The Translation Repressor 4E-BP2 Is Critical for eIF4F Complex Formation, Synaptic Plasticity, and Memory in the Hippocampus |...
Biochemical analysis. Hippocampal area CA1 regions were dissected, and homogenates were prepared in ice-cold homogenization ... Indeed, it was reported previously that the loss of G(iα1) resulted in enhanced HFS-induced hippocampal LTP in area CA1 and ... Stanton PK, Sarvey JM (1984) Blockade of long-term potentiation in rat hippocampal CA1 region by inhibitors of protein ... We have shown previously that NMDA receptor activation results in increased phosphorylation of eIF4E in hippocampal area CA1 ...http://www.jneurosci.org/content/25/42/9581.full
The area containing the stratum radiatum of the hippocampal CA1 region was trimmed. Images on a Hitachi H 7500 electron ... A-C, Dendritic spines on apical dendrites of the principal neurons in CA1, CA3, and DG hippocampal regions (3 weeks) were ... 6), TANC1 protein is more strongly expressed in the CA3 region and, to a lesser extent, in the DG and CA1 regions of ... the spine density in the CA3 region of TANC1−/− hippocampus was significantly reduced, but was normal in the DG and CA1 regions ...http://www.jneurosci.org/content/30/45/15102
Frontiers | Resilience to audiogenic seizures is associated with p-ERK1/2 dephosphorylation in the subiculum of Fmr1 knockout...
Basal FosB/ΔFosB immunoreactivity was higher (P,0.01 vs WT) in the CA1 and subiculum of P45 Fmr1 KO mice. Following the AGS ... To characterize the diverse response to AGS in various cerebral regions, we evaluated the activity markers FosB/ΔFosB and ... To characterize the diverse response to AGS in various cerebral regions, we evaluated the activity markers FosB/ΔFosB and ... In this region, p-ERK1/2-immunopositive cells significantly decreased (-75%, P,0.01) in P90 Fmr1 KO mice exposed to the AGS ...https://www.frontiersin.org/articles/10.3389/fncel.2013.00046/full
Neuroprotective Effect of Ginseng against Alteration of Calcium Binding Proteins Immunoreactivity in the Mice Hippocampus after...
Wide distribution of PV IR was noted in the hippocampal region throughout the CA1 and CA3 areas as well as in the dentate gyrus ... of the CA1 area. Intensely labeled single neurons were noted in the SR/SL region of the CA1 area of the SC and G1.6 groups, ... Significant difference was observed in the CA1 area (. ), CA3 area (. ), and GL (. ) of the E1.6 when compared with SC (Figure ... CA1 (a-c) and CA3 areas (g-i) show various CB-positive neurons. In the various layers of CA1, CB IR pyramidal (thin arrows) and ...https://www.hindawi.com/journals/bmri/2013/812641/
Mechanisms of Reversible GABAA Receptor Plasticity after Ethanol Intoxication | Journal of Neuroscience
... but also in hippocampal CA1 region and cortex (Matthews et al., 1998; Cagetti et al., 2003; Liang et al., 2004), areas of ... striatum and other brain areas, including the hippocampal CA1 region (Pirker et al., 2000). Consistent with this distribution, ... Arrow points to the hippocampal fissure. B, Examples of gels from the microdissected CA1 region incubated with ACSF or with the ... A cross-linking assay and Western blot analysis of microdissected CA1 area of hippocampal slices obtained 1 h after EtOH ...http://www.jneurosci.org/content/27/45/12367.long
Movement Enhances the Nonlinearity of Hippocampal Theta | Journal of Neuroscience
This evolution was modulated across hippocampal regions, being stronger in the dorsal CA1 relative to more intermediate areas. ... with the nonlinearity of the dorsal CA1 region dominating the nonlinearity of the intermediate CA1 region. This comparison ... Representative bispectral properties of hippocampal LFP in the dorsal and intermediate CA1 region from rat 7805. The ... we investigated the nonlinear character of the theta rhythm in the dorsal and intermediate regions of the hippocampal CA1 ...http://www.jneurosci.org/content/36/15/4218
A Depletable Pool of Adenosine in Area CA1 of the Rat Hippocampus | Journal of Neuroscience
2000) Direct measurement of adenosine release during hypoxia in the CA1 region of the rat hippocampal slice. J Physiol (Lond) ... Using a combination of extracellular and whole-cell recordings in the CA1 region of hippocampal slices from 12- to 24-d-old ... A Depletable Pool of Adenosine in Area CA1 of the Rat Hippocampus. Tim Pearson, Feruza Nuritova, Darren Caldwell, Nicholas Dale ... The sensor (overall width ∼500 μm) was placed on the surface of area CA1 with the recording electrode within 200 μm of the ...http://www.jneurosci.org/content/21/7/2298
... medial septum-diagonal band area, hippocampal CA1, hippocampal CA3, and prefrontal cortex). These results show that the ... Moreover, the performance in these two tests showed significant correlation with glucose use in only five regions (dentate ... learning impairments in the aged rats are related to the extent of decrease in glucose utilization in restricted areas of the ... differences in glucose utilization were found between the aged and young groups on some behaviors and in some brain regions. ...http://www.jneurosci.org/content/4/11/2856
Differential Effects of Short- and Long-Term Potentiation on Cell Firing in the CA1 Region of the Hippocampus | Journal of...
