Caspase-independent Cell Killing by Fas-associated Protein with Death Domain
FADD, a novel death domain-containing protein, interacts with the death domain of Fas and initiates apoptosis. Cell. 1995;81: ... Fas-associated protein with death domain (FADD), to the death domain of the Fas cytoplasmic region. This binding causes ... A novel protein that interacts with the death domain of Fas/ APO1 contains a sequence motif related to the death domain. J Biol ... Fas-associated protein with death domain. FKBP. FK506 binding protein. HA. hemagglutinin. PARP. poly(ADP-ribose) polymerase. ...http://pubmedcentralcanada.ca/pmcc/articles/PMC2133085/?lang=en-ca
Highly parallel identification of essential genes in cancer cells | Proceedings of the National Academy of Sciences
1995) FADD, a novel death domain-containing protein, interacts with the death domain of Fas and initiates apoptosis. Cell 81: ... 1D). The 5 genes include 3 with well-established roles in FAS-induced apoptosis (11, ,13-,15) (FAS, FADD, and CASP8) and 2 ... 1996) Involvement of MACH, a novel MORT1/FADD-interacting protease, in Fas/APO-1- and TNF receptor-induced cell death. Cell 85: ... 1991) The polypeptide encoded by the cDNA for human cell surface antigen Fas can mediate apoptosis. Cell 66:233-243. ...http://www.pnas.org/content/105/51/20380
Genomic Alterations in Human Malignant Glioma Cells Associate with the Cell Resistance to the Combination Treatment with Tumor...
FADD, a novel death domain-containing protein, interacts with the death domain of Fas and initiates apoptosis. Cell 1995;81:505 ... TRAIL interacts with its death receptors DR4 and DR5 to recruit intracellular Fas-associated death domain (FADD; ref. 12) and ... cell lines due to the recruitment of cellular Fas associate death domain-like IL-1β-converting enzyme-inhibitory protein (c- ... Cytotoxicity-dependent APO-1 (Fas/CD95)-associated proteins form a death-inducing signaling complex (DISC) with the receptor. ...http://clincancerres.aacrjournals.org/content/12/9/2716
FADD - Wikipedia
"The Fas-associated death domain protein is required in apoptosis and TLR-induced proliferative responses in B cells". Journal ... It contains two main domains: a C terminal death domain (DD) and an N terminal death effector domain (DED). Each domain, ... "Fas-associated death domain protein interacts with methyl-CpG binding domain protein 4: a potential link between genome ... "A Novel Protein That Interacts with the Death Domain of Fas/APO1 Contains a Sequence Motif Related to the Death Domain". ...https://en.wikipedia.org/wiki/FADD
Early Activation of Caspases during T Lymphocyte Stimulation Results in Selective Substrate Cleavage in Nonapoptotic Cells | JEM
Fas-associated death domain protein; HRP, horseradish peroxidase; IAP, inhibitor of apoptosis; PARP, poly(ADP-ribose) ... Indeed, interference with pathways leading to caspase processing, as in Fas-associated death domain protein (FADD) knockout, ... Death receptors such as TNFR and Fas can act as costimulatory molecules and enhance T cell proliferation (25)(26)(27). We have ... 1998) Fas-mediated apoptosis and activation-induced T-cell proliferation are defective in mice lacking FADD/Mort1. Nature. 392: ...http://jem.rupress.org/content/190/12/1879
T cells in the pathogenesis of type 1 diabetes | SpringerLink
... expression of dominant-negative Fas-associated death domain protein in beta cells protects against Fas ligand-induced apoptosis ... Thomas HE, Darwiche R, Corbett JA, Kay TW: Evidence that beta cell death in the nonobese diabetic mouse is Fas independent. J ... Amrani A, Verdaguer J, Thiessen S, et al.: IL-1alpha, IL-1beta, and IFN-gamma mark beta cells for Fas-dependent destruction by ... Yamada K, Takane-Gyotoku N, Yuan X, et al.: Mouse islet cell lysis mediated by interleukin-1-induced Fas. Diabetologia 1996, 39 ...https://link.springer.com/article/10.1007%2Fs11892-008-0019-9
The intracellular 52-kd RoSSA autoantigen in keratinocytes is up-regulated by tumor necrosis factor ╨Ю┬▒ via tumor...
