A Common Mutation in the Lipoprotein Lipase Gene (N291S) Alters the Lipoprotein Phenotype and Risk for Cardiovascular Disease...
... possible association with apolipoprotein E2 isoform. J Lipid Res. 1994;35:1066-1075. ... E2/E2, E3/E2 and E4/E2) who manifest with hyperlipidemia have increased frequency of an Asn291Ser mutation in the human LPL ... Despite its association with dyslipoproteinemia, the association between this common LPL mutation and premature CVD is still ... 2017 American Heart Association, Inc. All rights reserved. Unauthorized use prohibited. The American Heart Association is a ...http://circ.ahajournals.org/content/97/8/729
Lipoprotein Lipase S447X | Arteriosclerosis, Thrombosis, and Vascular Biology
... possible association with apolipoprotein E2 isoform. J Lipid Res. 1994; 35: 1066-1075. ... Chylomicronemia due to apolipoprotein CIII overexpression in apolipoprotein E-null mice. Apolipoprotein CIII-induced ... Apolipoprotein AIMilano. Accelerated binding and dissociation from lipids of a human apolipoprotein variant. J Biol Chem. 1985 ... 2018 American Heart Association, Inc. All rights reserved. Unauthorized use prohibited. The American Heart Association is a ...http://atvb.ahajournals.org/content/26/6/1236
Gestational hyperlipidemia and acute pancreatitis with underlying partial lipoprotein lipase deficiency and apolipoprotein E3...
... possible association with apolipoprotein E2 isoform. J Lipid Res 1994;35:1066-1075PMID : 8077845.. ... Copyright © 2018 The Korean Association of Internal Medicine. All rights reserved. About , Browse Articles , Current Issue , ... Type III hyperlipoproteinemia: defective metabolism of an abnormal apolipoprotein E. Science 1981;211:584-586PMID : 7455696.. ... The effect of partial LPL deficiency and dysbetalipoproteinemia can be modulated by other genes, such as apolipoprotein (apo) E ...http://www.kjim.org/journal/view.php?number=169159
Journal of Alzheimer's Disease - Volume 26, issue s3 - Journals - IOS Press
... apolipoprotein E2, apolipoprotein E3, apolipoprotein E4, genetic association studies, aging ... Keywords: Magnetic resonance imaging, cerebral cortex, brain, frontal lobe, apolipoproteins E, ... and that the pattern of this association would be diagnosis specific. Our findings primarily showed that lower …CSF Aβ1-42 and ... we tested the hypothesis that there would be an association among rates of regional brain atrophy, the CSF biomarkers Aβ1-42 , ...https://content.iospress.com/journals/journal-of-alzheimers-disease/26/s3
Association of apolipoprotein E phenotypes with late onset Alzheimer's disease: population based study | The BMJ
Three common alleles, e2, e3, and e4 determine the six apolipoprotein E phenotypes E2/2, E2/3, E2/4, E3/3, E4/3, and E4/4. ... Association of apolipoprotein E allele e4 with late-onset familial and sporadic Alzheimer's disease.Neurology1993;43:1467-72. ... Association of apolipoprotein E phenotypes with late onset Alzheimer's disease: population based study BMJ 1994; 309 :636 ... Association of apolipoprotein E phenotypes with late onset Alzheimer's disease: population based study. BMJ 1994; 309 doi: ...http://www.bmj.com/content/309/6955/636
Association between butyrylcholinesterase K variant and the Alzheimer type neuropathological changes in apolipoprotein E Îµ4...