We have addressed this question by examining E-S curves from rat hippocampal area CA1 in response to both PPF and LTP. We ... from area CA1 of rat hippocampal slices while delivering paired stimuli over a series of intervals and intensities. A schematic ... 1998) CA1 pyramidal to basket and bistratified cell EPSPs: dual intracellular recordings in rat hippocampal slices. J Physiol ( ... Differential Effects of Short- and Long-Term Potentiation on Cell Firing in the CA1 Region of the Hippocampus. Carrie P. Marder ...http://www.jneurosci.org/content/23/1/112.full.print
IJMS | Free Full-Text | Revisiting the Lamotrigine-Mediated Effect on Hippocampal GABAergic Transmission
When re-examining the LTG effect on GABAergic transmission in the cornus ammonis region 1 (CA1) area, we found that LTG ... Using whole-cell recording in rat hippocampal slices, we investigated the net LTG effect on BC output. We showed that bath ... in the hippocampal dentate gyrus. Notably, BCs express abundant Nav channels and HCN channels, both of which are able to ... When re-examining the LTG effect on GABAergic transmission in the cornus ammonis region 1 (CA1) area, we found that LTG ...http://www.mdpi.com/1422-0067/17/7/1191
Frontiers | Motor Areas Show Altered Dendritic Structure in an Amyotrophic Lateral Sclerosis Mouse Model | Neuroscience
We used a modified Golgi-Cox staining method to determine the progressive changes in dendritic structure of hippocampal CA1 ... We used a modified Golgi-Cox staining method to determine the progressive changes in dendritic structure of hippocampal CA1 ... The hippocampal CA1 region is a major output target of the entorhinal cortex, which also processes inputs from multiple ... Hippocampal CA1 pyramidal neurons for tracing were selected from sections between bregma ~−1.1 and −2.6 mm. A mouse brain atlas ...https://www.frontiersin.org/articles/10.3389/fnins.2017.00609/full
Frontiers | Three-dimensional atlas system for mouse and rat brain imaging data | Frontiers in Neuroinformatics
CA1, field CA1 of the hippocampus; th, thalamus, whole region; hi, hippocampal region; ec, external capsule; AHi, ... area 3; S1J, jaw region; S1Tr, trunk region; S1BF, barrel field; V2L, secondary visual cortex, lateral area; V2M, secondary ... hy, hypothalamus, whole region; ic, internal capsule; cc, corpus callosum; CA1, field CA1 of the hippocampus; CA2∕CA3, field ... Cg2, cingulate cortex area 2; Cg1, cingulate cortex area 1; S1, primary somatosensory cortex; S1HL, hindlimb region; S1FL, ...https://www.frontiersin.org/articles/10.3389/neuro.11.004.2007/full
The FXG: A Presynaptic Fragile X Granule Expressed in a Subset of Developing Brain Circuits | Journal of Neuroscience
2), hippocampal areas CA3 (Fig. 4) and CA1 (data not shown). However, we only observed presynaptic FMRP in those areas where ... While the region-specific pattern of FXG expression remained unchanged, the density within these brain areas was increased. ... 1). Furthermore, FXGs were not detected in hippocampal area CA1 at P7 or P15. Together, these results suggest that FXG ... 1998) Synaptogenesis via dendritic filopodia in developing hippocampal area CA1. J Neurosci 18:8900-8911. ...http://www.jneurosci.org/content/29/5/1514.long
2), hippocampal areas CA3 (Fig. 4) and CA1 (data not shown). However, we only observed presynaptic FMRP in those areas where ... While the region-specific pattern of FXG expression remained unchanged, the density within these brain areas was increased. ... 1). Furthermore, FXGs were not detected in hippocampal area CA1 at P7 or P15. Together, these results suggest that FXG ... 1998) Synaptogenesis via dendritic filopodia in developing hippocampal area CA1. J Neurosci 18:8900-8911. ...http://www.jneurosci.org/content/29/5/1514
Reward Expectancy Strengthens CA1 Theta and Beta Band Synchronization and Hippocampal-Ventral Striatal Coupling | Journal of...