FADD, a novel death domain-containing protein, interacts with the death domain of Fas and initiates apoptosis. Cell 1995;81:505 ... "death domains" of the p55 tumor necrosis factor (TNF) receptor and Fas/APO1 prompts signaling for TNF and Fas/APO1 effects. J ... Cytotoxicity-dependent APO-1 (Fas/CD95)associated proteins form a death-inducing signaling complex (DISC) with the receptor. ... mediated apoptosis is counteracted by constitutively expressed antiapoptotic proteins (46). TNFRI-induced apoptosis has been ...https://www.docme.ru/doc/2159017/the-intracellular-52-kd-rossa-autoantigen-in-keratinocyte..
Systemic FasL Neutralization Increases Eosinophilic Inflammation in a Mouse Model of Asthma
FADD, a novel death domain-containing protein, interacts with the death domain of Fas and initiates apoptosis. Cell. 1995;81: ... Engagement of a Fas-expressing target cell by a Fas Ligand (FasL) bearing effector can result in the programmed cell death of ... Cell-autonomous Fas(CD95)/Fas-ligand interaction mediates activation-induced apoptosis in T-cell hybridomas. Nature. 1995;373: ... Apoptosis, Proliferation, and Expression of Bcl-2, Fas, and Fas Ligand in Bronchial Biopsies from Asthmatics. American Journal ...http://pubmedcentralcanada.ca/pmcc/articles/PMC3278510/?lang=en-ca
Production of Type I IFN Sensitizes Macrophages to Cell Death Induced by Listeria monocytogenes | The Journal of Immunology
66) suggested a sensitizing effect of type I IFN to apoptosis through regulation of a Fas-associated death domain protein ... In case of some viruses, type I IFNs also promote programmed death of infected cells (13). Protein kinase R (PKR), an enzyme ... Possible involvement of double-stranded RNA-activated protein kinase in cell death by influenza virus infection. J. Virol. 70: ... The mechanism of cell death in Listeria monocytogenes-infected murine macrophages is distinct from apoptosis. Infect. Immun. 65 ...http://www.jimmunol.org/content/169/11/6522
C, Curcumin; CIAP, cleavage inhibitor of apoptosis; FADD, Fas-associated protein with death domain; FLIP, FLICE-like inhibitory ... conformational change in the receptors allows Fas-associated death domain (FADD) binding and recruits the death-induced ... Curcumin was shown to upregulate extrinsic apoptosis pathway signals via the Fas pathway. In TNF-related-apoptosis-inducing ... protein kinase C; PLC, phospholipase C; XIAP, X-linked inhibitor of apoptosis protein; VEGF, vascular endothelial growth factor ...http://cancerpreventionresearch.aacrjournals.org/content/6/5/387
Caspase-14, an apoptotic protease, nucleic acids encoding and methods of use - Patent # 6432628 - PatentGenius
... a Novel Death Domain-Containing Protein Interacts with the Death Doamin of Fas and Initiates Apoptosis," Cell 81: 505-512, 1995 ... "A Novel Protein That Interacts with the Death Domain of Fas/APO1 Contains a Sequence Motif Related to the Death Domain," J. ... Nagata and Golstein, "The Fas Death Factor," Science 267: 1449-1456, 1995... Nagata, "Apoptosis by Death Factor," Cell 88: 355- ... Kischkel et al., "Cytotoxicity-dependent APO-1 (Fas/CD95)-associated proteins form a death-inducing signaling complex (DISC) ...http://www.patentgenius.com/patent/6432628.html
Overview of Eukaryotic In Vitro Translation and Expression Systems - Current Protocols
FADD, a novel death domain‐containing protein, interacts with the death domain of Fas and initiates apoptosis. Cell 81:505‐512 ... Bik, a novel death‐inducing protein, shares a distinct sequence motif with Bcl‐2 family proteins and interacts with viral and ... Protein‐protein interaction between the transcriptional repressor E4BP4 and the TBP‐binding protein Dr1. Nucl. Acid Res. 24: ... Synthesizing proteins in vitro by transcription and translation of cloned genes. In Current Protocols in Molecular Biology (F.A ...http://www.currentprotocols.com/WileyCDA/CPUnit/refId-cb1101.html?quicktabs_cp=abstract
Nonapoptotic functions of Fas/CD95 in the immune response, Febs Journal | 10.1111/febs.14292 | DeepDyve
"Nonapoptotic functions of Fas/CD95 in the immune response, Febs Journal" on DeepDyve, the largest online rental service for ... FADD, a novel death domain‐containing protein, interacts with the death domain of fas and initiates apoptosis ... A novel protein that interacts with the death domain of Fas/APO1 contains a sequence motif related to the death domain ... Signal transduction mediated by Bid, a pro‐death Bcl‐2 family proteins, connects the death receptor and mitochondria apoptosis ...https://www.deepdyve.com/lp/wiley/nonapoptotic-functions-of-fas-cd95-in-the-immune-response-2MTbOcdod1
Histone Deacetylase Inhibitors Modulate the Sensitivity of Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand-Resistant...