The Apolipoprotein E (APOE) É›4 allele is the best-established genetic risk factor for sporadic Alzheimer's disease, and is ... Association between butyrylcholinesterase K variant and the Alzheimer type neuropathological changes in apolipoprotein E Îµ4 ... Home » Association between butyrylcholinesterase K variant and the Alzheimer type neuropathological changes in apolipoprotein E ... The APOE É›4 allele modulates brain white matter integrity in healthy adults. Heise, V.; Filippini, N.; Ebmeier, K. P.; Mackay ...http://connection.ebscohost.com/c/articles/66650302/association-between-butyrylcholinesterase-k-variant-alzheimer-type-neuropathological-changes-apolipoprotein-e-4-carriers-older-than-75-years
Japanese Americans - Wikipedia
... e2, *e3, and *e4)and was determined from research because of its known association with increased cholesterol levels and risk ... Specifically too, the apolipoprotein *e4 allele is linked to Alzheimer's disease as well. Also, there is increased coronary ... Some are classified as nihonjin gakkō or Japanese international schools operated by Japanese associations, and some are ... research has been put on concerning apolipoprotein E genotypes; this polymorphism has three alleles (* ...https://en.wikipedia.org/wiki/Japanese-American
Multiethnic Exome-Wide Association Study of Subclinical Atherosclerosis. - PubMed - NCBI
Apolipoprotein B-100/genetics. *Apolipoprotein E2/genetics. *Asymptomatic Diseases. *Carotid Artery Diseases/diagnostic imaging ... Association of each genotyped variant with CAC quantity. Plot of -log10(P) for association of genotyped variants by chromosomal ... Association of each genotyped variant with CIMT. Plot of -log10(P) for association of genotyped variants by chromosomal ... Multiethnic Exome-Wide Association Study of Subclinical Atherosclerosis.. Natarajan P, Bis JC, Bielak LF, Cox AJ, Dörr M, ...https://www.ncbi.nlm.nih.gov/pubmed/27872105
E4/E4 or E2/E3, E2E4 and E3/E4. If you inherit the Apolipoprotein E4 allele there has been strong association to both increased ... Well back to Apolipoprotein E which comes in three main genetic alleles Apo E2, Apo E3 and Apo E4. The bad allele to be worried ... These authors discuss that In addition to genotype-phenotype associations with vascular disease, the alleles and isoforms of ... Apolipoprotein E (APOE) genotype is the most influential Alzheimer disease (AD) risk factor after advanced age. The APOE4 ...http://www.treatmentonline.com/blog/index.asp?blog_id=354
Ask.com - What's Your Question?
... the frontal association cortex (Brodmann's area 8,9) were obtained from ..... in apoE3, 338.1 ± 18.5% in apoE4; p , 0.05, E2 vs ... Apolipoprotein E, Especially Apolipoprotein E4, Increases the ... www.jneurosci.org/content/32/43/15181 ... a low ..... Recent genome-wide association studies in AD patients have also identified a ..... A. Halle, V. Hornung, G.C. ... subsequent prospective studies showed an increased risk or no association (Doll et al. ..... Athan ES, Williamson J, Ciappa A, ...https://www.ask.com/web?q=Pozos%2C%20et%20al%20v.%20Stewart%20and%20Assoc%2C%20et%20al
Association of CETP TaqI and APOE polymorphisms with type II diabetes mellitus in North Indians: a case control study | BMC...
Goal of the present study was to determine the association of cholesteryl ester transfer protein Taq I B, D442G, and APOE Hha I ... Hsieh MC, Lin SR, Yang YC, Chen HC, Lin JN, Shin SJ: Higher frequency of apolipoprotein E2 allele in type 2 diabetic patients ... Horita K, Eto M, Makino I: Apolipoprotein E2, renal failure and lipid abnormalities in non-insulin-dependent diabetes mellitus ... We studied association of CETP Taq I B, CETP D442G, and APO E Hha I polymorphisms with T2DM and with complications associated ...https://bmcendocrdisord.biomedcentral.com/articles/10.1186/1472-6823-5-7
Reelin - Wikipedia
This strong genetic association has led to the proposal that ApoE receptors play a central role in the pathogenesis of ... All members of this family are receptors for Apolipoprotein E (ApoE). Therefore, they are often synonymously referred to as ' ... ApoE receptors'. ApoE occurs in 3 common isoforms (E2, E3, E4) in the human population. ApoE4 is the primary genetic risk ... One genome-wide association study indicates a possible role for RELN gene variation in otosclerosis, an abnormal growth of bone ...https://en.wikipedia.org/wiki/Reelin
Smell identification, cognition and hormone therapy - Australasian Menopause Society
Perhaps the link between cognition and olfactory function involves the apolipoprotein E É›4 allele (ApoE) that has been ... Association between olfactory dysfunction and amnestic mild cognitive impairment and Alzheimer disease dementia. JAMA Neurol ... Some studies found no association; as an example, Hughes and colleagues did a cross-sectional study of 62 postmenopausal women ... Oleson S, Murphy C. Olfactory dysfunction in ApoE É›4/4 homozygotes with Alzheimer's disease. J Alzheimers Dis 2015;46:791-803 ...https://www.menopause.org.au/members/ims-menopause-live/881-smell-identification-cognition-and-hormone-therapy
