*  Ciprofloxacin - Wikipedia
... and the demonstration that certain structural modifications including the attachment of a fluorine atom to the quinolone ring ... Ball, P. (2000). "Quinolone generations: Natural history or natural selection?". Journal of Antimicrobial Chemotherapy. 46: 17- ... Numerous pathogens, including enterococci, Streptococcus pyogenes and Klebsiella pneumoniae (quinolone-resistant) now exhibit ... Among the 46,766 quinolone users in the study, 38 (0.1%) cases of Achilles tendon rupture were identified. A study performed ...
  https://en.wikipedia.org/wiki/Cipro
*  Noroxin (Norfloxacin): Side Effects, Interactions, Warning, Dosage & Uses
Norfloxacin, a fluoroquinolone, differs from non-fluorinated quinolones by having a fluorine atom at the 6 position and a ... while taking quinolones. If patients need to be outdoors while using quinolones, they should wear loose-fitting clothes that ... that some quinolones may increase the effects of theophylline and/or caffeine (see PRECAUTIONS: DRUG INTERACTIONS). ... Quinolones, including NOROXIN, have been shown in vitro to inhibit CYP1A2. Concomitant use with drugs metabolized by CYP1A2 (e. ...
  https://www.rxlist.com/noroxin-drug.htm
*  Norfloxacin - Wikipedia
... and the demonstration that certain structural modifications including the attachment of a fluorine atom to the quinolone ring ... Some quinolones exert an inhibitory effect on the cytochrome P-450 system, thereby reducing theophylline clearance and ... Quinolones, including norfloxacin, may enhance the effects of oral anticoagulants, including warfarin or its derivatives or ... "Quinolones for uncomplicated acute cystitis in women". Cochrane Database Syst Rev. 3 (3): CD003597. doi:10.1002/14651858. ...
  https://en.wikipedia.org/wiki/Norfloxacin
*  Flumequine - Wikipedia
Flumequine is the first quinolone compound with a fluorine atom at the C6-position of the related quinolone basic molecular ... Allergy to quinolones Eight cases of quinolone allergy F. F. Arboit 1 , JC Bessot 2 , F. Arboit 1, JC Bessot 2, F. De Blay 2 , ... Although quinolones are highly toxic to mammalian cells in culture, its mechanism of cytotoxic action is not known. Quinolone ... Significant and harmful residues of quinolones have been found in animals treated with quinolones and later slaughtered and ...
  https://en.wikipedia.org/wiki/Flumequine
*  Quinolone antibiotic - Wikipedia
Nearly all quinolone antibiotics in use are fluoroquinolones, which contain a fluorine atom in their chemical structure and are ... Andriole, VT The Quinolones. Academic Press, 1989. *^ Andersson MI, MacGowan AP (2003). "Development of the quinolones". ... Quinolone antibiotic at Curlie (based on DMOZ). *Healthcare-associated Infections (HAIs)- Quinolones and the Clinical ... Norris, S; Mandell, GL (1988). "The quinolones: history and overview". The quinolones: history and overview. San Diego: ...
  https://en.wikipedia.org/wiki/Adverse_effects_of_fluoroquinolones
*  Amorphous Besifloxacin Solid - Shawer, Mohannad
On the other hand, quinolone carboxylic acid derivatives substituted with a fluorine atom at 6 position, such as norfloxacin, ... The atoms in a crystalline powder form a periodic array of coherent scatters. Diffraction from different planes of atoms within ... or quinolone carboxylic acid derivatives substituted with a chlorine atom at 8 position have been developed (Japanese Patent ... with carbon chains having about 12 or more carbon atoms (e.g., such as from about 12 to about 24 carbon atoms). Such compounds ...
  http://www.freepatentsonline.com/y2011/0144329.html
*  Fluoroquinolone | definition of fluoroquinolone by Medical dictionary
any of a subgroup of quinolones that contain one or more fluorine atoms attached to the central ring system that have a broader ... Antibiotics A quinolone with an added flourine on the parent quinolone structure. See Quinolone. fluor·o·quin·o·lone (flōr'ō- ... any of a subgroup of quinolones that have a broader spectrum of activity than quinolones such as nalidixic acid. ... flu·o·ro·quin·o·lone/ (-kwin´o-lōn) any of a subgroup of fluorine-substituted quinolones, having a broader spectrum of activity ...
  http://medical-dictionary.thefreedictionary.com/fluoroquinolone
*  US Patent # 8,129,533. Method for production of quinolone-containing lyophilized preparation - Patents.com
The present invention is directed to a lyophilized preparation which contains a synthetic quinolone antibacterial compound and ... In formula (1), X.sup.1 represents a halogen atom or a hydrogen atom. When X.sup.1 is a halogen atom, the halogen atom is ... The heteroaryl group contains one or more hetero atoms selected from among a nitrogen atom, an oxygen atom, and a sulfur atom. ... an oxygen atom, a nitrogen atom, or a sulfur atom and which is formed from X.sup.2, R.sup.1, and a part of the quinolone ...
  http://patents.com/us-8129533.html
*  Buy cheap acetaminophen
... with the oxygen atom of the quinolone carbonyl and one of the two oxygen atoms in the carboxylate chelating to Mg2 ions, ... H-Norfs act in a bidentate coordination mode through the oxygen atom of the quinolone carbonyl and one of the two oxygen atoms ... The N atom of the piperazine ring is protonated in both 1 and 2 and loses the coordination ability as confirmed by the crystal ... 2, is also a dimer, the bridging group is a chloride ion rather than a carboxylate oxygen atom. In addition, a higher molar ...
