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*  KAKEN - Research Projects | Molecular pathophysiological studies on arachidonate lipoxygenases (KAKENHI-PROJECT-07044273)
Publications] T.Arakawa: 'The transcriptional regulation of human arachidonate 12-lipoxygenase gene by NFκB/Rel' FEBS Lett.363 ... Publications] T.Arakawa: 'The transcriptional regulation of human arachidonate 12-lipoxygenase gene by NFkB/Rel' FEBS Lett.363 ... 15-Lipoxygenase is now under investigations.. 3) 12-Lipoxygenase of human uterine cervix : Nigam's group of Free University of ... Publications] M.Nakamura: 'Immunocytochemical localization of platelet-type arachidonate 12-lipoxygenase in mouse blood cells' ...
  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-07044273/
*  Effects of the Arachidonate Lipoxygenase Inhibitor BW755C on Traumatic and Peritumoural Brain Oedema | Springer for Research &...
It inhibits synthesis of prostaglandins and leukotrienes by inhibition in the cyclooxygenase and lipoxygenase pathways of... ... Effects of the Arachidonate Lipoxygenase Inhibitor BW755C on Traumatic and Peritumoural Brain Oedema. ... Higgs GA, Mugridge KG, Moncada S, Vane JR (1984) Inhibition of tissue damage by the arachidonate lipoxygenase inhibitor BW755C ... Ikeda Y., Long D.M. (1990) Effects of the Arachidonate Lipoxygenase Inhibitor BW755C on Traumatic and Peritumoural Brain Oedema ...
  https://rd.springer.com/chapter/10.1007/978-3-7091-9115-6_23
*  RCSB PDB - Protein Feature View - Arachidonate 15-lipoxygenase - P27479 (LOX15 BOVIN)
Arachidonate + O2 = 5Z,8Z,11Z,13E-15S-15-hydroperoxyicosa-5,8,11,13-tetraenoate. UniProt ...
  http://www.rcsb.org/pdb/protein/P27479
*  RCSB PDB - Protein Feature View - Arachidonate 5-lipoxygenase - P09917 (LOX5 HUMAN)
The PDB archive contains information about experimentally-determined structures of proteins, nucleic acids, and complex assemblies. As a member of the wwPDB, the RCSB PDB curates and annotates PDB data according to agreed upon standards. The RCSB PDB also provides a variety of tools and resources. Users can perform simple and advanced searches based on annotations relating to sequence, structure and function. These molecules are visualized, downloaded, and analyzed by users who range from students to specialized scientists.
  http://www.rcsb.org/pdb/protein/E5FPY8
*  ALOX15 - arachidonate 15-lipoxygenase - Tarsius syrichta (Philippine tarsier) - ALOX15 gene & protein
PS00711. LIPOXYGENASE_1. 1 hit. PS00081. LIPOXYGENASE_2. 1 hit. PS51393. LIPOXYGENASE_3. 1 hit. PS50095. PLAT. 1 hit. ... PS00711. LIPOXYGENASE_1. 1 hit. PS00081. LIPOXYGENASE_2. 1 hit. PS51393. LIPOXYGENASE_3. 1 hit. PS50095. PLAT. 1 hit. ... arachidonate 15-lipoxygenaseImported. ,p>Information which has been imported from another database using automatic procedures ... tr,A0A1U7SWG9,A0A1U7SWG9_TARSY arachidonate 15-lipoxygenase OS=Tarsius syrichta GN=ALOX15 PE=3 SV=1 ...
  http://www.uniprot.org/uniprot/A0A1U7SWG9
*  Arachidonate 8-lipoxygenase - Wikipedia
Arachidonate 8-lipoxygenase (EC 1.13.11.40) is an enzyme that catalyzes the chemical reaction arachidonate + O2 ⇌ {\ ... Other names in common use include 8-lipoxygenase, and 8(R)-lipoxygenase. This enzyme participates in arachidonic acid ... Bundy GL, Nidy EG, Epps DE, Mizsak SA, Wnuk RJ (1986). "Discovery of an arachidonic acid C-8 lipoxygenase in the gorgonian ... The systematic name of this enzyme class is arachidonate:oxygen 8-oxidoreductase. ...
