*  Subcellular Targeting of PDE4 in Cardiac Myocytes and Generation of Signaling Compartments | SpringerLink
Small heat-shock protein Hsp20 attenuates beta-agonist-mediated cardiac remodeling through apoptosis signal-regulating kinase 1 ... Edwards HV, Scott JD, Baillie GS (2012b) PKA phosphorylation of the small heat-shock protein Hsp20 enhances its ... Fan GC, Kranias EG (2011) Small heat shock protein 20 (HspB6) in cardiac hypertrophy and failure. J Mol Cell Cardiol 51(4):574- ... Calejo AI, Tasken K (2015) Targeting protein-protein interactions in complexes organized by a kinase anchoring proteins. Front ...
  https://link.springer.com/chapter/10.1007/978-3-319-54579-0_8
*  Frontiers | Targeting protein-protein interactions in complexes organized by A kinase anchoring proteins | Pharmacology
Here, we will focus on mechanisms for targeting protein-protein interaction, disruptors that modulate down-stream cAMP ... Here, we will focus on mechanisms for targeting protein-protein interaction, disruptors that modulate down-stream cAMP ... coordinated protein complexes with high-affinity peptidomimetics or small molecules to tease apart distinct protein-protein ... coordinated protein complexes with high-affinity peptidomimetics or small molecules to tease apart distinct protein-protein ...
  https://www.frontiersin.org/articles/10.3389/fphar.2015.00192/full
*  Intrasarcoplasmic Amyloidosis Impairs Proteolytic Function of Proteasomes in Cardiomyocytes by Compromising Substrate Uptake |...
Small heat-shock protein Hsp20 phosphorylation inhibits beta-agonist-induced cardiac apoptosis. Circ Res. 2004; 94: 1474-1482. ... Because CryAB can oligomerize with other small heat shock proteins (Hsp) and may function in heterooligomers,17 the results ... was not evident in CryAB-null hearts and inhibition of aberrant protein aggregation by Congo red or a heat shock protein ... Because aberrant protein aggregation and accumulation of ubiquitinated proteins, both indicative of malfunction in protein ...
  http://circres.ahajournals.org/content/97/10/1018
*  Hsp27 - Wikipedia
Hsp27 is a chaperone of the sHsp (small heat shock protein) group among ubiquitin, α-crystallin, Hsp20 and others. The common ... Charette SJ, Lavoie JN, Lambert H, Landry J (October 2000). "Inhibition of Daxx-mediated apoptosis by heat shock protein 27". ... Heat shock protein 27 (Hsp27) also known as heat shock protein beta-1 (HSPB1) is a protein that in humans is encoded by the ... "Phosphorylation of heat shock protein 27 antagonizes TNF-α induced HeLa cell apoptosis via regulating TAK1 ubiquitination and ...
  https://en.wikipedia.org/wiki/Hsp27
*  Heat shock protein - Wikipedia
Hsp20 also serves a significant role in preventing platelet aggregation, cardiac myocyte function and prevention of apoptosis ... Heat-shock proteins as DAMPs[edit]. Extracellular heat-shock proteins can be sensed by our immunity as danger associated ... How heat-shock proteins get into extracellular space[edit]. Heat-shock proteins can be secreted from immune cells or tumour ... Wikimedia Commons has media related to Heat-shock proteins.. *Heat-Shock+Proteins at the US National Library of Medicine ...
  https://en.wikipedia.org/wiki/Heat_shock_protein
*  Search
Thermotolerance, oxidative stress, apoptosis, heat-shock proteins and damages to reproductive cells of insecticide-susceptible ... weaker upregulation of two heat shock protein (hsp) genes (hsp69s and hsp20), and stronger upregulation of two apoptotic genes ... Adults of the Rc strain were less heat resistant than those of the Sm strain; they also had lower levels of enzymatic activity ... The greater injury observed in conditions of heat stress may be due to both the stronger upregulation of caspase genes and ...
  https://www.cambridge.org/core/search?filters%5BauthorTerms%5D=D.%20KONG&eventCode=SE-AU
*  Modulation of Hypercholesterolemia-Induced Oxidative/Nitrative Stress in the Heart
These miRNAs also drive the synthesis of important cardioprotective proteins including heat shock protein- (HSP-) 70, ... Y.-J. Kim, K.-J. Park, J.-K. Song et al., "The PPARγ agonist protects cardiomyocytes from oxidative stress and apoptosis via ... endothelial and inducible NOS, HSP-20, NAD-dependent deacetylase sirtuin-1 (Sirt1), and hypoxia-inducible factor 1a [34]. ... "Role of exercise-induced reactive oxygen species in the modulation of heat shock protein response," Free Radical Research, vol ...
  https://www.hindawi.com/journals/omcl/2016/3863726/
*  Peripheral Nociception Associated With Surgical Incision Elicits Remote Nonischemic Cardioprotection Via Neurogenic Activation...
