*  Metallothionein-3 modulates the amyloid β endocytosis of astrocytes through its effects on actin polymerization | Molecular...
Primary astrocytes plated on cover slips were stained with 5 μg/ml Alexa Fluor 594-WGA for 10 min at 37 °C. Stained astrocytes ... Actin disruption reduces Aβ uptake by astrocytes. a, b Confocal fluorescence micrographs of WT astrocytes were sham washed or ... Protein expression levels were measured in whole-cell extracts of cultured cortical astrocytes. Astrocytes obtained from both ... Although vehicle-treated control astrocytes exhibited a typical fibrillary pattern of actin staining (phalloidin), astrocytes ...
  https://molecularbrain.biomedcentral.com/articles/10.1186/s13041-015-0173-3
*  Morphological evidence for vesicular glutamate release from astrocytes. - Semantic Scholar
Astrocytes may respond to neuronal activity by such exocytotic release of glutamate. The astrocyte derived glutamate can in ... One transmitter that in a vast number of studies has been shown to be released from astrocytes is glutamate. Although ... Here we review the morphological data supporting that astrocytes possess the machinery for exocytosis of glutamate. We describe ... the presence of small synaptic-like microvesicles, SNARE proteins and vesicular glutamate transporters in astrocytes, as well ...
  https://www.semanticscholar.org/paper/Morphological-evidence-for-vesicular-glutamate-rel-Bergersen-Gundersen/3a8a513fd96cf3fd73337ee789834f63ed31dd3b
*  "Intracellular pH Regulation in Primary Rat Astrocytes and C6 Glioma Ce" by Lamara D. Shrode and Robert W. Putnam
Astrocytes, but not C6 cells, contain a fourth pH-regulating transporter, Na+ −HCO3− cotransport; in the presence of CO2, ... regulation in primary cultures of rat astrocytes and C6 glioma cells. Both cell types contain three pH-regulating transporters ... depolarization-induced alkalinization of astrocytes was seen only in the presence of CO2. ... Astrocytes, but not C6 cells, contain a fourth pH-regulating transporter, Na+ −HCO3− cotransport; in the presence of CO2, ...
  https://corescholar.libraries.wright.edu/ncbp/758/
*  Loss of Astrocyte Polarization in the Tg-ArcSwe Mouse Model of Alzheimer's Disease
... making AQP4 an excellent marker of astrocyte polarization. Loss of astrocyte polarization is known to compromise astrocytic ... Loss of Astrocyte Polarization in the Tg-ArcSwe Mouse Model of Alzheimer's Disease. Yang, Jing ... Thus, astrocytes exhibit a redistribution of AQP4 from endfoot membranes to non-endfoot membrane domains. The present data ... Aquaporin-4 (AQP4) is the predominant water channel in brain and is selectively expressed in astrocytes. Astrocytic endfoot ...
  http://uu.diva-portal.org/smash/record.jsf?pid=diva2:471282
*  Circadian Regulation of ATP Release in Astrocytes | Journal of Neuroscience
Astrocyte circadian rhythms depend on clock genes. To assess the molecular basis of circadian timing in astrocytes, we tested ... Astrocytes were derived from mice of different genotypes to assess whether the molecular basis of daily timing in astrocytes is ... 1A,B). Thus, ATP release from murine cortical astrocytes is circadian, consistent with findings in rat astrocytes, immortalized ... For comparison with dnSNARE and VIPP astrocytes, we used astrocytes from wild-type mice or littermates expressing only the ...
  http://www.jneurosci.org/content/31/23/8342
*  Binding and Uptake of A beta 1-42 by Primary Human Astrocytes In Vitro
Thus, primary human astrocytes derived from different sources can bind and internalize A beta 1-42, and fetal astrocytes were ... Thus, primary human astrocytes derived from different sources can bind and internalize A beta 1-42, and fetal astrocytes were ... In vitro studies confirmed that A beta is taken up by rodent astrocytes, but knowledge on human astrocyte-mediated A beta ... In vitro studies confirmed that A beta is taken up by rodent astrocytes, but knowledge on human astrocyte-mediated A beta ...
  https://lup.lub.lu.se/search/publication/1443637
*  The induction of intercellular adhesion molecule 1 (ICAM-1) expression on human fetal astrocytes by interferon-gamma, tumor...
