Intracoronary Thrombus and Platelet Glycoprotein IIb/IIIa Receptor Blockade With Tirofiban in Unstable Angina or Non-Q-Wave...
Platelet adhesion, activation, and aggregation play a critical role in initiating steps in the pathogenesis of platelet-rich ... Aspirin, heparin, or both to treat acute unstable angina. N Engl J Med. 1988;319:1105-1111. ... Platelet activation in unstable coronary disease. N Engl J Med. 1986;315:983-989. ... 24 25 Enhanced platelet activation and thrombin generation after clot lysis that could exacerbate thrombus formation and ...http://circ.ahajournals.org/content/100/15/1609
Atorvastatin, Aspirin, Oxidative Stress, Coagulation and Platelet Activation Indexes - Full Text View - ClinicalTrials.gov
... on platelet recruitment, platelet and serum isoprostanes, platelet and serum thromboxane A2, platelet and serum NOX2 activation ... Atorvastatin, Aspirin, Oxidative Stress, Coagulation and Platelet Activation Indexes. The recruitment status of this study is ... Effects on Oxidative Stress, Coagulation, Platelet Activation and Inflammatory Indexes of Atorvastatin and/or Aspirin Treatment ... In diabetic patients the concomitant aspirin treatment include a previous 30 days treatment with 100 mg daily of aspirin. ...https://clinicaltrials.gov/show/NCT01322711
Inflammation, oxidative stress and platelet activation in aspirin-treated critical limb ischaemia: beneficial effects of...
Inflammation, oxidative stress and platelet activation in aspirin-treated critical limb ischaemia: beneficial effects of ... Inflammation, oxidative stress and platelet activation in aspirin-treated critical limb ischaemia: beneficial effects of ... as in vivo indexes of thromboxane-dependent platelet activation and lipid peroxidation, respectively, and on platelet-derived ... as in vivo indexes of thromboxane-dependent platelet activation and lipid peroxidation, respectively, and on platelet-derived ...https://ricerca.unich.it/handle/11564/222409
The AMEDEO Literature Guide
In vivo platelet activation and aspirin responsiveness in type 1 diabetes mellitus.. Diabetes. 2015 Oct 15. pii: db150936.. ... Platelet Dysfunction in Type 1 Diabetes: Stressing the Thromboxanes.. Diabetes. 2016;65:349-51.. PubMed Text format *MASJKUR J ... Toll-Like Receptor 4 Activation Contributes to Diabetic Bladder Dysfunction in a Murine Model of Type I Diabetes.. Diabetes. ... betaig-h3 represses T cell activation in type 1 diabetes.. Diabetes. 2015 Oct 15. pii: db150638.. PubMed Text format Abstract ...http://amedeo.com/medicine/aut/diab.htm
Similar articles for PubMed (Select 16442186) - PubMed - NCBI
Inflammation, oxidative stress and platelet activation in aspirin-treated critical limb ischaemia: beneficial effects of ... Determinants of platelet activation in Alzheimer's disease.. Ciabattoni G, Porreca E, Di Febbo C, Di Iorio A, Paganelli R, ... Oxidative stress and platelet activation in homozygous homocystinuria.. Davì G, Di Minno G, Coppola A, Andria G, Cerbone AM, ... Platelet activation in patients with colorectal cancer.. Sciulli MG, Filabozzi P, Tacconelli S, Padovano R, Ricciotti E, Capone ...https://www.ncbi.nlm.nih.gov/pubmed?linkname=pubmed_pubmed&from_uid=16442186
Poor CD4 Recovery | Management of the Treatment-Experienced Patient | Adult and Adolescent ARV | AIDSinfo
Aspirin attenuates platelet activation and immune activation in HIV-infected subjects on antiretroviral therapy: A Pilot Study ... T cell activation is associated with lower CD4+ T cell gains in human immunodeficiency virus-infected patients with sustained ... Persistent Immune Activation and Inflammation. Although poor CD4 cell recovery likely contributes to morbidity and mortality ... Thus, clinical monitoring with immune activation or inflammatory markers is not currently recommended (AII). The focus of care ...https://aidsinfo.nih.gov/guidelines/html/1/adult-and-adolescent-arv/470/poor-cd4-recovery
Dual Anticoagulant and Antiplatelet Therapy for Coronary Artery Disease and Peripheral Artery Disease Patients |...