FADD, a novel death domain-containing protein, interacts with the death domain of Fas and initiates apoptosis. Cell 1995; 81: ... Fas, TNFR-1, TRAIL-R1, and TRAIL-R2) share a homophilic protein/protein intracellular domain, the death domain ( 41, 42), which ... the death domain of FADD binds to the death domain of TRAIL-R1 or TRAIL-R2. The death effector domain of FADD, in turn, ... Itoh N, Nagata S. A novel protein domain required for apoptosis. Mutational analysis of human Fas antigen. J Biol Chem 1993; ...http://cancerres.aacrjournals.org/content/66/1/499
DISC, death-inducing signaling complex; FADD, Fas-associated protein with death domain; IAP, inhibitor of apoptosis. ... down-regulation of the death signaling molecule Fas-associated protein with death domain and caspase-8 has been shown in ... it is not surprising that altered expression of these proteins in cancerous cells often allows them to resist apoptosis. Fas ... leading to apoptotic cell death. Engagement of the surface Fas, TRAIL, or TNF death receptors by their secreted or cell surface ...http://clincancerres.aacrjournals.org/content/14/14/4385
anti-FADD antibody | Rabbit Fas Associating Death Domain Containing Protein (FADD) Polyclonal Antibody-NP 034305.1
Rabbit Fas Associating Death Domain Containing Protein (FADD) Polyclonal Antibody-NP_034305.1 (MBS2004183) product datasheet at ... FADD: an adaptor molecule that mediates apoptosis. Recruited through its C-terminal death domain by Fas-receptor, tumor ... UniProt Protein Name FAS-associated death domain protein UniProt Synonym Protein Names FAS-associating death domain-containing ... NCBI Protein Information FAS-associated death domain protein ... Protein Family Fas-associated death domain protein UniProt Gene ...https://www.mybiosource.com/prods/Antibody/Polyclonal/Fas-Associating-Death-Domain-Containing-Protein-FADD/FADD/datasheet.php?products_id=2004183
Sindbis virus induces apoptosis through a caspase-dependent, CrmA-sensitive pathway. - Semantic Scholar
The specificity of CrmA indicates that the Sindbis virus-induced death pathway is similar to that induced by Fas or tumor ... inhibited Sindbis virus-induced cell death, suggesting that cellular caspases facilitate apoptosis induced by Sindbis virus. ... To study the role of caspases in virus-induced apoptosis, we determined the effects of specific caspase inhibitors on Sindbis ... cells and of neurons in mouse brains leads to programmed cell death exhibiting the classical characteristics of apoptosis. ...https://www.semanticscholar.org/paper/Sindbis-virus-induces-apoptosis-through-a-pathway.-Nava-Ros%C3%A9n/c2eb607b659f44b25893e5f957476e35fa3524ad
The caspase-8 inhibitor FLIP promotes act... & related info | Mendeley
... induces cell death through recruitment and activation of caspase-8 via the adaptor protein Fas-associated death domain protein ... Background: Activation of Fas (CD95) by its ligand (FasL) rapidly ... Fas signals do not always result in apoptosis but can also trigger a pathway that leads to proliferation. We investigated the ... induces cell death through recruitment and activation of caspase-8 via the adaptor protein Fas-associated death domain protein ...https://www.mendeley.com/research-papers/caspase8-inhibitor-flip-promotes-activation-nf%CE%BAb-erk-signaling-pathways/
Proapoptotic Chemotherapeutic Drugs Induce Noncanonical Processing and Release of IL-1β via Caspase-8 in Dendritic Cells | The...
cellular inhibitor of apoptosis protein. DC. dendritic cell. Dox. doxorubicin. FADD. Fas-associated death domain protein. IAP. ... Anti-caspase-1 (p10) rabbit polyclonal (sc-514), anti-actin goat polyclonal (sc-1615), anti-Fas-associated death domain protein ... inhibitor of apoptosis protein. Nec-1. necrostatin-1. P2X7R. P2X7 receptor. PARP. poly-ADP-ribosyltransferase. qPCR. ... Cellular inhibitors of apoptosis proteins cIAP1 and cIAP2 are required for efficient caspase-1 activation by the inflammasome. ...http://www.jimmunol.org/content/191/9/4789.long
NAVER Academic | Central role of IL-6 and MMP-1 for cross talk between human intestinal mast cells and human intestinal...
