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*  Patients with rheumatoid arthritis have an altered circulatory aggrecan profile | BMC Musculoskeletal Disorders | Full Text
Aggrecan depletion, mediated by aggrecanases is one of the first signs of early cartilage erosion. We investigated, whether ... is a chronic auto-immune disease with extensive articular cartilage destruction. ... Human articular cartilage. Human articular cartilage was obtained from the orthopaedic surgery unit during knee arthroplasty of ... The articular cartilage was isolated without the adhering subchondral bone. The study was conducted according to the ethical ...
  https://bmcmusculoskeletdisord.biomedcentral.com/articles/10.1186/1471-2474-9-74
*  Advances and Prospects in Stem Cells for Cartilage Regeneration
Articular cartilage and subchondral bone form an inseparable organic cartilage-bone unit; in fact, damage and degeneration of ... Arthroplasty has been used widely in the treatment of late-stage articular cartilage lesions, with replacement usually being of ... 4. Cartilage Injury Mechanisms and Treatment. 4.1. Articular Cartilage. Articular cartilage damage can occur through violent ... articular cartilage are certain to cause subchondral bone destruction [71]. Moreover, the separation of articular cartilage and ...
  https://www.hindawi.com/journals/sci/2017/4130607/
*  How I Treat: Elbow Osteoarthritis - WSAVA2013 - VIN
Grade IV cartilage damage is full thickness loss of cartilage and exposure and, in some cases, eburnation of the subchondral ... Management of articular cartilage lesions is based on the concept that providing blood with mesenchymal stem cell precursors ... Abrasion arthroplasty involves uniform removal of subchondral bone until bleeding is achieved. This can be accomplished in the ... Indications for abrasion arthroplasty or microfracture vary with the size and degree of cartilage loss. In general, lesions ...
  http://www.vin.com/apputil/content/defaultadv1.aspx?pId=11372&meta=Generic&catId=35307&id=5709947&ind=181&objTypeID=17
*  Microfracture technique versus osteochondral autologous transplantation mosaicplasty in patients with articular chondral...
The potential for regeneration of articular cartilage in defects created by chondral shaving and subchondral abrasion. An ... Various cartilage repair techniques have been developed. Resurfacing techniques include abrasion arthroplasty [24], Pridie ... Even though non-significant, all knees that underwent a second cartilage repair procedure (n = 3) or a total knee arthroplasty ... Årøen A, Løken S, Heir S, Alvik E, Ekeland A, Granlund OG, Engebretsen L (2004) Articular cartilage lesions in 993 consecutive ...
  https://link.springer.com/article/10.1007/s00167-014-2843-6
*  Patent US8092530 - Cartilage implants - Google Patents
The articular ends have a convex upper face and a concave lower face. The convex upper face has a first circular pitch radius ... Cartilage implant devices having oval articular ends are provided. ... and abrasion arthroplasty. These procedures generally involve penetrating the region of vascularization in the subchondral bone ... Articular cartilage implants. US8876902. 13 Apr 2012. 4 Nov 2014. Moirai Orthopaedics, Llc. Methods of articular cartilage ...
  http://www.google.com.au/patents/US8092530
*  Chronic Glenohumeral Dislocation: Anterior and Posterior
... due to softening of the humeral head articular cartilage and subchondral bone in the chronic setting. Finally, stability is ... necessitate bone graft reconstruction or if articular cartilage loss necessitates resurfacing with total shoulder arthroplasty ... Extra-articular fixation of the graft with capsulolabral repair can further protect the humeral head articular cartilage from ... either the humeral head articular cartilage has often undergone sufficient degeneration, or the subchondral and metaphyseal ...