Platelets and activation of PARs by coagulation proteases can enhance inflammation and atherosclerosis. Aspirin has anti- ... Aspirin reduces the thrombus by inhibiting platelet activation. Anticoagulants reduce the thrombus by inhibiting fibrin ... with aspirin and a P2Y12 inhibitor.5 Aspirin irreversibly inhibits cyclooxygenase-1 and prevents platelet-dependent thromboxane ... Clopidogrel and aspirin versus aspirin alone for the prevention of atherothrombotic events. N Engl J Med. 2006;354:1706-1717. ...http://atvb.ahajournals.org/content/38/4/726
The Effect of Serum LDL Lowering on Aspirin Resistance - Full Text View - ClinicalTrials.gov
Aspirin resistance is the persistent platelet activation, demonstrated by platelet function tests (1). ... On the fifth day optical platelet aggregation test, cholesterol content in platelet membranes, platelet function in the PFA-100 ... Platelet activation by oxidatively modified low density lipoproteins. Atherosclerosis. 1989 Apr;76(2-3):117-24. ... Platelet activation: assessment and quantification. Eur Heart J. 2001 Sep;22(17):1561-71. Review. ...https://clinicaltrials.gov/show/NCT00466154
The Marc and Ruti Bell Program in Vascular Biology and Disease | Leon H. Charney Division of Cardiology
Aspirin attenuates platelet activation and immune activation in HIV-infected subjects on antiretroviral therapy: A Pilot Study ... Berger's work on platelets and aspirin as well as Dr. Moore's work on miR-33 and HDL are featured in the 2013 Research Report. ... His work on platelet activity in high-risk patients and the response of platelets to antiplatelet and antithrombotic ... Berger's team studies platelet activity using various techniques, including whole blood and platelet rich plasma aggregometry, ...https://med.nyu.edu/medicine/cardiology/research/marc-and-ruti-bell-program-vascular-biology-and-disease
Evaluation of the Blood Compatibility of Materials, Cells, and Tissues: Basic Concepts, Test Models, and Practical Guidelines |...
Studies of platelet and coagulation activation and the effect of aspirin. Biomaterials 20(7):603-611PubMedCrossRefGoogle ... contact activation/coagulation) of the blood, which induces platelet and leukocyte activation. ... Activated human platelets induce factor XIIa-mediated contact activation. Biochem Biophys Res Commun 391(1):11-17PubMedCrossRef ... Effect of complement inhibition and heparin coating on artificial surface-induced leukocyte and platelet activation. Ann Thorac ...https://link.springer.com/chapter/10.1007%2F978-1-4614-4118-2_18
Search of: aspirin | Studies with Male Participants - List Results - ClinicalTrials.gov
Effects of Low Dose Aspirin Pre-treatment on Platelet Activation Undergoing Off-pump Coronary Artery Bypass Surgery. *Coronary ... Therapeutic Control of Aspirin-Exacerbated Respiratory Disease (Aspirin). *Asthma, Aspirin-Induced. *Aspirin Exacerbated Asthma ... In-Vivo Bleeding Volume Test for Platelet-Aspirin Interaction. *Healthy. *Drug: Aspirin ingestion followed by doing a Bleeding ... Genotypic and Phenotypic Correlates of Resistance to Aspirin. *Platelet Dysfunction Due to Aspirin ...https://clinicaltrials.gov/ct2/results?term=aspirin&state1=NA%3AUS%3ANY&gndr=Male&show_down=Y
Polycythemia vera - Wikipedia
... evidence for aspirin-suppressible platelet activation in vivo". Blood. 80 (8): 1965-71. PMID 1327286. Kumar, et al.: Robbin's ... Low dose aspirin (75-81 mg daily) is often prescribed. Research has shown that aspirin reduces the risk for various thrombotic ... Fjellner B, Hägermark O (1979). "Pruritus in polycythemia vera: treatment with aspirin and possibility of platelet involvement ... Erythromelalgia is caused by an increased platelet count or increased platelet "stickiness" (aggregation), resulting in the ...https://en.wikipedia.org/wiki/Polycythemia_vera
Retrospective | Philip W. Majerus (1937 - 2016)