Here, we show that human intestinal fibroblasts (FB) suppress apoptosis in human intestinal MC dependent on IL-6. Intestinal FB ... Mitogen-activated protein kinase kinase antagonized fas-associated death domain protein-mediated apoptosis by induced FLICE- ... Stimulation of the p38 Mitogen-Activated Protein Kinase Pathway in Neonatal Rat Ventricular Myocytes by the G Protein-Coupled ... PD 098059 is a specific inhibitor of the activation of mitogen-activated protein kinase kinase in vitro and in vivo. (1995) D R ...https://academic.naver.com/article.naver?doc_id=65287245
Transduction of Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand into Hematopoietic Cells Leads to Inhibition of...
Fas-associated protein with death domain (FADD)-independent recruitment of c-FLIPL to death receptor 5. J Biol Chem. 2004;279: ... Yang X, Khosravi-Far R, Chang HY, Baltimore D. Daxx, a novel Fas-binding protein that activates JNK and apoptosis. Cell. 1997; ... 4E), and the increased apoptosis was accompanied by positive staining of TRAIL protein in the tumor tissue (Fig. 4E), which ... TRAIL and apoptosis induction by TNF-family death receptors. Oncogene. 2003;22:8628-33. [PubMed] ...http://pubmedcentralcanada.ca/pmcc/articles/PMC2941891/
The MC159 Protein from the Molluscum Contagiosum Poxvirus Inhibits NF-κB Activation by Interacting with the IκB Kinase Complex ...
Death effector domain-containing herpesvirus and poxvirus proteins inhibit both Fas- and TNFR1-induced apoptosis. Proc. Natl. ... MC159 contains two tandem protein-protein interaction domains called death effector domains (DEDs; DEDA, DEDB) (17, 18). MC159 ... The MC159 protein is a viral FLIP and, as such, possesses two tandem death effector domains (DEDs). We show in this article ... The death effector domains (DEDs) of the molluscum contagiosum virus MC159 v-FLIP protein are not functionally interchangeable ...http://www.jimmunol.org/content/188/5/2371
The Kinase SGK1 in the Endoderm and Mesoderm Promotes Ectodermal Survival by Down-Regulating Components of the Death-Inducing...
Fas-associated death domain protein) and caspase-10, components of the death-inducing signaling complex (DISC). Inhibition of ... knockdown of SGK1 caused excessive apoptosis in the ectoderm. SGK1-depleted ectodermal explants showed little or no apoptosis, ... The Kinase SGK1 in the Endoderm and Mesoderm Promotes Ectodermal Survival by Down-Regulating Components of the Death-Inducing ... The Kinase SGK1 in the Endoderm and Mesoderm Promotes Ectodermal Survival by Down-Regulating Components of the Death-Inducing ...http://stke.sciencemag.org/content/4/156/ra2
Evidence that Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand Induction by 5-Aza-2′-Deoxycytidine Sensitizes Human...
... caspase-8 is recruited via Fas-associated death domain protein (FADD) to the death-inducing signaling complex (DISC) and is ... and because TRAIL-R4 has a truncated death domain, both TRAIL-R3 and TRAIL-R4 can antagonize TRAIL-induced apoptosis by ... Sensitization for death receptor- or drug-induced apoptosis by re-expression of caspase-8 through demethylation or gene ... Induction of TRAIL protein by 5-aza-CdR in MDA-231 cells. A, effects of 5-aza-CdR on TRAIL, DR4, and DR5 proteins. MDA-231 ...http://cancerres.aacrjournals.org/content/67/3/1203
Death Domain database - Wikipedia
... a novel death domain-containing protein, interacts with the death domain of fas and initiates apoptosis". Cell. 81 (4): 505-512 ... DEATH: DEATH domain, found in proteins involved in cell death (apoptosis)., retrieved 3 November 2016 O'Neill, LA; Dunne, A; ... The Death Domain database is a secondary database of protein-protein interactions (PPI) of the death domain superfamily. ... There are four types of death domain subfamilies: death effector domain (DED), caspase recruitment domain (CARD), pyrin domain ...https://en.wikipedia.org/wiki/Death_Domain_database