*  A Common Mutation in the Lipoprotein Lipase Gene (N291S) Alters the Lipoprotein Phenotype and Risk for Cardiovascular Disease...
... possible association with apolipoprotein E2 isoform. J Lipid Res. 1994;35:1066-1075. ... E2/E2, E3/E2 and E4/E2) who manifest with hyperlipidemia have increased frequency of an Asn291Ser mutation in the human LPL ... Despite its association with dyslipoproteinemia, the association between this common LPL mutation and premature CVD is still ... 2017 American Heart Association, Inc. All rights reserved. Unauthorized use prohibited. The American Heart Association is a ...
  http://circ.ahajournals.org/content/97/8/729
*  Lipoprotein Lipase S447X | Arteriosclerosis, Thrombosis, and Vascular Biology
... possible association with apolipoprotein E2 isoform. J Lipid Res. 1994; 35: 1066-1075. ... Chylomicronemia due to apolipoprotein CIII overexpression in apolipoprotein E-null mice. Apolipoprotein CIII-induced ... Apolipoprotein AIMilano. Accelerated binding and dissociation from lipids of a human apolipoprotein variant. J Biol Chem. 1985 ... 2018 American Heart Association, Inc. All rights reserved. Unauthorized use prohibited. The American Heart Association is a ...
  http://atvb.ahajournals.org/content/26/6/1236
*  Association between butyrylcholinesterase K variant and the Alzheimer type neuropathological changes in apolipoprotein E ε4...
The Apolipoprotein E (APOE) É›4 allele is the best-established genetic risk factor for sporadic Alzheimer's disease, and is ... Association between butyrylcholinesterase K variant and the Alzheimer type neuropathological changes in apolipoprotein E ε4 ... Home » Association between butyrylcholinesterase K variant and the Alzheimer type neuropathological changes in apolipoprotein E ... The APOE É›4 allele modulates brain white matter integrity in healthy adults. Heise, V.; Filippini, N.; Ebmeier, K. P.; Mackay ...
  http://connection.ebscohost.com/c/articles/66650302/association-between-butyrylcholinesterase-k-variant-alzheimer-type-neuropathological-changes-apolipoprotein-e-4-carriers-older-than-75-years
*  Japanese Americans - Wikipedia
Also, research has been put on concerning apolipoprotein E genotypes; this polymorphism has three alleles (*e2, *e3, and *e4) ... Some are classified as nihonjin gakkō or Japanese international schools operated by Japanese associations, and some are ... Specifically too, the apolipoprotein *e4 allele is linked to Alzheimer's disease as well. Also, there is increased coronary ... and was determined from research because of its known association with increased cholesterol levels and risk of coronary heart ...
  https://en.wikipedia.org/wiki/Japanese_Americans
*  Treatment Online
E4/E4 or E2/E3, E2E4 and E3/E4. If you inherit the Apolipoprotein E4 allele there has been strong association to both increased ... Well back to Apolipoprotein E which comes in three main genetic alleles Apo E2, Apo E3 and Apo E4. The bad allele to be worried ... These authors discuss that In addition to genotype-phenotype associations with vascular disease, the alleles and isoforms of ... Apolipoprotein E (APOE) genotype is the most influential Alzheimer disease (AD) risk factor after advanced age. The APOE4 ...
  http://www.treatmentonline.com/blog/index.asp?blog_id=354
*  Reelin - Wikipedia
This strong genetic association has led to the proposal that ApoE receptors play a central role in the pathogenesis of ... All members of this family are receptors for Apolipoprotein E (ApoE). Therefore, they are often synonymously referred to as ' ... ApoE receptors'. ApoE occurs in 3 common isoforms (E2, E3, E4) in the human population. ApoE4 is the primary genetic risk ... One genome-wide association study indicates a possible role for RELN gene variation in otosclerosis, an abnormal growth of bone ...
  https://en.wikipedia.org/wiki/Reelin
*  Viruses | Free Full-Text | CD81-Receptor Associations - Impact for Hepatitis C Virus Entry and Antiviral Therapies | HTML
E2 interacts with the LEL of CD81. E2-CD81 interaction is specific, since E2 does not bind other tetraspanins such as CD9 or ... Apolipoprotein E interacts with hepatitis C virus nonstructural protein 5A and determines assembly of infectious particles. ... 2. Co-Receptor Association(s) and HCV Entry. 2.1. CD81-HCV Interactions. Tetraspanins are not only essential for cell biology; ... Claudin association with CD81 defines hepatitis C virus entry. J. Biol. Chem. 2010, 285, 21092-21102. [Google Scholar] [ ...
