Developmentally Regulated Induction and Expression Mechanisms of Long-Term Potentiation at Hippocampal CA3 CA1 Synapses
... in CA1 area of the hippocampus and demonstrate its susceptibility to regulation via protein kinase C (PKC) signalling. Next, we ... We confirm a critical role for the membrane proximal region of GluA4 C-terminal domain in trafficking and identify a novel ... Developmentally Regulated Induction and Expression Mechanisms of Long-Term Potentiation at Hippocampal CA3 CA1 Synapses. Show ... In summary, we provide novel information on the pre- and postsynaptic plasticity mechanisms operating at hippocampal CA3 CA1 ...https://helda.helsinki.fi/handle/10138/156110
Protocols and Video Articles Authored by Julie Nys (Translated to Danish)
When intrinsic 'somatic' and synaptic plasticity in the CA1-region of hippocampal slices were examined, we found that early ... revealed phase-dependent differences in their expression between areas CA1 and CA3. During the initial learning phase, CA1 ... based either on numerosity comparison or on cumulative area comparison. Number of dots and cumulative area were congruent in ... AMIGO2 MRNA Expression in Hippocampal CA2 and CA3a Brain Structure & Function. Jan, 2013 , Pubmed ID: 22314660 AMIGO2, or ...https://www.jove.com/author/Julie_Nys?language=Danish
Frontiers | Involvement of BDNF in Age-Dependent Alterations in the Hippocampus | Frontiers in Aging Neuroscience
This age-related volume reduction of the hippocampus is not a consequence of an age-related loss of hippocampal neurons. The ... This age-related volume reduction of the hippocampus is not a consequence of an age-related loss of hippocampal neurons. The ... In this context, growth factors may play an important role in the maintenance of the postnatal hippocampal architecture. In ... Moreover, evidences suggest that disturbances in the BDNF-system also affect hippocampal dysfunctions, as e.g. seen in major ...https://www.frontiersin.org/articles/10.3389/fnagi.2010.00036/full
New MRI Approach Can Identify Sources Of Memory Loss In Humans - Columbia University Medical Center
Small, different processes that accompany aging impair memory by targeting distinct regions of the hippocampal area, so the ... "Vascular changes primarily target the CA1 region, and testosterone changes affect the dentate gyrus. If we can validate this ... precise stage of the task but has difficulty pinpointing precise activity to small regions of the brain-such as the hippocampal ... To precisely locate changes of resting activity over very small regions of the brain, however, Dr. Small and colleagues took a ...http://newsroom.cumc.columbia.edu/blog/2000/12/22/new-mri-approach-can-identify-sources-of-memory-loss-in-humans-4/
... ko males the splitting extended into the CA1 region (Fig. 1C). The hippocampus of Lis1+/ko;Dcxko/Y males was much smaller with ... hippocampal disorganization and loss of other brain areas. Scale bar, 1 mm. B, Cresyl violet (I-IV) and Testis-1 staining (V- ... the hippocampal pyramidal layer of Dcxko/Y males displayed moderate splitting of the CA3 region, while in Lis1+/ ... Cortical and hippocampal development is severely disrupted in Lis1+/ko;Dcxko/Y mutant brains. Based on the neonatal lethality ...http://www.jneurosci.org/content/30/8/3002
Robert Fisher, MD, PhD | Stanford Medicine Profiles
The region of maximal responsiveness to AG in CA1 coincided with the area of the dendritic tree receiving Schaffer collateral- ... Intracellular recordings from 20 region CA1 hippocampal cells demonstrated only transient and mild effects on resting membrane ... In transverse hippocampal CA1 slices from 104 rats, temperature increase from 34 degrees to 40 degrees C produced a series of ... In hippocampal CA1 cells, 3 microM tiletamine in the perfusate reversibly blocked the intracellularly recorded responses to ...https://med.stanford.edu/profiles/robert-fisher
Frontiers | Nitric Oxide Is Required for L-Type Ca2+ Channel-Dependent Long-Term Potentiation in the Hippocampus | Frontiers in...
