Therapeutic Targeting of the Survivin Pathway in Cancer | Clinical Cancer Research
Genetic Requirements of Apoptosis Induced by Survivin Targeting.. To map more precisely the genetic requirements of apoptosis ... Epidermal Growth Factor Receptor (EGFR) Is Overexpressed in Anaplastic Thyroid Cancer, and the EGFR Inhibitor Gefitinib ... mitogen-activated protein kinase-, and phosphatidylinositol 3′-kinase-dependent pathway (25) . As determined in previous ... C, induction of endothelial cell apoptosis in vivo. Tumors were prepared as described in A and analyzed for apoptosis by ...http://clincancerres.aacrjournals.org/content/9/7/2683.long
Frontiers | Effects of a Flavonoid-Rich Fraction on the Acquisition and Extinction of Fear Memory: Pharmacological and...
... serotonin type1A receptor (5-HT1ARs) and the gamma-aminobutyric acid type A receptors (GABAARs). Several studies showed that ... serotonin type1A receptor (5-HT1ARs) and the gamma-aminobutyric acid type A receptors (GABAARs). Several studies showed that ... We show for the first time that the serotoninergic and glutamatergic receptors are important targets for the effect of FfB on ... these receptors are involved in the acquisition and extinction of fear memory. This study assessed the effects of treatment ...https://www.frontiersin.org/articles/10.3389/fnbeh.2015.00345/full
Androgen-Regulated and Highly Tumorigenic Human Prostate Cancer Cell Line Established from a Transplantable Primary CWR22 Tumor...
Mitogen-activated protein kinase kinase kinase 1 activates androgen receptor-dependent transcription and apoptosis in prostate ... Androgen receptor expression in CWR22Pc cells. A, AR expression in CWR22Pc, LNCaP, and CWR22Rv1 cells. Cells were cultured in ... Two mutations identified in the androgen receptor of the new human prostate cancer cell line MDA PCa 2a. J Urol 1999;162:2192- ... Linja MJ, Visakorpi T. Alterations of androgen receptor in prostate cancer. J Steroid Biochem Mol Biol 2004;92:255-64. ...http://clincancerres.aacrjournals.org/content/14/19/6062.long
Agonist Stimulation of the Serotonin1A Receptor Causes Supression of Anoxia Induced Apoptosis via Mitogen-Activated Protein ...http://www.angelfire.com/yt/yas709neuroscience/Info.html
Table of Contents - April 15, 2002, 168 (8) | The Journal of Immunology
Roles for Extracellularly Regulated Kinase-Mitogen-Activated Protein Kinase in B Cell Antigen Receptor-Induced Apoptosis and ... Formation of the Killer Ig-Like Receptor Repertoire on CD4+CD28null T Cells Melissa R. Snyder, Lars-Olof Muegge, Chetan Offord ... Restricted Localization of the TNF Receptor CD120a to Lipid Rafts: A Novel Role for the Death Domain Vincent Cottin, Joyce E. S ... Cutting Edge: Biasing Immune Responses by Directing Antigen to Macrophage Fcγ Receptors Charles F. Anderson and David M. Mosser ...http://www.jimmunol.org/content/168/8
Epigenetically Controlled Fibroblast Growth Factor Receptor 2 Signaling Imposes on the RAS/BRAF/Mitogen-Activated Protein...
Apoptosis assays. To examine the extent of DNA fragmentation characteristic of apoptosis, we stained 4-μm sections of cell ... Epigenetically Controlled Fibroblast Growth Factor Receptor 2 Signaling Imposes on the RAS/BRAF/Mitogen-Activated Protein ... Epigenetically Controlled Fibroblast Growth Factor Receptor 2 Signaling Imposes on the RAS/BRAF/Mitogen-Activated Protein ... Epigenetically Controlled Fibroblast Growth Factor Receptor 2 Signaling Imposes on the RAS/BRAF/Mitogen-Activated Protein ...http://cancerres.aacrjournals.org/content/67/11/5461
WikiGenes - FHPI - 4-[4-(4-fluorophenyl)-5-pyridin-4-yl-1,3...
