*  Intracoronary Thrombus and Platelet Glycoprotein IIb/IIIa Receptor Blockade With Tirofiban in Unstable Angina or Non-Q-Wave...
Platelet adhesion, activation, and aggregation play a critical role in initiating steps in the pathogenesis of platelet-rich ... Aspirin, heparin, or both to treat acute unstable angina. N Engl J Med. 1988;319:1105-1111. ... Platelet activation in unstable coronary disease. N Engl J Med. 1986;315:983-989. ... 24 25 Enhanced platelet activation and thrombin generation after clot lysis that could exacerbate thrombus formation and ...
  http://circ.ahajournals.org/content/100/15/1609
*  Atorvastatin, Aspirin, Oxidative Stress, Coagulation and Platelet Activation Indexes - Full Text View - ClinicalTrials.gov
... on platelet recruitment, platelet and serum isoprostanes, platelet and serum thromboxane A2, platelet and serum NOX2 activation ... Atorvastatin, Aspirin, Oxidative Stress, Coagulation and Platelet Activation Indexes. The recruitment status of this study is ... Effects on Oxidative Stress, Coagulation, Platelet Activation and Inflammatory Indexes of Atorvastatin and/or Aspirin Treatment ... In diabetic patients the concomitant aspirin treatment include a previous 30 days treatment with 100 mg daily of aspirin. ...
  https://clinicaltrials.gov/show/NCT01322711
*  Inflammation, oxidative stress and platelet activation in aspirin-treated critical limb ischaemia: beneficial effects of...
Inflammation, oxidative stress and platelet activation in aspirin-treated critical limb ischaemia: beneficial effects of ... Inflammation, oxidative stress and platelet activation in aspirin-treated critical limb ischaemia: beneficial effects of ... as in vivo indexes of thromboxane-dependent platelet activation and lipid peroxidation, respectively, and on platelet-derived ... as in vivo indexes of thromboxane-dependent platelet activation and lipid peroxidation, respectively, and on platelet-derived ...
  https://ricerca.unich.it/handle/11564/222409
*  The AMEDEO Literature Guide
In vivo platelet activation and aspirin responsiveness in type 1 diabetes mellitus.. Diabetes. 2015 Oct 15. pii: db150936.. ... Platelet Dysfunction in Type 1 Diabetes: Stressing the Thromboxanes.. Diabetes. 2016;65:349-51.. PubMed Text format *MASJKUR J ... Toll-Like Receptor 4 Activation Contributes to Diabetic Bladder Dysfunction in a Murine Model of Type I Diabetes.. Diabetes. ... betaig-h3 represses T cell activation in type 1 diabetes.. Diabetes. 2015 Oct 15. pii: db150638.. PubMed Text format Abstract ...
  http://amedeo.com/medicine/aut/diab.htm
*  Similar articles for PubMed (Select 16442186) - PubMed - NCBI
Inflammation, oxidative stress and platelet activation in aspirin-treated critical limb ischaemia: beneficial effects of ... Determinants of platelet activation in Alzheimer's disease.. Ciabattoni G, Porreca E, Di Febbo C, Di Iorio A, Paganelli R, ... Oxidative stress and platelet activation in homozygous homocystinuria.. Davì G, Di Minno G, Coppola A, Andria G, Cerbone AM, ... Platelet activation in patients with colorectal cancer.. Sciulli MG, Filabozzi P, Tacconelli S, Padovano R, Ricciotti E, Capone ...
  https://www.ncbi.nlm.nih.gov/pubmed?linkname=pubmed_pubmed&from_uid=16442186
*  Poor CD4 Recovery | Management of the Treatment-Experienced Patient | Adult and Adolescent ARV | AIDSinfo
Aspirin attenuates platelet activation and immune activation in HIV-infected subjects on antiretroviral therapy: A Pilot Study ... T cell activation is associated with lower CD4+ T cell gains in human immunodeficiency virus-infected patients with sustained ... Persistent Immune Activation and Inflammation. Although poor CD4 cell recovery likely contributes to morbidity and mortality ... Thus, clinical monitoring with immune activation or inflammatory markers is not currently recommended (AII). The focus of care ...
  https://aidsinfo.nih.gov/guidelines/html/1/adult-and-adolescent-arv/470/poor-cd4-recovery
*  Dual Anticoagulant and Antiplatelet Therapy for Coronary Artery Disease and Peripheral Artery Disease Patients |...