Shaded areas represent SEM. *p , 0.002 (WMPSR). D, Filtered (0-23 Hz) single LFP traces recorded from the hippocampal CA1 ... 1996) Hippocampal CA3 region predicts memory sequences: accounting for the phase precession of place cells. Learn Mem 3:279-287 ... Impact of hippocampal theta and beta activity on target areas. Our results suggest that the continuation of structured CA1 ... 8A,B). These numbers were lower than for hippocampal area CA1 in both frequency bands, as expected from a limited connection ...http://www.jneurosci.org/content/36/41/10598
Sex differences in activation of the hypothalamic-pituitary-adrenal axis by methamphetamine - Zuloaga - 2014 - Journal of...
... cingulate cortex area 2 (Bregma ≈ 1.10 and 0.98 mm), dentate gyrus, CA1, and CA3 hippocampal regions (Bregma ≈ −0.82 and −0.94 ... MA also increased c-Fos immunoreactivity within the CA1 hippocampal region, although not in a sex-dependent fashion, and failed ... The CA3 hippocampal region plays a key role in negative feedback functions of the HPA axis (Silverman et al. 1981). Therefore, ... 2010). Other regions including the dorsomedial hypothalamus, anterodorsal preoptic area, and periaqueductal gray may be more ...http://onlinelibrary.wiley.com/doi/10.1111/jnc.12651/full?globalMessage=0
Age-related effects of the neuromodulator d-serine on neurotransmission and synaptic potentiation in the CA1 hippocampal area...
Zhi-Qiang Liu, Xun-Hu Gu, Yuan-Jian Yang, Xiao-ping Yin, Li-Jun Xu, Wei Wang, d-Serine in the nucleus accumbens region ... Age-related effects of the neuromodulator d-serine on neurotransmission and synaptic potentiation in the CA1 hippocampal area ... d-serine on glutamatergic neurotransmission and synaptic potentiation were studied in the CA1 hippocampal field of young (3-5 ... Finally, d-serine levels were dramatically reduced in hippocampal tissues of aged rats. Taken together, these results indicate ...http://onlinelibrary.wiley.com/doi/10.1111/j.1471-4159.2006.03944.x/abstract
Hippocampal CA1/subiculum-prefrontal cortical pathways induce plastic changes of nociceptive responses in cingulate and...
