Therapeutic Targeting of the Survivin Pathway in Cancer | Clinical Cancer Research
Genetic Requirements of Apoptosis Induced by Survivin Targeting.. To map more precisely the genetic requirements of apoptosis ... Epidermal Growth Factor Receptor (EGFR) Is Overexpressed in Anaplastic Thyroid Cancer, and the EGFR Inhibitor Gefitinib ... mitogen-activated protein kinase-, and phosphatidylinositol 3′-kinase-dependent pathway (25) . As determined in previous ... C, induction of endothelial cell apoptosis in vivo. Tumors were prepared as described in A and analyzed for apoptosis by ...http://clincancerres.aacrjournals.org/content/9/7/2683.long
Androgen-Regulated and Highly Tumorigenic Human Prostate Cancer Cell Line Established from a Transplantable Primary CWR22 Tumor...
Mitogen-activated protein kinase kinase kinase 1 activates androgen receptor-dependent transcription and apoptosis in prostate ... Androgen receptor expression in CWR22Pc cells. A, AR expression in CWR22Pc, LNCaP, and CWR22Rv1 cells. Cells were cultured in ... Two mutations identified in the androgen receptor of the new human prostate cancer cell line MDA PCa 2a. J Urol 1999;162:2192- ... Linja MJ, Visakorpi T. Alterations of androgen receptor in prostate cancer. J Steroid Biochem Mol Biol 2004;92:255-64. ...http://clincancerres.aacrjournals.org/content/14/19/6062.long
Epigenetically Controlled Fibroblast Growth Factor Receptor 2 Signaling Imposes on the RAS/BRAF/Mitogen-Activated Protein...
Apoptosis assays. To examine the extent of DNA fragmentation characteristic of apoptosis, we stained 4-μm sections of cell ... Epigenetically Controlled Fibroblast Growth Factor Receptor 2 Signaling Imposes on the RAS/BRAF/Mitogen-Activated Protein ... Epigenetically Controlled Fibroblast Growth Factor Receptor 2 Signaling Imposes on the RAS/BRAF/Mitogen-Activated Protein ... Epigenetically Controlled Fibroblast Growth Factor Receptor 2 Signaling Imposes on the RAS/BRAF/Mitogen-Activated Protein ...http://cancerres.aacrjournals.org/content/67/11/5461
Table of Contents - April 15, 2002, 168 (8) | The Journal of Immunology
Roles for Extracellularly Regulated Kinase-Mitogen-Activated Protein Kinase in B Cell Antigen Receptor-Induced Apoptosis and ... Formation of the Killer Ig-Like Receptor Repertoire on CD4+CD28null T Cells Melissa R. Snyder, Lars-Olof Muegge, Chetan Offord ... Restricted Localization of the TNF Receptor CD120a to Lipid Rafts: A Novel Role for the Death Domain Vincent Cottin, Joyce E. S ... Cutting Edge: Biasing Immune Responses by Directing Antigen to Macrophage Fcγ Receptors Charles F. Anderson and David M. Mosser ...http://www.jimmunol.org/content/168/8
WikiGenes - FHPI - 4-[4-(4-fluorophenyl)-5-pyridin-4-yl-1,3...
Induction of apoptosis by SB202190 through inhibition of p38beta mitogen-activated protein kinase. Nemoto, S., Xiang, J., Huang ... p38 mitogen-activated protein kinase pathway protects adult rat ventricular myocytes against beta -adrenergic receptor- ... ZBP-89-induced apoptosis is p53-independent and requires JNK. Bai, L., Yoon, S.O., King, P.D., Merchant, J.L. Cell Death Differ ... Activation of Rac1 and the p38 mitogen-activated protein kinase pathway in response to all-trans-retinoic acid. Alsayed, Y., ...https://www.wikigenes.org/e/chem/e/5353940.html
IRS4 - Insulin receptor substrate 4 - Homo sapiens (Human) - IRS4 gene & protein
Interaction with GRB2 enhances insulin-stimulated mitogen-activated protein kinase activity. May be involved in nonreceptor ... pathway and BAD phosphorylation during insulin stimulation without activation of RPS6KB1 or the inhibition of apoptosis. ... such as insulin receptor, IGF1R and FGFR1, and a complex network of intracellular signaling molecules containing SH2 domains. ... Acts as an interface between multiple growth factor receptors possessing tyrosine kinase activity, ...http://www.uniprot.org/uniprot/O14654
Cannabinoid Receptor-Mediated Apoptosis Induced by R(+)-Methanandamide and Win55,212-2 Is Associated with Ceramide Accumulation...
