*  Arachidonic acid - Wikipedia
... β-hydroxy β-methylbutyric acid, and phosphatidic acid. Arachidonic acid is one of the most abundant fatty acids in the brain, ... Arachidonic Acid at acnp.org Arachidonic Acid at the US National Library of Medicine Medical Subject Headings (MeSH). ... Arachidonic acid is also used in the biosynthesis of anandamide. Some arachidonic acid is converted into ... Like DHA, neurological health is reliant upon sufficient levels of arachidonic acid. Among other things, arachidonic acid helps ...
  https://en.wikipedia.org/wiki/Arachidonic_acid
*  Arachidonic acid 5-hydroperoxide - Wikipedia
Arachidonic acid 5-hydroperoxide (5-hydroperoxyeicosatetraenoic acid, 5-HPETE) is an intermediate in the metabolism of ... 5-Hydroxyicosatetraenoic acid and 5-oxo-eicosatetraenoic acid; or c) the specialized pro-resolving mediators of inflammation, ... arachidonic acid by the ALOX5 enzyme in humans or Alox5 enzyme in other mammals. The intermediate is then further metabolized ...
  https://en.wikipedia.org/wiki/Arachidonic_acid_5-hydroperoxide
*  Neurochemical - Wikipedia
Eicosanoids act as neuromodulators via the Arachidonic acid cascade. Orexins (-A and -B) are involved in a number of cognitive ... "Arachidonic Acid". Neuropsychopharmacology: The Fifth Generation of Progress. Retrieved 2006-03-03. "Neurotrophic factors". ...
  https://en.wikipedia.org/wiki/Neurochemical
*  15-hydroxyicosatetraenoate dehydrogenase - Wikipedia
This enzyme participates in arachidonic acid metabolism. Sok DE, Kang JB, Shin HD (1988). "15-Hydroxyeicosatetraenoic acid ... H+ The 3 substrates of this enzyme are 15-Hydroxyicosatetraenoic acid (i.e. 15(S)-15-hydroxy-5,8,11-cis-13-trans- ...
  https://en.wikipedia.org/wiki/15-hydroxyicosatetraenoate_dehydrogenase
*  Epoxide hydrolase 2 - Wikipedia
These enzymes epoxidize the double bonds in arachidonic acid to form four regioisomers. Arachidonic acid is also the precursor ... There are epoxides of other lipids besides arachidonic acid such as the omega three docosahexaenoic acid (DHA) and ... Moghaddam M, Motoba K, Borhan B, Pinot F, Hammock BD (August 1996). "Novel metabolic pathways for linoleic and arachidonic acid ... Spector AA (April 2009). "Arachidonic acid cytochrome P450 epoxygenase pathway". J. Lipid Res. 50 Suppl (Suppl): S52-6. doi: ...
  https://en.wikipedia.org/wiki/Epoxide_hydrolase_2
*  Prostaglandin-F synthase - Wikipedia
This enzyme participates in arachidonic acid metabolism. As of late 2007[update], 7 structures have been solved for this class ...
  https://en.wikipedia.org/wiki/Prostaglandin-F_synthase
*  Leukotriene-A4 hydrolase - Wikipedia
This enzyme participates in arachidonic acid metabolism. As of late 2007, 4 structures have been solved for this class of ... Enzymatic conversion into 5,6-dihydroxy-7,9,11,14-eicosatetraenoic acid by mouse liver cytosolic epoxide hydrolase". J. Biol. ... "Molecular cloning and amino acid sequence of leukotriene A4 hydrolase". Proc. Natl. Acad. Sci. U.S.A. 84 (19): 6677-81. doi: ...
  https://en.wikipedia.org/wiki/Leukotriene-A4_hydrolase
*  Prostaglandin-E2 9-reductase - Wikipedia
This enzyme participates in arachidonic acid metabolism. As of late 2007, 3 structures have been solved for this class of ...
  https://en.wikipedia.org/wiki/Prostaglandin-E2_9-reductase
*  15-hydroxyprostaglandin-D dehydrogenase (NADP+) - Wikipedia
This enzyme participates in arachidonic acid metabolism. Watanabe K, Shimizu T, Iguchi S, Wakatsuka H, Hayashi M, Hayaishi O ( ...
