*  Bevacizumab as a Palliative Treatment for Patients With Symptomatic Malignant Ascites Due to Advanced-stage Gastrointestinal...
Malignant ascites represents a severe clinical problem for physicians and patients being confronted with this common symptom of advanced-stage gastrointestinal cancer. Unfortunately, there is no standardized and evidence-based treatment for malignant ascites and therapies which are commonly being used are only temporarily effective. Newer modes of therapy, such as the application of the tri-functional antibody catumaxomab, are associated with significant side effects and are limited to patients in stages of good overall performance. Therefore, there is still an urgent need for more effective, longer-lasting, and less toxic modes of treatment for peritoneal effusions caused by gastrointestinal cancers.. Preclinical data strongly suggest that bevacizumab might be a very effective agent for the treatment of malignant ascites, which is in large part caused by the hyperpermeability-promoting factor VEGF. Emerging clinical results from cancer patients with ...
  https://clinicaltrials.gov/ct2/show/study/NCT01200121?view=results
*  Bevacizumab as a Palliative Treatment for Patients With Symptomatic Malignant Ascites Due to Advanced-stage Gastrointestinal...
Malignant ascites represents a severe clinical problem for physicians and patients being confronted with this common symptom of advanced-stage gastrointestinal cancer. Unfortunately, there is no standardized and evidence-based treatment for malignant ascites and therapies which are commonly being used are only temporarily effective. Newer modes of therapy, such as the application of the tri-functional antibody catumaxomab, are associated with significant side effects and are limited to patients in stages of good overall performance. Therefore, there is still an urgent need for more effective, longer-lasting, and less toxic modes of treatment for peritoneal effusions caused by gastrointestinal cancers.. Preclinical data strongly suggest that bevacizumab might be a very effective agent for the treatment of malignant ascites, which is in large part caused by the hyperpermeability-promoting factor VEGF. Emerging clinical results from cancer patients with ...
  https://clinicaltrials.gov/show/NCT01200121
*  Percutaneous Radiofrequency Ablation of Hepatocellular Carcinoma against the Diaphragm: Is Artificial Ascites Necessary?
Purpose: To evaluate the utility of artificial ascites induction for radiofrequency ablation (RFA) of peridiaphragmatic hepatocellular carcinoma (HCC) through retrospective cohort analysis comparing characteristics and complications of peridiaphragmatic HCC without the use of artificial ascites to non-peridiaphragmatic HCC. Materials and Methods: IRB approval was obtained. From September 2003 to December 2008, 150 consecutive patients with hepatic tumors received percutaneous RFA. 110 patients had presumed HCC, and of those 21 had lesions abutting the diaphragm. Of the remaining 89 patients with non-peridiaphragmatic HCC lesions, 21 were randomly selected for the comparison group. RFA volume, major and minor complication rates, pain, technical success, and recurrence rates were compared between the two groups. Results: There was no statistical difference in RFA volume (P = 0.962), overall major complication rate (P = 0.343) and minor complication rate (P = 0.118) ...
  http://www.scirp.org/journal/PaperInformation.aspx?paperID=43036
*  National Journal of Integrated Research in Medicine
Background: Differential diagnosis of ascites is a common clinical problem. Less expensive biochemical techniques are required to differentiate ascites with unknown etiology. Aim: To evaluate the diagnostic efficiency of ascitic fluid cholesterol, serum ascites albumin gradient (SAAG) and serum ascites cholesterol gradients (SACG) in differentiating cirrhotic, tuberculous and malignant ascites. Methods: 50 patients (25 with hepatic cirrhosis, 15 with tuberculosis and10 with malignancy) were evaluated for ascitic fluid total protein, albumin, cholesterol, SAAG and SACG. Results: The mean ascitic fluid cholesterol was significantly higher in malignant ascites when compared with cirrhosis and tuberculous ascites (p= 0.0001 each). The difference between tuberculous and cirrhotic ascites was also significant (p= 0.001). The mean value of SAAG was significantly higher in cirrhosis ...
