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*  Togaviridae - Wikipedia
The non-structural proteins are encoded at the 5' end, formed during the first of two characteristic rounds of translation. ... Assembly takes place at the cell surface, where the virus buds from the cell, acquiring the envelope. The replication cycle is ... "Viral Zone". ExPASy. Retrieved 15 June 2015. ICTV. "Virus Taxonomy: 2014 Release". Retrieved 15 June 2015. "Togaviridae". ... The formation of a sub-genomic fragment, encoding the structural proteins and a negative sense fragment, a template for further ...
  https://en.wikipedia.org/wiki/Togaviridae
*  Opposing mechanisms involving RNA and lipids regulate HIV-1 Gag membrane binding through the highly basic region of the matrix...
HIV-1 assembly is a multistep process mediated primarily by the viral structural protein, Gag. This protein, synthesized as a ... 2006) Structural basis for targeting HIV-1 Gag proteins to the plasma membrane for virus assembly. Proc Natl Acad Sci USA 103: ... 1982) Binding sites of viral protein P19 onto Rous sarcoma virus RNA and possible controls of viral functions. J Mol Biol 160: ... 1998) Efficient HIV-1 replication can occur in the absence of the viral matrix protein. EMBO J 17:2699-2708. ...
  http://www.pnas.org/content/107/4/1600.full
*  Bacteriophage P2 : genes involved in baseplate assembly.
Viral Proteins/genetics/metabolism, Viral Structural Proteins/*genetics, Virus Assembly/*physiology Identifikatorer. URN: urn: ... Viral, Genes; Viral/*genetics, Genome; Viral, Molecular Sequence Data, Mutation, Rabbits, Recombinant Proteins, Research ... Bacteriophage P2: genes involved in baseplate assembly.. Haggård-Ljungquist, Elisabeth Stockholms universitet, ... Viral/analysis, Electrophoresis; Polyacrylamide Gel, Gene Expression Regulation; ...
  http://su.diva-portal.org/smash/record.jsf?faces-redirect=true&language=no&searchType=SIMPLE&query=&af=%5B%5D&aq=%5B%5B%5D%5D&aq2=%5B%5B%5D%5D&aqe=%5B%5D&pid=diva2%3A178741&noOfRows=50&sortOrder=author_sort_asc&sortOrder2=title_sort_asc&onlyFullText=false&sf=all
*  Mempro™ CoA-dependent Acyltransferases Production Using Virus-Like Particles - Creative Biostructure
The expressed viral structural protein will perform the self-assembly within the plasmid membrane of host cells and then bud- ... they are highly organized subunits result in the self-assembly of viral structural proteins. VLPs can mimic many behaviors of ... We will perform the co-expression of target CoA-dependent acyltransferase and the core viral structural protein in the chosen ... But all of the VLPs are non-infectious because of lacking the native viral genetic materials. VLPs are ideal tools for the ...
  https://www.creative-biostructure.com/mempro%E2%84%A2-coa-dependent-acyltransferases-production-using-virus-like-particles-367.htm
*  Effects of Blocking Individual Maturation Cleavages in Murine Leukemia Virus Gag
Expression of the major viral structural protein, termed the Gag polyprotein, is sufficient for assembly of retrovirus ... viral maturation involves not only a change in the viral proteins but also a change in the conformation of the viral RNA. We ... Synthesis, assembly, and processing of viral proteins, p. 263-334. In J. M. Coffin, S. H. Hughes, and H. E. Varmus (ed.), ... Proteolytic refolding of the HIV-1 capsid protein amino-terminus facilitates viral core assembly. EMBO J. 17:1555-1568. [PubMed ...
  http://pubmedcentralcanada.ca/pmcc/articles/PMC321369/?lang=en-ca
*  Virus-like particle - Wikipedia
The expression of viral structural proteins, such as Envelope or Capsid, can result in the self-assembly of virus like ... The understanding of self-assembly of VLPs was once based on viral assembly. This is rational as long as the VLP assembly takes ... In some cases a protein of interest can be genetically fused to the viral coat protein. However, this approach sometimes leads ... VLPs contain repetitive, high density displays of viral surface proteins that present conformational viral epitopes that can ...
  https://en.wikipedia.org/wiki/Virus-like_particle
*  Protocols and Video Articles Authored by Sarah L. Veatch (Translated to Arabic)
... specific recruitment of tetherin to assembly sites has been observed as its colocalization with the viral structural protein ... We previously showed that the HIV-1 structural protein Gag localizes to the uropod, a rear-end structure of polarized T cells, ... Jan, 2015 , Pubmed ID: 25320329 HIV-1 incorporates various host membrane proteins during particle assembly at the plasma ... ICAM-1 and ICAM-3, uropod-directed proteins that do not copatch with Gag in T cells, and CD46, a non-uropod-directed protein, ...
  https://www.jove.com/author/Sarah++L._Veatch?language=Arabic
*  Orthopoxvirus - Wikipedia
... producing all viral structural proteins. Assembly of progeny virions begins in cytoplasmic viral factories, producing an ... Viral replication is cytoplasmic. Entry into the host cell is achieved by attachment of the viral proteins to host ... Fusion of the viral envelope with the plasma membrane releases the viral core into the host cytoplasm. Expression of early- ... The viral core is completely uncoated as early expression ends, releasing the viral genome into the cytoplasm. At this point, ...
