*  Tanneberger K et al. (2011), Structural and functional characterization of t... - Xenbase Paper
We show here that Amer1 directly interacts with the armadillo repeats of β-catenin via a domain consisting of repeated arginine ... and that Amer1 assembles the β-catenin destruction complex at the plasma membrane by recruiting β-catenin, adenomatous ... data suggest that Amer1 exerts its negative regulatory role in Wnt signaling by acting as a scaffold protein for the β-catenin ... binds to the tumor suppressor adenomatous polyposis coli and acts as an inhibitor of Wnt signaling by inducing β-catenin ...
  http://www.xenbase.org/literature/article.do?method=display&articleId=43661
*  RCSB PDB - 1M1E: Beta-catenin armadillo repeat domain bound to ICAT Structure Summary Page
ICAT inhibits Beta-catenin binding to Tcf/Lef-family transcription factors and the general coactivator p300 using independent ... Beta-catenin A 538 Mus musculus Fragment: Armadillo Repeat Region (RESIDUES 134-671) Gene Name(s): Ctnnb1 Catnb ... Beta-catenin armadillo repeat domain bound to ICAT. *DOI: 10.2210/pdb1m1e/pdb ...
  http://www.rcsb.org/pdb/explore/explore.do?structureId=1m1e
*  1m1e - Proteopedia, life in 3D
The C-terminal armadillo repeats of beta-catenin may be an attractive target for compounds designed to disrupt aberrant beta- ... The crystal structure of ICAT, an inhibitor of beta-catenin-mediated transcription, bound to the armadillo repeat domain of ... Categories: Human , Lk3 transgenic mice , Daniels, D L , Weis, W I , Armadillo repeat , Cell adhesion , Cytoskeleton , ... Catenin References *↑ Daniels DL, Weis WI. ICAT inhibits beta-catenin binding to Tcf/Lef-family transcription factors and the ...
  http://proteopedia.org/wiki/index.php/1m1e
*  armadillo repeat - oi
... originally described in the Drosophila β-catenin family protein armadillo. The armadillo repeat-containing proteins can be ... armadillo repeat' can also refer to... armadillo repeat C-terminal armadillo repeats are essential and sufficient for ... and the dispersion of the repeats throughout their sequences. Armadillo repeat proteins include catenins and plakophilins. ... The ARM Domain of ARMADILLO-REPEAT KINESIN 1 is Not Required for Microtubule Catastrophe But Can Negatively Regulate NIMA- ...
  http://oxfordindex.oup.com/view/10.1093/oi/authority.20110803095424222
*  β-Catenin signaling is required for neural differentiation of embryonic stem cells | Development
... β-catenin ΔC, last 113 amino acids truncated; andβ -catenin ΔArmadillo, armadillo repeats deleted (Fig. 4). Cells were ... I-L) Cells transfected with β-catenin ΔC. (M-P) Cells transfected withβ -catenin ΔN. The armadillo domain of β-catenin, but not ... The armadillo domain mediates neurogenesis promoted by β-catenin and RA acts synergistically to enhance β-catenin-mediated ... β-catenin ΔN induced a greater proportion of neurons than β-catenin ΔC did. Treatment with RA, along with either β-catenin ΔC ...
  http://dev.biologists.org/content/131/15/3545
*  Catenin - Wikipedia
α-catenin β-catenin δ-catenin γ-catenin All but α-catenin contain armadillo repeats. Several types of catenins work with N- ... The first two catenins that were identified became known as α-catenin and β-catenin. A-catenin can bind to β-catenin and can ... B-catenin binds the cytoplasmic domain of some cadherins. Additional catenins such as γ-catenin and δ-catenin have been ... Most studies investigating catenin actions focus on α-catenin and β-catenin. β-catenin is particularly interesting as it plays ...