Wada T and Penninger JM (2004) Mitogen-activated protein kinases in apoptosis regulation. Oncogene 23: 2838-2849. ... the role of each receptor and the signal transduction triggered by receptor ligation were investigated. Induction of apoptosis ... Anandamide induces apoptosis in human cells via vanilloid receptors. Evidence for a protective role of cannabinoid receptors. J ... R(+)-MA has recently been shown to induce apoptosis in a cannabinoid receptor independent manner in glioma cells (Hinz et al., ...http://molpharm.aspetjournals.org/content/70/5/1612.long
Increased Expression of Peroxisome Proliferator-Activated Receptor-α and -γ in Blood Vessels of Spontaneously Hypertensive Rats...
... induces apoptosis in vascular smooth muscle cells by stimulation of p38 mitogen-activated protein kinase. Hypertension. 2000; ... In vivo study of AT1 and AT2 angiotensin receptors in apoptosis in rat blood vessels. Hypertension. 1999; 34(pt 1): 617-624. ... Bishop-Bailey D, Hla T. Endothelial cell apoptosis induced by the peroxisome proliferator-activated receptor (PPAR) ligand 15- ... Peroxisome proliferator-activated receptors (PPARs) are nuclear hormone receptors1 that heterodimerize with retinoic acid-like ...http://hyper.ahajournals.org/content/38/2/249
What does p38 mitogen-activated protein kinases stand for?
Find out what is the full meaning of p38 mitogen-activated protein kinases on Abbreviations.com! 'Protein Kinase C' is one ... Looking for the definition of p38 mitogen-activated protein kinases? ... APOPTOSIS; and cellular responses to INFLAMMATION. The P38 MAP kinases are regulated by CYTOKINE RECEPTORS and can be activated ... What does p38 mitogen-activated protein kinases mean?. p38 Mitogen-Activated Protein Kinases. A mitogen-activated protein ...http://www.abbreviations.com/serp.php?st=p38%20mitogen-activated%20protein%20kinases&qtype=3
... type 2 receptor dephosphorylates bcl-2 by activating mitogen-activated protein kinase phosphatase-1 and induces apoptosis. J ... 1995) Angiotensin AT1 receptor-mediated vasopressin release and drinking are potentiated by an AT2 receptor antagonist. Eur J ... 1993) Expression cloning of type 2 angiotensin II receptor reveals a unique class of seven transmembrane receptors. J Biol Chem ... for AT2 receptor) at 94°C for 45 sec, 63°C (for PLA2) or 62°C (for AT2 receptor) for 1 min 40 sec, and 72°C for 2 min. After ...http://www.jneurosci.org/content/18/2/679
WikiGenes - MAP3K1 - mitogen-activated protein kinase kinase...
Androgen receptor acetylation governs trans activation and MEKK1-induced apoptosis without affecting in vitro sumoylation and ... Androgen receptor acetylation governs trans activation and MEKK1-induced apoptosis without affecting in vitro sumoylation and ... Regulation of c-Jun N-terminal kinase by MEKK-2 and mitogen-activated protein kinase kinase kinases in rheumatoid arthritis. ... Evidence for the importance of Ras in a pathway that is controlled by dual receptor stimulation. Faris, M., Kokot, N., Lee, L ...https://www.wikigenes.org/e/gene/e/4214.html
Lymphoid tissue phospholipase A2 group IID resolves contact hypersensitivity by driving antiinflammatory lipid mediators | JEM
Docosahexaenoic acid, a peroxisome proliferator-activated receptor-α ligand, induces apoptosis in vascular smooth muscle cells ... by stimulation of p38 mitogen-activated protein kinase. Hypertension. 36:851-855. doi:10.1161/01.HYP.36.5.851. ... Facilitation of Th1-mediated immune response by prostaglandin E receptor EP1. J. Exp. Med. 204:2865-2874. doi:10.1084/jem. ... GPR120 is an ω-3 fatty acid receptor mediating potent anti-inflammatory and insulin-sensitizing effects. Cell. 142:687-698. doi ...http://jem.rupress.org/content/early/2013/05/14/jem.20121887
Fish Oil's Benefits Defended | Hammer Nutrition
To clarify possible pathways of apoptosis, they evaluated the expression of phosphorylated p38 mitogen-activated protein ... Docosahexaenoic acid, a peroxisome proliferator-activated receptor-alpha ligand, induces apoptosis in vascular smooth muscle ... By triggering VSMC apoptosis, DHA may play a pathophysiological role in vascular remodeling in cardiovascular disease. Frenoux ... Numerous studies conclude that the anti-tumor effect of DHA is mainly related to its ability to induce (normal) apoptosis in ...https://www.hammernutrition.com/knowledge/endurance-library/fish-oils-benefits-defended/
Cross-Talk Between AT1 and AT2Angiotensin Receptors in Rat Anococcygeus Smooth Muscle | Journal of Pharmacology and...
