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*  IJMS | Free Full-Text | Aptamers and Their Potential to Selectively Target Aspects of EGF, Wnt/β-Catenin and TGFβ-Smad Family...
By their targeting of short, linear motif type of interactions, peptide aptamers have joined nucleic acid aptamers for use in ... Here, we present a brief survey of the use of aptamers in signaling pathways, in particular of polypeptide growth factors, ... We then discuss the opportunities for using aptamers in other complex pathways, including Wnt/β-catenin, and focus on ... We propose that peptide aptamers can provide a very useful and new alternative for interfering with protein-protein ...
  http://mdpi.com/1422-0067/14/4/6690/htm
*  17th week of 2013 patent applcation highlights part 49
... siRNa chimera may include an RNA aptamer that binds BAFF-R and an siRNA molecule conjugated to the RNA aptamer via a nucleotide ... In some embodiments, the RNA aptamer is conjugated, via a nucleotide linker, to an siRNA molecule that suppresses expression of ... In another embodiment, a B cell specific RNA aptamer is provided. The RNA aptamer may be a molecule that binds to BAFF-R that ... RNA APTAMERS AGAINST BAFF-R AS CELL-TYPE SPECIFIC DELIVERY AGENTS AND METHODS FOR THEIR USE - In one embodiment, a B cell ...
  http://www.patentsencyclopedia.com/hgl/04-25-13/04-25-13_49
*  Arfgef1 (untagged) - Mouse ADP-ribosylation factor guanine nucleotide-exchange factor 1(brefeldin A-inhibited) (Arfgef1), (10ug...
Mouse ADP-ribosylation factor guanine nucleotide-exchange factor 1(brefeldin A-inhibited) (Arfgef1), (10ug), 10 µg. ... Home » cDNA » Mouse cDNA » Arfgef1 (untagged) - Mouse ADP-ribosylation factor guanine nucleotide-exchange factor 1(brefeldin A- ... Properties for Arfgef1 (untagged) - Mouse ADP-ribosylation factor guanine nucleotide-exchange factor 1(brefeldin A-inhibited) ( ... MC224976 Arfgef1 (untagged) - Mouse ADP-ribosylation factor guanine nucleotide-exchange factor 1(brefeldin A-inhibited) ( ...
  https://www.acris-antibodies.com/cdna/mouse-cdna/arfgef1-untagged-mouse-adp-ribosylation-factor-guanine-nucleotide-exchange-factor-1-brefeldin-a-inhibited-arfgef1-10ug-mc224976.htm
*  The minimal primary structures of RNA aptamers selected to bind HIV-1 reverse transcriptase
Libraries consisting of aptamers including 32, 70 or 80 nucleotide variable regions were previously screened by Systematic ... and non-pseudoknot aptamers (Family III). Nucleic acid aptamers bind RT in the primer/template binding site. Aptamers are ... which is highly uncommon in RNA anti-RT aptamers. For at least one other aptamer I show that a pseudoknot is the important ... but inhibition depends on a single amino acid mutation at position 277 for other aptamers. Aptamers that are un-reactive to the ...
  https://mospace.umsystem.edu/xmlui/handle/10355/8117
*  Antiviral activity of a 45 nucleotide DNA aptamer during HSV-1 infection of the cornea. | IOVS | ARVO Journals
In this study, we use corneal model of HSV infection to report the high antiviral activity of a 45 nucleotide DNA aptamer ... Antiviral activity of a 45 nucleotide DNA aptamer during HSV-1 infection of the cornea. ... Antiviral activity of a 45 nucleotide DNA aptamer during HSV-1 infection of the cornea. ... Antiviral activity of a 45 nucleotide DNA aptamer during HSV-1 infection of the cornea.. Invest. Ophthalmol. Vis. Sci. 2017;58( ...
  https://iovs.arvojournals.org/article.aspx?articleid=2640870
*  Molecular Probes - Molecular Probe Summary Report | CureHunter
Nucleotide Aptamers Related Therapies and Procedures. 1. Quantum Dots (Quantum Dot) 2. Drug Therapy (Chemotherapy) ... 08/08/2006 - "The cell-based aptamer selection holds a great promise in developing specific molecular probes for cancer ... cell-based aptamer selection holds great promise for the development of specific molecular probes for cancer diagnosis and ...