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*  High incidence of plasmid-mediated quinolone resistance genes among ciprofloxacin-resistant clinical isolates of...
Plasmid-mediated quinolone resistance (PMQR) has received considerable attention recently. Data analysis in Jawaharlal ... PeerJ feeds - Atom , RSS 1.0 , RSS 2.0 , JSON PeerJ Computer Science feeds - Atom , RSS 1.0 , RSS 2.0 , JSON PeerJ Preprint ... Plasmid-mediated quinolone resistance genes, aac(6′)-Ib-cr, qnrS, qnrB, and qnrA, in urinary isolates of Escherichia coli and ... Plasmid-Mediated quinolone resistance in clinical isolates of escherichia coli from Shanghai, China.. Journal of Antimicrobial ...
  https://peerj.com/articles/1995/
*  Quinolone antibiotic - Wikipedia
The majority of quinolones in clinical use are fluoroquinolones, which have a fluorine atom attached to the central ring system ... Nearly all quinolone antibiotics in modern use are fluoroquinolones, which contain a fluorine atom in their chemical structure ... Quinolone antibiotic at Curlie (based on DMOZ) Healthcare-associated Infections (HAIs)- Quinolones and the Clinical Laboratory ... Although not formally a quinolone, nalidixic acid is considered the first quinolone drug. It was introduced in 1962 for ...
  https://en.wikipedia.org/wiki/Quinolone_antibiotic
*  GPATcrackers: Pharmacology and chemistry of quinolones: Broad spectrum antibiotics
Mechanism of Action of quinolones:. · Quinolones Inhibit DNA gyrase of gram negative and topoisomerase IV in gram positive ... Older quinolones were active against mainly gram negative strains. Quinolones contain N-1-alkylated 3-carboxy pyrid-4-one ring ... Drug interactions of quinolones:. · Quinolones increases the plasma con. Of theophylline, Caffeine and warfarin.. ... Quinolones are synthetic broad spectrum antimicrobial agents. ... Structure activity relationship of quinolones:. SAR of ...
  http://www.gpatcrackers.com/2014/09/pharmacology-and-chemistry-of-quionoles.html
*  Journal of the Brazilian Chemical Society
From a single-crystal X-ray analysis for a synthesised quinolone, quinolyl and naphtyl groups connected to the C3 and C24 ... carbon atoms are twisted by torsion angle of 65.2 .. http://dx.doi.org/10.5935/0103-5053.20150011. Published online: January 30 ...
  http://jbcs.sbq.org.br/default.asp?ed=214
*  Quinolones 101 - Quinolone Vigilance Foundation
The addition of the fluorine atom and a piperazine ring make quinolones more powerful, more able to penetrate the blood-brain ... The addition of a fluorine atom is what differentiates quinolones from fluoroquinolones. Fluorine is an element; F2 on the ... History and difference between quinolones and fluoroquinolones.. The words 'quinolone' and 'fluoroquinolone' are often ... Currently Prescribed Quinolones. We make every effort to keep this list up to date, but you should always carefully check every ...
  http://www.saferpills.org/quinolones-101/
*  The Toxoplasma Blog: Genetic Evidence for Cytochrome b Qi Site Inhibition by 4(1H)-quinolone-3-diarylethers and Antimycin in...
Genetic Evidence for Cytochrome b Qi Site Inhibition by 4(1H)-quinolone-3-diarylethers and Antimycin in Toxoplasma gondii ... Endochin-like-quinolones (ELQs) are preclinical compounds that are efficacious against apicomplexan-caused diseases including ...
  http://toxoplasmaparasite.blogspot.com/2016/12/genetic-evidence-for-cytochrome-b-qi.html
*  SS Pharmaceutical Co., Ltd. Patents
A quinolone carboxylic acid derivative having the following formula (1), ##STR1## wherein R.sup.1 is a hydrogen atom, an alkyl ... R.sub.2 is a hydrogen atom or a lower alkyl group, R.sub.3 is a hydrogen atom or a halogen atom, R.sub.4 and R.su. ... A quinolone carboxylic acid derivative having the following formula (1), ##STR1## wherein R.sup.1 is a hydrogen atom, an alkyl ... wherein R.sup.1 means a hydrogen atom, an amino group, a linear or branched alkyl group having 1-5 carbon atoms and an ...
  http://www.patentgenius.com/assignee/SSPharmaceuticalCoLtd.html
*  Sparfloxacin-Metal Complexes as Urease Inhibitors: Their Synthesis, Characterization, Antimicrobial, and Antienzymatic...