Majerus showed that aspirin interferes with platelet activation, reducing blood vessel constriction and dialing down the ... His work studying aspirin demonstrated that platelets play an active role in clotting, overturning the long-held idea that ... He showed that when molecules called clotting factors interact with receptors on the surface of platelets, the platelets ... "His work involving low-dose aspirin and its use to prevent heart attacks is a perfect example of this. But equally important, ...http://www.asbmb.org/asbmbtoday/201610/Retrospective/Majerus/
Vitamin B12 - Health Professional Fact Sheet
Effect of vitamins and aspirin on markers of platelet activation, oxidative stress and homocysteine in people at high risk of ...https://ods.od.nih.gov/factsheets/VitaminB12-HealthProfessional/
Impact of Aspirin Dosing on the Effects of P2Y12Inhibition in Patients with Acute Coronary Syndromes | SpringerLink
The discovery of the antiplatelet effect of low-dose aspirin led to the hugely successful strategy of dual antiplatelet therapy ... The effects of varying doses of aspirin on human platelet activation induced by PAF, collagen and arachidonic acid. British ... 2008). Aspirin and the in vitro linear relationship between thromboxane A2-mediated platelet aggregation and platelet ... In the Platelet Inhibition and Patients Outcome (PLATO) study, higher doses of aspirin appeared to neutralise the additional ...https://link.springer.com/article/10.1007%2Fs12265-013-9524-6
Antiphospholipid syndrome - Wikipedia
Often, this disease is treated by giving aspirin to inhibit platelet activation, and/or warfarin as an anticoagulant. The goal ... Other common findings, although not part of the APS classification criteria, are low platelet count, heart valve disease, and ... The lupus anticoagulant will inhibit all the contact activation pathway factors (factor VIII, factor IX, factor XI and factor ... Women with recurrent miscarriage are often advised to take aspirin and to start low molecular weight heparin treatment after ...https://en.wikipedia.org/wiki/Antiphospholipid_syndrome
Monitoring of Diabetic Late Complication | SpringerLink
The ATP-gated P2X1 receptor plays a pivotal role in activation of aspirin-treated platelets by thrombin and epinephrine. J Biol ... Characterization of the proteins released from activated platelets leads to localization of novel platelet proteins in human ... Koya D, King G (1998) PKC activation and the development of diabetic complications. Diabetes 47:859-866PubMedGoogle Scholar ... Reed GL (2004) Platelet secretory mechanism. Semin Thromb Hemost 30:441-450PubMedGoogle Scholar ...https://link.springer.com/referenceworkentry/10.1007/978-3-642-27728-3_70-1
Porous Titanium Granules and Blood for Bone Regeneration around Dental Implants: Report of Four Cases and Review of the...
Studies of platelet and coagulation activation and the effect of aspirin," Biomaterials, vol. 20, no. 7, pp. 603-611, 1999. ... N. Ferraz, J. Carlsson, J. Hong, and M. K. Ott, "Influence of nanoporesize on platelet adhesion and activation," Journal of ... N. Ferraz, J. Hong, and M. Karlsson Ott, "Procoagulant behavior and platelet microparticle generation on nanoporous alumina," ... M. B. Gorbet and M. V. Sefton, "Biomaterial-associated thrombosis: roles of coagulation factors, complement, platelets and ...https://www.hindawi.com/journals/crid/2013/410515/ref/
Randomized Clinical Trial of Aspirin and Simvastatin for Pulmonary Arterial Hypertension - American College of Cardiology
By targeting platelet activation and endothelial dysfunction, aspirin and statins have the potential to improve outcomes in ... Aspirin versus placebo: There was no difference in 6MWD between aspirin and placebo groups at 6 months after adjustment for ... Randomized Clinical Trial of Aspirin and Simvastatin for Pulmonary Arterial Hypertension - ASA-STAT. May 30, 2011 Share via: ... Aspirin provided by Bayer HealthCare, LLC, and simvastatin by Merck & Co., Inc.. Date Published:. 01/01/2011. Date Updated:. 05 ...http://www.acc.org/latest-in-cardiology/clinical-trials/2011/05/30/15/01/asa-stat
Neal Kleiman, MD | Houston Methodist