  http://www.mdpi.com/1999-4915/6/2/875/htm
*  Smell identification, cognition and hormone therapy - Australasian Menopause Society
Perhaps the link between cognition and olfactory function involves the apolipoprotein E ɛ4 allele (ApoE) that has been ... Association between olfactory dysfunction and amnestic mild cognitive impairment and Alzheimer disease dementia. JAMA Neurol ... Some studies found no association; as an example, Hughes and colleagues did a cross-sectional study of 62 postmenopausal women ... Oleson S, Murphy C. Olfactory dysfunction in ApoE ɛ4/4 homozygotes with Alzheimer's disease. J Alzheimers Dis 2015;46:791-803 ...
  https://www.menopause.org.au/members/ims-menopause-live/881-smell-identification-cognition-and-hormone-therapy
*  Alzheimer Disease: Advances in Pathogenesis, Diagnosis, and Therapy | Clinical Chemistry
E2 is associated with a decreased risk for AD. Much of the familial association of AD is accounted for by APOE genotype, but ... One of the biggest reasons for this is APOE (apolipoprotein E) genotype. There are 3 flavors of apo E: E2, E3, and E4. One copy ... There is also a strong genetic association between one variant of apolipoprotein E (apo E) and the risk for developing AD. ... apolipoprotein E; Aβ, amyloid-β protein; CSF, cerebrospinal fluid; NSAID, nonsteroidal antiinflammatory drug.. ...
  http://clinchem.aaccjnls.org/content/57/5/664.full
*  Apolipoprotein E - Wikipedia
A notable advantage of the E4 allele (relative to E2 and E3) is a positive association with higher levels of vitamin D, which ... of such patients are E2/E2, while only ∼2% of E2/E2 develop the disease, so other environmental and genetic factors are likely ... E2 is associated with both increased and decreased risk for atherosclerosis. Individuals with an E2/E2 combination may clear ... Sadigh-Eteghad S, Talebi M, Farhoudi M (October 2012). "Association of apolipoprotein E epsilon 4 allele with sporadic late ...
  https://en.wikipedia.org/wiki/Apolipoprotein_E
*  Full text] Role of apolipoprotein E in neurodegenerative diseases | NDT
Apolipoprotein E (APOE) is a lipid-transport protein abundantly expressed in most neurons in the central nervous system. APOE- ... Role of apolipoprotein E in neurodegenerative diseases Vo Van Giau,1 Eva Bagyinszky,1 Seong Soo A An,1 SangYun Kim2 1Department ... four different mutations give a band at the E2 position, E2 (Arg158 → Cys), E2 (Lys146 → Gln), E2 (Arg145 Cys), and E2- ... Identification and characterization of a novel apolipoprotein E variant, apolipoprotein E3′ (Arg136 → His): association with ...
  https://www.dovepress.com/role-of-apolipoprotein-e-in-neurodegenerative-diseases-peer-reviewed-fulltext-article-NDT
*  Moderate increase in dietary sucrose does not influence fasting or postprandial serum lipids regardless of the presence of...
Associations between Apolipoprotein E Genotype, Diet, Body Mass Index, and Serum Lipids in Lithuanian Adult Population. ... ɛ2 allele.Design:Controlled, parallel study.Subjects:There were 15 subjects with the apolipoprotein E (APOE)3/2 genotype and ... The aim of the present study was to evaluate the association between apolipoprotein E genotype and plasma lipid levels among a ... Associations between apolipoprotein E genotypes and serum levels of glucose, cholesterol, and triglycerides in a cognitively ...
  http://connection.ebscohost.com/c/articles/26444817/moderate-increase-dietary-sucrose-does-not-influence-fasting-postprandial-serum-lipids-regardless-presence-apolipoprotein-e2-allele-healthy-subjects
*  ApoB-100, ApoE and CYP7A1 gene polymorphisms in Mexican patients with cholesterol gallstone disease
Dixit M, Choudhuri G, Saxena R, Mittal B. Association of apolipoprotein A1-C3 gene cluster polymorphisms with gallstone disease ... for E2, 85.64% vs 78.22% (P = 0.052) for E3, 9.90% vs 15.84% (P = 0.075) for E4 of ApoE; and 25.74% vs 27.72% (P = 0.653) for C ... Influence of polymorphisms for apolipoprotein B (ins/del, XbaI, EcoRI) and apolipoprotein E on serum lipids and apolipoproteins ... Association between serum concentration of apolipoproteins A-I and B with gallbladder disease. Arch Med Res. 2003;34:194-199. [ ...