CA1/SB) areas to the prefrontal cortex (PFC), which are involved in memory and learning processes, produce long term synaptic ... HFS delivered to CA1 regions induced NMDA (N-Methyl-D-Aspartate)-mediated LTP in the PFC , indicating CA1-PFC pathways to be ... Projections from hippocampal CA1-subiculum (CA1/SB) areas to the prefrontal cortex (PFC), which are involved in memory and ... Long-term potentiation in the prefrontal cortex following stimulation of the hippocampal CA1/subicular region. Neurosci Lett. ...https://rd.springer.com/article/10.1186/1471-2202-11-100
Frontiers | A Handbook for Modeling Hippocampal Circuits | Frontiers in Computational Neuroscience
Hippocampal Microcircuits: A computational modeler's resource book. Springer, New York.In recent years, most areas of ... focusing in detail on the computational modeling of hippocampal physiology.No single researcher can be an expert in all areas, ... This book facilitates the development of hippocampal models by distilling the essential features of research into an accessible ... morphology and intrinsic properties of hippocampal neurons, progressing through different neurotransmitter and neuromodulatory ...https://www.frontiersin.org/articles/10.3389/fncom.2011.00002/full
... were taken from the hippocampal CA1 region (stratum radiatum, 225 × 225 μm) of 4 different WT brains. The relative area of ... In the hippocampus, all layers stained positive, including the stratum lacunosum-moleculare of the CA1 region (Fig. 1C). The ... Reduction of network excitability in hippocampal slices from KO mice. A, CA1 population spike amplitudes upon stimulation of ... This confirms previous data that rat CA1 hippocampal neurons displayed DIDS-sensitive HCO3−-dependent acid extrusion that ...http://www.jneurosci.org/content/31/20/7300
... established the importance of serial transfer of spatial information between the prelimbic cortex and hippocampal CA1 region ( ... The striatum receives inputs from a very broad range of cortical areas, but has far fewer neurons. How are the rich patterns of ... 2007) in The hippocampus book, Theories of hippocampal function, eds Andersen P, Morris RGM, Amaral D, Bliss TVP, O'Keefe J ( ... The blue-green region in medial SNpc and dorsal VTA receives inputs from the shell and contains retrogradely labeled cells ...http://www.jneurosci.org/content/29/41/12831
Intracranial Adeno-Associated Virus-Mediated Delivery of Anti-Pan Amyloid β, Amyloid β40, and Amyloid β42 Single-Chain Variable...
2A). The most striking expression was seen in the neuronal cell layers of hippocampal CA1 to CA3 region, choroid plexus, and ... hGFP-positive signals were also detected in the periventricular areas and the frontal cortex. Injection of 10-fold higher ... 1996) Rapid and reliable cloning of antibody variable regions and generation of recombinant single chain antibody fragments. ... mRNA isolation, cDNA synthesis, amplification of cDNAs encoding variable heavy and variable light regions, and construction of ...http://www.jneurosci.org/content/26/46/11923.full
Anticonvulsant and neuroprotective effects of Pimpinella anisum in rat brain | BMC Complementary and Alternative Medicine |...
The present study investigated the neuroprotective effects of anise oil in hippocampal CA1 area. Pyramidal neurons in the CA1 ... ATPases in the rat CA1 hippocampal region. J Neurophysiol. 2002, 88 (6): 2963-2978. 10.1152/jn.00244.2002.View ArticlePubMed ... Density of dark neurons in the hippocampal CA1 and CA3 areas was significantly decreased after administration of anise oil in ... Slides were examined with light microscope and digital photographs were taken from hippocampal CA1 and CA3 areas of both ...https://bmccomplementalternmed.biomedcentral.com/articles/10.1186/1472-6882-12-76
We prepared hippocampal slices from adult mice (7-9 weeks old) and induced LTD in the CA1 region by stimulating the Schaffer ... Cell density in area CA1 was also comparable in conditional Bax knock-out mice and their wild-type littermates (p = 0.178, two- ... In addition, our behavioral tests suggest that Bax in the hippocampal CA1 region contributes to depressive behavior. ... LTD is impaired, and LTP is intact in CA1-specific Bax knock-out mice. Hippocampal slices were prepared from CA1-specific Bax ...http://www.jneurosci.org/content/34/26/8741
Adult Neuroplasticity: More Than 40 Years of Research
... chronic cortisol changed the number of heterochromatin clusters only in hippocampal region CA1, but not in CA3, the region that ... Quantification of the clusters revealing areas larger than 1 μm² in the hippocampal region CA3 showed that there was more ... In contrast, in area CA1, the stress had no effect on the density of heterochromatin clusters (Figure 3; ). Although in ... a region of the hippocampal formation) plays a crucial role in learning and memory . However, experimental results on the ...https://www.hindawi.com/journals/np/2014/541870/