*  Bax-induced cytochrome c release from mitochondria depends on alpha-helices-5 and -6 | Biochemical Journal
Upon induction of apoptosis, Bax undergoes a conformational change and translocates to mitochondrial membranes, where it ... Bax-induced cytochrome c release from mitochondria depends on alpha-helices-5 and -6. Gerd HEIMLICH, Alastair D. McKINNON, ... mitochondria. Footnotes. *. Abbreviations used: Bax-ΔC, Bax lacking the C-terminal 20 amino acids; BH, Bcl-2 homology; CCCP, ... Bax-induced cytochrome c release from mitochondria depends on alpha-helices-5 and -6 ...
  http://www.biochemj.org/content/378/1/247
*  Mitochondrion - wikidoc
McMillin JB, Dowhan W (2002 Dec). "Cardiolipin and apoptosis". Biochim. et Biophys. Acta. 1585: 97-107. PMID 12531542. doi: ... The number of mitochondria in a cell varies widely by organism and tissue type. Many cells have only a single mitochondrion, ... In cell biology, a mitochondrion (plural mitochondria) is a membrane-enclosed organelle found in most eukaryotic cells.[1] ... Substantial numbers of mitochondria are in the liver, with about 1000-2000 mitochondria per cell making up 1/5th of the cell ...
  http://www.wikidoc.org/index.php/Mitochondrion
*  Therapeutic Targeting of the Survivin Pathway in Cancer | Clinical Cancer Research
Genetic Requirements of Apoptosis Induced by Survivin Targeting.. To map more precisely the genetic requirements of apoptosis ... Mitochondria were collected at the 1-1.5 M interphase by lateral suction through the tube, washed in 4 volumes of MS buffer at ... C, induction of endothelial cell apoptosis in vivo. Tumors were prepared as described in A and analyzed for apoptosis by ... Initiation of Mitochondrial Apoptosis and Suppression of Tumor-associated Angiogenesis. Olivier P. Blanc-Brude, Mehdi Mesri, ...
  http://clincancerres.aacrjournals.org/content/9/7/2683.long
*  Formation of elongated giant mitochondria in DFO-induced cellular senescence: Involvement of enhanced fusion process through...
... inhibition of mitochondrial Hsp90 induces mitochondrial elongation in Hep3B hepatocellular carcinoma cells undergoing apoptosis ... Elongated giant mitochondria were also observed in TGF β1- or H2O2-induced senescent Mv1Lu cells and in old human diploid ... Enlarged or giant mitochondria have often been documented in aged tissues although their role and underlying mechanism remain ... We report here how highly elongated giant mitochondria are formed in and related to the senescent arrest. The mitochondrial ...
  http://onlinelibrary.wiley.com/doi/10.1002/jcp.20753/full
*  Apoptosis-Inducing Factor Is a Key Factor in Neuronal Cell Death Propagated by BAX-Dependent and BAX-Independent Mechanisms |...
apoptosis Introduction. Mitochondria relay signals for both caspase-dependent and caspase-independent death pathways. The ... Mitochondria release proteins that propagate both caspase-dependent and caspase-independent cell death pathways. AIF (apoptosis ... Apoptosis-Inducing Factor Is a Key Factor in Neuronal Cell Death Propagated by BAX-Dependent and BAX-Independent Mechanisms. ... Apoptosis-Inducing Factor Is a Key Factor in Neuronal Cell Death Propagated by BAX-Dependent and BAX-Independent Mechanisms ...
  http://www.jneurosci.org/content/25/6/1324.long
*  mitochondria and apoptosis
... Aubrey de Grey ag24 at mole.bio.cam.ac.uk Sat Sep 12 07:21:57 EST 1998 *Previous message: Major ... spring wrote: , I have recently come upon an article that claims that apoptosis is , controlled by mitochondria. First is there ... mitochondria play a central and quite early role in apoptosis. A small protein called cytochrome c, which is normally part of ... to be massively released from mitochondria into the cytosol shortly before apoptosis occurs. We now know that, when released, ...
  http://www.bio.net/bionet/mm/ageing/1998-September/003319.html
*  Suppression of Excessive Histone Deacetylases Activity in Diabetic Hearts Attenuates Myocardial Ischemia/Reperfusion Injury via...