  https://en.wikipedia.org/wiki/Catenin
*  Beta-catenin (IPR013284) | InterPro | EMBL-EBI
Three-dimensional structure of the armadillo repeat region of beta-catenin.. Cell 90 871-82 1997 ... Three-dimensional structure of the armadillo repeat region of beta-catenin.. Cell 90 871-82 1997 ... Three-dimensional structure of the armadillo repeat region of beta-catenin.. Cell 90 871-82 1997 ... Three-dimensional structure of the armadillo repeat region of beta-catenin.. Cell 90 871-82 1997 ...
  http://www.ebi.ac.uk/interpro/entry/IPR013284
*  Plus it
2002) Densin-180 interacts with delta-catenin/neural plakophilin-related armadillo repeat protein at synapses. J Biol Chem 277: ... 1999) Interaction of S-SCAM with neural plakophilin-related Armadillo-repeat protein/delta-catenin. Biochem Biophys Res Commun ... A novel multiple PSD-95/Dlg-A/ZO-1 protein interacting with neural plakophilin-related armadillo repeat protein/delta-catenin ... The NPRAP mutant that lacked all the Armadillo repeats (HA-NPRAPΔARM), HA-NPRAPΔ3, which lacks the PDZ binding motif consisting ...
  http://www.jneurosci.org/content/27/32/8505
*  IJMS | Free Full-Text | Aptamers and Their Potential to Selectively Target Aspects of EGF, Wnt/β-Catenin and TGFβ-Smad Family...
We then discuss the opportunities for using aptamers in other complex pathways, including Wnt/β-catenin, and focus on ... named Armadillo repeats) present within β-catenin. These 12 repeats form a highly closed "superhelix" that, together with the ... Huber, A.H.; Nelson, W.J.; Weis, W.I. Three-dimensional structure of the armadillo repeat region of beta-catenin. Cell 1997, 90 ... and with β-catenin. Axin coordinates the initial phosphorylation of β-catenin at Ser45 by CK1α and, subsequently, at Thr41, ...
  http://mdpi.com/1422-0067/14/4/6690/htm
*  Gene Report for G00001803 - Genes2Cognition Neuroscience Research Programme
Interaction of S-SCAM with neural plakophilin-related Armadillo-repeat protein/delta-catenin.. Ide N, Hata Y, Deguchi M, Hirao ... delta-catenin/NPRAP, a member of the armadillo repeat family, is a nervous system-specific adherens junction protein originally ... delta-catenin is a mammalian brain protein in the Armadillo repeat superfamily with sequence similarity to the adherens ... Delta-catenin/NPRAP (neural plakophilin-related armadillo repeat protein) interacts with and activates sphingosine kinase 1.. ...
  http://www.genes2cognition.org/db/Gene/G00001803
*  UniProt: Q02248
"Three-dimensional structure of the armadillo repeat region of beta- RT catenin."; RL Cell 90:871-882(1997). RN [33] RP X-RAY ... FT REPEAT 151 191 ARM 1. FT REPEAT 193 234 ARM 2. FT REPEAT 235 276 ARM 3. FT REPEAT 277 318 ARM 4. FT REPEAT 319 360 ARM 5. FT ... REPEAT 361 389 ARM 6. FT REPEAT 400 441 ARM 7. FT REPEAT 442 484 ARM 8. FT REPEAT 489 530 ARM 9. FT REPEAT 531 571 ARM 10. FT ... "p120 Catenin-associated Fer and Fyn tyrosine kinases regulate beta- RT catenin Tyr-142 phosphorylation and beta-catenin-alpha- ...
  http://www.genome.jp/dbget-bin/www_bget?uniprot:Q02248
*  AXIN2 Gene - GeneCards | AXIN2 Protein | AXIN2 Antibody
The interaction between axin and beta-catenin occurs via the armadillo repeats contained in beta-catenin (By similarity). ... Down-regulates beta-catenin. Probably facilitate the phosphorylation of beta-catenin and APC by GSK3B (By similarity). *AXIN2_ ... Down-regulates beta-catenin. Probably facilitate the phosphorylation of beta-catenin and APC by GSK3B (By similarity). ... which leads to the degradation of beta-catenin. Apparently, the deregulation of beta-catenin is an important event in the ...
