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*  Caspase-independent Cell Killing by Fas-associated Protein with Death Domain
FADD, a novel death domain-containing protein, interacts with the death domain of Fas and initiates apoptosis. Cell. 1995;81: ... Fas-associated protein with death domain (FADD), to the death domain of the Fas cytoplasmic region. This binding causes ... A novel protein that interacts with the death domain of Fas/ APO1 contains a sequence motif related to the death domain. J Biol ... Fas-associated protein with death domain. FKBP. FK506 binding protein. HA. hemagglutinin. PARP. poly(ADP-ribose) polymerase. ...
  http://pubmedcentralcanada.ca/pmcc/articles/PMC2133085/?lang=en-ca
*  JCI - T cell apoptosis and reactive oxygen species
Mitogen-activated protein kinase kinase antagonized fas-associated death domain protein-mediated apoptosis by induced FLICE- ... The Fas- and TNF-α-independent pathway for T cell death has been referred to as passive cell death or death by neglect, ... domains 1-4. Class 2 proteins are proapoptotic and Bax-like and contain BH domains 1-3. Class 3 proteins are included in a ... ACAD and the role of Bcl-2-related proteins. While Fas signaling contributes to the death of some activated T cells, it ...
  https://www.jci.org/articles/view/18007
*  Highly parallel identification of essential genes in cancer cells | Proceedings of the National Academy of Sciences
1995) FADD, a novel death domain-containing protein, interacts with the death domain of Fas and initiates apoptosis. Cell 81: ... 1D). The 5 genes include 3 with well-established roles in FAS-induced apoptosis (11, ,13-,15) (FAS, FADD, and CASP8) and 2 ... 1996) Involvement of MACH, a novel MORT1/FADD-interacting protease, in Fas/APO-1- and TNF receptor-induced cell death. Cell 85: ... 1991) The polypeptide encoded by the cDNA for human cell surface antigen Fas can mediate apoptosis. Cell 66:233-243. ...
  http://www.pnas.org/content/105/51/20380
*  Genomic Alterations in Human Malignant Glioma Cells Associate with the Cell Resistance to the Combination Treatment with Tumor...
FADD, a novel death domain-containing protein, interacts with the death domain of Fas and initiates apoptosis. Cell 1995;81:505 ... TRAIL interacts with its death receptors DR4 and DR5 to recruit intracellular Fas-associated death domain (FADD; ref. 12) and ... cell lines due to the recruitment of cellular Fas associate death domain-like IL-1β-converting enzyme-inhibitory protein (c- ... Cytotoxicity-dependent APO-1 (Fas/CD95)-associated proteins form a death-inducing signaling complex (DISC) with the receptor. ...
  http://clincancerres.aacrjournals.org/content/12/9/2716
*  Autophagy Mechanism, Regulation, Functions, and Disorders
"Selective inactivation of a Fas-associated death domain protein (FADD)-dependent apoptosis and autophagy pathway in immortal ... Autophagy and Cell Death. Programmed cell death can be divided into apoptotic (type I) and autophagic (type II) cell death. In ... A. L. Edinger and C. B. Thompson, "Death by design: apoptosis, necrosis and autophagy," Current Opinion in Cell Biology, vol. ... E. M. Hammond, C. L. Brunet, G. D. Johnson et al., "Homology between a human apoptosis specific protein and the product of APG5 ...
  https://www.hindawi.com/journals/isrn/2012/927064/
*  FADD - Wikipedia
"The Fas-associated death domain protein is required in apoptosis and TLR-induced proliferative responses in B cells". Journal ... It contains two main domains: a C terminal death domain (DD) and an N terminal death effector domain (DED). Each domain, ... "Fas-associated death domain protein interacts with methyl-CpG binding domain protein 4: a potential link between genome ... "A Novel Protein That Interacts with the Death Domain of Fas/APO1 Contains a Sequence Motif Related to the Death Domain". ...