Bim blocks stress signals transduced from the cytoplasm to mitochondria and triggers the Bax-mediated mitochondria apoptosis ... Figure 6: Apoptosis rate and HDAC activity assessment in H9C2 cells. Apoptosis of H9C2 cells was assessed by flow cytometry. (b ... Apoptosis in H9C2 cardiomyocytes was assessed by cell viability (a) and LDH leakage (b) and apoptosis rate (c) in each group. ... Figure 4: HDAC inhibition attenuated mitochondria-associated apoptosis in diabetic rats. (a) Representative electron ...
  https://www.hindawi.com/journals/jdr/2017/8208065/
*  Mitochondria, apoptosis and cancer
Mitochondria are cells' energy centers and a central point where a number of signaling pathways leading to cell death converge ... Mitochondria are cells' energy centers and a central point where a number of signaling pathways leading to cell death converge ... Since both cellular metabolism and apoptotic pathways are compromised in many cancers, mitochondria-targeting drugs are ... Moreover, cellular homeostasis is regulated through mitophagy, the specific elimination of mitochondria through autophagy. ...
  http://meetings.embo.org/event/17-mito-cancer
*  Molecules | Free Full-Text | Thymoquinone Induces Mitochondria-Mediated Apoptosis in Acute Lymphoblastic Leukaemia in Vitro
The apoptosis was then confirmed by Annexin V and an increased number of cellular DNA breaks in treated cells were observed as ... The mitochondrial apoptosis was clearly associated with the S phase cell cycle arrest. In conclusion, the results from the ... Treatment of CEMss cells with TQ encouraged apoptosis with cell death-transducing signals by a down-regulation of Bcl-2 and up- ... The anti-cancer effect of TQ, via the induction of apoptosis resulting from mitochondrial dysfunction, was assessed in an acute ...
  http://www.mdpi.com/1420-3049/18/9/11219
*  Timosaponin A-III Induces Autophagy Preceding Mitochondria-Mediated Apoptosis in HeLa Cancer Cells | Cancer Research
Timosaponin A-III Induces Autophagy Preceding Mitochondria-Mediated Apoptosis in HeLa Cancer Cells. Lai-King Sy, Siu-Cheong Yan ... Mitochondria are selectively eliminated from eukaryotic cells after blockade of caspases during apoptosis. Curr Biol 2001; 11: ... Ly JD, Grubb DR, Lawen A. The mitochondrial membrane potential (Δψm) in apoptosis; an update. Apoptosis 2003; 8: 115-28. ... Timosaponin A-III Induces Autophagy Preceding Mitochondria-Mediated Apoptosis in HeLa Cancer Cells ...
  http://cancerres.aacrjournals.org/content/68/24/10229
*  Expression of P-170 glycoprotein sensitizes lymphoblastoid CEM cells to mitochondria-mediated apoptosis | Biochemical Journal
Expression of P-170 glycoprotein sensitizes lymphoblastoid CEM cells to mitochondria-mediated apoptosis. Paola MATARRESE, Ugo ... Expression of P-170 glycoprotein sensitizes lymphoblastoid CEM cells to mitochondria-mediated apoptosis ... Expression of P-170 glycoprotein sensitizes lymphoblastoid CEM cells to mitochondria-mediated apoptosis ... Expression of P-170 glycoprotein sensitizes lymphoblastoid CEM cells to mitochondria-mediated apoptosis ...
  http://www.biochemj.org/content/355/3/587
*  Autophagy-Regulated ROS from Xanthine Oxidase Acts as an Early Effector for Triggering Late Mitochondria-Dependent Apoptosis in...
