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*  Gynecomastia - Wikipedia
Testicular tumors such as Leydig cell tumors or Sertoli cell tumors (such as in Peutz-Jeghers syndrome) or hCG-secreting ... A few cases of gynecomastia caused by the rare disorders aromatase excess syndrome and Peutz-Jeghers syndrome have responded to ... Fukami, M; Miyado, M; Nagasaki, K; Shozu, M; Ogata, T (March 2014). "Aromatase excess syndrome: a rare autosomal dominant ... found to be effective in rare cases of gynecomastia from disorders such as aromatase excess syndrome or Peutz-Jeghers syndrome ...
  https://en.wikipedia.org/wiki/Gynecomastia
*  NW Newborn Clinical Guideline - Initial Assessment and Investigation of Ambiguous Genitalia
A uterus almost always indicates no functioning testes are present while no uterus indicates functioning Sertoli cells and ... Androgen excess *Fetal (e.g.: 21-Hydroxylase deficiency (1:15,000 births), 11β-Hydroxylase deficiency ... Disorders of AMH and AMH receptor (persistent mullerian duct syndrome). *Other (e.g.: severe hypospadias, cloacal extrophy) ... Fetoplacental (e.g.: aromatase deficiency). *Maternal (e.g.: luteoma, exogenous) *Structural/idiopathic ...
  http://www.adhb.govt.nz/newborn/Guidelines/Endocrine/AmbiguousGenitalia.htm
*  Endocrinology - Reproductive Endocrinology Flashcards by Josh Davies | Brainscape
Sertoli cell, germ cell, and granulosa cell), choriocarcinomas, and adrenal tumors. Male breast cancer is an uncommon cause.. 3 ... Various syndromes, such as Kallmann syndrome, Laurence-Moon-Bardet-Biedl syndrome, and Prader-Willi syndrome are also ... Androgen excess (due to adrenal tumors, PCOS, tumors with high human choriogonadotropin, and congenital adrenal hyperplasia). ... 4) Increased activity of enzyme that catalyzes estrogen production (aromatase) that is found in obesity, hyperthyroidism, and ...
  https://www.brainscape.com/flashcards/endocrinology-reproductive-endocrinology-5678820/packs/7933764
*  Revistas
Cross-Ethnic Meta-Analysis of Genetic Variants for Polycystic Ovary Syndrome. *Genomic Basis of Aromatase Excess Syndrome: ... Loss of heterozygosity of STK11, measured by the absence of LKB1 immunofluorescence, was observed in Sertoli cells of abnormal ... Genomic Basis of Aromatase Excess Syndrome: Recombination- and Replication-Mediated Rearrangements Leading to CYP19A1 ... Genomic rearrangements at 15q21 have been shown to cause overexpression of CYP19A1 and resultant aromatase excess syndrome ( ...
  http://www.webpediatrica.com/endocrinoped/detalle_revista.php?tipo=endocrino&n_revista=0&n_noticia=1
*  Sex hormone binding globulin | definition of Sex hormone binding globulin by Medical dictionary
... and increased aromatase activity contributing to relative estrogen excess.. Androgen deficiency, diabetes, and the metabolic ... Estrogen and androgen regulation of sex hormone binding globulin secretion by a human liver cell line.. Sex hormone-binding ... Late-onset hypogonadism in male patients over 60 years of age with metabolic syndrome / Altmis Yas Ustu Metabolik Sendromlu ... Conversely, diabetes and the metabolic syndrome can be risk factors for hypogonadism through some similar but mostly distinct ...
  http://medical-dictionary.thefreedictionary.com/Sex+hormone+binding+globulin
*  1P - Pathology of Male Repro Tract Flashcards - Cram.com
2) Sertoli cells respond to FSH and are support cells for maturation of spermatogonia.. 3) Also secretes inhibin, a feedback ... What is Kallman's syndrome? Migration problems of GnRH neurons from olfactory placode.. Patients have difficulty smelling.. ... Do ANDROGEN or ESTROGEN excess cause problems with testicular development? YES! Estrogen negatively feedbacks at Anterior ... Can be converted to estradiol via aromatase (c19 --, c18) What do Sertoli cells do? ...
