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*  Cytochrome c Release Assay Kit | GeneTex
The cytochrome c/Apaf-1 complex activates caspase-9, which then activates caspase-3 and other downstream caspases. GeneTex's ... An apoptotic stimulus triggers the release of cytochrome c from the mitochondria into cytosol where it binds to Apaf-1. ... An apoptotic stimulus triggers the release of cytochrome c from the mitochondria into cytosol where it binds to Apaf-1. The ... cytochrome c/Apaf-1 complex activates caspase-9, which then activates caspase-3 and other downstream caspases. GeneTex's ...
  http://www.genetex.com/Cytochrome-c-Release-Assay-Kit-GTX85531.html
*  Therapeutic Targeting of the Survivin Pathway in Cancer | Clinical Cancer Research
The percentage of cells with apoptotic nuclear morphology was determined by fluorescence microscopy. B, caspase processing. ... B, caspase activation. HUVECs transduced with pAd-GFP or pAd-T34A were analyzed for expression of active caspase-3 by Western ... The percentage of apoptotic cells was calculated by direct counting of nuclei with apoptotic morphology (condensed chromatin, ... Differential requirement for caspase-9 in apoptotic pathways in vivo. Cell, 94: 339-352, 1998. ...
  http://clincancerres.aacrjournals.org/content/9/7/2683.long
*  Apoptosis-Inducing Factor Is a Key Factor in Neuronal Cell Death Propagated by BAX-Dependent and BAX-Independent Mechanisms |...
Simultaneous inhibition of AIF and caspases provides extended neuroprotection against BAX-mediated apoptotic pathways. We have ... Mitochondria relay signals for both caspase-dependent and caspase-independent death pathways. The caspase-dependent pathway is ... Cregan SP, Dawson VL, Slack RS (2004) Role of AIF in caspase-dependent and caspase-independent cell death. Oncogene 23: 2785- ... 4A,B). These results show that, by inhibiting both caspase-dependent and caspase-independent death pathways, neurons are ...
  http://www.jneurosci.org/content/25/6/1324.long
*  Suppression of Interleukin-33 Bioactivity through Proteolysis by Apoptotic Caspases
... that IL-33 bioactivity is diminished through caspase-dependent proteolysis within apoptotic cells. Thus, caspase-mediated ... caspase-3 and -7) but was not a physiological substrate for caspases associated with inflammation (caspase-1, -4, and -5). ... Suppression of Interleukin-33 Bioactivity through Proteolysis by Apoptotic Caspases.pdf (published (author copy) peer-reviewed ... Suppression of Interleukin-33 Bioactivity through Proteolysis by Apoptotic Caspases, Immunity, 31, 1, 2009, 84-98 ...
  http://www.tara.tcd.ie/handle/2262/31286
*  Insulin Deprivation Decreases Caspase-Dependent Apoptotic Signaling in Cultured Rat Sertoli Cells
The activation of caspase-3 turns the apoptotic pathway irreversible and thus we evaluated caspase-3 mRNA levels and caspase-3 ... Following the apoptotic cascade, we assessed caspase-9 and caspase-3 levels. We observed a significant downregulation of ... Once activated, caspase-9 cleaves and activates the effector caspase-3. Caspase-3 is usually known as an endpoint for apoptosis ... caspase-9, and caspase-3. The Bax/Bcl-2 ratio was also evaluated. Finally, caspase-3 activity was determined as an endpoint ...
  https://www.hindawi.com/journals/isrn/2013/970370/
*  Insulin Deprivation Decreases Caspase-Dependent Apoptotic Signaling in Cultured Rat Sertoli Cells
... T. R. Dias, L. Rato, A. D. ... "Apoptotic and nonapoptotic function of caspase 7 in spermatogenesis.," Asian journal of andrology, vol. 19, no. 1, pp. 47-51, . ...
  https://www.hindawi.com/journals/isrn/2013/970370/citations/
*  Role of Apoptotic Nuclease Caspase-Activated DNase in Etoposide-Induced Treatment-Related Acute Myelogenous Leukemia | Cancer...
Role of Apoptotic Nuclease Caspase-Activated DNase in Etoposide-Induced Treatment-Related Acute Myelogenous Leukemia. Eszter S. ... Role of Apoptotic Nuclease Caspase-Activated DNase in Etoposide-Induced Treatment-Related Acute Myelogenous Leukemia ... Role of Apoptotic Nuclease Caspase-Activated DNase in Etoposide-Induced Treatment-Related Acute Myelogenous Leukemia ... Role of Apoptotic Nuclease Caspase-Activated DNase in Etoposide-Induced Treatment-Related Acute Myelogenous Leukemia ...
  http://cancerres.aacrjournals.org/content/66/18/8975
*  Inositol hexaphosphate down-regulates both constitutive and ligand-induced mitogenic and cell survival signaling, and causes...
