*  17th week of 2013 patent applcation highlights part 49
... siRNa chimera may include an RNA aptamer that binds BAFF-R and an siRNA molecule conjugated to the RNA aptamer via a nucleotide ... In some embodiments, the RNA aptamer is conjugated, via a nucleotide linker, to an siRNA molecule that suppresses expression of ... In another embodiment, a B cell specific RNA aptamer is provided. The RNA aptamer may be a molecule that binds to BAFF-R that ... RNA APTAMERS AGAINST BAFF-R AS CELL-TYPE SPECIFIC DELIVERY AGENTS AND METHODS FOR THEIR USE - In one embodiment, a B cell ...
  http://www.patentsencyclopedia.com/hgl/04-25-13/04-25-13_49
*  Inhibition of S1P induced ERK1/2 phosphorylation in HUV | Open-i
Aptamers, Nucleotide/pharmacology*. *Lysophospholipids/antagonists & inhibitors*. *Sphingosine/analogs & derivatives*/ ... Employing in vitro selection techniques, we identified an L-aptamer (Spiegelmer®) to S1P designated NOX-S93. The binding ... Employing in vitro selection techniques, we identified an L-aptamer (Spiegelmer®) to S1P designated NOX-S93. The binding ...
  https://openi.nlm.nih.gov/detailedresult.php?img=PMC4109837_bj2013-1422i005&req=4
*  S1P-binding sequence variants and lead Spiegelmer® NOX | Open-i
Aptamers, Nucleotide/pharmacology*. *Lysophospholipids/antagonists & inhibitors*. *Sphingosine/analogs & derivatives*/ ... By deleting the terminal A/U base pair of 215-F9-001, a length of 44 nucleotides was defined as the minimal binder (215-F9-002 ... By deleting the terminal A/U base pair of 215-F9-001, a length of 44 nucleotides was defined as the minimal binder (215-F9-002 ... Employing in vitro selection techniques, we identified an L-aptamer (Spiegelmer®) to S1P designated NOX-S93. The binding ...
  https://openi.nlm.nih.gov/detailedresult.php?img=PMC4109837_bj2013-1422i001&req=4
*  Molecular phenotype of the inhibitory HSF aptamer. (A) | Open-i
A) Effect of aptamer monomer (M) on the level of HS genes measured by conventional RT-PCR. 'R1' is a s ... Aptamers, Nucleotide/chemistry/genetics/metabolism*. *DNA-Binding Proteins/antagonists & inhibitors*. *Gene Expression ... Figure 4: Molecular phenotype of the inhibitory HSF aptamer. (A) Effect of aptamer monomer (M) on the level of HS genes ... Figure 4: Molecular phenotype of the inhibitory HSF aptamer. (A) Effect of aptamer monomer (M) on the level of HS genes ...
  https://openi.nlm.nih.gov/detailedresult.php?img=PMC2926621_gkq529f4&req=4
*  Protein Links for PubMed (Select 23139410) - Protein - NCBI
Chain A, Crystal Structure Of Human Pdgf-Bb In Complex With A Modified Nucleotide Aptamer (Somamer Sl4) ... Chain A, Crystal Structure Of Human Pdgf-Bb In Complex With A Modified Nucleotide Aptamer (Somamer Sl5) ... The tool works with standard single letter nucleotide or protein codes including ambiguities and can match Prosite patterns in ... The tool works with standard single letter nucleotide or protein codes including ambiguities and can match Prosite patterns in ...
  https://www.ncbi.nlm.nih.gov/protein?LinkName=pubmed_protein&from_uid=23139410
*  Patent US5759794 - Assay of blood or other biologic samples for target analytes - Google Patents
... nucleotides and their complementary nucleotides; aptamers (nucleotides which bind to a target analyte molecule) and their ... nucleotides, or other active binding substances whose complement, or binding partners, (which are designated herein as "target ... complementary nucleotide sequences; effector/receptor molecules; enzyme cofactors/enzymes; enzyme inhibitors/enzymes; a peptide ...
  http://www.google.com.au/patents/US5759794
*  研究成果の検索 - Yokohama National University
Kinetic and Thermodynamic Analyses of Interaction between a High-Affinity RNA Aptamer and Its Target Protein. Amano, R., Takada ...
  https://ynu.pure.elsevier.com/ja/publications/?format=&page=7
*  The CD spectra of d(GGGGTTTTGGGG) and d(TGGGGTTGGGGT) i | Open-i
Aptamers, Nucleotide. *Base Sequence. *Circular Dichroism. *Deoxyadenosines/chemistry. *G-Quadruplexes. *Nucleic Acid ... different from that of the telomere repeats of Tetrahymena and Oxytricha as well as that of the thrombin binding aptamer. These ... different from that of the telomere repeats of Tetrahymena and Oxytricha as well as that of the thrombin binding aptamer. These ...