Novel cardioprotective role of a small heat-shock protein, Hsp20, against ischemia/reperfusion injury. Circulation. 2005; 111: ... Remote Preconditioning of Trauma Attenuates Infarct Size and Reduces Apoptosis After I/R. We observed a 5- to 6-fold reduction ... MicroRNA-320 is involved in the regulation of cardiac ischemia/reperfusion injury by targeting heat-shock protein 20. ... Cardiac stress protein elevation 24 hours after brief ischemia or heat stress is associated with resistance to myocardial ...
  http://circ.ahajournals.org/content/120/11_suppl_1/S1
*  Plus it
Novel cardioprotective role of a small heat-shock protein, Hsp20, against ischemia/reperfusion injury. Circulation111 :1792 - ... Impact of RAGE on apoptosis in diabetic hearts after I/R. Diabetic wild-type, RAGE KO, Tg DN PPET RAGE, and Tg DN MSR RAGE mice ... Sell DR, Strauch CM, Shen W, Monnier VM: 2-Aminoadipic acid is a marker of protein carbonyl oxidation in the aging human skin: ... Zhao ZQ, Morris CD, Budde JM, Wang NP, Muraki S, Sun HY, Guyton RA: Inhibition of myocardial apoptosis reduces infarct size and ...
  http://diabetes.diabetesjournals.org/content/57/7/1941
*  HSPB1 (Heat-Shock 27 kDa Protein 1)
Heat-Shock 27 kDa Protein 1), Authors: Ewa Laskowska, Dorota Kuczyńska-Wiśnik, Ewelina Matuszewska. Published in: Atlas Genet ... Heat shock protein 27 controls apoptosis by regulating Akt activation.. Rane MJ, Pan Y, Singh S, Powell DW, Wu R, Cummins T, ... Comparison of the small heat shock proteins alphaB-crystallin, MKBP, HSP25, HSP20, and cvHSP in heart and skeletal muscle.. ... Heat shock protein 27 and alpha B-crystallin can form a complex, which dissociates by heat shock.. ...
  http://atlasgeneticsoncology.org/Genes/HSPB1ID40880ch7q11.html
*  CRYAB - Wikipedia
... and are members of the small heat shock protein (sHSP also known as the HSP20) family. They act as molecular chaperones ... as well as inhibit apoptosis and contribute to intracellular architecture. Post-translational modifications decrease the ... Alpha-crystallin B chain is a protein that in humans is encoded by the CRYAB gene. It is part of the small heat shock protein ... Kato K, Shinohara H, Goto S, Inaguma Y, Morishita R, Asano T (April 1992). "Copurification of small heat shock protein with ...
  https://en.wikipedia.org/wiki/CRYAB
*  Protein phosphatase 1 regulatory subunits (PPP1R) Gene Family | HUGO Gene Nomenclature Committee
heat shock protein family B (small) member 6. PPP1R91, FLJ32389, Hsp20. 19q13.12. ... FK506 binding protein 15. KIAA0674. FKBP133, WAFL, PPP1R76. 9q32. AATK apoptosis associated tyrosine kinase. AATYK1, PPP1R77, ... tumor protein p53 binding protein 2. ASPP2, 53BP2, PPP1R13A. 1q41. PPP1R13B protein phosphatase 1 regulatory subunit 13B. ... protein phosphatase 1 regulatory subunit 3D. PPP1R6. 20q13.33. PPP1R3E protein phosphatase 1 regulatory subunit 3E. FLJ00089. ...
  https://www.genenames.org/cgi-bin/genefamilies/set/694
*  HSPB6 - Heat shock protein beta-6 - Homo sapiens (Human) - HSPB6 gene & protein
Small heat shock protein which functions as a molecular chaperone probably maintaining denatured proteins in a folding- ... "Heat shock protein 20 (HSP20) is a novel substrate for protein kinase D1 (PKD1).". Sin Y.Y., Baillie G.S.. Cell Biochem. Funct ... Phosphorylated at Ser-16 by PKA and probably PKD1K; required to protect cardiomyocytes from apoptosis.By similarity. ,p> ... "Heat shock protein 20 (HSP20) is a novel substrate for protein kinase D1 (PKD1).". Sin Y.Y., Baillie G.S.. Cell Biochem. Funct ...