Collectively, mitochondria-dependent apoptosis is regulated by autophagy-regulated early ROS, which serves as an early effector ... Autophagy-Regulated ROS from Xanthine Oxidase Acts as an Early Effector for Triggering Late Mitochondria-Dependent Apoptosis in ... a long-term follow-up study to investigate the relationship between early autophagy and late mitochondria-dependent apoptosis. ... We demonstrated that early ROS generation is critical for mitochondria damage and the activation of intrinsic apoptotic pathway ...
  https://www.sigmaaldrich.com/catalog/papers/26029922
*  Potent activation of mitochondria-mediated apoptosis and arrest in S and M phases of cancer cells by a broccoli sprout extract....
Potent activation of mitochondria-mediated apoptosis and arrest in S and M phases of cancer cells by a broccoli sprout extract. ... Potent activation of mitochondria-mediated apoptosis and arrest in S and M phases of cancer cells by a broccoli sprout extract. ... Potent activation of mitochondria-mediated apoptosis and arrest in S and M phases of cancer cells by a broccoli sprout extract. ... Potent activation of mitochondria-mediated apoptosis and arrest in S and M phases of cancer cells by a broccoli sprout extract. ...
  http://cancerres.aacrjournals.org/content/66/8_Supplement/1315.3
*  Molecules | Free Full-Text | Clematichinenoside (AR) Attenuates Hypoxia/Reoxygenation-Induced H9c2 Cardiomyocyte Apoptosis via...
These results showed that the application of AR decreased the ratio of apoptosis and the extent of mPTP opening, but increased ... We hypothesize that AR may improve mitochondrial function to inhibit MI/R-induced cardiomyocyte apoptosis. In this study, we ... The viability of H9c2 cardiomyocytes was determined by MTT assay; apoptosis was evaluated by flow cytometry and TUNEL ... Taken together, these results revealed that AR protects H9c2 cardiomyocytes against H/R-induced apoptosis through mitochondrial ...
  http://www.mdpi.com/1420-3049/21/6/683
*  CI431, an Aqueous Compound from Ciona intestinalis L., Induces Apoptosis through a Mitochondria-Mediated Pathway in Human...
CI431, an Aqueous Compound from Ciona intestinalis L., Induces Apoptosis through a Mitochondria-Mediated Pathway in Human ... Induces Apoptosis through a Mitochondria-Mediated Pathway in Human Hepatocellular Carcinoma Cells," Evidence-Based ...
  https://www.hindawi.com/journals/ecam/2011/292873/cta/
*  Crosstalk between p38 MAPK and caspase-9 regulates mitochondria-mediated apoptosis induced by tetra-α-(4-carboxyphenoxy)...
However, the manner in which p38 MAPK and caspase-9 are involved in the regulation of mitochondria-mediated apoptosis in the T ... Furthermore, the results revealed that siRNA-p38 MAPK had more significant inhibitory effects on apoptosis and mitochondria ... Crosstalk between p38 MAPK and caspase-9 regulates mitochondria-mediated apoptosis induced by tetra-α-(4-carboxyphenoxy) ... Crosstalk between p38 MAPK and caspase-9 regulates mitochondria-mediated apoptosis induced by tetra-α-(4-carboxyphenoxy) ...
  https://www.spandidos-publications.com/or/39/1/61
*  Suppression of GSK-3β activation by M-cadherin protects myoblasts against mitochondria-associated apoptosis during myogenic...