  https://openi.nlm.nih.gov/detailedresult.php?img=PMC1074753_gki345f6&req=4
*  Structural stabilization and sequence requirements of t | Open-i
Proposed secondary structures from mfold of (A) the original FC5 mini-aptamer ... Structural stabilization and sequence requirements of the FC5 mini-aptamer stems. ... the FC5 mini-aptamer with a stabilized base stem composed of randomly-selected nucleotides (FC5L-S2). Mentions: The base stems ... Proposed secondary structures from mfold of (A) the original FC5 mini-aptamer (FC5L), (B) the FC5 mini-aptamer with a ...
  https://openi.nlm.nih.gov/detailedresult.php?img=PMC1636496_gkl718f7&req=4
*  Nyquist Diagram of: (a) Electrode-buffer •, (b) Aptam | Open-i
Aptamer of thrombin (AptThr) , and (c) AptThr-Thr ○ 10 pM [Thr]. The arrow in each spectrum denotes the freq ... Aptamers, Nucleotide/chemistry*. *Dielectric Spectroscopy*. *Epoxy Resins/chemistry*. *Graphite/chemistry*. *Thrombin/analysis* ... The aptamer of thrombin forms a single-strand oligonucleotide, a chain that recognizes the protein by a three-dimensional ... The aptamer of thrombin forms a single-strand oligonucleotide, a chain that recognizes the protein by a three-dimensional ...
  https://openi.nlm.nih.gov/detailedresult.php?img=PMC3376577_sensors-12-03037f5&req=4
*  Brevetto CA2526690A1 - Structure based and combinatorially selected oligonucleoside ... - Google Brevetti
The resulting aptamers have the same nucleotide base sequence as the original aptamer but, by virtue of the inclusion of ... The concatenated aptamer may include two or more concatenated thio-modified aptamers, wherein one or more of the aptamers is ... In yet another example, at least a portion of non-adjacent dA, dC, dG, or dT phosphate sites of the modified nucleotide aptamer ... Synthesis may proceed with further iterations of mixing or with distinct nucleotide addition.. Aptamers may be defined as ...
  https://books.google.it/patents/CA2526690A1?hl=it&cl=en
*  HIGH THROUGHPUT INTEGRATED MICROFLUIDIC SYSTEM AND DEVICE - Patent application
Immobilized affinity ligands may include, but are limited to; antibodies, aptamers, nucleotides, small molecules, etc. This ... acids and aptamers. [0040]As used herein, "affinity micro-column" refers to a micro-column in which affinity ligand has been ...
  http://www.patentsencyclopedia.com/app/20100267581
*  EGFR APTAMER INHIBITOR FOR USE IN THERAPY AND DIAGNOSIS - Patent application
Preferably the nucleotide aptamer is nuclease-resistant. Still preferably the nucleotide aptamer has at least one or all of the ... the nucleotide aptamer according to claim 1; and measuring the binding of the nucleotide aptamer to the sample. 13. The method ... incubating the sample with the nucleotide aptamer as defined above;. [0016] measuring the binding of the nucleotide aptamer to ... 0057] CL4 42-81 aptamer is a 2'-fluoropyrimidine (2'F-Py), nuclease-resistant RNA aptamer consisting of 39 nucleotides (nt) ( ...
  http://www.patentsencyclopedia.com/app/20130177556
*  In Vitro Selection of RNA Aptamers Directed Against Protein E: A Haemophilus influenzae Adhesin. : a Haemophilus influenzae...
Adhesins, Bacterial, Aptamers, Nucleotide, Base Sequence, Biotechnology, DNA, Bacterial, Haemophilus influenzae, Humans, In ... Biacore experiments indicated that one of the aptamers had a higher binding affinity for PE as compared to the other aptamers. ... Biacore experiments indicated that one of the aptamers had a higher binding affinity for PE as compared to the other aptamers. ... Aptamers, Nucleotide,Base Sequence,Biotechnology,DNA, Bacterial,Haemophilus influenzae,Humans,In Vitro Techniques,Molecular ...
  https://lup.lub.lu.se/search/publication/4431486
*  New sensor sends electronic signal when estrogen is detected | EurekAlert! Science News
Once the appropriate sequence of nucleotides is known, the aptamers can be easily generated. ... The beauty of the aptamer plus CNT FET sensors is that the aptamers can be easily replaced with new ones that target a ... They found that in the presence of estrogen the short aptamer device produced an electrical signal, while the long aptamer ... "Aptamers are a potentially powerful tool for sensors because they are so versatile and selective," said Natalie Plank, a ...
  https://www.eurekalert.org/pub_releases/2015-11/aiop-nss112415.php
*  Archemix Announces ARC1779 Data to Be Presented at Upcoming American Society of Hematology (ASH) Annual Meeting, December 6-9,...