The best in vivo data showing that astrocytes serve as intracerebral APCs is the finding that astrocytes in multiple sclerosis ... If astrocytes function as immunocompetent APCs within the brain, it would seem that they would also be able to express ... Here, we present the first data that indicates that human astrocytes are capable of expressing ICAM-1 in response to cytokines ... This hypothesis is based upon the ability to induce the expression of the class II MHC antigens on astrocytes, and on their ...
  https://www.ndorms.ox.ac.uk/publications/482693
*  北京大学医学部机构知识库(IR@PKUHSC): The association of 14-3-3 gamma and actin plays a role in cell division and apoptosis in astrocytes
The association of 14-3-3 gamma and actin plays a role in cell division and apoptosis in astrocytes.pdf(372KB). 期刊论文. 出版稿. 限制开放 ... 14-3-3 gamma ; actin ; astrocyte ; ischemia ; cell division ; mitosis ; apoptosis 刊名: BIOCHEMICAL AND BIOPHYSICAL RESEARCH ... However, in apoptotic astrocytes, the intensity of immunostaining of 14-3-3gamma proteins in the cytoplasm decreased. The ... The association of 14-3-3 gamma and actin plays a role in cell division and apoptosis in astrocytes[J]. BIOCHEMICAL AND ...
  http://ir.bjmu.edu.cn/handle/400002259/67757
*  Different in vitro response to rIL-1 beta of newborn and adult rat astroglia. - Semantic Scholar
In contrast, rIL-1 beta induces an increase of GFAP immunoreactivity both in newborn and in adult astrocytes, as compared to ... Thus, it appears likely that different factors, other than rIL-1 beta, are needed by adult astrocytes to proliferate. ... only newborn astrocytes can respond to this lymphokine with proliferation. ... In newborn, but not in adult astrocytes, 100 U/ml of rIL-1 beta increase [3H]thymidine incorporation with a maximal response by ...
  https://www.semanticscholar.org/paper/Different-in-vitro-response-to-rIL-1-beta-of-newbo-Colasanti-Ramacci/d9d480c9affce6497f8eedd10ab3be3d2751fd66
*  Transplantation of Specific Human Astrocytes Promotes Functional Recovery after Spinal Cord Injury
... by generating astrocytes from embryonic human glial precursor cells using two different astrocyte differentiation inducing ... The resulting astrocytes differed in expression of multiple proteins thought to either promote or inhibit central nervous ... We have focused on the less-studied replacement of astrocytes, the major support cell in the central nervous system, ... In addition, our studies provide a specific population of human astrocytes that appears to be particularly suitable for further ...
  http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0017328
*  Live Imaging of Neuroinflammation Reveals Sex and Estrogen Effects on Astrocyte Response to Ischemic Injury | Stroke
Astrocyte response to ischemic injury in live animals was studied in GFAP-luc mice. Previous work by Zhu and colleagues16 ... Reactive astrocytes: cellular and molecular cues to biological function. Trends Neurosci. 1997; 20: 570-577. ... Live Imaging of Neuroinflammation Reveals Sex and Estrogen Effects on Astrocyte Response to Ischemic Injury. Pierre Cordeau, ... At the early time point after OVX, we did not observe an increase in astrocyte response after MCAO, which may in part be ...
  http://stroke.ahajournals.org/content/39/3/935
*  A latent neurogenic program in astrocytes regulated by Notch signaling in the mouse | Science
Astrocytes' hidden ability to generate neurons. New neurons could be useful in the brain to respond to damage done by disease, ... Astrocytes can produce neuroblasts in response to stroke and can be artificially triggered to do so in the absence of injury. ... Astrocytes can produce neuroblasts in response to stroke and can be artificially triggered to do so in the absence of injury. ... They found that astrocytes, spidery cells that are interspersed between neurons, carry a latent neurogenic program. The ability ...