  https://en.wikipedia.org/wiki/Arachidonate_8-lipoxygenase
*  Arachidonate 5-lipoxygenase - Wikipedia
Arachidonate 5-lipoxygenase, also known as ALOX5, 5-lipoxygenase, 5-LOX, or 5-LO, is a non-heme iron-containing enzyme (EC 1.13 ... Arachidonate 5-lipoxygenase is a member of the lipoxygenase family of enzymes. It transforms essential fatty acids (EFA) ... "Alox5 - arachidonate 5-lipoxygenase". WikiGenes. Fahel JS, de Souza MB, Gomes MT, Corsetti PP, Carvalho NB, Marinho FA, de ... Arachidonate 5-Lipoxygenase at the US National Library of Medicine Medical Subject Headings (MeSH) Human ALOX5 genome location ...
  https://en.wikipedia.org/wiki/Arachidonate_5-lipoxygenase
*  Arachidonate 5-lipoxygenase inhibitor - Wikipedia
Arachidonate 5-lipoxygenase inhibitors are compounds that slow or stop the action of the arachidonate 5-lipoxygenase (5- ... Arachidonate 5-lipoxygenase ...Specific function: Catalyzes the first step in leukotriene biosynthesis, and thereby plays a ... Lipoxygenase inhibitors at the US National Library of Medicine Medical Subject Headings (MeSH) MeSH list of agents 82016859. ... Zileuton is a specific inhibitor of 5-lipoxygenase and thus inhibits leukotriene (LTB4, LTC4, LTD4, and LTE4) formation. Both ...
  https://en.wikipedia.org/wiki/Arachidonate_5-lipoxygenase_inhibitor
*  Arachidonate 15-lipoxygenase type B knockdown leads to reduced lipid accumulation and inflammation in atherosclerosis.
We have shown previously that arachidonate 15-lipoxygenase type B (ALOX15B) is more highly expressed in human atherosclerotic ... Arachidonate 15-Lipoxygenase / metabolism*. Atherosclerosis / complications, enzymology*, pathology. Cytokines / metabolism. ... Arachidonate 15-Lipoxygenase Type B Knockdown Leads to Reduced Lipid Accumulation and Inflammation in Atherosclerosis Alternate ... Arachidonate 15-lipoxygenase (ALOX15) catalyzes the production of eicosanoids that activate monocyte integrins and thereby ...
  http://www.biomedsearch.com/nih/Arachidonate-15-lipoxygenase-type-B/22912809.html
*  Arachidonate 5-lipoxygenase elisa and antibody
Recombinant Protein and Arachidonate 5-lipoxygenase Antibody at MyBioSource. Custom ELISA Kit, Recombinant Protein and Antibody ... Arachidonate 5-lipoxygenase. Arachidonate 5-lipoxygenase ELISA Kit. Arachidonate 5-lipoxygenase Recombinant. Arachidonate 5- ... lipoxygenase Antibody. Also known as Arachidonate 5-lipoxygenase (5-LO) (5-lipoxygenase).. Catalyzes the first step in ... Below are the list of possible Arachidonate 5-lipoxygenase products. If you cannot find the target and/or product is not ...
  https://www.mybiosource.com/protein_family.php?root=arachidonate-5-lipoxygenase
*  Arachidonate 15-lipoxygenase - Wikidata
All structured data from the main and property namespace is available under the Creative Commons CC0 License; text in the other namespaces is available under the Creative Commons Attribution-ShareAlike License; additional terms may apply. By using this site, you agree to the Terms of Use and Privacy Policy. ...