  http://nicpdjournals.com/?mno=10072
*  A) Abdomen X-ray at admission showed moderate ascites | Open-i
(A) Abdomen X-ray at admission showed moderate ascites and mild paralytic ileus. Sengstaken Blakemore tube was inserted in stomach. (B) Follow up chest X-ray at
  https://openi.nlm.nih.gov/detailedresult.php?img=PMC4285008_ic-46-264-g001&req=4
*  Plus it
Ovarian cancer has often spread beyond the ovary to involve the peritoneal cavity at the time of diagnosis (2) and associated with malignant ascites formation (29-31). Debulking surgery followed by i.v. chemotherapy may allow clinical remission of the disease but disease recurrence in the peritoneal cavity is common and will eventually lead to demise of the patient. In the present study, we report that ovarian cancer xenografts growing in SCID mice are inhibited by bevacizumab and rapamycin. Both rapamycin and bevacizumab as a single treatment have a defined effect on the inhibition of tumor growth, tumor cell dissemination, and prolongation of survival. When combined with rapamycin, however, bevacizumab reduces tumor growth by ∼94% and significantly prolongs survival. Indeed, the combination of BEV/RAPA induces a significant decrease in the number of proliferating cells, the mean of Ki-67-positive cells, the mean vessel density, and ascites formation and inhibited tumor ...
  http://mct.aacrjournals.org/content/6/11/2959
*  Catumaxomab - Wikipedia
Catumaxomab (trade name Removab) is a rat-mouse hybrid monoclonal antibody which is used to treat malignant ascites, a condition occurring in people with metastasizing cancer. It binds to antigens CD3 and EpCAM. It is in clinical trials in the United States currently and is used in Europe. It was developed by Fresenius Biotech and Trion Pharma (Germany). The drug is used for the treatment of malignant ascites in people with EpCAM-positive cancer if a standard therapy is not available. Ascites is an accumulation of fluid in the peritoneal cavity. The usual treatment of malignant ascites is to puncture the peritoneum to let the accumulated fluid drain out. After the puncture, catumaxomab is given as an intraperitoneal infusion. The procedure is repeated four times within about eleven days. It has been shown that puncture free survival can be increased from 11 to 46 days with this treatment. Common adverse effects include fever, nausea and ...
  https://en.wikipedia.org/wiki/Catumaxomab
*  Propranolol improves endothelial dysfunction in advanced cirrhosis: the 'endothelial exhaustion' hypothesis | Gut
We read with interest the recent work of Leithead and coworkers about the use of non-selective β-blockers (NSBBs) in patients in the transplant waiting list. They studied 322 patients, among those 117 had refractory ascites and observed higher survival rate in those using NSBB, including the ones with refractory ascites (HR mortality=0.35; confidence interval (CI) 95%: 0.14 to 0.86).1 However, the use of NSBB has been a polemic issue since the hypothesis proposed by Krag and coworkers suggesting the existence of a 'therapeutic window', according to which NSBB would not be beneficial to patients in early or end-stage cirrhosis with refractory ascites, when it would impair the compensatory cardiac output increase, worsening organ perfusion in decompensated cirrhosis.2. Considering current controversies about the use of propranolol (PPL) in advanced cirrhosis, and its possible deleterious effect on haemodynamic and organ perfusion, we have investigated the ...
  http://gut.bmj.com/content/early/2016/03/16/gutjnl-2016-311696
*  Plus it
LPA levels are consistently elevated in the ascites of ovarian cancer patients (41 , 42) and likely contributing to the pathophysiology of ovarian cancer (6) . The mechanisms leading to the elevated levels of LPA in ovarian cancer ascites are not currently clear. Although ovarian cancer cells can release LPA into cell supernatants (11 , 12) , it is not known whether ovarian cancer cells or other cellular components in ascites are the primary source of LPA. Furthermore, it is not known whether the increased levels are because of increased rates of production or decreased rates of degradation. We have demonstrated that the major mechanism of LPA degradation by ovarian cancer cells is through an LPP-like activity (16) .. The LPP family includes at least three members, LPP-1, LPP-2, and LPP-3 isoforms (13 , 38 , 39) . LPP-like properties serve to terminate the receptor-directed signaling functions of LPA and hydrolyze LPA, PA, ceramide 1-phosphate, and ...