  http://www.genecards.org/cgi-bin/carddisp.pl?gene=AXIN2
*  Armadillo repeat - Wikipedia
The term armadillo derives from the historical name of the β-catenin gene in the fruitfly Drosophila where the armadillo repeat ... Proteins that contain armadillo repeats typically contain several tandemly repeated copies. Each armadillo repeat is composed ... The 3-dimensional fold of an armadillo repeat was first observed in the crystal structure of beta-catenin, where the 12 repeats ... Huber AH, Nelson WJ, Weis WI (September 1997). "Three-dimensional structure of the armadillo repeat region of beta-catenin". ...
  https://en.wikipedia.org/wiki/Armadillo_repeat
*  Formation of extra centrosomal structures is dependent on β-catenin | Journal of Cell Science
The β-catenin armadillo repeat domain (ARM) is necessary and sufficient for localization of β-catenin to centrosomes (Bahmanyar ... Schematic representation of β-catenin protein. N-terminal (NT) and C-terminal (CT) domains and the 12 central armadillo repeats ... GFP-β-catenin in pEGFP-C1, GFP-β-catenin without the ARM domain (GFP-ΔARM; Elul et al., 2003), β-catenin-engrailed chimera (ENG ... The total amount of β-catenin in the β-cat* stable lines was higher than that of wild-type β-catenin in parental cells (Fig. 1B ...
  http://jcs.biologists.org/content/123/18/3125
*  Vinculin regulates cell-surface E-cadherin expression by binding to β-catenin | Journal of Cell Science
... β-catenin is comprised of a central armadillo repeat and flexible N- and C-termini. Previous studies suggested that α-catenin ... GST FL β-catenin) or mutant β-catenin (GST FL β-catenin M8P). Purified GST FL β-catenin or GST FL β-catenin M8P attached to the ... β-catenin binding is required for vinculin effects on E-cadherin. Like α-catenin, β-catenin has been identified as a ligand of ... Substitution of A50I blocks β-catenin binding to vinculin, but not α-catenin. (A) In vitro binding analysis of α-catenin ...
  http://jcs.biologists.org/content/123/4/567
*  MAGI2 - Wikipedia
1999). "Interaction of S-SCAM with neural plakophilin-related Armadillo-repeat protein/delta-catenin". Biochem. Biophys. Res. ... The protein encoded by this gene interacts with atrophin-1. Atrophin-1 contains a polyglutamine repeat, expansion of which is ... 2002). "Interaction of synaptic scaffolding molecule and Beta -catenin". J. Neurosci. 22 (3): 757-65. PMID 11826105. Nakayama M ...
  https://en.wikipedia.org/wiki/MAGI2
*  p120-catenin is essential for terminal end bud function and mammary morphogenesis | Development
... p120-catenin (hereafter p120) and β-catenin are armadillo repeat domain proteins that bind directly to distinct regions of the ... catenin connects the cadherins physically and/or functionally to the actin cytoskeleton through a mechanism involving α-catenin ... 1999). The catenin p120(ctn) interacts with Kaiso, a novel BTB/POZ domain zinc finger transcription factor. Mol. Cell. Biol. 19 ... 2010). p120-catenin is essential for maintenance of barrier function and intestinal homeostasis in mice. J. Clin. Invest. 120, ...
  http://dev.biologists.org/content/139/10/1754
*  SMART: ARM domain annotation
In plakoglobin arm repeats bind alpha-catenin and N-cadherin.. Interpro abstract (IPR000225):. The armadillo (Arm) repeat is an ... Crystal Structure of a Full-Length Zebrafish Beta-Catenin. 2z6h. Crystal Structure of Beta-Catenin Armadillo Repeat Region and ... CRYSTAL STRUCTURE OF THE XTCF3-CBD/BETA-CATENIN ARMADILLO REPEAT COMPLEX. 1i7w. BETA-CATENIN/PHOSPHORYLATED E-CADHERIN COMPLEX ... The 3-dimensional fold of an armadillo repeat is known from the crystal structure of beta-catenin, where the 12 repeats form a ...