  http://www.cram.com/flashcards/1p-pathology-of-male-repro-tract-466106
*  Hypogonadism and Testosterone Treatment
... an important product of Sertoli cells in the seminiferous tubules. A careful history and physical examination can provide clues ... Wikström, AM, Dunkel, L. "Klinefelter syndrome". Best Pract Res Clin Endocrinol Metab. vol. 25. 2011. pp. 239-250. ... or evidence of other pituitary hormone loss or excess, especially if there is no obvious cause (e.g., morbid obesity, common ... or to estradiol by aromatase (e.g., bone, adipose tissue, brain). ... Klinefelter syndrome (XXY karyotype, most common cause of ...
  https://www.neurologyadvisor.com/hospital-medicine/hypogonadism-and-testosterone-treatment/article/605199/
*  Androgen insensitivity syndrome - Wikipedia
"Incidental detection of Sertoli-Leydig cell tumor by FDG PET/CT imaging in a patient with androgen insensitivity syndrome". Ann ... 20 lyase deficiency 17β-hydroxysteroid dehydrogenase deficiency 5α-reductase deficiency Androgen excess in 46,XX individuals: ... 11β-hydroxylase deficiency Aromatase deficiency Glucocorticoid receptor mutations Maternal virilizing tumor (e.g. luteoma) ... and Goldberg-Maxwell syndrome; PAIS includes Reifenstein syndrome, Gilbert-Dreyfus syndrome, Lub's syndrome, "incomplete ...
  https://en.wikipedia.org/wiki/Androgen_insensitivity_syndrome
*  Most recent papers with the keyword CYP17A1 | Read by QxMD
Leydig cell dysfunction is associated with post-transcriptional deregulation of CYP17A1 in men with Sertoli cell-only syndrome. ... Although its etiology is unknown, excess androgens are thought to be a critical factor driving the pathology of PCOS. We ... previously demonstrated that continuous exposure to the aromatase inhibitor letrozole (LET) in mice produces many hallmarks of ... cell-dysfunction-is-associated-with-post-transcriptional-deregulation-of-cyp17a1-in-men-with-sertoli-cell-only-syndrome ...
  https://www.readbyqxmd.com/keyword/119416
*  Estrogen - Wikipedia
... such as estrogen insensitivity syndrome, aromatase deficiency, and aromatase excess syndrome. ... Note that in males, estrogen is also produced by the Sertoli cells when FSH binds to their FSH receptors. ... whereas theca cells express these enzymes and 17β-HSD but lack aromatase. Hence, both granulosa and theca cells are essential ... doi:10.1016/j.cell.2009.07.036. PMC 2851224. PMID 19804754.. *^ Rochira V, Carani C (October 2009). "Aromatase deficiency in ...
  https://en.wikipedia.org/wiki/Oestrogen
*  Role of Orphan Nuclear Receptor DAX-1/NR0B1 in Development, Physiology, and Disease
In the adult gonads, Dax-1 is expressed in Leydig and Sertoli cells in the testis and in granulosa and theca cells in the ovary ... Z. J. Wang, B. Jeffs, M. Ito et al., "Aromatase (Cyp19) expression is up-regulated by targeted disruption of Dax1," Proceedings ... L. M. Ludbrook, P. Bernard, S. Bagheri-Fam et al., "Excess DAX1 leads to XY ovotesticular disorder of sex development (DSD) in ... AHC is a hereditary disease of the adrenal cortex, which in the majority of cases manifests as a syndrome of adrenal ...
  https://www.hindawi.com/journals/ab/2014/582749/
*  Gynecomastia: What Causes Man Boobs
Leydig/Sertoli cell tumors, or hCG-secreting choriocarcinoma.. Tumors that arise in other glands and are involved in disturbing ... In contrast, excess consumption of foods containing estrogen-like substances known as phytoestrogens may also cause ... Gynecomastia is also a feature of Klinefelter Syndrome, a genetic disorder caused by an extra X chromosome. These individuals ... Medicine for gynecomastia includes aromatase inhibitors that include testolactone and selective estrogen receptor modulators ...
  http://guidetomanboobs.com/gynecomastia-etiology-man-boobs/
*  Congenital adrenal hyperplasia due to 21-hydroxylase deficiency - Wikipedia
2007). "Testicular adrenal rest tumors and Leydig and Sertoli cell function in boys with classical congenital adrenal ... This conversion is mediated by aromatase and can be inhibited by aromatase blockers such as testolactone. Blocking the effects ... The androgen excess is mild enough that virilization is not apparent or goes unrecognized at birth and in early childhood. ... These clinical features, of course, are those of polycystic ovary syndrome, and a small percentage of women with Polycystic ...
  https://en.wikipedia.org/wiki/Congenital_adrenal_hyperplasia_due_to_21-hydroxylase_deficiency
*  Potential role of orexin A binding the receptor 1 for orexins in normal and cryptorchid dogs | BMC Veterinary Research | Full...