  http://clincancerres.aacrjournals.org/content/9/10/3534
*  Phase I Trial of Intraperitoneal Bevacizumab in Refractory Malignant Ascites. - AdisInsight
This study will investigate the efficacy and tolerability of escalated doses of bevacizumab [Avastin] in patients with refractory malignant ascites. The primary
  http://adisinsight.springer.com/trials/700232870?error=cookies_not_supported&code=53f638c1-794d-4298-838a-b4cf97adc257
*  Inhibitors of Neutrophil Chemotaxis in Cirrhotic Ascites | Clinical Science
Thank you for your interest in spreading the word about Clinical Science.. NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address.. ...
  http://www.clinsci.org/content/72/s16/50P.2
*  Quantitative modeling of the physiology of ascites in portal hypertension.
Although the factors involved in cirrhotic ascites have been studied for a century, a number of observations are not understood, including the action of diuretics in the treatment of ascites and the ability of the plasma-ascitic albumin gradient to d
  http://www.biomedsearch.com/nih/Quantitative-modeling-physiology-Ascites-in/22453061.html
*  Serum Ascites Albumin Gradient (SAAG) - MDCalc
The Serum Ascites Albumin Gradient (SAAG) defines presence of portal hypertension (does not differentiate cause) in patients with ascites.
  https://www.mdcalc.com/serum-ascites-albumin-gradient-saag
*  Home Remedies For Ascites Treatment Naturally - Nollywood
Soup produced using steed gram has turned out to be effective in treating ascites. At the point when taken in fitting extents once a day, it demonstrates its impact in a split second. Ascites is not a significant ailment, unless it gets to be not kidding. It can be cured with the home remedies said above. All the fixings are effortlessly accessible. They are not medications, yet are a piece of a healthy eating regimen. At the point when taken in the right extents routinely, these remedies can offer relief from ascites and its connected symptoms. Yet it is likewise vital to stay off things that can bother the circumstances. Liquor is one of the significant reasons for ascites. It ought to be dodged regardless. Utilization of abundance water ought to likewise be dodged, as ought to salt. To stay healthy, at times we have to make presents. In spite of the fact that staying off your most loved sustenance and drink may feel like a discipline, yet ...
  http://nollywoodscene.com/2016/12/14/home-remedies-for-ascites-treatment-naturally/
*  Cardiogenic ascites | Article about cardiogenic ascites by The Free Dictionary
Looking for cardiogenic ascites? Find out information about cardiogenic ascites. An abnormal accumulation of serous fluid in the abdominal cavity Explanation of cardiogenic ascites
  https://encyclopedia2.thefreedictionary.com/cardiogenic+ascites
*  Market Report Store: Ascites Pipeline Review, H1 2012 - Latest Report
Ascites Pipeline Review, H1 2012', provides an overview of the Ascites therapeutic pipeline. This report provides information on the therapeutic development for Ascites, complete with latest updates, and special features on late-stage and discontinued projects. It also reviews key players involved in the therapeutic development for Ascites. 'Ascites - Pipeline Review, H1 2012' is built using data and information sourced from Global Markets Direct's proprietary databases, Company/University websites, SEC filings, investor presentations and featured press releases from company/university sites and industry-specific third party sources, put together by Global Markets Direct's team ...
