*  17th week of 2013 patent applcation highlights part 49
... siRNa chimera may include an RNA aptamer that binds BAFF-R and an siRNA molecule conjugated to the RNA aptamer via a nucleotide ... In some embodiments, the RNA aptamer is conjugated, via a nucleotide linker, to an siRNA molecule that suppresses expression of ... In another embodiment, a B cell specific RNA aptamer is provided. The RNA aptamer may be a molecule that binds to BAFF-R that ... RNA APTAMERS AGAINST BAFF-R AS CELL-TYPE SPECIFIC DELIVERY AGENTS AND METHODS FOR THEIR USE - In one embodiment, a B cell ...
  http://www.patentsencyclopedia.com/hgl/04-25-13/04-25-13_49
*  In Vitro Selection and Characterization of DNA Aptamers to a Small Molecule Target - Current Protocols
Aptamers, synthetic oligonucleotide‐based molecular recognition probes, have found use in a wide array of biosensing ... Random nucleotide spacers are indicated by a bold N, and the barcodes that are complementary to the index adapters are bold and ... Support Protocol 3: Aptamer Truncation. Materials * 50 μM 5′‐fluorescein‐labeled DNA (truncated aptamer designs) dissolved in ... Chaou, T., Vialet, B., & Azema, L. (2016). DNA aptamer selection in methanolic media: Adenine‐aptamer as proof‐of‐concept. ...
  http://www.currentprotocols.com/WileyCDA/CPUnit/refId-cpch28.html
*  The minimal primary structures of RNA aptamers selected to bind HIV-1 reverse transcriptase
Libraries consisting of aptamers including 32, 70 or 80 nucleotide variable regions were previously screened by Systematic ... and non-pseudoknot aptamers (Family III). Nucleic acid aptamers bind RT in the primer/template binding site. Aptamers are ... which is highly uncommon in RNA anti-RT aptamers. For at least one other aptamer I show that a pseudoknot is the important ... but inhibition depends on a single amino acid mutation at position 277 for other aptamers. Aptamers that are un-reactive to the ...
  https://mospace.umsystem.edu/xmlui/handle/10355/8117
*  L-Ribonucleic acid aptamer - Wikipedia
L-RNA aptamers are a form of aptamers. Due to their L-nucleotides, they are highly resistant to degradation by nucleases. ... such as PEGylated L-RNA aptamers, show a prolonged plasma half-life. Unlike other aptamers, L-RNA aptamers are not directly ... This information is used for the synthesis of the oligonucleotide's enantiomer, the L-RNA aptamer, using L-nucleotides. ... Like other aptamers, L-RNA aptamers are able to bind molecules such as peptides, proteins, and substances of low molecular ...
  https://en.wikipedia.org/wiki/L-Ribonucleic_acid_aptamer
*  Anti-thrombin aptamers - Wikipedia
... lacking the first and the last nucleotides of 29-mer form) nucleotides. This aptamer recognizes the exosite II of thrombin, ... Despite that this aptamer only shows moderate effect on fibrinogen regulation, the affinity of this aptamer is slightly higher ... The aptamer HD22 (also known as HTDQ) is an optimized aptamer with 29 (5'-AGTCCGTGGTAGGGCAGGTTGGGGTGACT-3') or 27 ( ... These two aptamers have high affinity and good specificity and have been widely studied and used for the development of aptamer ...
  https://en.wikipedia.org/wiki/Anti-thrombin_aptamers
*  Antiviral activity of a 45 nucleotide DNA aptamer during HSV-1 infection of the cornea. | IOVS | ARVO Journals
In this study, we use corneal model of HSV infection to report the high antiviral activity of a 45 nucleotide DNA aptamer ... Antiviral activity of a 45 nucleotide DNA aptamer during HSV-1 infection of the cornea. ... Antiviral activity of a 45 nucleotide DNA aptamer during HSV-1 infection of the cornea. ... Antiviral activity of a 45 nucleotide DNA aptamer during HSV-1 infection of the cornea.. Invest. Ophthalmol. Vis. Sci. 2017;58( ...