  https://www.wikidata.org/wiki/Q3621201
*  Arachidonate 5-lipoxygenase-activating protein
Lipoxin and resolvin biosynthesis is dependent on 5-lipoxygenase activating protein.. 26159646. 2015. Variants in the ... Inhibitors of its function impede translocation of 5-lipoxygenase from the cytoplasm to the cell membrane and inhibit 5- ... Required for leukotriene biosynthesis by ALOX5 (5-lipoxygenase). Anchors ALOX5 to the membrane. Binds arachidonic acid, and ... This gene encodes a protein which, with 5-lipoxygenase, is required for leukotriene synthesis. Leukotrienes are arachidonic ...
  https://pharos.nih.gov/idg/targets/P20292
*  Arachidonate 12-lipoxygenase, 12R-type
The role of lipoxygenases in epidermis.. 23621129. 2013. Non-syndromic autosomal recessive congenital ichthyosis in the Israeli ... Lipoxygenases mediate the effect of essential fatty acid in skin barrier formation: a proposed role in releasing omega- ... This review covers the background to discovery of the two key lipoxygenases (LOX) involved in epidermal barrier function, 12R- ... It was shown that 12R-lipoxygenase is involved in MUC5AC expression via ERK- and Sp1-signalling pathways.. ...
  https://pharos.nih.gov/idg/targets/O75342
*  ALOXE3 gene - Genetics Home Reference - NIH
OMIM: ARACHIDONATE LIPOXYGENASE 3. *. Eckl KM, Krieg P, Küster W, Traupe H, André F, Wittstruck N, Fürstenberger G, Hennies HC ... arachidonate lipoxygenase 3. Enable Javascript to view the expand/collapse boxes.. Printable PDF Open All Close All ... This enzyme is part of a family of enzymes called arachidonate lipoxygenases. Most enzymes in this family help add an oxygen ... Lipoxygenase-3 (ALOXE3) and 12(R)-lipoxygenase (ALOX12B) are mutated in non-bullous congenital ichthyosiform erythroderma (NCIE ...
  https://ghr.nlm.nih.gov/gene/ALOXE3
*  Autosomal Recessive Congenital Ichthyosis - GeneReviews® - NCBI Bookshelf
Arachidonate 12-lipoxygenase, 12R-type. ALOX12B database. ALOX12B. ALOX12B. ALOXE3. 17p13. ​.1. Hydroperoxide isomerase ALOXE3 ... Normal gene product. The protein product of ALOX12B, the enzyme arachidonate 12-lipoxygenase, 12R-type (12R-LOX), has 701 amino ... Lipoxygenase-3 (ALOXE3) and 12(R)-lipoxygenase (ALOX12B) are mutated in non-bullous congenital ichthyosiform erythroderma (NCIE ... Human 12(R)-lipoxygenase and the mouse ortholog. Molecular cloning, expression, and gene chromosomal assignment. J Biol Chem. ...
  https://www.ncbi.nlm.nih.gov/books/NBK1420/
*  Old HGNC Gene Families/Groupings Nomenclature (Archive) | HUGO Gene Nomenclature Committee
Arachidonate lipoxygenases (ALOX) *Argonaute/PIWI family *Armadillo repeat containing (ARMC). *Arylsulfatase family (ARS) ...
  https://www.genenames.org/genefamilies/a-z
*  A - Genes - Genetics Home Reference - NIH
ALOX12B: arachidonate 12-lipoxygenase, 12R type. *ALOXE3: arachidonate lipoxygenase 3. *ALPL: alkaline phosphatase, ...
  https://ghr.nlm.nih.gov/gene
*  12-Hydroxyeicosatetraenoic acid - Wikipedia
In humans, Arachidonate 12-lipoxygenase (12-LO, 12-LOX, ALO12, or platelet type 12-lipoxygenase) is encoded by the ALOX12 gene ... 12-lipoxygenase gene, see lipoxygenase#mouse lipoxygenases) are resistant to a) streptozotocin-induced, b) high fat diet- ... Arachidonate 12-lipoxygenase, 12R type, also termed 12RLOX and encoded by the ALOX12B gene, is expressed primarily in skin and ... express platelet type 12-lipoxygenase but also a leukocyte type 12-lipoxygenase (also termed 12/15-lipoxygenase, 12/15-LOX or ...