... and causes caspase-mediated apoptotic death of human prostate carcinoma PC3 cells. Mallikarjuna Gu, Rana P. Singh, Sivanandhan ... and causes caspase-mediated apoptotic death of human prostate carcinoma PC3 cells ... and causes caspase-mediated apoptotic death of human prostate carcinoma PC3 cells ... and causes caspase-mediated apoptotic death of human prostate carcinoma PC3 cells ...
  http://cancerres.aacrjournals.org/content/66/8_Supplement/1125.2
*  Caspase-8 Serves Both Apoptotic and Nonapoptotic Roles | The Journal of Immunology
Caspase-8 plays an apoptotic role in hepatocytes in vivo. Although there is extensive evidence for caspase-8 participation in ... Caspase-8 Serves Both Apoptotic and Nonapoptotic Roles. Tae-Bong Kang, Tehila Ben-Moshe, Eugene E. Varfolomeev, Yael Pewzner- ... Caspase-8 Serves Both Apoptotic and Nonapoptotic Roles. Tae-Bong Kang, Tehila Ben-Moshe, Eugene E. Varfolomeev, Yael Pewzner- ... Caspase-8 Serves Both Apoptotic and Nonapoptotic Roles Message Subject (Your Name) has forwarded a page to you from The Journal ...
  http://www.jimmunol.org/content/173/5/2976.long
*  Caspase 7 (Apoptotic Protease Mch 3 or ICE Like Apoptotic Protease 3 or CMH 1 or CASP7 or EC 3.4.22.60) - Companies Involved...
Apoptotic Protease Mch 3 or ICE Like Apoptotic Protease 3 or CMH 1 or CASP7 or EC 3.4.22.60) - ... Caspase 7 (Apoptotic Protease Mch 3 or ICE Like Apoptotic Protease 3 or CMH 1 or CASP7 or EC 3.4.22.60) - Caspase-7 (CASP7) is ... Caspase 7 (Apoptotic Protease Mch 3 or ICE Like Apoptotic Protease 3 or CMH 1 or CASP7 or EC 3.4.22.60) - Overview. Caspase 7 ( ... The report reviews Caspase 7 (Apoptotic Protease Mch 3 or ICE Like Apoptotic Protease 3 or CMH 1 or CASP7 or EC 3.4.22.60) ...
  https://www.medgadget.com/2017/12/caspase-7-apoptotic-protease-mch-3-or-ice-like-apoptotic-protease-3-or-cmh-1-or-casp7-or-ec-3-4-22-60-companies-involved-novartis-ag-shire-plc-in-therapeutics-development-pipeline-review.html
*  Auxin-induced rapid degradation of inhibitor of caspase-activated DNase (ICAD) induces apoptotic DNA fragmentation, caspase...
Auxin-induced rapid degradation of inhibitor of caspase-activated DNase (ICAD) induces apoptotic DNA fragmentation, caspase ... Auxin-induced Rapid Degradation of Inhibitor of Caspase-activated DNase (ICAD) Induces Apoptotic DNA Fragmentation, Caspase ... Auxin-induced Rapid Degradation of Inhibitor of Caspase-activated DNase (ICAD) Induces Apoptotic DNA Fragmentation, Caspase ... Auxin-induced Rapid Degradation of Inhibitor of Caspase-activated DNase (ICAD) Induces Apoptotic DNA Fragmentation, Caspase ...
  https://www.ncbi.nlm.nih.gov/pubmed/25248749
*  DIGITAL.CSIC: DeadEasy Caspase: Automatic Counting of Apoptotic Cells in Drosophila
DeadEasy Caspase: Automatic Counting of Apoptotic Cells in Drosophila. Autor: Forero, Manuel G.; Pennack, Jenny A.; Learte, ... DeadEasy Caspase will be freely available as an ImageJ plug-in, and it can be modified for use in other sample types. It is of ... DeadEasy Caspase is a powerful tool for the analysis of cell survival and cell death in development and in disease, such as ... We call the resulting programme DeadEasy Caspase. It has been validated for Drosophila and we present examples of its power to ...
  https://digital.csic.es/handle/10261/24289
*  Caspase 7 (Apoptotic Protease Mch 3 or ICE Like Apoptotic Protease 3 or CMH 1 or CASP7 or EC 3.4.22.60) - Pipeline Review, H1...