... and carrying out independent physiologic studies examining such issues as aspirin dosing, platelet activation during coronary ... leukocyte activation following GP IIb/IIIa administration, the role of platelet P-selectin on leukocyte membrane changes, and ... and the relation of platelet turnover and COX-2 expression to aspirin sensitivity. The laboratory has also collaborated with ... Kleiman established the Applied Platelet Physiology Laboratory at Baylor, now at the Houston Methodist DeBakey Heart and ...https://www.houstonmethodist.org/faculty/neal-kleiman/
Kleiman Lab | Houston Methodist
... and carrying out independent physiologic studies examining issues such as aspirin dosing, platelet activation during coronary ... leukocyte activation following GP IIb/IIIa administration, the role of platelet P-selectin on leukocyte membrane changes, and, ... and the relation of platelet turnover and COX-2 expression to aspirin sensitivity. The laboratory has also collaborated with ... To learn more or schedule resources for the Applied Platelet Physiology Laboratory, please log in to iLab or contact our Lab ...https://www.houstonmethodist.org/research/our-faculty/labs/kleiman-lab/
KAKEN - Research Projects | Establishment of the monitoring method in anti-platehet therapy using with modified collagen bead...
ADP scavengers and ADP receptor blockers but not aspirin appears to support platelet activation in this system. Blood samples ... Platelet retention rates (%) were calculated as 100 x [(platelet count before the passage)-(platelet count after the passage ... Among many methods for the evaluation of platelet functions and the evaluation of anti-platelet drugs on platelet functions, ... small sized collagen beads column / anti-platelet drugs / platelet function test / ticlopidine / platelet retention rate / 血小板停 ...https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-15590481/
Omega-3 polyunsaturated fatty acids and cancer: lessons learned from clinical trials | SpringerLink
2011). Insights into the inhibition of platelet activation by omega-3 polyunsaturated fatty acids: beyond aspirin and ... Goodnight, S. J., Harris, W. S., & Connor, W. E. (1981). The effects of dietary omega 3 fatty acids on platelet composition and ... 2004). Consumption of (n-3) fatty acids is related to plasma biomarkers of inflammation and endothelial activation in women. ... 1995). Prolonged inhibition of platelet aggregation after n-3 fatty acid ethyl ester ingestion by healthy volunteers. The ...https://link.springer.com/article/10.1007/s10555-015-9572-2
Oxidative Stress and Antioxidant Therapy in Chronic Kidney and Cardiovascular Disease | IntechOpen
Insights into the inhibition of platelet activation by omega-3 polyunsaturated fatty acids: Beyond aspirin and clopidogrel. ... 98 - Pat B, Yang T, Kong C, Watters D, Johnson DW, Gobe G. Activation of ERK in renal fibrosis after unilateral ureteral ... This may indicate the induction of free radicals in response to receptor activation by a cognate ligand in a process that is ... Activation of L-arginine transport in undialysed chronic renal failure and continuous ambulatory peritoneal dialysis patients. ...https://www.intechopen.com/books/oxidative-stress-and-chronic-degenerative-diseases-a-role-for-antioxidants/oxidative-stress-and-antioxidant-therapy-in-chronic-kidney-and-cardiovascular-disease/
The Mortality and Myocardial Effects of Antidepressants Are Moderated by Preexisting Cardiovascular Disease: A Meta-Analysis -...
Norepinephrine-induced human platelet activation in vivo is only partly counteracted by aspirin. Circulation 1994;89:1951-1957 ... Davì G, Patrono C: Platelet activation and atherothrombosis. N Engl J Med 2007;357:2482-2494. External Resources * Pubmed/ ... Heger CD, Collins RN: Platelet activation and "crossover appeal": rab and rho families united by common links to serotonin. Mol ... Bakkaloglu B, Yabanoglu S, Ozyuksel BR, Uaar G, Ertugrul A, Demir B, Ulug B: Platelet and plasma serotonin levels and platelet ...https://www.karger.com/Article/Abstract/477940