Induction of apoptosis by SB202190 through inhibition of p38beta mitogen-activated protein kinase. Nemoto, S., Xiang, J., Huang ... p38 mitogen-activated protein kinase pathway protects adult rat ventricular myocytes against beta -adrenergic receptor- ... ZBP-89-induced apoptosis is p53-independent and requires JNK. Bai, L., Yoon, S.O., King, P.D., Merchant, J.L. Cell Death Differ ... Activation of Rac1 and the p38 mitogen-activated protein kinase pathway in response to all-trans-retinoic acid. Alsayed, Y., ...https://www.wikigenes.org/e/chem/e/5353940.html
Regulation of Signal Transduction by Glutathione Transferases
... apoptosis signal-regulating kinase 1; MEKK1:Mitogen-activated protein kinase kinase kinase1; JNK: c-Jun N-terminal kinase 1; ... For example, binding of TNFα on its receptors, TNF Receptor 1 or 2, leads to the homotypic aggregation of these receptors which ... It has also been reported to modulate several cell-surface receptors, to activate epithelial growth factor receptor and ... Furthermore, NF-κB with upstream participation of TNFα, signaling through TNF receptor 1 (TNFR1) together with IL-6 and signal ...https://www.hindawi.com/journals/ijh/2012/137676/
Cannabinoid Receptor-Mediated Apoptosis Induced by R(+)-Methanandamide and Win55,212-2 Is Associated with Ceramide Accumulation...
Wada T and Penninger JM (2004) Mitogen-activated protein kinases in apoptosis regulation. Oncogene 23: 2838-2849. ... the role of each receptor and the signal transduction triggered by receptor ligation were investigated. Induction of apoptosis ... Anandamide induces apoptosis in human cells via vanilloid receptors. Evidence for a protective role of cannabinoid receptors. J ... R(+)-MA has recently been shown to induce apoptosis in a cannabinoid receptor independent manner in glioma cells (Hinz et al., ...http://molpharm.aspetjournals.org/content/70/5/1612.long
IRS4 - Insulin receptor substrate 4 - Homo sapiens (Human) - IRS4 gene & protein
Interaction with GRB2 enhances insulin-stimulated mitogen-activated protein kinase activity. May be involved in nonreceptor ... pathway and BAD phosphorylation during insulin stimulation without activation of RPS6KB1 or the inhibition of apoptosis. ... such as insulin receptor, IGF1R and FGFR1, and a complex network of intracellular signaling molecules containing SH2 domains. ... Acts as an interface between multiple growth factor receptors possessing tyrosine kinase activity, ...http://www.uniprot.org/uniprot/O14654
Increased Expression of Peroxisome Proliferator-Activated Receptor-α and -γ in Blood Vessels of Spontaneously Hypertensive Rats...
... induces apoptosis in vascular smooth muscle cells by stimulation of p38 mitogen-activated protein kinase. Hypertension. 2000; ... In vivo study of AT1 and AT2 angiotensin receptors in apoptosis in rat blood vessels. Hypertension. 1999; 34(pt 1): 617-624. ... Bishop-Bailey D, Hla T. Endothelial cell apoptosis induced by the peroxisome proliferator-activated receptor (PPAR) ligand 15- ... Peroxisome proliferator-activated receptors (PPARs) are nuclear hormone receptors1 that heterodimerize with retinoic acid-like ...http://hyper.ahajournals.org/content/38/2/249
WikiGenes - MAP3K1 - mitogen-activated protein kinase kinase...
Androgen receptor acetylation governs trans activation and MEKK1-induced apoptosis without affecting in vitro sumoylation and ... Androgen receptor acetylation governs trans activation and MEKK1-induced apoptosis without affecting in vitro sumoylation and ... Regulation of c-Jun N-terminal kinase by MEKK-2 and mitogen-activated protein kinase kinase kinases in rheumatoid arthritis. ... Evidence for the importance of Ras in a pathway that is controlled by dual receptor stimulation. Faris, M., Kokot, N., Lee, L ...https://www.wikigenes.org/e/gene/e/4214.html
What does p38 mitogen-activated protein kinases stand for?