... type 2 receptor dephosphorylates Bcl-2 by activating mitogen-activated protein kinase phosphatase-1 and induces apoptosis. J ... 1996) Mitogen-activated protein kinases in rat brain neuronal cultures are activated by angiotensin II type 1 receptors and ... 1995) The angiotensin II type 2 (AT2) receptor antagonizes the growth effects of the AT1 receptor: gain-of-function study using ... Indeed, AT2 receptor subtypes antagonize both pressor and growth effects of the AT1 receptor subtypes (Hein et al., 1995; ...http://jpet.aspetjournals.org/content/303/1/333
Chinese Medical Journal
... apoptosis, and HCRT receptor 1/2 (orexin receptor 1 [OX1R] and orexin receptor 2 [OX2R]) expression. The signaling pathways ... Orexin-A Receptor and Orexin-B Receptor Messenger Ribonucleic Acid Expression and Represses Mitogen-activated Protein Kinase ... Methods: The effects of XSTQ on proliferation and apoptosis in SH-SY5Y cells were assessed using cell counting kit-8 and ... Western blotting for mitogen-activated protein kinase (MAPK) pathway activation was performed to further assess the signaling ...http://cmj.org/showstats.asp?issn=0366-6999
Pre-clinical evaluation of a novel class of anti-cancer agents, the Pyrrolo-1, 5-benzoxazepines
... mitogen-activated protein kinase; TRAIL, TNF-related apoptosis-inducing ligand; DR5, death receptor 5; c-FLIP, cellular FADD- ... PBOX-15, a novel microtubule targeting agent, induces apoptosis, upregulates death receptors, and potentiates TRAIL-mediated ... Apoptosis. Most anti-cancer agents destroy malignant cells by inducing apoptosis (50). Other types of cell death include; ... Pyrrolo-1, 5-benzoxazepines induce apoptosis in HL-60, Jurkat, and Hut-78 cells: a new class of apoptotic agents. J Pharmacol ...http://www.jcancer.org/v07p2367.htm
The Extracellular Membrane-Proximal Domain of Human Membrane IgE Controls Apoptotic Signaling of the B Cell Receptor in the...
... roles for extracellularly regulated kinase-mitogen-activated protein kinase in B cell antigen receptor-induced apoptosis and ... Mitochondria connects the antigen receptor to effector caspases during B cell receptor-induced apoptosis in normal human B ... Dissection of pathways leading to antigen receptor-induced and Fas/CD95-induced apoptosis in human B cells. J. Immunol. 160: ... Differential activation of the ERK, JNK, and p38 mitogen-activated protein kinases by CD40 and the B cell antigen receptor. J. ...http://www.jimmunol.org/content/177/6/3597.full
Epigenetic Activation of μ-Opioid Receptor Gene via Increased Expression and Function of Mitogen- and Stress-Activated Protein...
2010) The role of p38 MAPK in valproic acid induced microglia apoptosis. Neurosci Lett 482:51-56. ... mitogen-activated protein kinase. MOR. μ-opioid receptor. MSK. mitogen- and stress-activated protein kinase. NaB. sodium ... 2008) Acetylation of mitogen-activated protein kinase phosphatase-1 inhibits Toll-like receptor signaling. J Exp Med 205:1491- ... Epigenetic Activation of μ-Opioid Receptor Gene via Increased Expression and Function of Mitogen- and Stress-Activated Protein ...http://molpharm.aspetjournals.org/content/91/4/357
Toward understanding non-coding RNA roles in intracranial aneurysms and subarachnoid hemorrhage : Translational Neuroscience
P2X7 receptor antagonism inhibits p38 mitogen-activated protein kinase activation and ameliorates neuronal apoptosis after ... Neuronal apoptosis usually occurs in EBI after SAH (Figure 1) . P2X7R stimulation activates p38 mitogen-activated protein ... Cannabinoid receptor type 2 agonist attenuates apoptosis by activation of phosphorylated CREB-Bcl-2 pathway after subarachnoid ... Gao Y., Wu H., He D., Hu X., Li Y., Downregulation of BCL11A by siRNA induces apoptosis in B lymphoma cell lines, Biomedical ...https://www.degruyter.com/view/j/tnsci.2017.8.issue-1/tnsci-2017-0010/tnsci-2017-0010.xml
The Molecular Basis for Distinct β-Adrenergic Receptor Subtype Actions in Cardiomyocytes | Circulation Research
Cardiotrophin 1 (CT-1) inhibition of cardiac myocyte apoptosis via a mitogen-activated protein kinase-dependent pathway. J Biol ... Dissociation of p44 and p42 mitogen-activated protein kinase activation from receptor-induced hypertrophy in neonatal rat ... Altered expression of β-adrenergic receptor kinase and β1-adrenergic receptors in the failing human heart. Circ Res. 1993;87: ... Cardiotrophin (CT-1) inhibition of cardiac myocyte apoptosis via a mitogen-activated protein kinase-dependent pathway: ...http://circres.ahajournals.org/content/85/11/1101.long
Gonadal Hormone Withdrawal, Apoptosis, and Generation of Beta Amyloid Peptide: A Vicious Cycle of Amyloidogenesis and...