  http://pubmedcentralcanada.ca/pmcc/articles/PMC2951519/
*  Increased Apolipoprotein Deposits in Early Atherosclerotic Lesions Distinguish Symptomatic From Asymptomatic Patients |...
2018 American Heart Association, Inc. All rights reserved. Unauthorized use prohibited. The American Heart Association is a ... Studies of familial type III hyperlipoproteinemia using as a genetic marker the apoE phenotype E2/2. J Lipid Res. 1982; 23: ... Human apolipoprotein E. Determination of the heparin binding sites of apolipoprotein E3. J Biol Chem. 1986; 261: 2068-2076. ... Apolipoprotein E (apoE) and apolipoprotein B100 (apoB) are synthesized in the liver and other organs. Both apoE and apoB ...
  http://atvb.ahajournals.org/content/26/2/359
*  Abstracts from the British Association for the Study of the Liver Meeting Held on 13-14 September 2001 at the Royal Free...
Antibody responses to E2 and FrC were assessed by ELISA.. Results: In vitro expression of FrC-E2 and the E2 construct was ... We have reported4, that the defective apolipoprotein (apo) E allele, ∼2 (C-*T; Argi 58Cys), can be converted to the fully- ... Aim: To design an effective DNA vaccine against HCV using a fusion of the gene encoding Tetanus toxin to a fragment of the E2 ... 35 NO ASSOCIATION BETWEEN FUNCTIONAL SNPS IN THE ENDOTOXIN RECEPTORS CD14 AND TLR4 AND ALCOHOLIC LIVER DISEASE: IS ENDOTOXIN ...
  http://gut.bmj.com/content/50/5/e1
*  角谷寛 - 研究者 - researchmap
Association between apolipoprotein E epsilon4 and sleep-disordered breathing in adults.. Kadotani H, Kadotani T, Young T, ... Resetting of peripheral circadian clock by prostaglandin E2.. Tsuchiya Y, Minami I, Kadotani H, Nishida E ... Association between sleep apnea, sleep duration and serum lipid profile in an urban male working population in Japan. ... Association of different neural processes during different emotional perceptions of white noise and pure tone auditory stimuli. ...
  https://researchmap.jp/hiro_kad/
*  CiNii 論文 - Renal Diseases and Abnormal Lipid Metabolism
Association of a novel 3-amino acid deletion mutation of apolipoprotein E (Apo E Tokyo) with lipoprotein glomerulopathy KONISHI ... Apolipoprotein E2/E5 variants in lipoprotein glomerulopathy recurred in transplanted kidney MIYATA T ... A novel apolipoprotein e mutation, e2 (arg25cys), in lipoprotein glomerulopathy MATSUNAGA Akira ... Diminished LDL receptor and high heparin binding of apolipoprotein E2 Sendai associated with lipoprotein glomerulopathy ...
  https://ci.nii.ac.jp/naid/10018764257
*  Biomarkers for the Early Detection and Progression of Alzheimer's Disease | Springer for Research & Development
Association between genetic traits for immune-mediated diseases and Alzheimer disease. JAMA Neurol 2016;73:691-697.PubMed ... The cerebrospinal fluid "Alzheimer profile": easily said, but what does it mean? Alzheimers Dement 2014;10:713-23 e2.PubMed ... Given the effects of apolipoprotein E4 (ApoE4) gene dosage on the risk of AD and age at dementia onset [48], several groups ... An association between ApoE4 and increased PiB PET retention was reported in cross-sectional [140] and longitudinal [141] ...