Sertoli cells and gonocytes in the cryptic gonad. In the normal testis, OX1R-IR was described in Leydig cells, in pachytene and ... In the cryptic testis OX1R-IR was distributed in Leydig and Sertoli cells. The presence of prepro-orexin and OX1R was ... OxA-immunoreactivity (IR) was described in interstitial Leydig cells of the normal gonad, and Leydig, ... Germ cells of the mouse testis express P450 aromatase. Endocrinology. 1993;132(3):1396-401.View ArticlePubMedGoogle Scholar. ...
  https://bmcvetres.biomedcentral.com/articles/10.1186/s12917-018-1375-6
*  Ovarian Cancer - Germ Cell and Stromal Cancers
Secondary surgical debulking is often utilized in the setting of recurrent granulosa cell and Sertoli-Leydig cell tumors. ... such as Turner's syndrome (karyotype 45, XO), Klinefelter's syndrome (karyotype 47, XXY), and Swyer's syndrome (karyotype 46, ... These tumors are hormonally active, therefore use of agents such as anastrazole (an aromatase inhibitor), GnRH agonists, megace ... Patients can also present with stigmata of hormonal excess. Patients with embryonal carcinoma, nongestational choriocarcinoma, ...
  https://www.infectiousdiseaseadvisor.com/obstetrics-and-gynecology/ovarian-cancer--germ-cell-and-stromal-cancers/article/617785/
*  US Patent # 8,168,658. Inhibitors of histone deacetylase - Patents.com
... granulosa-thecal cell tumors, Sertoli-Leydig cell tumors, dysgerminoma, malignant teratoma), vulva (squamous cell carcinoma, ... the neoplastic cell is unable to complete differentiation and leads to excess proliferation of the leukemic cell line. U.S. Pat ... Syndrome of central autonomic nervous system failure (Shy-Drager syndrome). VI. Syndromes of muscular weakness and wasting ... agonist, an inhibitor of cell proliferation and survival signaling, a bisphosphonate, an aromatase inhibitor, an siRNA ...
  http://patents.com/us-8168658.html
*  Hormones Primer - Hormone Correction
Excesses. The most common disease of GH excess is a pituitary tumor composed of somatotroph cells of the anterior pituitary. ... Estradiol is produced in the Sertoli cells of the testes. There is evidence that estradiol is to prevent apoptosis of male ... Hyperthyroidism (an example is Graves Disease) is the clinical syndrome caused by an excess of circulating free thyroxine, free ... the enzyme aromatase converts testosterone into estradiol that is responsible for masculinization of the brain in a male mice. ...
  http://hormonecorrection.com/hormones/hormones-primer/
*  First Pass Miss Exam 3 Flashcards by Matthew Miller | Brainscape
Aromatase -> they can make estrogens. Both cell types make progesterone, progesterones are transferred to theca cells to become ... Androgen binding protein - used by Sertoli cells to keep T concentrations high in the lumen. Sex hormone binding globulin - ... Elevated GnRH levels due to primary gonadal failure, as in gonadal dygenesis of Turner syndrome (deletion or rearrangement of X ... Cushing's: ACTH excess - slight overproduction of aldosterone -> hypertension + hypokalemia. Addison's: ACTH deficiency - ...
  https://www.brainscape.com/flashcards/first-pass-miss-exam-3-5760970/packs/8410892
*  Pesticide-Induced Diseases: Sexual and Reproductive Dysfunction - Beyond Pesticides
The Sertoli cells provide the physical and nutritional support for the spermatogenic cells. Over 400 genes were differentially ... Some common pathologies associated with aromatase disruption include breast cancer, prostate cancer, polycystic ovary syndrome ... Except for an excess of Attention Deficit Hyperactivity Disorder - ADHD (OR = 3.6, 1.3-9.6) among children born to glyphosate ... Roundup disrupts male reproductive functions by triggering calcium-mediated cell death in rat testis and Sertoli cells.. The ...