  https://en.wikipedia.org/wiki/Orthopoxvirus
*  Federal Register :: Government-Owned Inventions; Availability for Licensing
... consist of viral structural proteins that are capable of Start Printed Page 6912self-assembly into a nanoparticle, but are non- ... GAG-Cre) co-packaged with GAG-protease to deliver protein of interest in target site as a fully-processed protein rather than ... The technology also provides for a two-VLP protein delivery system designed to deliver a protein of interest into a target cell ... The claims also provide for methods of targeting a protein to a cell, methods of protein therapy and methods of treating ...
  https://www.federalregister.gov/documents/2009/02/11/E9-2822/government-owned-inventions-availability-for-licensing
*  Viral matrix protein - Wikipedia
Structural proteins linking the viral envelope with the virus core. They play a crucial role in virus assembly, and interact ... This assembly complex will now bud out of the cell as new mature viruses. Viral matrix proteins, like many other viral proteins ... In herpesviruses, the viral matrix is usually called viral tegument and contains many proteins involved in viral entry, early ... An example is the M1 protein of the influenza virus, showing affinity to the glycoproteins inserted in the host cell membrane ...
  https://en.wikipedia.org/wiki/Viral_matrix_protein
*  Clinical Overview of HIV Disease
The HIV viral protease enzyme acts following virion assembly to cleave viral proteins into functional structural and enzymatic ... The major viral proteins (some of which contain ,1 protein subunit) are classified as structural proteins (Gag, Pol, and Env), ... and fully spliced versions of viral RNA direct the synthesis of different viral proteins by the cell ribosomes. New viral ... cleaving protein products of the viral structural genes into the functional subunits needed to create new infectious virions. ...
  http://hivinsite.ucsf.edu/InSite?page=kb-00&doc=kb-03-01-01
*  Structure and genome of HIV - Wikipedia
Viral structural proteins are encoded by long ORFs, whereas smaller ORFs encode regulators of the viral life cycle: attachment ... The single-strand RNA is tightly bound to p17 nucleocapsid proteins, late assembly protein p6, and enzymes essential to the ... nucleocapsid protein, p7); SP2 (spacer peptide 2, p1) and P6 protein. pol codes for viral enzymes reverse transcriptase (RT) ... encoding major structural proteins as well as essential enzymes. These are synthesized as polyproteins which produce proteins ...
  https://en.wikipedia.org/wiki/Structure_and_genome_of_HIV
*  Frontiers | Intracellular Crosslinking of Filoviral Nucleoproteins with Xintrabodies Restricts Viral Packaging | Immunology
By retuning sdAb specificity, the approach of crosslinking highly conserved regions of assembly critical proteins may well be ... The RNCs are transported through the cytosol for packaging into virions through association with viral matrix proteins at cell ... The RNCs are transported through the cytosol for packaging into virions through association with viral matrix proteins at cell ... We hypothesized that RNC would be ideal targets for cross-linkers engineered to promote aberrant protein-protein interactions, ...
  https://www.frontiersin.org/articles/10.3389/fimmu.2017.01197/full
*  Medical Virology
Late genes encode mostly viral structural proteins or viral proteins necessary for the assembly and egress of the virus from ... Viral Assembly and Egress For most viruses, nucleic acid and structural protein synthesis is accompanied by the assembly of ... including a viral matrix protein that coats the viral RNA. Viral RNA polymerase/integrase, matrix protein, and cellular tRNA ... These mRNAs encode for the viral RNA polymerase and accessory factors as well as for viral structural proteins. Influenza virus ...
  http://www.gkhub.info/medical-virology.html
*  Most recent papers with the keyword hiv miRNA | Read by QxMD
This occurs when miRNAs bind nonspecifically to the viral structural protein Gag, interfering with viral RNA-mediated Gag ... Inhibition of retroviral Gag assembly by non-silencing miRNAs promotes autophagic viral degradation. ... Tat is a 101-residue protein codified by two exons that regulates the elongation of viral transcripts. The first exon of Tat ( ... www.readbyqxmd.com/read/28884441/inhibition-of-retroviral-gag-assembly-by-non-silencing-mirnas-promotes-autophagic-viral- ...
  https://www.readbyqxmd.com/keyword/97904
*  Camelpox - Wikipedia
When all of the structural proteins have been produced, viral assembly takes place. The newly formed virus particles can be ... The DNA is encased in the viral core. Two lateral bodies are found outside the viral core, and are believed to hold the enzymes ... The most common medication used to treat Camelpox is Cidofovir, a broad spectrum anti-viral that acts by inhibiting the viral ... The viral genetic material is contained in double stranded linear DNA consisting of 202,182 tightly packed base pairs. ...
  https://en.wikipedia.org/wiki/Camelpox
*  Resistance Analysis and Characterization of a Thiazole Analogue, BP008, as a Potent Hepatitis C Virus NS5A Inhibitor |...