  https://www.clinicalpainadvisor.com/shoulder-and-elbow/chronic-glenohumeral-dislocation-anterior-and-posterior/article/626936/
*  Patent US7604641 - System and method for joint resurface repair - Google Patents
An embodiment of the system may include a first element having a positional reference relative to an articular surface. The ... further include a second element capable of indicating the positional reference of the first element relative to said articular ... A system for positioning an element relative to an articular surface. ... This involves using a series of dowel cutting instruments to harvest a plug of articular cartilage and subchondral bone from a ...
  http://www.google.com.au/patents/US7604641
*  Patente US20090228104 - Cartilage implants and methods of use - Google Patentes
The implant devices have circular, or oblong, articular ends. The articular ends have a convex upper face and a concave lower ... Cartilage implant devices, and method of using the same, are provided. ... and abrasion arthroplasty. These procedures generally involve penetrating the region of vascularization in the subchondral bone ... The cartilage implant 100 preferably has an articular end 105 and a stem 130. The articular end 105 may be a disk of uniform ...
  http://www.google.es/patents/US20090228104
*  Microfracture surgery - Wikipedia
... the size and localization of the articular cartilage defect, the surgical technique, e.g., how the subchondral bone plate is ... and can have a significantly shorter recovery time than an arthroplasty (knee replacement). Chronic articular cartilage defects ... a cell based articular cartilage repair procedure that aims to provide complete hyaline repair tissues for articular cartilage ... forcing the patient to reengage in articular cartilage repair. The effectiveness of cartilage growth after microfracture ...
  https://en.wikipedia.org/wiki/Microfracture_surgery
*  Shoulder Osteoarthritis: Diagnosis and Management - American Family Physician
As the joint surface degenerates, the subchondral bone remodels, losing its sphericity and congruity. The joint capsule also ... Osteoarthritis of the shoulder is a gradual wearing of the articular cartilage that leads to pain and stiffness. ... Muskuloskeletal (cartilage imaging). Articular cartilage in the shoulder: correlation of MR arthrography and surgical ... Shoulder arthroplasty with or without resurfacing of the glenoid in patients who have osteoarthritis. J Bone Joint Surg Am. ...
  https://www.aafp.org/afp/2008/0901/p605.html
*  Patent US8080010 - Device and template for canine humeral slide osteotomy - Google Patents
FCP is characterized by fragmentation of the cartilage and subchondral bone on the lateral aspect of the medial coronoid ... These techniques presume that the proximal ulnar articular surface is elevated above the radial articular surface leading to ... Lewis, Evaluation of shelf arthroplasty as a treatment for hip dysplasia in dogs, J Am Vet Med Assoc, 1996, p. 1838-45, vol. ... cartilage degeneration and subchondral bone fragmentation. A joint surface contact study simulating radio-ulnar incongruence ...
  http://www.google.com/patents/US8080010?dq=7,812,828
*  Common Shoulder Disorders in the Dog and Cat - WSAVA2013 - VIN
The subchondral bed is treated by abrasion arthroplasty or curettage to remove necrotic bone or cartilage. Microfracture or ... This is due to thickening of the articular cartilage and deviation of the subchondral bone line. As the disease progresses, a ... The edge of the lesion should also be debrided with a curette so that the cartilage edge is perpendicular to the subchondral ... The tenets of surgical treatment include removal of the cartilage flap and treatment of the subchondral bed. The edges of the ...
  http://www.vin.com/apputil/content/defaultadv1.aspx?pId=11372&catId=35304&id=5709721&ind=131&objTypeID=17
*  Beneficial effect of resveratrol on phenotypic features and activity of osteoarthritic osteoblasts. - Wellness Resources
Osteoarthritis (OA) is a complex disease, which affects multiple tissues, namely the subchondral bone, articular cartilage and ... prepared primary human Ob using the subchondral bone plate of tibial plateaus of OA patients undergoing total knee arthroplasty ... Alterations of the subchondral bone include an increased, yet under mineralized osteoid matrix, abnormal osteoblast cell ... Sirt1 expression and production were reduced in OA subchondral bone tissue compared to normal tissue. RSV upregulated Sirt1 and ...