Denigma: SchÃ¤chter F et al., 1994
APOE apolipoprotein E. Longevity Variant Associations (p-value): *APOE e2/e4 (0.001) ... Genetic associations with human longevity at the APOE and ACE loci.. Authors: SchÃ¤chter F; Faure-Delanef L; GuÃ©not F; Rouger ... SchÃ¤chter F, Faure-Delanef L, GuÃ©not F, Rouger H, Froguel P, Lesueur-Ginot L, Cohen D (1994) Genetic associations with human ... Here we report results on two genes, chosen for their impact on cardiovascular risk, encoding apolipoprotein E (ApoE), ...http://denigma.de/datasets/reference/510
Alzheimer Disease: Advances in Pathogenesis, Diagnosis, and Therapy | Clinical Chemistry
E2 is associated with a decreased risk for AD. Much of the familial association of AD is accounted for by APOE genotype, but ... One of the biggest reasons for this is APOE (apolipoprotein E) genotype. There are 3 flavors of apo E: E2, E3, and E4. One copy ... There is also a strong genetic association between one variant of apolipoprotein E (apo E) and the risk for developing AD. ... apolipoprotein E; Aβ, amyloid-β protein; CSF, cerebrospinal fluid; NSAID, nonsteroidal antiinflammatory drug.. ...http://clinchem.aaccjnls.org/content/57/5/664.full
Full text] Role of apolipoprotein E in neurodegenerative diseases | NDT
Apolipoprotein E (APOE) is a lipid-transport protein abundantly expressed in most neurons in the central nervous system. APOE- ... Role of apolipoprotein E in neurodegenerative diseases Vo Van Giau,1 Eva Bagyinszky,1 Seong Soo A An,1 SangYun Kim2 1Department ... four different mutations give a band at the E2 position, E2 (Arg158 → Cys), E2 (Lys146 → Gln), E2 (Arg145 Cys), and E2- ... Identification and characterization of a novel apolipoprotein E variant, apolipoprotein E3′ (Arg136 → His): association with ...https://www.dovepress.com/role-of-apolipoprotein-e-in-neurodegenerative-diseases-peer-reviewed-fulltext-article-NDT
ApoB-100, ApoE and CYP7A1 gene polymorphisms in Mexican patients with cholesterol gallstone disease
Dixit M, Choudhuri G, Saxena R, Mittal B. Association of apolipoprotein A1-C3 gene cluster polymorphisms with gallstone disease ... for E2, 85.64% vs 78.22% (P = 0.052) for E3, 9.90% vs 15.84% (P = 0.075) for E4 of ApoE; and 25.74% vs 27.72% (P = 0.653) for C ... Influence of polymorphisms for apolipoprotein B (ins/del, XbaI, EcoRI) and apolipoprotein E on serum lipids and apolipoproteins ... Association between serum concentration of apolipoproteins A-I and B with gallbladder disease. Arch Med Res. 2003;34:194-199. [ ...http://pubmedcentralcanada.ca/pmcc/articles/PMC2951519/
Apolipoprotein E - Wikipedia
A notable advantage of the E4 allele (relative to E2 and E3) is a positive association with higher levels of vitamin D, which ... of such patients are E2/E2, while only ∼2% of E2/E2 develop the disease, so other environmental and genetic factors are likely ... E2 is associated with both increased and decreased risk for atherosclerosis. Individuals with an E2/E2 combination may clear ... Sadigh-Eteghad S, Talebi M, Farhoudi M (October 2012). "Association of apolipoprotein E epsilon 4 allele with sporadic late ...https://en.wikipedia.org/wiki/Apolipoprotein_E
Kognitive Reserve und Risiko einer postoperativen kognitiven Dysfunktion
Eine Studie (e2) zeigte einen Trend f r ein erh htes POCD-Risiko bei Analphabeten, der jedoch keine statistische Signifikanz ... American Psychiatric Association: Diagnostic and statistical manual of mental disorders, 5th edition. United States: American ... McDonagh DL, Mathew JP, White WD, et al.: Cognitive function after major noncardiac surgery, apolipoprotein E4 genotype, and ... Beim Poolen der Effektsch tzer ber vier Studien hinweg (19, 27, e2, e3) war ein High-School-Abschluss mit einem um 71 % erh ...https://www.aerzteblatt.de/fachgebiete/neurologie/arbeiten?nid=&aid=186325
Alzheimer's Disease | eMedMD.com
An association has also been found between AD2 and mutations in the gene encoding apolipoprotein E (APOE), located on ... There are at least three forms or alleles of the APOE gene: e2, e3, and e4. Since each person inherits one APOE gene from each ... The relatively rare APOE e2 allele may be associated with a lower risk for AD or a later age of onset. Individuals with one ... Apolipoprotein E (APOE)-A protein that transports cholesterol throughout the body. One form of this protein, APOE e4, is ...http://emedmd.com/content/alzheimers-disease
Antecedents of Soft Drusen, the Specific Deposits of Age-Related Macular Degeneration, in the Biology of Human Macula | IOVS |...