... we sought to determine if NO functions in L-VGCC-dependent LTP in mouse CA3-CA1 synapses. When elicited by a burst type of ... we sought to determine if NO functions in L-VGCC-dependent LTP in mouse CA3-CA1 synapses. When elicited by a burst type of ... In CA3-CA1 synapses in the hippocampus, NMDAR-dependent LTP appears to be primarily expressed postsynaptically whereas L-VGCC- ... In CA3-CA1 synapses in the hippocampus, NMDAR-dependent LTP appears to be primarily expressed postsynaptically whereas L-VGCC- ...https://www.frontiersin.org/articles/10.3389/fnsyn.2016.00017/full
Frontiers | Rapid Estradiol Modulation of Neuronal Connectivity and Its Implications for Disease | Endocrinology
... mounting evidence has been presented demonstrating that estrogens have rapid effects within specific areas of the brain. The ... mounting evidence has been presented demonstrating that estrogens have rapid effects within specific areas of the brain. The ... Interestingly, a recent study of rapid estradiol actions in CA1 hippocampal cells demonstrated that estradiol increased the ... in CA1 region of female rat hippocampus. Neuroscience 152, 360-370. Psychopharmacology (Berl.) 179, 637-643. ...https://www.frontiersin.org/articles/10.3389/fendo.2011.00077/full
Excitatory postsynaptic potential - Wikipedia
In other regions than CA1 of the hippocampus, the field EPSP may be far more complex and harder to interpret as the source and ... However, in some areas of the brain, such as the hippocampus, neurons are arranged in such a way that they all receive synaptic ... In studies of hippocampal long-term potentiation (LTP), figures are often given showing the field EPSP (fEPSP) in stratum ... In regions such as the striatum, neurotransmitters such as dopamine, acetylcholine, GABA and others may also be released and ...https://en.wikipedia.org/wiki/Excitatory_postsynaptic_potential
Immunohistochemical Distribution of RGS7 Protein and Cellular Selectivity in Colocalizing with Gαq Proteins in the Adult Rat...
... hilus area of the hippocampal formation, and cerebellar Golgi cells. To assess the ability of Gαq/11‐mediated signaling ... Our results provide novel information on the region‐ and cell‐specific pattern of distribution of RGS7 with the transmembrane ... with faint to nondetectable immunolabeling within the dentate gyrus granule cells and CA1‐CA3 subfield pyramidal cells. ... hilus area of the hippocampal formation, and cerebellar Golgi cells. To assess the ability of Gαq/11‐mediated signaling ...https://www.deepdyve.com/lp/wiley/immunohistochemical-distribution-of-rgs7-protein-and-cellular-1Om00K70sR
Disease-Modifying Effects of Filgastrim in a Mouse Model of AD - Juan Sanchez-Ramos
... increase in total microgliosis and increased areas of synaptophysin immunostaining in hippocamal CA1 and CA3 regions. ... Additional preliminary results obtained from G-CSF administration to tg AD mice include stimulation of hippocampal neurogenesis ... Methods: Cellular and molecular biology techniques, immunohistochemistry, hippocampal slice electrophysiology and behavioral ... stimulates hippocampal neurogenesis and restores synaptic functional activity in a mouse model of AD. Aim 1 : The hypothesis ...http://grantome.com/grant/NIH/I01-BX000632-04
A novel method for evaluating microglial activation using ionized calcium-binding adaptor protein-1 staining: cell body to cell...
CA1) hippocampal region and in layer III of the PFC (Zilles's Cg1). ... a) The total cell size (pixels) in the area of interest; (b) The total cell body size (pixels) in the area of interest; (c) The ... The area of interest was selected. The image analysis software automatically analyzes the picture and bases on the color ... In addition, the number of cell bodies was counted to give the number of microglia in the area of interest. The total size of ...http://nnjournal.net/article/view/79
Anthony D Wagner's Profile | Stanford Profiles
The hippocampal formation is one of the most extensively studied regions of the brain, with well-described anatomy and basic ... Prediction strength modulates responses in human area CA1 to sequence violations JOURNAL OF NEUROPHYSIOLOGY Chen, J., Cook, P. ... Associative retrieval processes in the human medial temporal lobe: Hippocampal retrieval success and CA1 mismatch detection ... but not in CA1 tissue. Quantitative analyses of Golgi-stained hippocampal neurons showed an increase in spine density on CA3 ...https://profiles.stanford.edu/anthony-wagner?tab=publications&releaseVersion=7.4.2
Hippocampal CA1/subiculum-prefrontal cortical pathways induce plastic changes of nociceptive responses in cingulate and...