  https://www.wellnessresources.com/studies/beneficial-effect-of-resveratrol-on-phenotypic-features-and-activity-of-osteoarthritic-osteoblasts
*  The Evolution of Cartilage Restoration | SpringerLink
... cartilage restoration continues to be a highly dynamic field. Not only are the cartilage implants changing, but also the ... Characterization of subchondral bone repair for marrow-stimulated chondral defects and its relationship to articular cartilage ... Long-term results of abrasion arthroplasty for full-thickness cartilage lesions of the medial femoral condyle. Arthroscopy. ... Characterization of subchondral bone repair for marrow-stimulated chondral defects and its relationship to articular cartilage ...
  https://link.springer.com/chapter/10.1007%2F978-3-319-77152-6_1
*  Cartilage repair: A review of Stanmore experience in the treatment of osteochondral defects in the knee with various surgical...
It involves the debridement of damaged articular cartilage down to the underlying subchondral bone-plate whilst preserving a ... Abrasion arthroplasty (Debridement). Cartilage surrounding symptomatic lesions is usually fibrillated and non-functional; hence ... which have been used in the management of articular cartilage injury.. Cartilage injury. Joints are lined with smooth articular ... Mitchell N, Shepard N. The resurfacing of adult rabbit articular cartilage by multiple perforations through the subchondral ...
  http://pubmedcentralcanada.ca/pmcc/articles/PMC2911921/
*  Chondroitin sulphate reduces both cartilage volume loss and bone marrow lesions in knee osteoarthritis patients starting as...
Subchondral bone marrow edema in patients with degeneration of the articular cartilage of the knee joint. Radiology 2006;238: ... Bone marrow edema in the knee in osteoarthrosis and association with total knee arthroplasty within a three-year follow-up. ... Inhibition of articular cartilage degradation by glucosamine-HCl and chondroitin sulphate. Equine Vet J Suppl 2002:224-9. ... CS belongs to the glycosaminoglycans and is a major component of articular cartilage. On OA joint tissues, CS has been shown to ...
  http://ard.bmj.com/content/70/6/982
*  Osteoarthritis: Practice Essentials, Background, Anatomy
... trauma to articular cartilage or subchondral bone). Secondary osteoarthritis can occur in relatively young individuals (see ... Total hip arthroplasty in rapidly destructive osteoarthritis of the hip: a case series. HSS J. 2009 Sep. 5(2):117-9. [Medline] ... The normal articular surface of synovial joints consists of articular cartilage (composed of chondrocytes) surrounded by an ... With advancing age come reductions in cartilage volume, proteoglycan content, cartilage vascularization, and cartilage ...
  https://emedicine.medscape.com/article/330487-overview
*  Rehabilitation following total hip arthroplasty evaluation over short follow-up time: Randomized clinical trial
... subchondral bone sclerosis, and osteophyte formation in the articular borders, OA leads to clinical signs of pain, stiffness, ... Characterized by focal degeneration in joint cartilage, microfractures, cysts, ... total hip arthroplasty, THAP = total hip arthroplasty protocol, THAPCP = total hip arthroplasty physiotherapy care protocol. ... A relationship between stem orientation and function following total hip arthroplasty. J Arthroplasty. 1991;6(3):229-35.. [PMID ...
  https://www.rehab.research.va.gov/jour/2014/5110/jrrd-2014-05-0132.html
*  Wetenschappelijk onderzoek - Foliumzuur waarschuwing
... altering the tissue homeostasis of articular cartilage and subchondral bone, determine the predominance of destructive over ... seen in aging exhibit molecular changes in matrix turnover similar to those seen in OA articular cartilage at arthroplasty, but ... Effects of shear stress on articular chondrocyte metabolism. The articular cartilage of diarthrodial joints experiences a ... The pathobiology of focal lesion development in aging human articular cartilage and molecular matrix changes characteristic of ...