... developing and commercializing aptamer therapeutics, today announced that data fro ... Archemix's lead aptamer product candidate, ARC1779, is a PEGylated aptamer consisting of 40 nucleotides that is administered ... About Aptamers. Aptamers are synthetically-derived oligonucleotides, or short nucleic acid sequences, that bind to protein ... "Proof of Concept for the Anti Von Willebrand Factor Aptamer in Patients with Relapsing Thrombotic Thrombocytopenic Purpura (TTP ...
  https://www.drugs.com/clinical_trials/archemix-announces-arc1779-data-presented-upcoming-american-society-hematology-ash-annual-meeting-6374.html
*  Theses completed - Chair of Computational Biology
Master Thesis: Prediction of Binding Affinity of Nucleotide Aptamers Against Protein Binding Domains Using a PWM-based Scoring ...
  http://gepard.bioinformatik.uni-saarland.de/Members/theses-completed
*  Theses completed
Master Thesis: Prediction of Binding Affinity of Nucleotide Aptamers Against Protein Binding Domains Using a PWM-based Scoring ...
  https://www-cbi.cs.uni-saarland.de/people/theses-completed/
*  US Patent # 7,422,746. Chemically programmable immunity - Patents.com
Preferably, the at least one second binding site is a DNA aptamer made from modified nucleotides. Such DNA molecules are very ... For purposes of stability in biological fluids, a preferred aptamer contains one or more modified nucleotides such as 2'-fluoro ... In other embodiments, the first and/or second binding sites comprise an aptamer nucleic acid, and more preferably an aptamer ... The aptamers to any target can be generated in hours or days, linked to the linker portion and the first binding site of the ...
  http://www.patents.com/us-7422746.html
*  Regulation of expression of PI3Kβ protein in tumors - Universita' Degli Studi di Torino
... aptamers, antisense nucleotides, RNA-based inhibitors, siRNAs, antibodies, peptides, and dominant negative proteins. 3. The ... The probe comprises at least 300 contiguous nucleotides selected from the complement of SEQ ID NO.:1. A test compound which ...
  http://www.freepatentsonline.com/8105796.html
*  Biosensors | Free Full-Text | MIPs and Aptamers for Recognition of Proteins in Biomimetic Sensing
The two major approaches use either "evolution in the test tube" of nucleotides for the preparation of aptamers or total ... On the other hand, the overall negative charge of the nucleotides makes aptamers prone to non-specific adsorption of positively ... This article belongs to the Special Issue Aptamer Sensors) View Full-Text , Download PDF [2385 KB, uploaded 18 July 2016] , ... MIPs and Aptamers for Recognition of Proteins in Biomimetic Sensing. Marcus Menger 1,* , Aysu Yarman 2,3. ...
  http://www.mdpi.com/2079-6374/6/3/35
*  List of MeSH codes (D13) - Wikipedia
... aptamers, nucleotide MeSH D13.695.578.424.450 --- oligodeoxyribonucleotides MeSH D13.695.578.424.450.275 --- dna primers MeSH ... thymine nucleotides MeSH D13.695.740.706.788 --- thymidine monophosphate MeSH D13.695.740.850 --- uracil nucleotides MeSH ... deoxyadenine nucleotides MeSH D13.695.201.150 --- deoxycytosine nucleotides MeSH D13.695.201.150.200 --- deoxycytidine ... monophosphate MeSH D13.695.201.175 --- deoxyguanine nucleotides MeSH D13.695.201.200 --- deoxyuracil nucleotides MeSH D13.695. ...
  https://en.wikipedia.org/wiki/List_of_MeSH_codes_(D13)
*  Noncoding RNAs - CHEMICAL BIOLOGY
High resolution crystal structures exist for the liganded forms of both the 68 nucleotide aptamer domain of the guanine-sensing ... Atomic resolution structures of the liganded forms of both the 71 nucleotide adenine-sensing aptamer domain of the add ... and it participates in eight direct H-bonding interactions with four aptamer nucleotides: three H-bonds represent a canonical ... the 120 nucleotide 5S RNA, and the 2900 nucleotide 23 S RNA) of the ribosome, together with the initiator tRNA that is charged ...
  http://schoolbag.info/chemistry/chemical_biology/149.html
*  Plus it
A 19 nucleotide (nt) aptamer that binds to human EpCAM with 12 nmol/L affinity (19) was identified by SELEX (42, 43). A handful ... Evolution of aptamers with a new specificity and new secondary structures from an ATP aptamer. RNA 2003;9:1456-63. ... Aptamer-linked siRNAs, known as aptamer-siRNA chimeras (AsiC), have been used in small animal models to treat prostate cancer ... An aptamer drug, pegatanib (Macugen) is approved for macular degeneration and at least 8 aptamer drugs are in clinical trials, ...
  http://mct.aacrjournals.org/content/14/10/2279