  http://marketreportstore.blogspot.com/2012/04/ascites-pipeline-review-h1-2012-latest.html
*  Ascites in Chickens
Ascites refers to the accumulation of fluid in the outer surface of the chicken's abdominal (peritoneal) cavity. Mild or early stages of ascites may have no associated clinical signs; however as more fluid accumulates, it will cause chickens to appear bloated with an enlarged or swollen-looking abdomen. The fluid present (ascitic fluid) is usually serous in nature, which is a
  http://www.poultrydvm.com/condition/ascites-syndrome
*  Ascites, CT scan - Stock Image C018/7158 - Science Photo Library
Ascites of the liver. Coloured computed tomography (CT) scan of the abdomen of a patient with ascites, the accumulation of fluid in the peritoneal cavity. This is a result of alcoholic cirrhosis. The liver is at left, the stomach is at centre right and the spleen is at bottom right. Treatment is of the underlying condition, but diuretics and draining the fluid can be used to reduce the ascites. - Stock Image C018/7158
  http://www.sciencephoto.com/media/558820/view
*  ascites or the CA125 test? | Cancer Survivors Network
I had three and a half litres removed from my abdominal cavity in March. I was diagnosed when the surgeons took a fluid sample and they were able to see that there were cancer cells there. Not everyone who has peritoneal cancer has ascites though and the doctor may have seen evidence of inflammation instead. Plus, not everyone who has ascites/abdominal bloating has cancer as ascites can be caused by other conditions. It's hard to know how advanced your girlfriend's cancer is, but I always think it's best to wait to see what the doctors have to say. I know it's easy for me to say, but the imagination is such a powerful thing. I'm wishing your girlfriend well and let us all hope and pray that she has a condition that is helped much more quickly. :) ...
  https://csn.cancer.org/node/224040
*  Ascites Market Review H1, 2016 Growth & Analysis, Forecasts | Healthcare
Before It's News). "Ascites Global Clinical Trials Review, H1, 2016″ provides an overview of Ascites clinical trials scenario. This report provides top line data relating to the clinical trials on Ascites. Report includes an overview of trial numbers and their average enrollment in top countries conducted across the globe. The report offers coverage of disease clinical trials by region, country (G7 & E7), phase, trial status, end points status and sponsor type. Report also provides prominent drugs for in-progress trials (based on number of ongoing trials). GlobalData Clinical Trial Reports are generated using GlobalData's proprietary database - Pharma eTrack Clinical trials database. Clinical trials are collated from 80+ different clinical trial registries, conferences, journals, news etc across the globe. Clinical trials database undergoes periodic update by dynamic process. For more information ...
  http://beforeitsnews.com/healthcare/2016/11/ascites-market-review-h1-2016-growth-analysis-forecasts-2491256.html
*  ascites | pathology | Britannica.com
ascites: Accumulation of fluid in the peritoneal cavity, between the membrane lining the abdominal wall and the membrane covering the abdominal organs. The most common causes of ascites...
  https://www.britannica.com/science/ascites
*  Ascites | Johns Hopkins Medicine Health Library
Ascites is a condition in which fluid collects in spaces within your abdomen. They can be painful and keep you from moving around comfortably. Ascites can set the stage for an infection in your abdomen. Fluid may also move into your chest and surround your lungs. This makes it hard to breathe.
  http://www.hopkinsmedicine.org/healthlibrary/conditions/liver_biliary_and_pancreatic_disorders/ascites_134,79
*  Ascites - Memorial Health System
Ascites is a condition in which fluid collects in spaces within your abdomen. They can be painful and keep you from moving around comfortably. Ascites can set the stage for an infection in your abdomen. Fluid may also move into your chest and surround your lungs. This makes it hard to breathe.
  http://mhsystem.staywellsolutionsonline.com/Library/DiseasesConditions/Adult/Liver/134,79
*  Ascites
... is a condition in which fluid collects in spaces within your abdomen. They can be painful and keep you from moving around comfortably. Ascites can set the stage for an infection in your abdomen. Fluid may also move into your chest and surround your lungs. This makes it hard to breathe.
  http://carefirst.staywellsolutionsonline.com/Library/DiseasesConditions/Adult/Liver/134,79