  http://www.uniprot.org/uniprot/O14558
*  DnaJ (Hsp40) Homolog, Subfamily B, Member 6 (DNAJB6) Antibodies
DnaJ heat shock protein family (Hsp40) member B6 (DNAJB6) antibody * DnaJ heat shock protein family (Hsp40) member B6 (Dnajb6) ... mRNA levels of HSP family members (HSP70B', HSP72 (show HSPA1A Antibodies), HSP40/DNAJ (show DNAJB1 Antibodies), and HSP20 ( ... the cytoprotective effects of DNAJB6(S) may be mediated, at least in part, by the mitochondrial pathway of apoptosis. ... dnaJ homolog subfamily B member 6-B , DnaJ-like 2 protein , dnaJ homolog subfamily B member 6 , heat shock protein J2 , HSJ-2 ...
  http://www.antibodies-online.com/abstract/DnaJ+
*  An analysis of the transcriptome of Teladorsagia circumcincta: its biological and biotechnological implications | BMC Genomics ...
Heat shock proteins, such as HSP-20 are reported to be present in the parasitic nematode, H. contortus (barber's pole worm) ... apoptosis and T cell polarization are the few immune processes in which C-type lectins and galectins are involved [66]. CTLs ... proteins of O. ostertagi, transthyretin proteins, saposin-like protein 1, C-type lectin-1, globin-like protein, Na-ASP-2, a PR- ... proteins and VAL proteins beside mammalian cysteine-rich sperm proteins (CRISPs). No rational function for this protein family ...
  https://bmcgenomics.biomedcentral.com/articles/10.1186/1471-2164-13-S7-S10
*  Most recent papers with the keyword TrkB | Read by QxMD
... deficits in rats with TBI and determined the contribution of hippocampal and cortical expression of heat shock protein 20 ( ... Reduced proliferation and enhanced apoptosis of β cells in diabetes mellitus are associated with a deficiency of brain-derived ... Exercise Rehabilitation Attenuates Cognitive Deficits in Rats with Traumatic Brain Injury by Stimulating the Cerebral HSP20/ ... The TRK family contains three members, TRKA, TRKB, and TRKC, and these proteins are encoded by the genes NTRK1, NTRK2, and ...
  https://www.readbyqxmd.com/keyword/103648
*  Citations for Immunoprecipitation with Dynabeads | Thermo Fisher Scientific
Dynabeads Protein G. Novel cardioprotective role of a small heat-shock protein, Hsp20, against ischemia/reperfusion injury. ... MafB promotes atherosclerosis by inhibiting foam-cell apoptosis. 2014. Nat Commun. Dynabeads Protein A. ... Dynabeads Protein G. The polo box is required for multiple functions of Plx1 in mitosis. 2004. J Biol Chem. Dynabeads Protein G ... Dynabeads Protein G. Regulation of Mdm2 protein stability and the p53 response by NEDD4-1 E3 ligase. 2014. Oncogene. Dynabeads ...
  https://www.thermofisher.com/au/en/home/life-science/protein-biology/protein-assays-analysis/immunoprecipitation/dynabeads-magnetic-beads-citations.html
*  JoVE Author Search: Baillie GS
Proteins, Heat, Shock, Heart, Cells, Technology, Apoptosis, Protein Kinase A, Regulation, Hypertrophy, Role, Adenosine, Ability ... PKA phosphorylation of the small heat-shock protein Hsp20 enhances its cardioprotective effects.. Abstract. ... Research Interests: Kinase, Phosphorylation, Protein Kinase, Cell, Proteins, Heat, Shock, Heart, Cells, Technology, Apoptosis, ... Protein Kinase A, Regulation, Hypertrophy, Role, Adenosine, Ability, Association, Second Messenger, Heat-shock Protein. ...
  http://labindex.jove.com/author/Baillie-GS
*  JoVE | Peer Reviewed Scientific Video Journal - Methods and Protocols
Heat shock protein 20 (HSP20), which is a member of the small heat shock protein family, is known to participate in many ... Infection of Ad-HSP20, but not control adenovirus (Ad-GFP), reduced viability and induced massive apoptosis in a time-dependent ... Decreased expression of heat shock protein 20 in colorectal cancer and its implication in tumorigenesis. ... In addition, immunohistochemical analysis of 94 CRC specimens for HSP20 protein showed that reduced HSP20 expression was ...