I. Turel, "The interactions of metal ions with quinolone antibacterial agents," Coordination Chemistry Reviews, vol. 232, no. 1 ... Sparfloxacinato ligand binds with metals through pyridone and oxygen atom of carboxylic group. The biological actives of ... I. Turel, "The interactions of metal ions with quinolone antibacterial agents," Coordination Chemistry Reviews, vol. 232, no. 1 ... Four new metal complexes (S12-S15) of SPFX (third-generation quinolones) via heavy metals have been synthesized in good yield ...
  https://www.hindawi.com/journals/jchem/2013/306385/
*  Nalidixic acid - Wikipedia
... which has a single nitrogen atom. Synthetic quinolone antibiotics were discovered by George Lesher and coworkers as a byproduct ... In a technical sense, it is a naphthyridone, not a quinolone: its ring structure is a 1,8-naphthyridine nucleus that contains ... Amfonelic acid Oxolinic acid Emmerson AM, Jones AM (May 2003). "The quinolones: decades of development and use" (pdf). The ... Nalidixic acid (tradenames Nevigramon, Neggram, Wintomylon and WIN 18,320) is the first of the synthetic quinolone antibiotics ...
  https://en.wikipedia.org/wiki/Nalidixic_acid
*  Chemical structure and pharmacokinetics of novel quinolone agents represented by avarofloxacin, delafloxacin, finafloxacin,...
Quinolones are potent antimicrobial agents with a basic chemical structure of bicyclic ring. Fluorine atom at position C-6 and ... The first quinolone agents were nalidixic acid, cinoxacin and oxolinic acid, each had basic bicyclic quinolone ring. These ... Chemical structureClinical trialsPharmacokineticsQuinolonesSafetyTolerabilityToxicity. Background. Quinolones are potent ... The pharmacokinetic properties of quinolones are listed in Table 1.. Table 1 Pharmacokinetic features of quinolones ...
  https://ann-clinmicrob.biomedcentral.com/articles/10.1186/s12941-016-0150-4
*  1 - List of stocks that have mini options
Reed, since it contains a fluorine atom at position-6, and a carboxylic acid moiety at position-3 of the 4-quinolone nucleus. ...
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*  Glossary - Quinolone Vigilance Foundation
The fluorine atom is attached to the active ingredients in fluoroquinolones in order to allow them to cross the blood-brain ...
  http://www.saferpills.org/glossary/
*  Hinolon - Википедија, слободна енциклопедија
Andriole, VT The Quinolones. Academic Press, 1989.. *↑ Andersson, MI, MacGowan, AP. Development of the quinolones. J. ... koji imaju atom fluora vezan za centralni prsten, tipično u poziciji 6, ili na C-7. ... Wentland MP: In memoriam: George Y. Lesher, Ph.D., in Hooper DC, Wolfson JS (eds): Quinolone antimicrobial agents, ed 2., ...
  https://sr.wikipedia.org/wiki/Fluorokinolon
*  DiVA - Latest publications
Where 4-quinolones were synthesised via a carbonylation/cyclisation sequence. Using a similar synthetic strategy, three ... Carbon monoxide serves as an atom-efficient, one-carbon building block, which allows for further structural elaboration of the ...
  http://www.diva-portal.org/smash/latest.jsf?dswid=7389
*  SUBSTITUTED PYRROLIDINE DERIVATIVE - Patent application
... the carbon atom on the extreme right is bonded to the nitrogen atom of the quinolone skeleton). [0060] The compound (I) of the ... 0058] X1 represents a hydrogen atom or a halogen atom. A hydrogen atom or a fluorine atom is preferred, with a fluorine atom ... The cyclic structure may contain, as a ring-constituting atom, an oxygen atom, a nitrogen atom, or a sulfur atom, and may be ... The leaving group may be a halogen atom. The halogen atom is preferably a bromine atom or an iodine atom. Introduction of a ...
  http://www.patentsencyclopedia.com/app/20110166131
*  Patent US5622821 - Luminescent lanthanide chelates and methods of use - Google Patents
Exemplary sensitzers include 2- or 4-quinolones, 2- or 4-coumarins, or derivatives thereof e.g. carbostyril 124 (7-amino-4- ... methyl-2-quinolone), coumarin 120 (7-amino-4-methyl-2-coumarin), coumarin 124 (7-amino-4-(trifluoromethyl)-2-coumarin), ... The celates comprise a lanthanide chelator covalently joined to a coumarin-like or quinolone-like sensitizer. ... the first position 2-8 carbon atom is the position 2 or 4 carbon atom, the second carbon atom is the position 7 carbon atom, ...
  http://www.google.co.uk/patents/US5622821