Stage-specific association of apolipoprotein A-I and E in developing mouse retina. Invest Ophthalmol Vis Sci. 2007; 48: 1815- ... Human apolipoprotein E2 transgenic mice show lipid accumulation in retinal pigment epithelium and altered expression of VEGF ... Genetic association of apolipoprotein E with age-related macular degeneration. Am J Hum Genet. 1998; 63: 200-206. ... Yet, positive association between plasma concentrations of lutein and HDL does not always imply an association between ...https://iovs.arvojournals.org/article.aspx?articleid=2708008
Moderate increase in dietary sucrose does not influence fasting or postprandial serum lipids regardless of the presence of...
Associations between Apolipoprotein E Genotype, Diet, Body Mass Index, and Serum Lipids in Lithuanian Adult Population. ... É›2 allele.Design:Controlled, parallel study.Subjects:There were 15 subjects with the apolipoprotein E (APOE)3/2 genotype and ... The aim of the present study was to evaluate the association between apolipoprotein E genotype and plasma lipid levels among a ... Associations between apolipoprotein E genotypes and serum levels of glucose, cholesterol, and triglycerides in a cognitively ...http://connection.ebscohost.com/c/articles/26444817/moderate-increase-dietary-sucrose-does-not-influence-fasting-postprandial-serum-lipids-regardless-presence-apolipoprotein-e2-allele-healthy-subjects
Abstracts from the British Association for the Study of the Liver Meeting Held on 13-14 September 2001 at the Royal Free...
Antibody responses to E2 and FrC were assessed by ELISA.. Results: In vitro expression of FrC-E2 and the E2 construct was ... We have reported4, that the defective apolipoprotein (apo) E allele, ∼2 (C-*T; Argi 58Cys), can be converted to the fully- ... Aim: To design an effective DNA vaccine against HCV using a fusion of the gene encoding Tetanus toxin to a fragment of the E2 ... 35 NO ASSOCIATION BETWEEN FUNCTIONAL SNPS IN THE ENDOTOXIN RECEPTORS CD14 AND TLR4 AND ALCOHOLIC LIVER DISEASE: IS ENDOTOXIN ...http://gut.bmj.com/content/50/5/e1
角谷寛 - 研究者 - researchmap
Association between apolipoprotein E epsilon4 and sleep-disordered breathing in adults.. Kadotani H, Kadotani T, Young T, ... Resetting of peripheral circadian clock by prostaglandin E2.. Tsuchiya Y, Minami I, Kadotani H, Nishida E ... Association between sleep apnea, sleep duration and serum lipid profile in an urban male working population in Japan. ... Association of different neural processes during different emotional perceptions of white noise and pure tone auditory stimuli. ...https://researchmap.jp/hiro_kad/
Xanthomas, plane (planar xanthoma, palmar xanthoma, intertriginous xanthoma, diffuse xanthoma, xanthelasma) - Cancer Therapy...
Patients with this inherited disorder have abnormal apolipoprotein-E isoform, apo-E2. When the apo-E2 isoform is present (in ... However, given their association with systemic illnesses, paraproteinemia, and malignancy a thorough history, physical, and ... In dysbetalipoproteinemia there is an abnormal apolipoprotein-E isoform, apo-E2. When the apo-E2 isoform is present there is ... The diagnosis of dysbetalipoproteinemia can be confirmed by the identification of the mutant apolipoprotein-E2 allele. ...https://www.cancertherapyadvisor.com/dermatology/xanthomas-plane-planar-xanthoma-palmar-xanthoma-intertriginous-xanthoma-diffuse-xanthoma-xanthelasma/article/592225/