CA1/SB) areas to the prefrontal cortex (PFC), which are involved in memory and learning processes, produce long term synaptic ... HFS delivered to CA1 regions induced NMDA (N-Methyl-D-Aspartate)-mediated LTP in the PFC , indicating CA1-PFC pathways to be ... Projections from hippocampal CA1-subiculum (CA1/SB) areas to the prefrontal cortex (PFC), which are involved in memory and ... Long-term potentiation in the prefrontal cortex following stimulation of the hippocampal CA1/subicular region. Neurosci Lett. ...https://rd.springer.com/article/10.1186/1471-2202-11-100
Protocols and Video Articles Authored by Karl W. Kafitz
Multi-photon Intracellular Sodium Imaging Combined with UV-mediated Focal Uncaging of Glutamate in CA1 Pyramidal Neurons' ... we analyzed changes in their expression and function following a mechanical lesion in the CA1 area of organotypic hippocampal ... and the magnitude of LTP in the CA1 region. Experiments in slices from transgenic mice revealed that the effect on PS amplitude ... At hippocampal Schaffer collateral to CA1 pyramidal cell synapses, such activity-induced astrocyte calcium transients modulate ...https://www.jove.com/author/Karl+W._Kafitz
Hippocampus anatomy - Wikipedia
The hippocampal sulcus (sulc.) or fissure is a cell-free region that separates the CA1 field from the dentate gyrus. Because ... After CA1 comes an area called the subiculum. After this comes a pair of ill-defined areas called the presubiculum and ... A weak commissural projection connects both CA1 regions together. Subiculum has no commissural inputs or outputs. Hippocampal ... They pass through hippocampal commissures to reach contralateral regions of hippocampus. Hippocampal commissures have dorsal ...https://en.wikipedia.org/wiki/Hippocampus_anatomy
Neuroprotective Effects of Propofol in Models of Cerebral Ischemia:Inhibition of Mitochondrial Swelling as a Possible Mechanism...
PI staining increased dramatically in the hippocampal CA1 area 24 h later (fig. 1A). Selective vulnerability of CA1 pyramidal ... C ) Propofol significantly reduced the areas of the infarct in the most forebrain regions (slices 1-3). Infarcted areas were ... C ) Propofol significantly reduced the areas of the infarct in the most forebrain regions (slices 1-3). Infarcted areas were ... C ) Propofol significantly reduced the areas of the infarct in the most forebrain regions (slices 1-3). Infarcted areas were ...http://anesthesiology.pubs.asahq.org/article.aspx?articleid=1923340
Re: VIAGRA COULD REDUCE MS SYMPTOMS
... improved short-term memory by suppressing ischemia-induced apoptotic neuronal cell death in the hippocampal CA1 region, and ... Location: Northern Calif Monterey Bay Area. Top. Re: VIAGRA COULD REDUCE MS SYMPTOMS. by Cece » Fri Nov 04, 2011 1:38 pm ... Also, tadalafil suppressed the ischemia-induced increase in cell proliferation in the hippocampal dentate gyrus. We showed that ... Tadalafil [Cialis] improves short-term memory by suppressing ischemia-induced apoptosis of hippocampal neuronal cells in ...http://www.thisisms.com/forum/chronic-cerebrospinal-venous-insufficiency-ccsvi-f40/topic16642-30.html
PPT - WK7 - Hebbian Learning PowerPoint Presentation - ID:6779351
Ex1- Hippocampal Model: There has been strong support up today to suggest that the brain area known as hipocampus uses a Hebb ... A model which captures the interactions of the hippocampus (DG / CA3 /CA1) with the immediate surrounding regions (Entorhinal ... The connections from CA1 Ent. Coertx use Hebbian learning *Simulations of the model showed that one-shot learning is possible ...https://www.slideserve.com/sylvana-silas/wk7-hebbian-learning
β2 subunit mRNA was detected specifically in layer VI of the cerebral cortex, CA1, and dentate gyrus of the hippocampal ... ANOVAs of each brain area showed a significant genotype effect on nicotine evoked [3H]GABA release in all brain areas (p , ... 3H]GABA release was measured in response to a 12 sec exposure to 30 μm nicotine in four brain regions (n= 4 for each genotype ... β2 ko mice with both transgenes (β2 tr) expressed the β2 subunit inducibly in different brain regions. β2 tr, β2 wt, and het ...http://www.jneurosci.org/content/23/9/3837
Selective Hippocampal Neurodegeneration in Transgenic Mice Expressing Small Amounts of Truncated Aβ Is Induced by Pyroglutamate...