  https://iovs.arvojournals.org/article.aspx?articleid=2640870
*  Inhibition of S1P induced ERK1/2 phosphorylation in HUV | Open-i
Aptamers, Nucleotide/pharmacology*. *Lysophospholipids/antagonists & inhibitors*. *Sphingosine/analogs & derivatives*/ ... Employing in vitro selection techniques, we identified an L-aptamer (Spiegelmer®) to S1P designated NOX-S93. The binding ... Employing in vitro selection techniques, we identified an L-aptamer (Spiegelmer®) to S1P designated NOX-S93. The binding ...
  https://openi.nlm.nih.gov/detailedresult.php?img=PMC4109837_bj2013-1422i005&req=4
*  S1P-binding sequence variants and lead Spiegelmer® NOX | Open-i
Aptamers, Nucleotide/pharmacology*. *Lysophospholipids/antagonists & inhibitors*. *Sphingosine/analogs & derivatives*/ ... By deleting the terminal A/U base pair of 215-F9-001, a length of 44 nucleotides was defined as the minimal binder (215-F9-002 ... By deleting the terminal A/U base pair of 215-F9-001, a length of 44 nucleotides was defined as the minimal binder (215-F9-002 ... Employing in vitro selection techniques, we identified an L-aptamer (Spiegelmer®) to S1P designated NOX-S93. The binding ...
  https://openi.nlm.nih.gov/detailedresult.php?img=PMC4109837_bj2013-1422i001&req=4
*  Molecular phenotype of the inhibitory HSF aptamer. (A) | Open-i
A) Effect of aptamer monomer (M) on the level of HS genes measured by conventional RT-PCR. 'R1' is a s ... Aptamers, Nucleotide/chemistry/genetics/metabolism*. *DNA-Binding Proteins/antagonists & inhibitors*. *Gene Expression ... Figure 4: Molecular phenotype of the inhibitory HSF aptamer. (A) Effect of aptamer monomer (M) on the level of HS genes ... Figure 4: Molecular phenotype of the inhibitory HSF aptamer. (A) Effect of aptamer monomer (M) on the level of HS genes ...
  https://openi.nlm.nih.gov/detailedresult.php?img=PMC2926621_gkq529f4&req=4
*  Protein Links for PubMed (Select 23139410) - Protein - NCBI
Chain A, Crystal Structure Of Human Pdgf-Bb In Complex With A Modified Nucleotide Aptamer (Somamer Sl4) ... Chain A, Crystal Structure Of Human Pdgf-Bb In Complex With A Modified Nucleotide Aptamer (Somamer Sl5) ... The tool works with standard single letter nucleotide or protein codes including ambiguities and can match Prosite patterns in ... The tool works with standard single letter nucleotide or protein codes including ambiguities and can match Prosite patterns in ...
  https://www.ncbi.nlm.nih.gov/protein?LinkName=pubmed_protein&from_uid=23139410
*  Patent US5759794 - Assay of blood or other biologic samples for target analytes - Google Patents
... nucleotides and their complementary nucleotides; aptamers (nucleotides which bind to a target analyte molecule) and their ... nucleotides, or other active binding substances whose complement, or binding partners, (which are designated herein as "target ... complementary nucleotide sequences; effector/receptor molecules; enzyme cofactors/enzymes; enzyme inhibitors/enzymes; a peptide ...
  http://www.google.com.au/patents/US5759794
*  Hannah McDonald
16 - Fully modified nucleotide aptamer selection against cancer biomarker Igf-1r for theragnostic application ... is to isolate an aptamer that binds tightly and specifically to cancer biomarker Igf-1r. Such an aptamer is intended for use as ... Aptamers are short oligonucleotides that are designed to bind protein targets with high affinity and specificity. To be ... The last of these requirements is central to this study as €natural€ DNA and RNA aptamers are susceptible to nuclease ...