  https://pilliewillie.nl/bot-en-gewrichtsaandoeningen/artrose/wetenschappelijk-onderzoek/
*  Application # 2016/0175479. COMPOSITE MATERIAL FOR TISSUE REPAIR - Patents.com
... including defects in cartilage. The biocompatible composite includes a fibrous polymeric ... 0006] Treatment options for cartilage defects include debridement, shaving and abrasion arthroplasty, subchondral drilling, ... 0097] Preparation of Articular Cartilage. Articular cartilage blocks (9.times.5.times.2 mm.sup.3) are harvested from knees (the ... The tensile modulus of articular cartilage may be from about 1 to about 8 MPa, while the tensile modulus of cartilage in the ...
  http://patents.com/us-20160175479.html
*  US8920499B2 - Method of use of trochlear implants - Google Patents
The articular end has an upper surface, a side surface, and a lower surface. The upper surface and lower surface each intersect ... The stem extends from the lower surface in a direction away from the upper surface of the articular end. ... The implant devices of the methods herein have an articular end and a stem, the stem having an oval-shaped cross-section. ... c) forming a cavity in the articular cartilage, subchondral bone, and cancellous bone; and ...
  https://patents.google.com/patent/US8920499B2/en
*  Upper limb trauma - shoulder and humerus Flashcards by Ethan Fraser | Brainscape
Shear fracture of articular cartilage. - Articular cartilage separation with very little subchondral bone attached Type III ( ... 1. Radial Head Arthroplasty a. Indications b. Outcomes 2. Retrograde titanium nail reduction and stabilization. a. Indications ... 2. Vascularity of articular segment is more likely to be preserved if ≥ _______ is attached to articular segment 3. The 3 most ... Type II: Articular incongruity - Type III: Articular surface malalignment >45° in the coronal, sagittal, or axial planes ...
  https://www.brainscape.com/flashcards/upper-limb-trauma-shoulder-and-humerus-7059211/packs/11322073
*  US20070219638A1 - Prosthetic glenoid component - Google Patents
Articular cartilage varies from 2-4 mm in thickness in the large joints of adults. [Unsworth, A., Roberts, B., and Thompson, J ... Glenoid arthroplasty and offset reamers US9814588B2 (en) 2015-08-10. 2017-11-14. Catalyst Orthoscience Inc.. Glenoid ... Compliant layer technology also provides a medium through which loads are distributed more evenly across the subchondral layer ... In contrast the soft articular cartilage of the natural joint promotes fluid film lubrication and almost zero wear throughout ...
  https://patents.google.com/patent/US20070219638
*  Current Perspectives in Mesenchymal Stem Cell Therapies for Osteoarthritis
M. B. Goldring and S. R. Goldring, "Articular cartilage and subchondral bone in the pathogenesis of osteoarthritis," Annals of ... The lack of successful conventional treatments often leads to arthroplasty in end-stage OA patients. Total knee arthroplasty is ... Figure 2: Three different ways in which MSCs can be recruited for articular cartilage repair. (a) Direct intra-articular ... R. Kuroda, K. Ishida, T. Matsumoto et al., "Treatment of a full-thickness articular cartilage defect in the femoral condyle of ...
  https://www.hindawi.com/journals/sci/2014/194318/
*  How To Treat Hallux Rigidus In Runners | Podiatry Today
One should perform subchondral drilling on all cartilage defects whether the surgeon opts for osteotomy or a simple cheilectomy ... This means that the internal structure of the joint (i.e. the articular cartilage) is subjected to a 10-fold increase of stress ... A modification of this involves a Valenti arthroplasty, which is a V-shaped resection of the dorsal half of the head of the ... Surgeons may restore articular cartilage via stimulation of local chondrogenic source, transplant autograft tissue. One may ...
  https://www.podiatrytoday.com/how-to-treat-hallux-rigidus-in-runners?page=4