  http://www.curehunter.com/public/keywordSummaryD015335.do
*  angioma of retina 2005:2010[pubdate] *count=100 - BioMedLib™ search engine
Aptamers, Nucleotide; 0 / VEGFA protein, human; 0 / Vascular Endothelial Growth Factor A; 0 / pegaptanib; 2S9ZZM9Q9V / ... A2.1.5.3.1. Nucleotide Sequence. A2.1.5.3.2. Amino Acid Sequence. A2.1.5.3.3. Carbohydrate Sequence. A2.1.5.4. Geographic Area ... Nucleic Acid, Nucleoside, or Nucleotide. A1.4.1.2.1.6. Organophosphorus Compound. A1.4.1.2.1.7. Amino Acid, Peptide, or Protein ... Polymorphism, Single Nucleotide. Protein Structure, Quaternary. Proto-Oncogene Proteins c-ret / genetics. Retinal Neoplasms / ...
  http://www.bmlsearch.com/?kwr=angioma+of+retina+2005:2010%5Bpubdate%5D&cxts=100&stmp=b0
*  Inhibition of S1P induced ERK1/2 phosphorylation in HUV | Open-i
Aptamers, Nucleotide/pharmacology*. *Lysophospholipids/antagonists & inhibitors*. *Sphingosine/analogs & derivatives*/ ... Employing in vitro selection techniques, we identified an L-aptamer (Spiegelmer®) to S1P designated NOX-S93. The binding ... Employing in vitro selection techniques, we identified an L-aptamer (Spiegelmer®) to S1P designated NOX-S93. The binding ...
  https://openi.nlm.nih.gov/detailedresult.php?img=PMC4109837_bj2013-1422i005&req=4
*  S1P-binding sequence variants and lead Spiegelmer® NOX | Open-i
Aptamers, Nucleotide/pharmacology*. *Lysophospholipids/antagonists & inhibitors*. *Sphingosine/analogs & derivatives*/ ... Employing in vitro selection techniques, we identified an L-aptamer (Spiegelmer®) to S1P designated NOX-S93. The binding ... Employing in vitro selection techniques, we identified an L-aptamer (Spiegelmer®) to S1P designated NOX-S93. The binding ... In order to select for the best binding aptamers, the stringency of the selection process was gradually increased by decreasing ...
  https://openi.nlm.nih.gov/detailedresult.php?img=PMC4109837_bj2013-1422i001&req=4
*  Molecular phenotype of the inhibitory HSF aptamer. (A) | Open-i
A) Effect of aptamer monomer (M) on the level of HS genes measured by conventional RT-PCR. 'R1' is a s ... Aptamers, Nucleotide/chemistry/genetics/metabolism*. *DNA-Binding Proteins/antagonists & inhibitors*. *Gene Expression ... Figure 4: Molecular phenotype of the inhibitory HSF aptamer. (A) Effect of aptamer monomer (M) on the level of HS genes ... Figure 4: Molecular phenotype of the inhibitory HSF aptamer. (A) Effect of aptamer monomer (M) on the level of HS genes ...
  https://openi.nlm.nih.gov/detailedresult.php?img=PMC2926621_gkq529f4&req=4
*  Protein Links for PubMed (Select 23139410) - Protein - NCBI
Chain A, Crystal Structure Of Human Pdgf-Bb In Complex With A Modified Nucleotide Aptamer (Somamer Sl4) ... Chain A, Crystal Structure Of Human Pdgf-Bb In Complex With A Modified Nucleotide Aptamer (Somamer Sl5) ... The tool works with standard single letter nucleotide or protein codes including ambiguities and can match Prosite patterns in ... The tool works with standard single letter nucleotide or protein codes including ambiguities and can match Prosite patterns in ...