Structural and functional characterization of nonstructural protein 2 for its role in hepatitis C virus assembly. J. Biol. Chem ... The hepatitis C virus NS5A inhibitor (BMS-790052) alters the subcellular localization of the NS5A non-structural viral protein ... viral assembly, and release (1, 21, 22, 40). HCV NS3 is a bifunctional protein with an amino-terminal domain that has serine ... Phosphorylation of hepatitis C virus nonstructural protein 5A modulates its protein interactions and viral RNA replication. ...
  https://aac.asm.org/content/56/1/44
*  Virus Replication
... structural proteins) or those involved in viral assembly. ... The outer proteins of the virus both protect the viral genome ( ... Different viral genes are expressed at different stages of replication. Those expressed earlier on are often regulatory, or ... Some RNA viruses do this by using their viral genome as an mRNA when they enter their host cell, whereas those that require ... The initial interaction between a virus and its host cell is mediated by proteins (often with attached sugars) on the surface ...
  http://www.els.net/WileyCDA/ElsArticle/refId-a0000438.html
*  Human papillomavirus infection - Wikipedia
... the late genes L1 and L2 are transcribed/translated and serve as structural proteins that encapsidate the amplified viral ... This assembly/maturation event stabilizes virions, and increases their specific infectivity.[101] Virions can then be sloughed ... The E6/E7 proteins inactivate two tumor suppressor proteins, p53 (inactivated by E6) and pRb (inactivated by E7).[14] The viral ... serves as an E7 mRNA to translate E7 protein.[99] However, viral early transcription subjects to viral E2 regulation and high ...
  https://en.wikipedia.org/wiki/Human_papillomavirus
*  Most recent papers with the keyword Protein structure prediction | Read by QxMD
... be used to characterize the assembly competency of all single amino acid variants of a self-assembling viral structural protein ... The functional oligomeric state of tegument protein GP41 is essential for baculovirus BV and ODV assembly. ... Protein Corona in Response to Flow: Effect on Protein Concentration and Structure. ... segments of different lengths coding for at least 11 viral proteins. A heterotrimeric polymerase complex is bound to the ...
  https://www.readbyqxmd.com/keyword/59622
*  Lactimidomycin is a broad-spectrum inhibitor of dengue and other RNA viruses
... we utilized a replicon system in which the viral structural proteins are replaced by a luciferase reporter, thus permitting ... analysis of viral RNA translation and replication in the absence of viral entry, assembly, and egress (Clyde et al., 2008). In ... we believe that potent but transient inhibition of protein production (viral and host) may impair and/or delay the spread of ... and as a marker of both viral translation and replication of the viral RNA at later time points ((Carocci et al., 2015) and ...
  http://pubmedcentralcanada.ca/pmcc/articles/PMC4850914/
*  Molecular virology - Wikipedia
Assembly process involves putting together and modifying newly-made viral nucleic acids and structural proteins to form the ... Transport of viral proteins to the apical membranes and interaction of matrix protein with glycoproteins in the assembly of ... The process includes the transcription of mRNA, synthesis, and assembly of viral proteins and is regulated by protein ... proteins. The host range of a virus is determined by the specificity of the binding. The attachment causes the viral protein to ...
  https://en.wikipedia.org/wiki/Molecular_virology
*  Revision #59 - Flaviviridae - Positive-sense RNA Viruses - International Committee on Taxonomy of Viruses (ICTV)
... viral proteases cleave all non-structural protein junctions. Virus assembly is believed to occur by budding into vesicles from ... An additional protein, p7 (believed to have properties of an ion channel protein important in viral assembly) is incompletely ... Proteins. The HCV virion comprises at least three proteins: the nucleocapsid core protein C (p19-21), and two envelope ... Virus-specific antibodies to recombinant-expressed structural proteins (C, E1 and E2) and nonstructural proteins (principally ...
  https://talk.ictvonline.org/ictv-reports/ictv_online_report/positive-sense-rna-viruses/w/flaviviridae/362/genus-hepacivirus/revision/59
*  Mastadenovirus - Wikipedia
... mostly encoding structural proteins. Host translation shutoff performed by the viral 100K protein. Assembly of new virions in ... The genome codes for 40 proteins. Viral replication is nuclear. Entry into the host cell is achieved by attachment of the viral ... Import of the viral genome into host nucleus mediated by core protein VII. Transcription of early genes (E genes) by host RNA ... Microtubular transport toward nucleus of the viral genome still protected by the core protein VII and a partial capsid mainly ...
  https://en.wikipedia.org/wiki/Mastadenovirus
*  Human Papilloma Virus Associated Squamous Cell Carcinoma of the Head and Neck
... and viral transcription; the late region forms structural proteins (L1-L2) essential for virion assembly; and the long control ... The genome consists of double-stranded DNA bound to cellular histones and surrounded by a protein capsid [4]. The eight open ... The common methods being used in diagnosis of HPV are viral DNA detection with polymerase chain reaction (PCR) or In Situ ... G. Y. F. Ho, P. R. Palan, J. Basu et al., "Viral characteristics of human papillomavirus infection and antioxidant levels as ...
  https://www.hindawi.com/journals/jstd/2015/791024/