  https://en.wikipedia.org/wiki/15-hydroxyprostaglandin-D_dehydrogenase_(NADP+)
*  Leukotriene-E4 20-monooxygenase - Wikipedia
This enzyme participates in arachidonic acid metabolism. Orning L (1987). "Omega-oxidation of cysteine-containing leukotrienes ...
  https://en.wikipedia.org/wiki/Leukotriene-E4_20-monooxygenase
*  Leukotriene-C4 synthase - Wikipedia
This enzyme participates in arachidonic acid metabolism. As of late 2007, 3 structures have been solved for this class of ...
  https://en.wikipedia.org/wiki/Leukotriene-C4_synthase
*  Omega-3 fatty acid - Wikipedia
arachidonic acid) than those of omega−3. This necessitates that omega−6 and omega−3 be consumed in a balanced proportion; ... Omega−3 fatty acids-also called ω−3 fatty acids or n−3 fatty acids-are polyunsaturated fatty acids (PUFAs) with a double bond ( ... "Omega−3 fatty acids, fish oil, alpha-linolenic acid: Related terms". Omega−3 fatty acids, fish oil, alpha-linolenic acid. Mayo ... Three omega−3 fatty acids are important in human physiology, α-linolenic acid (18:3, n-3; ALA), eicosapentaenoic acid (20:5, n- ...
  https://en.wikipedia.org/wiki/Omega-3_fatty_acid
*  Zanvil A. Cohn - Wikipedia
Regulation of arachidonic acid metabolites in macrophages. J. Exp. Med. 152:324-335. 1982 With W. A. Scott, N. A. Pawlowski, H ... Regulation of arachidonic acid metabolism by macrophage activation. J. Exp. Med. 155:1148-1160. With W. C. Van Voorhis, G. ... Bacterial lipopolysaccharides prime macrophages for enhanced release of arachidonic acid metabolites. J. Exp. Med. 164:165-179 ...
  https://en.wikipedia.org/wiki/Zanvil_A._Cohn
*  Leukotriene-B4 20-monooxygenase - Wikipedia
This enzyme participates in arachidonic acid metabolism. It employs one cofactor, heme. Romano MC, Eckardt RD, Bender PE, ...
  https://en.wikipedia.org/wiki/Leukotriene-B4_20-monooxygenase
*  Arachidonate 8-lipoxygenase - Wikipedia
Bundy GL, Nidy EG, Epps DE, Mizsak SA, Wnuk RJ (1986). "Discovery of an arachidonic acid C-8 lipoxygenase in the gorgonian ... This enzyme participates in arachidonic acid metabolism. As of late 2007, only one structure has been solved for this class of ...
  https://en.wikipedia.org/wiki/Arachidonate_8-lipoxygenase
*  Prostaglandin-D synthase - Wikipedia
This enzyme participates in arachidonic acid metabolism. In March 2012 American scientists reported a discovery that shows this ...
  https://en.wikipedia.org/wiki/Prostaglandin-D_synthase
*  Leukotriene B4 receptor 2 - Wikipedia
... see 12-Hydroxyeicosatetraenoic acid, by a member of the 15-lipoxygenase pathway of arachidonic acid metabolism, 15(S)-HETE (see ... Eicosanoid receptor 12-Hydroxyheptadecatrienoic acid 12-Hydroxyeicosatetraenoic acid 15-Hydroxyicosatetraenoic acid GRCh38: ... Cabral M, Martín-Venegas R, Moreno JJ (Aug 2013). "Role of arachidonic acid metabolites on the control of non-differentiated ... These messenger ligands are any one of a range of structurally different arachidonic acid metabolites made and released by ...
  https://en.wikipedia.org/wiki/Leukotriene_B4_receptor_2
*  Fever - Wikipedia
When these cytokine factors bind, the arachidonic acid pathway is then activated. One model for the mechanism of fever caused ... PGE2 release comes from the arachidonic acid pathway. This pathway (as it relates to fever), is mediated by the enzymes ... In other words, exogenous factors cause release of endogenous factors, which, in turn, activate the arachidonic acid pathway. ...
  https://en.wikipedia.org/wiki/Fever
*  PLA2G2D - Wikipedia
Leslie CC (2004). "Regulation of arachidonic acid availability for eicosanoid production". Biochem. Cell Biol. 82 (1): 1-17. ... 2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415-8. doi:10.1093/nar/gkj139. PMC 1347501 . ...