  http://science.sciencemag.org/content/346/6206/237
*  A crucial role for Olig2 in white matter astrocyte development | Development
A crucial role for Olig2 in white matter astrocyte development. Jeff Cai, Ying Chen, Wen-Hui Cai, Edward C. Hurlock, Heng Wu, ... A crucial role for Olig2 in white matter astrocyte development. Jeff Cai, Ying Chen, Wen-Hui Cai, Edward C. Hurlock, Heng Wu, ... A crucial role for Olig2 in white matter astrocyte development. Jeff Cai, Ying Chen, Wen-Hui Cai, Edward C. Hurlock, Heng Wu, ... A crucial role for Olig2 in white matter astrocyte development Message Subject (Your Name) has sent you a message from ...
  http://dev.biologists.org/content/early/2007/04/11/dev.02847
*  The impact of defective gp130/SOCS3 signaling on the astrocyte response to hyper-IL6 (38.17) | The Journal of Immunology
Some 99 genes were downregulated in WT astrocytes and of those 55 were not decreased in Y757F astrocytes. In WT astrocytes ... 28 did not increase in Y757F astrocytes. Of 238 genes upregulated in Y757F astrocytes, 9 were not upregulated in WT astrocytes ... A number of candidate genes upregulated by hyper-IL6 in WT and Y757F astrocytes were not upregulated in astrocytes lacking ... Compared with WT astrocytes, Y757F astrocytes treated with hyper-IL6, had higher and more sustained activation of STAT3, while ...
  http://www.jimmunol.org/content/182/1_Supplement/38.17
*  How might brain "astrocytes" alter nerve cell connections and contribute to Autism Spectrum Disorder?
... Investigating astrocyte- ... Key functions of astrocytes are altered in some cases of ASD, including Fragile X syndrome where astrocyte transporter function ... Research suggests that astrocytes can produce both advantageous and deleterious effects. In the developing brain, astrocytes ... Astrocytes surround neurons, and their star-shaped "processes" closely associate with synapses enabling astrocytes to ...
  http://www.dana.org/Media/GrantsDetails.aspx?id=123059
*  Meteorin: a secreted protein that regulates glial cell differentiation and promotes axonal extension | The EMBO Journal
... and is not detected in two major types of astrocytes in the adult cerebrum, fibrous astrocytes and protoplasmic astrocytes ( ... To confirm that this transformation represented a direct effect of Meteorin on astrocytes, we isolated astrocytes from the ... Among three subclasses of astrocytes in the adult cerebellar cortex, bushy protoplasmic astrocytes, smooth protoplasmic ... astrocytes (Figure 6M). These observations thus suggest that Meteorin acts on cells that have committed to the astrocyte ...
  http://emboj.embopress.org/content/23/9/1998
*  A model for glioma cell migration on collagen and astrocytes | Journal of The Royal Society Interface
3.2 Migration on a monolayer of astrocytes. We considered two layers in the model: one layer is that of the astrocytes on top ... 2.1.2 Primary astrocyte cultures. Primary astrocyte cultures were obtained by mechanical mincing and passing through a nylon ... In this case the astrocytes are not confluent, contrary to what happens in monolayers of astrocytes. It is likely that the ... This means that half of the time cells avoid sites above astrocytes and astrocytes act as obstacles. This explains why ...
  http://rsif.royalsocietypublishing.org/content/5/18/75
*  Glial-derived proteins activate cultured astrocytes and enhance beta amyloid-induced glial activation.
Treatment of astrocytes with ACT, IL-1beta, or S100beta resulted in glial activation, as assessed by reactive morphology, ... In contrast, BChE alone did not activate astrocytes and had no effect on Abeta-induced activation. These results suggest that ... The ability of Abeta to induce astrocyte activation was also enhanced in the presence of each of these three proteins. ... Glial-derived proteins activate cultured astrocytes and enhance beta amyloid-induced glial activation.. * ...