  https://beyondpesticides.org/resources/pesticide-induced-diseases-database/sexual-and-reproductive-dysfunction
*  List of syndromes - Wikipedia
... mineralocorticoid excess syndrome Arakawa's syndrome II Ardalan-Shoja-Kiuru syndrome AREDYLD syndrome Aromatase excess syndrome ... Sertoli cell-only syndrome Serum sickness-like reaction Setleis syndrome Severe acute respiratory syndrome Shaken baby syndrome ... syndrome Wende-Bauckus syndrome Werner syndrome Wernicke-Korsakoff syndrome West syndrome Westerhof syndrome Wet lung syndrome ... syndrome Levator ani syndrome Leydig cell hypoplasia Liddle's syndrome Liebenberg syndrome LIG4 syndrome Lima syndrome Limb ...
  https://en.wikipedia.org/wiki/List_of_syndromes
*  Endocrine/Repro Flashcards - Cram.com
LH stim theca to produce testosterone, goes to granulosa cells for aromatase to convert to 17beta estradiol (2nd stp stim by ... FSH act on Sertoli maintain spermatogenesis), also makes inhibin which inhib FSH sxn ... GH excess would do what to glucose levels glucose intolerance bc GH prevents glu uptake by cells ... the primordial germ cell arrives in the ovary at 4wk and difft into oogonia (46,2N). enter meiosis I to form 1 oocytes (46, 4N ...
  http://www.cram.com/flashcards/endocrinerepro-290465
*  How to Reverse Testicular Atrophy - Mitch Medical Healthcare
1997). Aromatase activity is present in Sertoli cells but has also been found in germ cells (spermatocytes, spermatids and ... clinical features depend on the predominant excess steroid production glucocorticoid-secreting tumors cause Cushing's syndrome ... In the testis, germ cells but not somatic cells are vulnerable to heat stress. In response to heat stress, germ cells undergo ... Normal prostate cells are also hormone sensitive and also shrink in response to hormone therapy. Prostate cancer cells that are ...
  https://www.mitchmedical.us/testicular-atrophy.html
*  DNA Demethylation and USF Regulate the Meiosis-Specific Expression of the Mouse | proLékaře.cz
KATNAL1 Regulation of Sertoli Cell Microtubule Dynamics Is Essential for Spermiogenesis and Male Fertility ... However, the addition of 50-excess or 100-excess of unlabelled methylated oligo DNA or E2 mutant did not affect the complex ... Následující článek A Duplication CNV That Conveys Traits Reciprocal to Metabolic Syndrome and Protects against Diet-Induced ... JiangBMendelsonCR 2005 O2 enhancement of human trophoblast differentiation and hCYP19 (aromatase) gene expression are mediated ...
  https://www.prolekare.cz/casopisy/plos-genetics/2012-5/dna-demethylation-and-usf-regulate-the-meiosis-specific-expression-of-the-mouse-42975
*  28. Endocrine Disorder 부산백병원 산부인과 R4 서 영 진. - ppt download
... result of androgen excess → abnormalities of ovary, adrenal gland : increase expression of androgen effect Virilization : rare ... between granulosa cell tumor and Sertoli cell tumor : with Peutz-jeghers syndrome - bilateral & benign without Peutz-jeghers ... 1. 5α-reductase in skin determines the presence or absence of hirsutism 2. fat cell: aromatase & 17β-HSD activity ↑ 3. with ... Polycystic Ovarian Syndrome (PCOS) is a disorder that causes menstrual and ovulation irregularities, androgen excess, and ...
  http://slideplayer.com/slide/6239836/
*  Free Medical Flashcards about biochem test 2 2011
Leydig cells do what?. produce testosterone from androstenedione, then send it to the sertoli cells (testicle)Stimulated by LH ... Granulosa cells=estrogens. Corpus Luteum=progesterone. These are regulated by FSH via aromatase. ... DiGeorge's syndrome is associated with a partial or complete lack of what organ?. Thymus, presents early with infections ... How is ketoacidosis conected to the high NADH from excess alcohol consumption?. (malnourished, fasted, esp) high NADH decreases ...
  https://www.studystack.com/flashcard-674385