  http://www.beckman-foundation.org/symposium-poster-presentation/hannah-mcdonald
*  研究成果の検索 - Yokohama National University
Kinetic and Thermodynamic Analyses of Interaction between a High-Affinity RNA Aptamer and Its Target Protein. Amano, R., Takada ...
  https://ynu.pure.elsevier.com/ja/publications/?format=&page=7
*  The CD spectra of d(GGGGTTTTGGGG) and d(TGGGGTTGGGGT) i | Open-i
Aptamers, Nucleotide. *Base Sequence. *Circular Dichroism. *Deoxyadenosines/chemistry. *G-Quadruplexes. *Nucleic Acid ... different from that of the telomere repeats of Tetrahymena and Oxytricha as well as that of the thrombin binding aptamer. These ... different from that of the telomere repeats of Tetrahymena and Oxytricha as well as that of the thrombin binding aptamer. These ...
  https://openi.nlm.nih.gov/detailedresult.php?img=PMC1074753_gki345f6&req=4
*  Structural stabilization and sequence requirements of t | Open-i
Proposed secondary structures from mfold of (A) the original FC5 mini-aptamer ... Structural stabilization and sequence requirements of the FC5 mini-aptamer stems. ... the FC5 mini-aptamer with a stabilized base stem composed of randomly-selected nucleotides (FC5L-S2). Mentions: The base stems ... Proposed secondary structures from mfold of (A) the original FC5 mini-aptamer (FC5L), (B) the FC5 mini-aptamer with a ...
  https://openi.nlm.nih.gov/detailedresult.php?img=PMC1636496_gkl718f7&req=4
*  Nyquist Diagram of: (a) Electrode-buffer •, (b) Aptam | Open-i
Aptamer of thrombin (AptThr) , and (c) AptThr-Thr ○ 10 pM [Thr]. The arrow in each spectrum denotes the freq ... Aptamers, Nucleotide/chemistry*. *Dielectric Spectroscopy*. *Epoxy Resins/chemistry*. *Graphite/chemistry*. *Thrombin/analysis* ... The aptamer of thrombin forms a single-strand oligonucleotide, a chain that recognizes the protein by a three-dimensional ... The aptamer of thrombin forms a single-strand oligonucleotide, a chain that recognizes the protein by a three-dimensional ...
  https://openi.nlm.nih.gov/detailedresult.php?img=PMC3376577_sensors-12-03037f5&req=4
*  Brevetto CA2526690A1 - Structure based and combinatorially selected oligonucleoside ... - Google Brevetti
The resulting aptamers have the same nucleotide base sequence as the original aptamer but, by virtue of the inclusion of ... The concatenated aptamer may include two or more concatenated thio-modified aptamers, wherein one or more of the aptamers is ... In yet another example, at least a portion of non-adjacent dA, dC, dG, or dT phosphate sites of the modified nucleotide aptamer ... Synthesis may proceed with further iterations of mixing or with distinct nucleotide addition.. Aptamers may be defined as ...
  https://books.google.it/patents/CA2526690A1?hl=it&cl=en
*  STABILIZING ALKYLGLYCOSIDE COMPOSITIONS AND METHODS THEREOF - Patent application
Spiegelmer nucleotide aptamers 103. CGRP (calcitonin gene related protein) 104. Amylin 105. IL-21 106. melanotan 107. ... Spiegelmer nucleotide aptamers, CGRP (calcitonin gene related protein), Urocortin, Amylin, IL-21, melanotan, valpreotide, ACV-1 ... covalent attachment of a nucleotide or nucleotide derivative, covalent attachment of a lipid or lipid derivative, covalent ... Changes in the nucleotide sequence of the variant may or may not alter the amino acid sequence of a polypeptide encoded by the ...