  https://rd.springer.com/article/10.1007/s13311-016-0481-z
*  Association of apolipoprotein E phenotypes with late onset Alzheimer's disease: population based study | The BMJ
Three common alleles, e2, e3, and e4 determine the six apolipoprotein E phenotypes E2/2, E2/3, E2/4, E3/3, E4/3, and E4/4. ... Association of apolipoprotein E allele e4 with late-onset familial and sporadic Alzheimer's disease.Neurology1993;43:1467-72. ... Association of apolipoprotein E phenotypes with late onset Alzheimer's disease: population based study BMJ 1994; 309 :636 ... Association of apolipoprotein E phenotypes with late onset Alzheimer's disease: population based study. BMJ 1994; 309 doi: ...
  http://www.bmj.com/content/309/6955/636
*  Regulation of Endogenous Apolipoprotein E Secretion by Macrophages | Arteriosclerosis, Thrombosis, and Vascular Biology
Age-dependent association of apolipoprotein E genotype with coronary and aortic atherosclerosis in middle-aged men: an autopsy ... Fan D, Qiu S, Overton CD, Yancey PG, Swift LL, Jerome WG, Linton MF, Fazio S. Impaired secretion of apolipoprotein E2 from ... The recycling of apolipoprotein E in macrophages: influence of HDL and apolipoprotein A-I. J Lipid Res. 2005; 46: 1433-1439. ... Apolipoprotein A-I promotes cholesterol release and apolipoprotein E recruitment from THP-1 macrophage-like foam cells. J Lipid ...
  http://atvb.ahajournals.org/content/28/6/1060
*  Estrogen Receptor Control of Atherosclerotic Calcification and Smooth Muscle Cell Osteogenic Differentiation
... using aged apolipoprotein E-null mice with advanced ath... ... E2) to stimulate calcification of vascular smooth muscle cells ... Silastic E2 capsules were implanted into male and female apolipoprotein E-null mice aged 34 weeks. Plaque and calcified area ... area in a site-specific manner in the aortic sinus independently of plaque growth or lipid levels and occurred in association ... In vitro, E2 suppressed ERβ expression and increased VSMC mineralization, demonstrating increased collagen I and II, ...
  https://insights.ovid.com/pubmed?PMID=28473445
*  Early Markers | About memory
Alzheimer's & Dementia: The Journal of the Alzheimer's Association [Internet]. 2014 ;10(6):799 - 807.e2. Available from: http ... Plasma levels of apolipoprotein E and risk of dementia in the general population. Annals of Neurology [Internet]. 2015 ;77(2): ... The association may be related to a loss in the sense of smell, and increasing apathy. The association was not found with men, ... Apolipoprotein E in the brain is strongly associated with Alzheimer's, with the ApoE4 gene the strongest genetic factor linked ...
  http://www.memory-key.com/research/topic/early-markers
*  APOE gene - Genetics Home Reference
Most people with this disorder have two copies of the APOE e2 allele, leading researchers to conclude that the e2 allele plays ... apolipoprotein E. Enable Javascript to view the expand/collapse boxes.. Printable PDF Open All Close All ... However, other studies have not found these associations. More research is needed to clarify what role, if any, APOE gene ... The APOE e2 allele has been shown to greatly increase the risk of a rare condition called hyperlipoproteinemia type III. ...
  https://ghr.nlm.nih.gov/gene/APOE
*  Apo B | definition of apo B by Medical dictionary
While studies of the exact role of apolipoproteins in health and disease continue, there is a very strong association between ... The Apo E2 isoform demonstrates significantly less LDL receptor binding, which results in impaired clearance of chylomicrons, ... Apolipoproteins. (redirected from apo B). Also found in: Acronyms. Apolipoproteins: A, B, and E. Synonym/acronym: Apo A (Apo A1 ... Apolipoprotein E in apolipoprotein B (apo B)- and non-apo B-containing lipoproteins in 3523 participants in the Stanislas ...
  https://medical-dictionary.thefreedictionary.com/apo+B
*  Genetic and host factors for dementia in Down's syndrome | The British Journal of Psychiatry
Tyrrell, J., Cosgrave, M., Hawi, Z., et al (1998) A protective effect of apolipoprotein E e2 allele on dementia in Down's ... If the association between age at menopause and onset of dementia can be confirmed and supporting hormonal data provided, ... Lippa, C. F., Smith, T. W., Saunders, A. M., et al (1997) Apolipoprotein E-2 and Alzheimer's disease: genotype influences ... Corder, E. H., Saunders, A. M., Strittmatter, W. J., et al (1993) Gene dose of apolipoprotein E type 4 allele and the risk of ...
  http://bjp.rcpsych.org/content/180/5/405