Apoptotic Protease Mch 3 or ICE Like Apoptotic Protease 3 or CMH 1 or CASP7 or EC 3.4.22.60) - Pipeline Review, H1 2018 ... Caspase 7 (Apoptotic Protease Mch 3 or ICE Like Apoptotic Protease 3 or CMH 1 or CASP7 or EC 3.4.22.60) - Caspase-7 (CASP7) is ... Caspase 7 (Apoptotic Protease Mch 3 or ICE Like Apoptotic Protease 3 or CMH 1 or CASP7 or EC 3.4.22.60) - Overview. Caspase 7 ( ... Caspase 9 (Apoptotic Protease Mch 6 or Apoptotic Protease Activating Factor 3 or ICE Like Apoptotic Protease 6 or CASP9 or EC ...
  https://www.researchandmarkets.com/reports/4576099/caspase-7-apoptotic-protease-mch-3-or-ice-like
*  Caspase 6 (Apoptotic Protease Mch 2 or CASP6 or EC 3.4.22.59) - Pipeline Review, H2 2016 : ReportsnReports
Caspase 6 (Apoptotic Protease Mch 2 or CASP6 or EC... ... Apoptotic Protease Mch 2 or CASP6 or EC 3.4.22.59) - Pipeline ... Caspase 6 (Apoptotic Protease Mch 2 or CASP6 or EC 3.4.22.59) - Dormant Projects 34. Caspase 6 (Apoptotic Protease Mch 2 or ... Caspase 6 (Apoptotic Protease Mch 2 or CASP6 or EC 3.4.22.59) Overview 6. Therapeutics Development 7. Caspase 6 (Apoptotic ... Caspase 6 (Apoptotic Protease Mch 2 or CASP6 or EC 3.4.22.59) - Products under Development by Therapy Area 8. Caspase 6 ( ...
  http://www.reportsnreports.com/reports/697541-caspase-6-apoptotic-protease-mch-2-or-casp6-or-ec-342259-pipeline-review-h2-2016.html
*  Caspase-14, an apoptotic protease, nucleic acids encoding and methods of use - Patent # 6432628 - PatentGenius
... corresponding to coding or non-coding strands of the caspase-14 nucleotide sequence. Isolated caspase-14 polypeptides or ... The invention also relates to an isolated gene encoding caspase-14, as well as functional fragments thereof. The gene or ... In addition, the invention relates to methods of identifying compounds that modulate caspase-14 activity. ... caspase-14 polypeptide or functional fragment thereof, a vector that contains the nucleic acid molecule and a host cell that ...
  http://www.patentgenius.com/patent/6432628.html
*  Presence of a pre-apoptotic complex of pro-caspase-3, Hsp60 and Hsp10 in the mitochondrial fraction of jurkat cells.
... Samali A. ... Activation of pro-caspase-3 is a central event in the execution phase of apoptosis and appears to serve as the convergence ... In the present study, we demonstrate that pro-caspase-3 is present in the mitochondrial fraction of Jurkat T cells in a complex ... In in vitro systems, recombinant Hsp60 and Hsp10 accelerated the activation of pro-caspase-3 by cytochrome c and dATP in an ATP ...
  https://www.uniprot.org/citations/10205158
*  Dual Site Phosphorylation of Caspase-7 by PAK2 Blocks Apoptotic Activity by Two Distinct Mechanisms (Journal Article) | DOE...
Abstract: Caspase-independent, non-apoptotic cell death in ischemic heart disease is considered to be one of the important ... Eron, Scott J., Raghupathi, Kishore, and Hardy, Jeanne A.. Dual Site Phosphorylation of Caspase-7 by PAK2 Blocks Apoptotic ... Eron, Scott J., Raghupathi, Kishore, & Hardy, Jeanne A.. Dual Site Phosphorylation of Caspase-7 by PAK2 Blocks Apoptotic ... title = {Dual Site Phosphorylation of Caspase-7 by PAK2 Blocks Apoptotic Activity by Two Distinct Mechanisms},. author = {Eron ...
  https://www.osti.gov/pages/biblio/1415490-dual-site-phosphorylation-caspase-pak2-blocks-apoptotic-activity-two-distinct-mechanisms
*  Role of factors downstream of caspases in nuclear disassembly during apoptotic execution | Philosophical Transactions of the...