Find out what is the full meaning of p38 mitogen-activated protein kinases on Abbreviations.com! 'Protein Kinase C' is one ... Looking for the definition of p38 mitogen-activated protein kinases? ... APOPTOSIS; and cellular responses to INFLAMMATION. The P38 MAP kinases are regulated by CYTOKINE RECEPTORS and can be activated ... What does p38 mitogen-activated protein kinases mean?. p38 Mitogen-Activated Protein Kinases. A mitogen-activated protein ...http://www.abbreviations.com/serp.php?st=p38%20mitogen-activated%20protein%20kinases&qtype=3
Lymphoid tissue phospholipase A2 group IID resolves contact hypersensitivity by driving antiinflammatory lipid mediators | JEM
Docosahexaenoic acid, a peroxisome proliferator-activated receptor-α ligand, induces apoptosis in vascular smooth muscle cells ... by stimulation of p38 mitogen-activated protein kinase. Hypertension. 36:851-855. doi:10.1161/01.HYP.36.5.851. ... Facilitation of Th1-mediated immune response by prostaglandin E receptor EP1. J. Exp. Med. 204:2865-2874. doi:10.1084/jem. ... GPR120 is an ω-3 fatty acid receptor mediating potent anti-inflammatory and insulin-sensitizing effects. Cell. 142:687-698. doi ...http://jem.rupress.org/content/early/2013/05/14/jem.20121887
... type 2 receptor dephosphorylates bcl-2 by activating mitogen-activated protein kinase phosphatase-1 and induces apoptosis. J ... 1995) Angiotensin AT1 receptor-mediated vasopressin release and drinking are potentiated by an AT2 receptor antagonist. Eur J ... 1993) Expression cloning of type 2 angiotensin II receptor reveals a unique class of seven transmembrane receptors. J Biol Chem ... for AT2 receptor) at 94°C for 45 sec, 63°C (for PLA2) or 62°C (for AT2 receptor) for 1 min 40 sec, and 72°C for 2 min. After ...http://www.jneurosci.org/content/18/2/679
Fish Oil's Benefits Defended | Hammer Nutrition
To clarify possible pathways of apoptosis, they evaluated the expression of phosphorylated p38 mitogen-activated protein ... Docosahexaenoic acid, a peroxisome proliferator-activated receptor-alpha ligand, induces apoptosis in vascular smooth muscle ... By triggering VSMC apoptosis, DHA may play a pathophysiological role in vascular remodeling in cardiovascular disease. Frenoux ... Numerous studies conclude that the anti-tumor effect of DHA is mainly related to its ability to induce (normal) apoptosis in ...https://www.hammernutrition.com/knowledge/endurance-library/fish-oils-benefits-defended/
Cross-Talk Between AT1 and AT2Angiotensin Receptors in Rat Anococcygeus Smooth Muscle | Journal of Pharmacology and...
... type 2 receptor dephosphorylates Bcl-2 by activating mitogen-activated protein kinase phosphatase-1 and induces apoptosis. J ... 1996) Mitogen-activated protein kinases in rat brain neuronal cultures are activated by angiotensin II type 1 receptors and ... 1995) The angiotensin II type 2 (AT2) receptor antagonizes the growth effects of the AT1 receptor: gain-of-function study using ... Indeed, AT2 receptor subtypes antagonize both pressor and growth effects of the AT1 receptor subtypes (Hein et al., 1995; ...http://jpet.aspetjournals.org/content/303/1/333
Pre-clinical evaluation of a novel class of anti-cancer agents, the Pyrrolo-1, 5-benzoxazepines
... mitogen-activated protein kinase; TRAIL, TNF-related apoptosis-inducing ligand; DR5, death receptor 5; c-FLIP, cellular FADD- ... PBOX-15, a novel microtubule targeting agent, induces apoptosis, upregulates death receptors, and potentiates TRAIL-mediated ... Apoptosis. Most anti-cancer agents destroy malignant cells by inducing apoptosis (50). Other types of cell death include; ... Pyrrolo-1, 5-benzoxazepines induce apoptosis in HL-60, Jurkat, and Hut-78 cells: a new class of apoptotic agents. J Pharmacol ...http://www.jcancer.org/v07p2367.htm
The Extracellular Membrane-Proximal Domain of Human Membrane IgE Controls Apoptotic Signaling of the B Cell Receptor in the...