  http://smart.embl-heidelberg.de/smart/do_annotation.pl?BLAST=dummy&DOMAIN=ARM
*  Deepak Gaur - Wikipedia
"Evidence for the Nucleo-Apical Shuttling of a Beta-Catenin Like Plasmodium falciparum Armadillo Repeat Containing Protein". ...
  https://en.wikipedia.org/wiki/Deepak_Gaur
*  LRRC7 - Wikipedia
"Densin-180 interacts with delta-catenin/neural plakophilin-related armadillo repeat protein at synapses". J. Biol. Chem. United ... "Densin-180 interacts with delta-catenin/neural plakophilin-related armadillo repeat protein at synapses". J. Biol. Chem. 277 (7 ... beta-Catenin, delta-Catenins and NCadherin (via the Catenins). The nature and function of these interactions, detailed in ... Leucine rich repeat containing 7 also known as LRRC7, Densin-180, or LAP1 is a protein which in humans is encoded by the LRRC7 ...
  https://en.wikipedia.org/wiki/LRRC7
*  Plakoglobin - Wikipedia
Plakoglobin is highly homologous to β-catenin; both have 12 armadillo repeats as well as N-terminal and C-terminal globular ... Ozawa M, Terada H, Pedraza C (Nov 1995). "The fourth armadillo repeat of plakoglobin (gamma-catenin) is required for its high ... Plakoglobin is a member of the catenin family, since it contains a distinct repeating amino acid motif called the armadillo ... "Identification of the domain of alpha-catenin involved in its association with beta-catenin and plakoglobin (gamma-catenin)". ...
  https://en.wikipedia.org/wiki/Plakoglobin
*  CDH2 - Wikipedia
"Densin-180 interacts with delta-catenin/neural plakophilin-related armadillo repeat protein at synapses". J. Biol. Chem. 277 (7 ... N-cadherins interact with catenins to play an important role in learning and memory (For full article see Cadherin-catenin ... Wahl JK, Kim YJ, Cullen JM, Johnson KR, Wheelock MJ (May 2003). "N-cadherin-catenin complexes form prior to cleavage of the ... Lu Q, Paredes M, Medina M, Zhou J, Cavallo R, Peifer M, Orecchio L, Kosik KS (1999). "delta-catenin, an adhesive junction- ...
  https://en.wikipedia.org/wiki/CDH2
*  Protein domain - Wikipedia
Armadillo repeats : named after the β-catenin-like Armadillo protein of the fruit fly Drosophila. Basic Leucine zipper domain ( ... The repeats have diverged so widely that there is no obvious sequence similarity between them. The active site is located at a ... The simplest multidomain organization seen in proteins is that of a single domain repeated in tandem. The domains may interact ... The DNA-binding region comprises a number of basic aminoacids such as arginine and lysine Cadherin repeats : Cadherins function ...
  https://en.wikipedia.org/wiki/Protein_domain
*  Title page for ETD etd-10282010-173834
Both Siah-1 and TBL1 bind to the armadillo repeat domain of β-catenin, suggesting poly-ubiquitination of β-catenin is regulated ... This study revealed that Siah-1 alone was able to poly-ubiquitinate β-catenin. Moreover, TBL1 was found to protect β-catenin ... complex in the poly-ubiquitination and proteasomal degradation of β-catenin under UV-induced genotoxic stress. Over-expression ... and purification protocols were developed for each of the SCF(TBL1) proteins, enabling a systematic analysis of β-catenin ...
  https://etd.library.vanderbilt.edu/available/etd-10282010-173834/
*  Kifap3 kinesin-associated protein 3 [Mus musculus (house mouse)] - Gene - NCBI
ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified ... ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified ... ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified ... ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified ...
  https://www.ncbi.nlm.nih.gov/gene?cmd=search&term=NM_010629