Extracts from 'execution-stage' apoptotic cells induce apoptotic events in added nuclei in a caspase-independent manner. ... Role of factors downstream of caspases in nuclear disassembly during apoptotic execution. K. Samejima, P. Villa, W. C. Earnshaw ... These apoptotic changes appear to require the function of multiple caspases (cysteine aspar-tases, a specialized class of ... Role of factors downstream of caspases in nuclear disassembly during apoptotic execution ...
  http://rstb.royalsocietypublishing.org/content/354/1389/1591
*  An Investigation of the Cytotoxicity and Caspase-Mediated Apoptotic Effect of Green Synthesized Zinc Oxide Nanoparticles Using...
An Investigation of the Cytotoxicity and Caspase-Mediated Apoptotic Effect of Green Synthesized Zinc Oxide Nanoparticles Using ... An Investigation of the Cytotoxicity and Caspase-Mediated Apoptotic Effect of Green Synthesized Zinc Oxide Nanoparticles Using ... An Investigation of the Cytotoxicity and Caspase-Mediated Apoptotic Effect of Green Synthesized Zinc Oxide Nanoparticles Using ... Keywords: anticancer actions; caspase study; zinc oxide nanoparticles; Eclipta prostrata anticancer actions; caspase study; ...
  http://libros.duhnnae.com/2017/jun5/149752163584-An-Investigation-of-the-Cytotoxicity-and-Caspase-Mediated-Apoptotic-Effect-of-Green-Synthesized-Zinc-Oxide-Nanoparticles-Using-Eclipta-prostrata-on-Hu.php
*  'deoxyribonuclease i' Protocols and Video...
In Vivo Biosensor Tracks Non-apoptotic Caspase Activity in Drosophila', 'Myeloid Cell Isolation from Mouse Skin and Draining ... In Vivo Biosensor Tracks Non-apoptotic Caspase Activity in Drosophila. Ho Lam Tang1, Ho Man Tang1, Ming Chiu Fung2, J. Marie ...
  https://www.jove.com/keyword/deoxyribonuclease+i
*  Targeting cytochrome P450-dependent cancer cell mitochondria: cancer associated CYPs and where to find them | springermedizin.de
Novel roles of apoptotic caspases in tumor repopulation, epigenetic reprogramming, carcinogenesis, and beyond. ... caspase activation, and apoptosis in carcinoma cells treated with arsenic trioxide. [Research Support, N.I.H., Intramural ...
  https://www.springermedizin.de/targeting-cytochrome-p450-dependent-cancer-cell-mitochondria-can/15991544
*  Alan Cantor, MD, PhD | Boston Children's Hospital
Death-defying apoptotic caspases in thrombopoiesis. Blood. 2012 May 03; 119(18):4098-9. View abstract ...
  http://www.childrenshospital.org/directory/physicians/c/alan-cantor
*  Epithelial-derived IL-33 and its receptor ST2 are dysregulated in ulcerative colitis and in experimental Th1/Th2 driven...
2009) Suppression of interleukin-33 bioactivity through proteolysis by apoptotic caspases. Immunity 31:84-98. ... 2009) The IL-1-like cytokine IL-33 is inactivated after maturation by caspase-1. Proc Natl Acad Sci USA 106:9021-9026. ... 2009) Interleukin-33 is biologically active independently of caspase-1 cleavage. J Biol Chem 284:19420-19426. ... it was originally proposed that IL-33 was synthesized as a 30-kDa precursor molecule and cleaved by caspase-1 upon inflammasome ...
  http://www.pnas.org/content/107/17/8017.long
*  Search | eLife
Tumor-promoting function of apoptotic caspases by an amplification loop involving ROS, macrophages and JNK in Drosophila ...
  https://elifesciences.org/search?for=oncogenic%20RAS
*  Dronc caspase exerts a non-apoptotic function to restrain phospho-Numb-induced ectopic neuroblast formation in Drosophila - CORE
Dronc caspase exerts a non-apoptotic function to restrain phospho-Numb-induced ectopic neuroblast formation in Drosophila By ... We identify Dronc caspase as a novel binding partner of Numb, and demonstrate that overexpression of Dronc suppresses the ... Our findings uncover a molecular mechanism that regulates Numb activity and suggest a novel role for Dronc caspase in ... effects of Numb-TS4D in a non-apoptotic and possibly non-catalytic manner. Reduction of Dronc activity facilitates ENF induced ...
  https://core.ac.uk/display/8562819