  https://www.ncbi.nlm.nih.gov/protein?LinkName=pubmed_protein&from_uid=23139410
*  Hannah McDonald
16 - Fully modified nucleotide aptamer selection against cancer biomarker Igf-1r for theragnostic application ... is to isolate an aptamer that binds tightly and specifically to cancer biomarker Igf-1r. Such an aptamer is intended for use as ... Aptamers are short oligonucleotides that are designed to bind protein targets with high affinity and specificity. To be ... The last of these requirements is central to this study as €natural€ DNA and RNA aptamers are susceptible to nuclease ...
  http://www.beckman-foundation.org/symposium-poster-presentation/hannah-mcdonald
*  研究成果の検索 - Yokohama National University
Kinetic and Thermodynamic Analyses of Interaction between a High-Affinity RNA Aptamer and Its Target Protein. Amano, R., Takada ...
  https://ynu.pure.elsevier.com/ja/publications/?format=&page=7
*  The CD spectra of d(GGGGTTTTGGGG) and d(TGGGGTTGGGGT) i | Open-i
Aptamers, Nucleotide. *Base Sequence. *Circular Dichroism. *Deoxyadenosines/chemistry. *G-Quadruplexes. *Nucleic Acid ... different from that of the telomere repeats of Tetrahymena and Oxytricha as well as that of the thrombin binding aptamer. These ... different from that of the telomere repeats of Tetrahymena and Oxytricha as well as that of the thrombin binding aptamer. These ...
  https://openi.nlm.nih.gov/detailedresult.php?img=PMC1074753_gki345f6&req=4
*  Structural stabilization and sequence requirements of t | Open-i
Proposed secondary structures from mfold of (A) the original FC5 mini-aptamer ... Structural stabilization and sequence requirements of the FC5 mini-aptamer stems. ... Aptamers, Nucleotide/chemistry*. *Codeine/analysis/chemistry*. *Narcotics/analysis/chemistry*. *Surface Plasmon Resonance/ ... Proposed secondary structures from mfold of (A) the original FC5 mini-aptamer (FC5L), (B) the FC5 mini-aptamer with a ...
  https://openi.nlm.nih.gov/detailedresult.php?img=PMC1636496_gkl718f7&req=4
*  Nyquist Diagram of: (a) Electrode-buffer •, (b) Aptam | Open-i
Aptamer of thrombin (AptThr) , and (c) AptThr-Thr ○ 10 pM [Thr]. The arrow in each spectrum denotes the freq ... Aptamers, Nucleotide/chemistry*. *Dielectric Spectroscopy*. *Epoxy Resins/chemistry*. *Graphite/chemistry*. *Thrombin/analysis* ... The aptamer of thrombin forms a single-strand oligonucleotide, a chain that recognizes the protein by a three-dimensional ... The aptamer of thrombin forms a single-strand oligonucleotide, a chain that recognizes the protein by a three-dimensional ...
  https://openi.nlm.nih.gov/detailedresult.php?img=PMC3376577_sensors-12-03037f5&req=4
*  Brevetto CA2526690A1 - Structure based and combinatorially selected oligonucleoside ... - Google Brevetti
The resulting aptamers have the same nucleotide base sequence as the original aptamer but, by virtue of the inclusion of ... The concatenated aptamer may include two or more concatenated thio-modified aptamers, wherein one or more of the aptamers is ... In yet another example, at least a portion of non-adjacent dA, dC, dG, or dT phosphate sites of the modified nucleotide aptamer ... Synthesis may proceed with further iterations of mixing or with distinct nucleotide addition.. Aptamers may be defined as ...
  https://books.google.it/patents/CA2526690A1?hl=it&cl=en
*  Tandem riboswitches form a natural Boolean logic gate to control purine metabolism in bacteria | eLife
... and this novel RNA sensor commonly operates in tandem with a guanine aptamer to function like a Boolean logic gate. ... To evaluate PRPP binding and riboswitch aptamer function, we examined a 106 nucleotide singlet aptamer arbitrarily derived from ... Ligand binding by tandem guanine and PRPP aptamers.. (A) Sequence and secondary structure of the 208 nucleotide RNA derived ... We speculated that the structural role of the G nucleotide missing in ppGpp aptamers might be performed by the guanine base of ...