  http://www.prohealth.com/library/showarticle.cfm?libid=1723
*  Astrocytes Give Rise to New Neurons in the Adult Mammalian Hippocampus | Journal of Neuroscience
... it is also possible that some astrocytes may divide symmetrically to generate two astrocytes, whereas neighboring astrocytes ... SGL astrocytes seem to combine functions of both progenitors and glial cells. The radial processes of SGL astrocytes that ... Because new neurons are born at a time when [3H]thymidine-labeled astrocytes were observed, we infer that astrocytes function ... The appearance of small electron-dense cells (D cells) after division of SGL astrocytes suggests that SGL astrocytes may not ...
  http://www.jneurosci.org/content/21/18/7153.long
*  Astrocyte - Wikipedia
After astrocyte specification has occurred in the developing CNS, it is believed that astrocyte precursors migrate to their ... When in proximity to the pia mater, all three forms of astrocytes send out processes to form the pia-glial membrane. Astrocytes ... Gömöri-positive astrocytes. These are a subset of protoplasmic astrocytes that contain numerous cytoplasmic inclusions, or ... Because of this ability of astrocytes to communicate with their neighbors, changes in the activity of one astrocyte can have ...
  https://en.wikipedia.org/wiki/Astrocyte
*  Alzheimer type II astrocyte - Wikipedia
Although these astrocytes are present in this disease, it has not yet been determined if Alzheimer type II astrocytes are a ... Like other astrocytes, it is a non-neuronal glial cell. They are not associated with Alzheimer's disease. Astrocytes belong to ... Alzheimer type II astrocytes are visually characterized by an enlarged size and lack of cytoplasm. These astrocytes appear to ... For example, astrocytes have many transporters and ion channels that allow for ion balance and static pH levels in order to ...
  https://en.wikipedia.org/wiki/Alzheimer_type_II_astrocyte
*  Astrocyte - Wikipedia
The astrocytes next to neurons in the frontal cortex and hippocampus store and release glucose. Thus, astrocytes can fuel ... Astrocytes are depicted in red. Cell nuclei are depicted in blue. Astrocytes were obtained from brains of newborn mice ... Astrocytes are macroglial cells in the central nervous system. Astrocytes are derived from heterogeneous populations of ... Gömöri-positive astrocytes. These are a subset of protoplasmic astrocytes that contain numerous cytoplasmic inclusions, or ...
  https://en.wikipedia.org/wiki/Astrocytes
*  Metabolic Interactions between Neurons and Astrocytes | SpringerLink
Hertz, L. and Schousboe, A., Role of astrocytes in compartmentation of amino acid and energy metabolism. In:Astrocytes, ... Walz, W. and Hinks, E., A transmembrane sodium cycle in astrocytes, Brain Res. 368: 226-232 (1986).PubMedCrossRefGoogle Scholar ... Code, W.E., White, H.S. and Hertz, L., The effect of midazolam on calcium signaling in astrocytes, Ann. N.Y. Acad. Sci. 625: ... Yu, A.C.H., Gregory, G.A. and Chan, P.H., Hypoxia-induced dysfunction and injury of astrocytes in primary cell cultures, J. ...
  https://link.springer.com/chapter/10.1007/978-1-4757-9486-1_1
*  Astrocytes help separate man from mouse
... fibrous astrocytes »human brain »information processing »interlaminar astrocytes »protoplasmic astrocytes »spinal cord injury » ... fibrous astrocytes , human brain , information processing , interlaminar astrocytes , protoplasmic astrocytes , spinal cord ... Alzheimer's »Calcium »Epilepsy »Human astrocytes »astrocytes »blood flow »blood vessel »brain cell »brain function and sensory ... Further reports about: , Alzheimer's , Calcium , Epilepsy , Human astrocytes , astrocytes , blood flow , blood vessel , brain ...
  http://www.innovations-report.com/html/reports/life-sciences/astrocytes-separate-man-mouse-129901.html
*  A role for astrocytes in learning and memory?
Astrocytes, once thought little more than passive, structurally supportive brain cells, are increasingly recognized as having a ... have found that individual star-shaped glial cells called astrocytes release a specific signalling molecule, called D-serine, ... Long-term potentiation depends on release of D-serine from astrocytes. Nature ( doi:10.1038/nature08673).. ...
  http://www.ucl.ac.uk/ion/articles/archive-2010/Rusakov