  https://en.wikipedia.org/wiki/PLA2G2D
*  Myosin-light-chain phosphatase - Wikipedia
However, it is unclear how arachidonic acid functions as an inhibitor. Two competing theories are that either arachidonic acid ... One other proposed regulatory strategy involves arachidonic acid. When arachidonic acid is added to tensed muscle tissue, the ... such as arachidonic acid and cAMP, also regulate the enzyme. Smooth muscle tissue is mostly made of actin and myosin, two ... Myosin's regulatory subunit MLC20 binds to both the hydrophobic and acid grooves of PP1 and MYPT1, the regulatory site on ...
  https://en.wikipedia.org/wiki/Myosin-light-chain_phosphatase
*  Efferocytosis - Wikipedia
Specialized pro-resolving mediators are cell-derived metabolites of certain polyunsaturated fatty acids viz.: arachidonic acid ... n-3 docosapentaenoic acid which is metabolized to the n-3 docosapentaenoic acid-derived resolvins and n-3 docosapentaenoic acid ... Shinohara M, Serhan CN (2016). "Novel Endogenous Proresolving Molecules:Essential Fatty Acid-Derived and Gaseous Mediators in ... which is metabolized to the lipoxins; eicosapentaenoic acid which is metabolized to the Resolvin E's; docosahexaenoic acid ...
  https://en.wikipedia.org/wiki/Efferocytosis
*  PLA2G6 - Wikipedia
Tay HK, Melendez AJ (May 2004). "Fcgamma RI-triggered generation of arachidonic acid and eicosanoids requires iPLA2 but not ... The encoded protein may play a role in phospholipid remodelling, arachidonic acid release, leukotriene and prostaglandin ... Leslie CC (Feb 2004). "Regulation of arachidonic acid availability for eicosanoid production". Biochemistry and Cell Biology = ... The protein encoded by this gene is a phospholipase A2 enzyme, a subclass of enzyme that catalyzes the release of fatty acids ...
  https://en.wikipedia.org/wiki/PLA2G6
*  12-Hydroxyeicosatetraenoic acid - Wikipedia
12-Hydroxyeicosatetraenoic acid (12-HETE) is a derivative of the 20 carbon polyunsaturated fatty acid, arachidonic acid, ... it metabolizes arachidonic acid to 12(R)-HpETE. Cytochrome P450 enzymes convert arachidonic acid to a variety of hydroperoxy, ... ALOX12 metabolizes arachidonic acid almost exclusively to 12(S)-hydroperoxy-5Z,8Z,10E,14Z-eicosatetraenoic acid (12(S)-HpETE or ... Oliw, E. H. (1993). "Bis-Allylic hydroxylation of linoleic acid and arachidonic acid by human hepatic monooxygenases". ...
  https://en.wikipedia.org/wiki/12-Hydroxyeicosatetraenoic_acid
*  Cyclooxygenase - Wikipedia
Fish oils provide alternative fatty acids to arachidonic acid. These acids can be turned into some anti-inflammatory ... "Conversion of acetaminophen to the bioactive N-acylphenolamine AM404 via fatty acid amide hydrolase-dependent arachidonic acid ... Arachidonic acid Cyclooxygenase 1 Cyclooxygenase 2 NSAID Discovery and development of COX-2 selective inhibitors COX-2 ... amino acid sequence homology and near-identical catalytic sites. The most significant difference between the isoenzymes, which ...
  https://en.wikipedia.org/wiki/Cyclooxygenase
*  Biochemical cascade - Wikipedia
Examples: PIP3, DAG, phosphatidic acid, arachidonic acid and ceramide. They are involved in regulation of kinases and ... These include genes associated with bile acid metabolism, glycolysis metabolism and fatty acid metabolism pathways, supporting ... Yeh, C. S.; Wang, J. Y.; Cheng, T. L.; Juan, C. H.; Wu, C. H.; Lin, S. R. (2006). "Fatty acid metabolism pathway play an ... Kanehisa, M (2002). "The KEGG databases at GenomeNet". Nucleic Acids Res. 30: 42-46. doi:10.1093/nar/30.1.42. Boyle, E. I. ( ...
  https://en.wikipedia.org/wiki/Biochemical_cascade