  https://elifesciences.org/articles/33908
*  STABILIZING ALKYLGLYCOSIDE COMPOSITIONS AND METHODS THEREOF - Patent application
Spiegelmer nucleotide aptamers 103. CGRP (calcitonin gene related protein) 104. Amylin 105. IL-21 106. melanotan 107. ... Spiegelmer nucleotide aptamers, CGRP (calcitonin gene related protein), Urocortin, Amylin, IL-21, melanotan, valpreotide, ACV-1 ... covalent attachment of a nucleotide or nucleotide derivative, covalent attachment of a lipid or lipid derivative, covalent ... Changes in the nucleotide sequence of the variant may or may not alter the amino acid sequence of a polypeptide encoded by the ...
  http://www.patentsencyclopedia.com/app/20090305958
*  EGFR APTAMER INHIBITOR FOR USE IN THERAPY AND DIAGNOSIS - Patent application
Preferably the nucleotide aptamer is nuclease-resistant. Still preferably the nucleotide aptamer has at least one or all of the ... the nucleotide aptamer according to claim 1; and measuring the binding of the nucleotide aptamer to the sample. 13. The method ... incubating the sample with the nucleotide aptamer as defined above;. [0016] measuring the binding of the nucleotide aptamer to ... 1. CL4 42-81 aptamer. A) Nucleotide sequence of CL4 42-81 aptamer. All the pyrimidines of the sequence are 2'-fluoropyrimidine ...
  http://www.patentsencyclopedia.com/app/20130177556
*  Convergent evolution to an aptamer observed in small populations on DNA microarrays. - Oxford Big Data Institute
... these nine distinct evolutionary runs are observed to develop aptamers with high affinity and to converge on the same motif not ... The development of aptamers on custom synthesized DNA microarrays, which has been demonstrated in recent publications, can ... Aptamers, Nucleotide ... The development of aptamers on custom synthesized DNA ... Convergent evolution to an aptamer observed in small populations on DNA microarrays. ...
  https://www.bdi.ox.ac.uk/publications/693582
*  In Vitro Selection of RNA Aptamers Directed Against Protein E: A Haemophilus influenzae Adhesin. : a Haemophilus influenzae...
Adhesins, Bacterial, Aptamers, Nucleotide, Base Sequence, Biotechnology, DNA, Bacterial, Haemophilus influenzae, Humans, In ... Biacore experiments indicated that one of the aptamers had a higher binding affinity for PE as compared to the other aptamers. ... Biacore experiments indicated that one of the aptamers had a higher binding affinity for PE as compared to the other aptamers. ... Aptamers, Nucleotide,Base Sequence,Biotechnology,DNA, Bacterial,Haemophilus influenzae,Humans,In Vitro Techniques,Molecular ...
  https://lup.lub.lu.se/search/publication/4431486
*  Publications | Max Planck Institute for Biophysical Chemistry
Wachowius, F.; Höbartner, C.: Probing essential nucleobase functional groups in aptamers and deoxyribozymes by nucleotide ...
  https://www.mpibpc.mpg.de/publications?year=2011
*  Forsøgsdyrenes Værn's research grants help animals
... to develop a nucleotide aptamer alternative to animal-derived antibody detection of Type VII collagen; and use the developed ... These two parts represents the peptide aptamer. By inserting both target and peptide aptamers in a reporter system, protein- ... The aim of the project was to replace the use of antibodies with peptide aptamers. Since it has been shown, that they have ... When we have a target protein the first step is to find a peptide aptamer, that is able to participate in protein-protein ...
  http://forsoegsdyrenes-vaern.dk.linux4.scannetserver.dk/four-research-projects-supported-by-forsogsdyrenes-vaern-in-2016/
*  Theses completed - Chair of Computational Biology
Master Thesis: Prediction of Binding Affinity of Nucleotide Aptamers Against Protein Binding Domains Using a PWM-based Scoring ...
  http://gepard.bioinformatik.uni-saarland.de/Members/theses-completed