in canine atrial myocytes. A, Typical currents recorded from left atrial myocytes were similar to those ... on atrial flutter, atrial refractoriness, and conduction delay in a canine sterile pericarditis model. J Cardiovasc Pharmacol.. ... Delayed rectifier outward K+ current is composed of two currents in guinea pig atrial cells. Am J Physiol.. 1991;260:H393-H399 ...
  http://circres.ahajournals.org/content/78/1/26
*  Channelpedia
KCNE1 antisense oligos also reduce IKr density in the atrial tumor cell line (AT1 cell). A study in horse heart has provided ... 930] provided evidence that different concentrations of free PAs may underlie differences between atrial and ventricular IK1 in ... Intracellular urate was shown to enhance Kv1.5 protein expression and activity in cultured mouse atrial myocytes [2038] ... and only prolonged the dramatically altered AP in preparations from patients in chronic atrial fibrillation [1585] ...
  http://channelpedia.epfl.ch/reports/interaction
*  Open resource
A separate use of an anticholinergic agent during anesthesia might be to treat paroxysmal atrial tachycardia (PAT); for this ... Hyperthyroid patients given PB may develop atrial fibrillation, but although caution is recommended in general when giving ... The compound 4-aminopyridine, used as a bird repellent in Europe but not approved by the Food and Drug Administration for sale ... Estimates of the bioavailability of PB after oral administration have ranged from a low of 3-4% to a high of nearly 30%, with a ...
  http://studyres.com/doc/5832139/open-resource
*  C:\1 revista\edições\vol 5 num
atrial electrical wave velocity. Such effects lead to a Evers, A.S. & C.M. Crowder, 2001. General anesthetics,. Goodman and ... Ca2+ release mechanisms, atrial nodal cells of the rabbit heart. J. Gen. Physiol.. Ca2+ spark, and local control of excitation- ... reduction of the spontaneous atrial pacemaker rate,depolarization of atrial cells (quiescent: 3.46 ± 1.2 mV; under electrical ... impulse velocity, the atrial pacemaker frequency was Their hearts were removed immediately and immersed set at a rate 20% ...
  http://healthdrugpdf.com/b/biologiageralexperimental.bio.br1.html
*  Transcription Enhancer Factor-1-Related Factor-Transgenic Mice Develop Cardiac Conduction Defects Associated With Altered...
Elevated atrial weights reflect distension of atrial myocardium and presence of organized thrombus. All values are mean±SEM, n≥ ... With age, RTEF-1 mice develop spontaneous atrial arrhythmias that probably contribute to progressive atrial dilatation. The ... Progressive atrial dilatation in RTEF-1 mice. A, Atrial weights are significantly elevated in Founder 3 RTEF-1 mice compared ... Consistent with gene dosage and the onset of atrial arrhythmias, RTEF-1 mice develop atrial dilatation (Figure 4A) without ...
  http://circ.ahajournals.org/content/110/19/2980
*  Electrophysiological Effects of Ranolazine, a Novel Antianginal Agent With Antiarrhythmic Properties | Circulation
Amiodarone is a potent antiarrhythmic agent used in the management of both atrial and ventricular arrhythmias. In addition to ... Figure 4 illustrates the effect of ranolazine on the maximal rate of increase of the upstroke (Vmax) of the action potential ... The preferential prolongation of epicardial APD was more apparent at a [K+]o of 2 mmol/L than at 4 mmol/L (Figure 5, right). ... Figure 4. Concentration-dependent effects of ranolazine on rate of rise of upstroke of a Purkinje fiber action potential (Vmax ...
  http://circ.ahajournals.org/content/110/8/904
*  Protocols and Video Articles Authored by Elizabeth M. McNally (Translated to German)
Arrhythmias affecting both atrial and ventricular rhythms occur and may be life threatening. The degree to which ... Older mutant animals were found to have elongated P wave duration, elevated atrial and ventricular effective refractory periods ... We now studied response to a form of chronic stress, namely that induced by 4 wk of daily exercise on SUR2 mutant mice. Control ... Since Mini-Gamma represents removal of 4 of the 7 coding exons in γ-sarcoglycan, this approach provides a viable strategy to ...
  https://www.jove.com/author/Elizabeth++M._McNally?language=German
*  Unanticipated Lessening of the Rise in Extracellular Potassium During Ischemia by Pinacidil | Circulation
The atrial and left ventricular free wall were removed and the ventricular septum was attached, left side down, to a wax ... The heart rate was maintained between 100 and 120 bpm by atrial pacing in the experiments using a single rate. In those ... Lower panels demonstrate similar parameters during atrial pacing at 100 bpm in the absence of pinacidil and 150 bpm in the ... Fig 4⇓ illustrates these effects in the rabbit (n=5). Before pinacidil, the [K+]e rise during ischemia was significantly ...
  http://circ.ahajournals.org/content/95/7/1937