Platelets and activation of PARs by coagulation proteases can enhance inflammation and atherosclerosis. Aspirin has anti- ... Aspirin reduces the thrombus by inhibiting platelet activation. Anticoagulants reduce the thrombus by inhibiting fibrin ... with aspirin and a P2Y12 inhibitor.5 Aspirin irreversibly inhibits cyclooxygenase-1 and prevents platelet-dependent thromboxane ... Clopidogrel and aspirin versus aspirin alone for the prevention of atherothrombotic events. N Engl J Med. 2006;354:1706-1717. ...
  http://atvb.ahajournals.org/content/38/4/726
*  The Effect of Serum LDL Lowering on Aspirin Resistance - Full Text View - ClinicalTrials.gov
Aspirin resistance is the persistent platelet activation, demonstrated by platelet function tests (1). ... On the fifth day optical platelet aggregation test, cholesterol content in platelet membranes, platelet function in the PFA-100 ... Platelet activation by oxidatively modified low density lipoproteins. Atherosclerosis. 1989 Apr;76(2-3):117-24. ... Platelet activation: assessment and quantification. Eur Heart J. 2001 Sep;22(17):1561-71. Review. ...
  https://clinicaltrials.gov/show/NCT00466154
*  The Marc and Ruti Bell Program in Vascular Biology and Disease | Leon H. Charney Division of Cardiology
Aspirin attenuates platelet activation and immune activation in HIV-infected subjects on antiretroviral therapy: A Pilot Study ... Berger's work on platelets and aspirin as well as Dr. Moore's work on miR-33 and HDL are featured in the 2013 Research Report. ... His work on platelet activity in high-risk patients and the response of platelets to antiplatelet and antithrombotic ... Berger's team studies platelet activity using various techniques, including whole blood and platelet rich plasma aggregometry, ...
  https://med.nyu.edu/medicine/cardiology/research/marc-and-ruti-bell-program-vascular-biology-and-disease
*  Search of: aspirin | Studies with Male Participants - List Results - ClinicalTrials.gov
Effects of Low Dose Aspirin Pre-treatment on Platelet Activation Undergoing Off-pump Coronary Artery Bypass Surgery. *Coronary ... Therapeutic Control of Aspirin-Exacerbated Respiratory Disease (Aspirin). *Asthma, Aspirin-Induced. *Aspirin Exacerbated Asthma ... In-Vivo Bleeding Volume Test for Platelet-Aspirin Interaction. *Healthy. *Drug: Aspirin ingestion followed by doing a Bleeding ... Genotypic and Phenotypic Correlates of Resistance to Aspirin. *Platelet Dysfunction Due to Aspirin ...
  https://clinicaltrials.gov/ct2/results?term=aspirin&state1=NA%3AUS%3ANY&gndr=Male&show_down=Y
*  Retrospective | Philip W. Majerus (1937 - 2016)
Majerus showed that aspirin interferes with platelet activation, reducing blood vessel constriction and dialing down the ... His work studying aspirin demonstrated that platelets play an active role in clotting, overturning the long-held idea that ... He showed that when molecules called clotting factors interact with receptors on the surface of platelets, the platelets ... "His work involving low-dose aspirin and its use to prevent heart attacks is a perfect example of this. But equally important, ...
  http://www.asbmb.org/asbmbtoday/201610/Retrospective/Majerus/
*  Polycythemia vera - Wikipedia
... evidence for aspirin-suppressible platelet activation in vivo". Blood. 80 (8): 1965-71. PMID 1327286. Kumar, et al.: Robbin's ... Low dose aspirin (75-81 mg daily) is often prescribed. Research has shown that aspirin reduces the risk for various thrombotic ... Fjellner B, Hägermark O (1979). "Pruritus in polycythemia vera: treatment with aspirin and possibility of platelet involvement ... Erythromelalgia is caused by an increased platelet count or increased platelet "stickiness" (aggregation), resulting in the ...