  https://www.jove.com/visualize?author=Hee-Bok%20Park%20
*  Anti Alpha B Crystallin Antibody (PrecisionAb™ Monoclonal Antibody) | Bio-Rad Antibodies (formerly AbD Serotec)
... also known as heat shock protein beta-5, heat-shock 20 kD like ... also known as heat shock protein beta-5, heat-shock 20 kD like- ... Alpha crystallins can be induced by heat shock and are members of the small heat shock protein (sHSP also known as the HSP20) ... Research Areas Apoptosis & Autophagy Cancer Cell Biology Cell Health Immunology Innate Immunology Microbiology Stem cells ... Reporter Protein Antibodies Matched Antibody Pairs Antibody Kits Conjugation Kits Application Buffers, Reagents & Sera Proteins ...
  https://www.bio-rad-antibodies.com/human-alpha-b-crystallin-antibody-vma00425.html
*  How do bifidobacteria counteract environmental challenges? Mechanisms involved and physiological consequences | SpringerLink
... the gene hsp20, coding for a member of the small heat-shock protein family, has been shown to be highly over-expressed after ... The stress-response proteins poly (ADP-ribose) polymerase and NF-kappaB protect against bile salt-induced apoptosis. Cell Death ... Firstly described as heat-shock proteins (HSPs), molecular chaperones include GroEL (HSP60), DnaK (HSP70), ClpB (HSP100), and ... Savijoki K, Suokko A, Palva A, Valmu L, Kalkkinen N, Varmanen P (2005) Effect of heat-shock and bile salts on protein synthesis ...
  https://link.springer.com/article/10.1007%2Fs12263-010-0207-5
*  Compositions and Methods for Redox Modulated Proteins - Patent application
... heat shock proteins, ion channels, mitochondrial proteins, and cytoskeletal proteins. During oxidative stress GSSP level ... Cardiac Apoptosis: [0100] 1) Bcl-2 [0101] 2) Bax [0102] 3) Caspase-3 [0103] 4) Cleaved caspase-3 [0104] 5) Caspase-9 [0105] 6) ... 0052] 7) Hsp20/cvHSP (cardiovascular HSP) [0053] IV. Cardiac Hypertrophy/Signaling: [0054] 1) Akt/p-Akt [0055] 2) GSK3-alpha [ ... proteins other than the redox modulated protein, such as other proteins in the same family of proteins). An antibody that binds ...
  http://www.patentsencyclopedia.com/app/20110230649
*  HSP (Inhibitors Agonists Modulators Antagonists)-MedChemExpress.com
Heat shock proteins appear to serve a significant cardiovascular role. Hsp90, Hsp84, Hsp70, Hsp27, Hsp20 and alpha B crystallin ... and can induce apoptosis. ... Heat shock proteins) are a group of proteins induced by heat ... The dramatic upregulation of the heat shock proteins is a key part of the heat shock response and is induced primarily by heat ... Ganetespib is a unique non-geldanamycin heat shock protein 90 (HSP90) inhibitor, with IC50 of 4 nM in OSA 8 cells. ...
  http://www.medchemexpress.com/Targets/HSP.html
*  Frontiers | ALA6, a P4-type ATPase, Is Involved in Heat Stress Responses in Arabidopsis thaliana | Plant Science
Here, we show that a loss-of-function mutant of ALA6 (ala6) exhibits clear sensitivity to heat stress, including both basal and ... In addition, ala6 displays higher ion-leakage during heat treatment, suggesting that the lipid flippase activity of ALA6 plays ... In addition, ala6 displays higher ion-leakage during heat treatment, suggesting that the lipid flippase activity of ALA6 plays ... Transcriptome analysis reveals differences in gene expression between ala6 and wild-type plants with or without heat stress. ...
  https://www.frontiersin.org/articles/10.3389/fpls.2017.01732/full
*  Anti-HDAC1 antibody - ChIP Grade (ab7028) References | Abcam
Karolczak-Bayatti M et al. Acetylation of heat shock protein 20 (hsp20) regulates human myometrial activity. J Biol Chem 286: ... Singh AP et al. Brg1 Enables Rapid Growth of the Early Embryo by Suppressing Genes That Regulate Apoptosis and Cell Growth ... Cox JL et al. Sox2 uses multiple domains to associate with proteins present in Sox2-protein complexes. PLoS One 5:e15486 (2010 ... involvement of specificity protein-1 (Sp1), Sp3, Sp4, Sp-like proteins, and histone deacetylases. J Clin Endocrinol Metab 90: ...
  http://www.abcam.com/hdac1-antibody-chip-grade-ab7028-references.html