... roles for extracellularly regulated kinase-mitogen-activated protein kinase in B cell antigen receptor-induced apoptosis and ... Mitochondria connects the antigen receptor to effector caspases during B cell receptor-induced apoptosis in normal human B ... Dissection of pathways leading to antigen receptor-induced and Fas/CD95-induced apoptosis in human B cells. J. Immunol. 160: ... Differential activation of the ERK, JNK, and p38 mitogen-activated protein kinases by CD40 and the B cell antigen receptor. J. ...http://www.jimmunol.org/content/177/6/3597.full
Otolaryngology and Rhinology | Clinical Group
... apoptosis; death receptor; caspases; mitochondrion; tumorigenic viruses; Epstein-Barr virus (EBV). ... Research Interest: Nasopharyngeal carcinoma (NPC); Tumor suppressor genes; cell cycle; cyclins; signal transduction; mitogen ... Liver X receptors activation, through TO901317 binding, reduces neuroinflammation in Parkinson's disease. PLoS One. 12(4): ... Cannabinoid receptor agonists are mitochondrial inhibitors: a unified hypothesis of how cannabinoids modulate mitochondrial ...https://www.peertechz.com/journals/archives-of-otolaryngology-and-rhinology/home
The Molecular Basis for Distinct β-Adrenergic Receptor Subtype Actions in Cardiomyocytes | Circulation Research
Cardiotrophin 1 (CT-1) inhibition of cardiac myocyte apoptosis via a mitogen-activated protein kinase-dependent pathway. J Biol ... Dissociation of p44 and p42 mitogen-activated protein kinase activation from receptor-induced hypertrophy in neonatal rat ... Altered expression of β-adrenergic receptor kinase and β1-adrenergic receptors in the failing human heart. Circ Res. 1993;87: ... Cardiotrophin (CT-1) inhibition of cardiac myocyte apoptosis via a mitogen-activated protein kinase-dependent pathway: ...http://circres.ahajournals.org/content/85/11/1101.long
A Novel Pathway for Presynaptic Mitogen-Activated Kinase Activation via AMPA Receptors | Journal of Neuroscience
... and apoptosis. Presynaptically, MAPK activation is triggered by neurotrophic factors and cytosolic calcium elevations (for ... Plasticity of Signaling by Spinal Estrogen Receptor α, κ-Opioid Receptor, and Metabotropic Glutamate Receptors over the Rat ... A Novel Pathway for Presynaptic Mitogen-Activated Kinase Activation via AMPA Receptors. Ursula Schenk, Elisabetta Menna, ... We show here that stimulation of presynaptic AMPA receptors induces activation of mitogen-activated protein kinase (MAPK) ...http://www.jneurosci.org/content/25/7/1654
Epigenetic Activation of μ-Opioid Receptor Gene via Increased Expression and Function of Mitogen- and Stress-Activated Protein...
2010) The role of p38 MAPK in valproic acid induced microglia apoptosis. Neurosci Lett 482:51-56. ... mitogen-activated protein kinase. MOR. μ-opioid receptor. MSK. mitogen- and stress-activated protein kinase. NaB. sodium ... 2008) Acetylation of mitogen-activated protein kinase phosphatase-1 inhibits Toll-like receptor signaling. J Exp Med 205:1491- ... Epigenetic Activation of μ-Opioid Receptor Gene via Increased Expression and Function of Mitogen- and Stress-Activated Protein ...http://molpharm.aspetjournals.org/content/91/4/357
Mitogen-activated S6 kinase is stimulated via protein kinase C-dependent and independent pathways in Swiss 3T3 cells. -...
The mitogen-activated kinase had an apparent Mr of about 85,000 as determined with Sephacryl S-300, but eluted with an apparent ... Fractionation of the cytosolic extracts from mitogen- or TPA-treated cells on Sephacryl S-300, TSK-400, and DEAE-Sephacel ... Soluble extracts prepared from quiescent Swiss mouse 3T3 cells that had been briefly exposed to various mitogens exhibited a 2 ... The pleckstrin homology and phosphotyrosine binding domains of insulin receptor substrate 1 mediate inhibition of apoptosis by ...https://www.semanticscholar.org/paper/Mitogen-activated-S6-kinase-is-stimulated-via-and-Pelech-Krebs/518b8e18aa4f16f97b3c0511f8d12d186a94593d
Toward understanding non-coding RNA roles in intracranial aneurysms and subarachnoid hemorrhage : Translational Neuroscience
P2X7 receptor antagonism inhibits p38 mitogen-activated protein kinase activation and ameliorates neuronal apoptosis after ... Neuronal apoptosis usually occurs in EBI after SAH (Figure 1) . P2X7R stimulation activates p38 mitogen-activated protein ... Cannabinoid receptor type 2 agonist attenuates apoptosis by activation of phosphorylated CREB-Bcl-2 pathway after subarachnoid ... Gao Y., Wu H., He D., Hu X., Li Y., Downregulation of BCL11A by siRNA induces apoptosis in B lymphoma cell lines, Biomedical ...https://www.degruyter.com/view/j/tnsci.2017.8.issue-1/tnsci-2017-0010/tnsci-2017-0010.xml