  https://en.wikipedia.org/wiki/Polycythemia_vera
*  Vitamin B12 - Health Professional Fact Sheet
Effect of vitamins and aspirin on markers of platelet activation, oxidative stress and homocysteine in people at high risk of ...
  https://ods.od.nih.gov/factsheets/VitaminB12-HealthProfessional/
*  Impact of Aspirin Dosing on the Effects of P2Y12Inhibition in Patients with Acute Coronary Syndromes | SpringerLink
The discovery of the antiplatelet effect of low-dose aspirin led to the hugely successful strategy of dual antiplatelet therapy ... The effects of varying doses of aspirin on human platelet activation induced by PAF, collagen and arachidonic acid. British ... 2008). Aspirin and the in vitro linear relationship between thromboxane A2-mediated platelet aggregation and platelet ... In the Platelet Inhibition and Patients Outcome (PLATO) study, higher doses of aspirin appeared to neutralise the additional ...
  https://link.springer.com/article/10.1007%2Fs12265-013-9524-6
*  Monitoring of Diabetic Late Complication | SpringerLink
The ATP-gated P2X1 receptor plays a pivotal role in activation of aspirin-treated platelets by thrombin and epinephrine. J Biol ... Characterization of the proteins released from activated platelets leads to localization of novel platelet proteins in human ... Koya D, King G (1998) PKC activation and the development of diabetic complications. Diabetes 47:859-866PubMedGoogle Scholar ... Reed GL (2004) Platelet secretory mechanism. Semin Thromb Hemost 30:441-450PubMedGoogle Scholar ...
  https://link.springer.com/referenceworkentry/10.1007/978-3-642-27728-3_70-1
*  Antiphospholipid syndrome - Wikipedia
Often, this disease is treated by giving aspirin to inhibit platelet activation, and/or warfarin as an anticoagulant. The goal ... Other common findings, although not part of the APS classification criteria, are low platelet count, heart valve disease, and ... The lupus anticoagulant will inhibit all the contact activation pathway factors (factor VIII, factor IX, factor XI and factor ... Women with recurrent miscarriage are often advised to take aspirin and to start low molecular weight heparin treatment after ...
  https://en.wikipedia.org/wiki/Antiphospholipid_syndrome
*  Randomized Clinical Trial of Aspirin and Simvastatin for Pulmonary Arterial Hypertension - American College of Cardiology
By targeting platelet activation and endothelial dysfunction, aspirin and statins have the potential to improve outcomes in ... Aspirin versus placebo: There was no difference in 6MWD between aspirin and placebo groups at 6 months after adjustment for ... Randomized Clinical Trial of Aspirin and Simvastatin for Pulmonary Arterial Hypertension - ASA-STAT. May 30, 2011 Share via: ... Aspirin provided by Bayer HealthCare, LLC, and simvastatin by Merck & Co., Inc.. Date Published:. 01/01/2011. Date Updated:. 05 ...
  http://www.acc.org/latest-in-cardiology/clinical-trials/2011/05/30/15/01/asa-stat
*  Omega-3 polyunsaturated fatty acids and cancer: lessons learned from clinical trials | SpringerLink
2011). Insights into the inhibition of platelet activation by omega-3 polyunsaturated fatty acids: beyond aspirin and ... Goodnight, S. J., Harris, W. S., & Connor, W. E. (1981). The effects of dietary omega 3 fatty acids on platelet composition and ... 2004). Consumption of (n-3) fatty acids is related to plasma biomarkers of inflammation and endothelial activation in women. ... 1995). Prolonged inhibition of platelet aggregation after n-3 fatty acid ethyl ester ingestion by healthy volunteers. The ...
  https://link.springer.com/article/10.1007/s10555-015-9572-2
*  Oxidative Stress and Antioxidant Therapy in Chronic Kidney and Cardiovascular Disease | IntechOpen
Insights into the inhibition of platelet activation by omega-3 polyunsaturated fatty acids: Beyond aspirin and clopidogrel. ... 98 - Pat B, Yang T, Kong C, Watters D, Johnson DW, Gobe G. Activation of ERK in renal fibrosis after unilateral ureteral ... This may indicate the induction of free radicals in response to receptor activation by a cognate ligand in a process that is ... Activation of L-arginine transport in undialysed chronic renal failure and continuous ambulatory peritoneal dialysis patients. ...
  https://www.intechopen.com/books/oxidative-stress-and-chronic-degenerative-diseases-a-role-for-antioxidants/oxidative-stress-and-antioxidant-therapy-in-chronic-kidney-and-cardiovascular-disease/
*  The Mortality and Myocardial Effects of Antidepressants Are Moderated by Preexisting Cardiovascular Disease: A Meta-Analysis -...