  http://www.patentsencyclopedia.com/app/20090305958
*  HIGH THROUGHPUT INTEGRATED MICROFLUIDIC SYSTEM AND DEVICE - Patent application
Immobilized affinity ligands may include, but are limited to; antibodies, aptamers, nucleotides, small molecules, etc. This ... acids and aptamers. [0040]As used herein, "affinity micro-column" refers to a micro-column in which affinity ligand has been ...
  http://www.patentsencyclopedia.com/app/20100267581
*  EGFR APTAMER INHIBITOR FOR USE IN THERAPY AND DIAGNOSIS - Patent application
Preferably the nucleotide aptamer is nuclease-resistant. Still preferably the nucleotide aptamer has at least one or all of the ... the nucleotide aptamer according to claim 1; and measuring the binding of the nucleotide aptamer to the sample. 13. The method ... incubating the sample with the nucleotide aptamer as defined above;. [0016] measuring the binding of the nucleotide aptamer to ... 0057] CL4 42-81 aptamer is a 2'-fluoropyrimidine (2'F-Py), nuclease-resistant RNA aptamer consisting of 39 nucleotides (nt) ( ...
  http://www.patentsencyclopedia.com/app/20130177556
*  In Vitro Selection of RNA Aptamers Directed Against Protein E: A Haemophilus influenzae Adhesin. : a Haemophilus influenzae...
Adhesins, Bacterial, Aptamers, Nucleotide, Base Sequence, Biotechnology, DNA, Bacterial, Haemophilus influenzae, Humans, In ... Biacore experiments indicated that one of the aptamers had a higher binding affinity for PE as compared to the other aptamers. ... Biacore experiments indicated that one of the aptamers had a higher binding affinity for PE as compared to the other aptamers. ... Aptamers, Nucleotide,Base Sequence,Biotechnology,DNA, Bacterial,Haemophilus influenzae,Humans,In Vitro Techniques,Molecular ...
  https://lup.lub.lu.se/search/publication/4431486
*  NOPR: Expanding the applications of locked nucleic acids
LNA;modified nucleotides;nucleoside triphosphates;aptamers;polymerases;enzymatic incorporation. Issue Date: Dec-2009. ...
  http://nopr.niscair.res.in/handle/123456789/6858
*  New sensor sends electronic signal when estrogen is detected | EurekAlert! Science News
Once the appropriate sequence of nucleotides is known, the aptamers can be easily generated. ... The beauty of the aptamer plus CNT FET sensors is that the aptamers can be easily replaced with new ones that target a ... They found that in the presence of estrogen the short aptamer device produced an electrical signal, while the long aptamer ... "Aptamers are a potentially powerful tool for sensors because they are so versatile and selective," said Natalie Plank, a ...
  https://www.eurekalert.org/pub_releases/2015-11/aiop-nss112415.php
*  Archemix Announces ARC1779 Data to Be Presented at Upcoming American Society of Hematology (ASH) Annual Meeting, December 6-9,...
... developing and commercializing aptamer therapeutics, today announced that data fro ... Archemix's lead aptamer product candidate, ARC1779, is a PEGylated aptamer consisting of 40 nucleotides that is administered ... About Aptamers. Aptamers are synthetically-derived oligonucleotides, or short nucleic acid sequences, that bind to protein ... "Proof of Concept for the Anti Von Willebrand Factor Aptamer in Patients with Relapsing Thrombotic Thrombocytopenic Purpura (TTP ...
  https://www.drugs.com/clinical_trials/archemix-announces-arc1779-data-presented-upcoming-american-society-hematology-ash-annual-meeting-6374.html
*  Theses completed - Chair of Computational Biology
Master Thesis: Prediction of Binding Affinity of Nucleotide Aptamers Against Protein Binding Domains Using a PWM-based Scoring ...
  http://gepard.bioinformatik.uni-saarland.de/Members/theses-completed