To further investigate the impact of M-cadherin RNAi on mitochondria as a mediator of apoptosis, we examined the cardiolipin ... Apoptosis assays. DNA fragmentation. DNA fragmentation was used to assess the level of apoptosis in muscle cells using an ELISA ... This suggests that the apoptosis induced by M-cadherin RNAi is mediated by the intrinsic mitochondria-associated pathway. ... D) Mitochondria were isolated from C2C12 myoblasts that had undergone the same treatments as described in B. The mitochondria ...
  http://jcs.biologists.org/content/124/22/3835
*  Apoptosis inducing factor, mitochondria associated 3 - Wikipedia
... pylori-induced apoptosis in human gastric cancer cells mediated via the release of apoptosis-inducing factor from mitochondria ... Apoptosis inducing factor, mitochondria associated 3 is a protein that in humans is encoded by the AIFM3 gene. GRCh38: Ensembl ... Apoptosis inducing factor, mitochondria associated 3". Retrieved 2017-10-24. Xie Q, Lin T, Zhang Y, Zheng J, Bonanno JA (2005 ... induces apoptosis and enhances radiosensitivity in hypoxic human hepatoma cells in vitro". Exp. Cell Res. 318 (8): 944-54. doi: ...
  https://en.wikipedia.org/wiki/Apoptosis_inducing_factor,_mitochondria_associated_3
*  Mitochondria and apoptosis - Cancer Ecology
... especially its role in apoptosis. Now I read that the same results are being obtained by Dr. Michelakis and colleagues at the ... A couple of posts ago I mentioned this research in which RNAi was used to restore the functionality of the mitochondria, ... Mitochondria and apoptosis. 06/02/2007. David Basanta1 Comment A couple of posts ago I mentioned this research in which RNAi ... was used to restore the functionality of the mitochondria, especially its role in apoptosis. Now I read that the same results ...
  https://cancerevo.wordpress.com/2007/02/06/mitochondria-and-apoptosis/
*  Mitochondria and Apoptosis - Geras Healthcare Productions
Just finished a new internal landscape 3D painting. Hope you like it! It's entitled, Glomeruli of the Kidney, and features the structure of the basic filtration unit within the renal cortex, the glomerulus. ...
  http://audrageras.com/mitochondria-and-apoptosis-1/
*  The Role of Sulfur Dioxide in the Regulation of Mitochondrion-Related Cardiomyocyte Apoptosis in Rats with Isopropylarterenol...
The Role of Sulfur Dioxide in the Regulation of Mitochondrion-Related Cardiomyocyte Apoptosis in Rats with Isopropylarterenol- ... Furthermore, cardiomyocyte apoptosis in the left ventricular tissues was augmented, left ventricular tissue bcl-2 expression ... Hence, SO2 attenuated myocardial injury in association with the inhibition of apoptosis in myocardial tissues, and the bcl-2/ ... Cardiac function was measured and cardiomyocyte apoptosis was detected. Bcl-2, bax and cytochrome c (cytc) expressions, and ...
  http://liu.diva-portal.org/smash/record.jsf?pid=diva2:640736
*  Thimerosal induces neuronal cell apoptosis by causing cytochrome c and apoptosis-inducing factor release from mitochondria
... * ... Thimerosal induces neuronal cell apoptosis by causing cytochrome c and apoptosis-inducing factor release from mitochondria. ... Thimerosal induces neuronal cell apoptosis by causing cytochrome c and apoptosis-inducing factor release from mitochondria'. ... Thimerosal induces neuronal cell apoptosis by causing cytochrome c and apoptosis-inducing factor release from mitochondria'. ...
  https://www.spandidos-publications.com/ijmm/16/6/971
*  Tanshinone IIA Induces Apoptosis in Human Oral Cancer KB Cells through a Mitochondria-Dependent Pathway
... Pao-Yu Tseng,1 Wei- ... X. Wang, "The expanding role of mitochondria in apoptosis," Genes and Development, vol. 15, no. 22, pp. 2922-2933, 2001. View ... D. R. Green and J. C. Reed, "Mitochondria and apoptosis," Science, vol. 281, no. 5381, pp. 1309-1312, 1998. View at Google ... Tan IIA was already known to induce apoptosis in HeLa cells through a mitochondria-dependent pathway [3]. ...
  https://www.hindawi.com/journals/bmri/2014/540516/ref/