  https://en.wikipedia.org/wiki/12-Hydroxyeicosatetraenoic_acid
*  Formation and Role of Lipoxygenase Products in Human Platelets | SpringerLink
Nugteren, D.H., 1975, Arachidonate lipoxygenase in blood platelets, Biochim. Biophys. Acta 380:299-307.PubMedCrossRefGoogle ... Ho, P.P.K., Walters, P., and Sullivan, H.R., 1977, A particulate arachidonate lipoxygenase in human blood platelets, Biochem. ... Aharony, D., Smith, J.B., and Silver, M.J., 1982, Regulation of arachidonate induced platelet aggregation by the lipoxygenase ... Arachidonic Acid Platelet Aggregation Human Platelet Lipoxygenase Activity Lipoxygenase Pathway These keywords were added by ...
  https://link.springer.com/chapter/10.1007/978-1-4684-4946-4_8
*  ALOX15 gene - Genetics Home Reference - NIH
arachidonate 15-lipoxygenase. Enable Javascript to view the expand/collapse boxes.. Open All Close All ... This gene encodes a member of the lipoxygenase family of proteins. The encoded enzyme acts on various polyunsaturated fatty ...
  https://ghr.nlm.nih.gov/gene/ALOX15
*  ALOX5AP Gene - GeneCards | AL5AP Protein | AL5AP Antibody
Arachidonate 5-Lipoxygenase Activating Protein, including: function, proteins, disorders, pathways, orthologs, and expression. ... arachidonate 5-lipoxygenase activating protein,expressed in cells of myeloid origin,localized in the nuclear envelop,involved ... ALOX5AP (Arachidonate 5-Lipoxygenase Activating Protein) is a Protein Coding gene. Diseases associated with ALOX5AP include ... 5- and 12-Lipoxygenase inhibitor. 491-67-8. BAY-X 1005. Orally active 5-lipoxygenase activating protein (FLAP) inhibitor. ...
  https://www.genecards.org/cgi-bin/carddisp.pl?gene=ALOX5AP
*  ALOX12B gene - Genetics Home Reference
arachidonate 12-lipoxygenase, 12R type. Enable Javascript to view the expand/collapse boxes.. Printable PDF Open All Close All ... OMIM: ARACHIDONATE 12-LIPOXYGENASE, R TYPE. *. Eckl KM, Krieg P, Küster W, Traupe H, André F, Wittstruck N, Fürstenberger G, ... Arachidonate lipoxygenases add oxygen molecules at different locations on the arachidonic acid molecule, producing a variety of ... This enzyme is part of a family of enzymes called arachidonate lipoxygenases. Most of these enzymes help add an oxygen molecule ...
  https://ghr.nlm.nih.gov/gene/ALOX12B
*  anti-ALOXE3 antibody [N1N3] | GeneTex
... arachidonate lipoxygenase 3) for IHC-P, WB. Anti-ALOXE3 pAb (GTX107325) is tested in Human samples. 100% Ab-Assurance. ... epidermal lipoxygenase antibody, epidermis-type lipoxygenase 3 antibody, arachidonate lipoxygenase 3 antibody. ... arachidonate lipoxygenase 3. Background. The leukotrienes constitute a group of arachidonic acid-derived compounds with ... Epidermis-type lipoxygenases, a distinct subclass within the multigene family of mammalian lipoxygenases, are novel isoenzymes ...
  http://www.genetex.com/ALOXE3-antibody-N1N3-GTX107325.html
*  ATP-Driven Ca2+ Pump Activity of Macrophage and Neutrophil Plasma Membrane | SpringerLink
Biogenesis of chemotactic molecules by the arachidonate lipoxygenase system of platelets. Nature 257: 680.PubMedCrossRefGoogle ...
  https://link.springer.com/chapter/10.1007/978-1-4684-8088-7_44