Estrogen-induced activation of the mitogen-activated protein kinase cascade in the cerebral cortex of estrogen receptor-alpha ... I think that the best way to sort out whether estrogen receptor alpha or estrogen receptor beta is involved would be to study ... The hormone/neuroprotection/apoptosis data dovetail well with observations from others, indicating that activation of apoptosis ... June: Richard, what about brain androgen receptors in Down patients?. Richard L. Bowen: June, I do not know. We have tried to ...http://www.alzforum.org/webinars/gonadal-hormone-withdrawal-apoptosis-and-generation-beta-amyloid-peptide-vicious-cycle
A Novel Pathway for Presynaptic Mitogen-Activated Kinase Activation via AMPA Receptors | Journal of Neuroscience
... and apoptosis. Presynaptically, MAPK activation is triggered by neurotrophic factors and cytosolic calcium elevations (for ... Plasticity of Signaling by Spinal Estrogen Receptor α, κ-Opioid Receptor, and Metabotropic Glutamate Receptors over the Rat ... A Novel Pathway for Presynaptic Mitogen-Activated Kinase Activation via AMPA Receptors. Ursula Schenk, Elisabetta Menna, ... We show here that stimulation of presynaptic AMPA receptors induces activation of mitogen-activated protein kinase (MAPK) ...http://www.jneurosci.org/content/25/7/1654
Granulocyte apoptosis | Springer for Research & Development
Neutrophil apoptosis (programmed cell death) is now recognised to play a fundamental role in the physiological resolution of ... Mycobacterium tuberculosis triggers apoptosis in peripheral neu trophils involving Toll-like receptor 2 and p38 mitogen protein ... Micheau O, Tschopp J (2003) Induction of TNF receptor I-mediated apoptosis via two sequential signalling complexes. Cell 114: ... Walker BA, Rocchini C, Boone RH, Ip S, Jacobson MA (1997) Adenosine A2a receptor activation delays apoptosis in human ...https://rd.springer.com/chapter/10.1007/978-3-7643-7506-5_2
G-Protein-Coupled Receptor Kinase Interacting Protein-1 Mediates Intima Formation by Regulating Vascular Smooth Muscle...
GIT1 Reduced VSMC Apoptosis. It has been shown that VSMC apoptosis plays a key role in vascular remodeling.13 To elucidate the ... Previously, we showed that GIT1 was a scaffold protein for PLCγ and mitogen-activated protein kinase-1, and was required for ... apoptosis, and migration through PLCγ and ERK1/2 pathway induced by GPCR and tyrosine kinase receptor, which subsequently ... Evidence for apoptosis in human atherogenesis and in a rat vascular injury model. Am J Pathol. 1995;147:267-277. ...http://atvb.ahajournals.org/content/33/5/999
Pharmaceuticals | Free Full-Text | Role of Transient Receptor Potential Vanilloid 1 in Inflammation and Autoimmune Diseases |...
... is a receptor activated by high temperatures and chemical agonists such as the vanilloids and protons. Because of these ... Transient receptor potential vanilloid 1 (TRPV1), a non-selective cation channel, ... TRPV1 channels are involved in the control of early apoptosis during retinal development, and mitogen-activated protein kinase ... The polymodal ion channel transient receptor potential vanilloid 4 modulates calcium flux, spiking rate, and apoptosis of mouse ...http://www.mdpi.com/1424-8247/5/8/837/htm