Norepinephrine-induced human platelet activation in vivo is only partly counteracted by aspirin. Circulation 1994;89:1951-1957 ... Davì G, Patrono C: Platelet activation and atherothrombosis. N Engl J Med 2007;357:2482-2494. External Resources * Pubmed/ ... Heger CD, Collins RN: Platelet activation and "crossover appeal": rab and rho families united by common links to serotonin. Mol ... Bakkaloglu B, Yabanoglu S, Ozyuksel BR, Uaar G, Ertugrul A, Demir B, Ulug B: Platelet and plasma serotonin levels and platelet ...
  https://www.karger.com/Article/Abstract/477940
*  Enhanced Shear-Induced Platelet Aggregation in Patients Who Experience Subacute Stent Thrombosis | JACC: Journal of the...
2001) Uniform platelet activation exists before coronary stent implantation despite aspirin therapy. Am Heart J 142:611-616. ... platelet-rich plasma. SAT. subacute stent thrombosis. SIPA. shear-induced platelet aggregation. vWF. von Willebrand factor. ... The aim of the present study was to assess differences of platelet activation/aggregation in patients with versus without SAT ... The analysis of the inhibitory effect of aspirin/clopidogrel on platelet reactivity to physiological agonists and shear stress ...
  http://www.onlinejacc.org/content/45/11/1753?ijkey=964e7061a00c6aabc81e9bd34ffd678f44820756&keytype2=tf_ipsecsha
*  Search
... along with the finding that aspirin inhibited prostaglandin synthesis and platelet activation. Indeed, finding inhibitors to ... The activation of platelets to arrest bleeding at sites of vascular damage results in platelet adhesion to the vessel wall, ... Activated platelets secrete and synthesize further platelet agonists, inflammatory mediators, and vasoactive substances. ... Platelets are anucleate, discoid cell fragments measuring 1.5 to 3.0 μM in diameter. They are derived from bone-marrow ...
  https://www.cambridge.org/core/search?filters%5BauthorTerms%5D=B.%20O%E2%80%99Donoghue&eventCode=SE-AU
*  Combining Drugs Doesn't Improve Arterial Disease Outcome - Drugs.com MedNews
Aspirin and other drugs such as Plavix prevent the activation of platelets, blood cells that join to form clots. Coumadin ... Anand said she would use aspirin first, in part because it is much less expensive than Plavix. One trial has shown that Plavix ... For the time being, single-drug treatment with a medication that acts against platelets will continue to be the mainstay of PAD ... It was a disappointment, because earlier studies found the combination of the clot-preventing drug, either aspirin or Plavix, ...
  https://www.drugs.com/news/combining-doesn-t-improve-arterial-outcome-8691.html
*  Aspirin Therapy for Heart Attack & Stroke Side Effects & Guidelines
Side effects of aspirin include gastritis, vertigo, tinnitus, abdominal pain, and ulcers. People with an allergy to NSAIDs; ... pregnant woman; women who are breastfeeding; people with ulcers; aspirin allergy, advanced kidney disease; teens or children ... Aspirin therapy is recommended for people between the ages of 50 and 59 to prevent heart attack and stroke according to the ... with the flu or chickenpox, and people at risk for hemorrhage should not use aspirin therapy. ...
  https://www.medicinenet.com/aspirin_and_antiplatelet_medications/article.htm
*  In The News - Life Extension
... aspirin inhibits cancer; vitamin D relieves back pain; and updated disease protocols. ... The research was designed to determine how inhibition of platelet activation through the use of aspirin might affect the ... Aspirin was then added to all three groups.. Results showed that a low aspirin dose stopped platelets from prompting growth and ... Aspirin is an anti-platelet drug, and low doses have been known to reduce the risk of some gastrointestinal cancers by ...
  https://www.lifeextension.com/Magazine/2017/9/In-The-News/Page-01