2K) when compared with the corresponding CA1 area in WT mice (Fig. 2J). Electron microscopic analysis of the CA1 area ... For quantification of neuronal loss in the hippocampal CA1 region of TBA2.1 mice, NeuN-stained 8 μm coronal sections were ... Double immunofluorescent labeling of the hippocampal CA1 area with anti-Aβ (red) and anti-QC (green) antibodies (A-F) shows ... Progressing astrogliosis, microglial activation, and neuronal loss in the hippocampal CA1 region in TBA2.1 mice is associated ...http://www.jneurosci.org/content/31/36/12790?ct=ct
Poly(ADP-ribose)polymerase-1 modulates microglial responses to amyloid β | Journal of Neuroinflammation | Full Text
Microglial morphology was analyzed in hippocampal CA1 and DG areas and in perirhinal cortex, with the exception of Aβ-injected ... uniform-sized regions of interest with the ImageJ program (NIH). Values were measured on three comparable sections from each ... Relative to the hAPPJ20 mice, the hAPPJ20/PARP-1 -/- mice had less calbindin depletion in the hippocampal CA1, but not in the ... The hAPPJ20 mice developed microglial activation, reduced hippocampal CA1 calbindin expression, and impaired novel object ...https://jneuroinflammation.biomedcentral.com/articles/10.1186/1742-2094-8-152
Perirhinal cortex - Wikipedia
Area 36d projects to 36v and then to 35, which forms the primary output region of perirhinal cortex. Inputs to area 35 more ... It also has direct connections with hippocampus region CA1 and the subiculum. Perirhinal cortex projects to distal CA1 ... Double dissociation between the effects of peri-postrhinal cortex and hippocampal lesions on tests of object recognition and ... The perirhinal cortex is composed of two regions: areas 36 and 35. Area 36 is sometimes divided into three subdivisions: 36d is ...https://en.wikipedia.org/wiki/Perirhinal_cortex
Neuropil - Wikipedia
0.035 for the stratum radiatum of hippocampal field CA1. The overall average is 0.585 ± 0.043; these values are not ... A significant non-human area of neuropil is the barrel cortex found in mammals with whiskers (e.g. cats, dogs and rodents); ... In chimpanzees and humans the neuropil provides a proxy measure of total connectivity within a local region because it is ... Neuropil (or "neuropile") is any area in the nervous system composed of mostly unmyelinated axons, dendrites and glial cell ...https://en.wikipedia.org/wiki/Neuropil
Effects of nitric oxide synthase inhibition in the CA1 region of rat hippocampus on spatial learning | Annals of General...
Bon CL, Garthwaite J: On the role of nitric oxide in hippocampal long-term potentiation. J Neurosci. 2003, 23: 1941-1948.PubMed ... Nitric oxide (NO) is thought to be involved in synaptic plasticity contributing to learning and memory in several brain areas ... Rats cannulated in the CA1 region of their hippocampus received bilateral injections of vehicle (saline) or N-omega-nitro L- ... Effects of nitric oxide synthase inhibition in the CA1 region of rat hippocampus on spatial learning. ...https://annals-general-psychiatry.biomedcentral.com/articles/10.1186/1744-859X-7-S1-S118