  https://en.wikipedia.org/wiki/FADD
*  Early Activation of Caspases during T Lymphocyte Stimulation Results in Selective Substrate Cleavage in Nonapoptotic Cells | JEM
Fas-associated death domain protein; HRP, horseradish peroxidase; IAP, inhibitor of apoptosis; PARP, poly(ADP-ribose) ... Indeed, interference with pathways leading to caspase processing, as in Fas-associated death domain protein (FADD) knockout, ... Death receptors such as TNFR and Fas can act as costimulatory molecules and enhance T cell proliferation (25)(26)(27). We have ... 1998) Fas-mediated apoptosis and activation-induced T-cell proliferation are defective in mice lacking FADD/Mort1. Nature. 392: ...
  http://jem.rupress.org/content/190/12/1879
*  T cells in the pathogenesis of type 1 diabetes | SpringerLink
... expression of dominant-negative Fas-associated death domain protein in beta cells protects against Fas ligand-induced apoptosis ... Thomas HE, Darwiche R, Corbett JA, Kay TW: Evidence that beta cell death in the nonobese diabetic mouse is Fas independent. J ... Amrani A, Verdaguer J, Thiessen S, et al.: IL-1alpha, IL-1beta, and IFN-gamma mark beta cells for Fas-dependent destruction by ... Yamada K, Takane-Gyotoku N, Yuan X, et al.: Mouse islet cell lysis mediated by interleukin-1-induced Fas. Diabetologia 1996, 39 ...
  https://link.springer.com/article/10.1007%2Fs11892-008-0019-9
*  FADD - What does FADD stand for? The Free Dictionary
FADD, a novel death domain-containing protein, interacts with the death domain of Fas and initiates apoptosis.. Down-regulation ... Fas-Associated Death Domain) o TRADD (en ingles: TNF Receptor-Associated Death Domain), las cuales activan caspasas iniciadoras ... S]) found on the death receptor adaptor protein FADD and the domain of procaspase-8.. Construction of mammalian cell expression ... del ingles Fas-Associated Death Domain), interaccion molecular que lleva a la activacion de la via de las caspasas.. Celulas NK ...
  http://acronyms.thefreedictionary.com/FADD
*  The intracellular 52-kd RoSSA autoantigen in keratinocytes is up-regulated by tumor necrosis factor ╨Ю┬▒ via tumor...
FADD, a novel death domain-containing protein, interacts with the death domain of Fas and initiates apoptosis. Cell 1995;81:505 ... "death domains" of the p55 tumor necrosis factor (TNF) receptor and Fas/APO1 prompts signaling for TNF and Fas/APO1 effects. J ... Cytotoxicity-dependent APO-1 (Fas/CD95)associated proteins form a death-inducing signaling complex (DISC) with the receptor. ... mediated apoptosis is counteracted by constitutively expressed antiapoptotic proteins (46). TNFRI-induced apoptosis has been ...
  https://www.docme.ru/doc/2159017/the-intracellular-52-kd-rossa-autoantigen-in-keratinocyte..
*  Systemic FasL Neutralization Increases Eosinophilic Inflammation in a Mouse Model of Asthma
FADD, a novel death domain-containing protein, interacts with the death domain of Fas and initiates apoptosis. Cell. 1995;81: ... Engagement of a Fas-expressing target cell by a Fas Ligand (FasL) bearing effector can result in the programmed cell death of ... Cell-autonomous Fas(CD95)/Fas-ligand interaction mediates activation-induced apoptosis in T-cell hybridomas. Nature. 1995;373: ... Apoptosis, Proliferation, and Expression of Bcl-2, Fas, and Fas Ligand in Bronchial Biopsies from Asthmatics. American Journal ...
  http://pubmedcentralcanada.ca/pmcc/articles/PMC3278510/?lang=en-ca
*  С ?? ҩ ??.??Ϣ?? .11256001??11256500
Expression of Dominant-Negative Fas-Associated Death Domain Protein in Cells Protects against Fas Ligand-Induced Apoptosis and ... 11256382:Differential Involvement of BB Loops of Toll-IL-1 Resistance(TIR) Domain-Containing Adapter Proteins in TLR4- versus ... 11256483:Targeting Positive Regulatory Domain I-Binding Factor 1 and X Box-Binding Protein 1 Transcription Factors by Multiple ... 11256266:Receptor-Binding Domain of Severe Acute Respiratory Syndrome Coronavirus Spike Protein Contains Multiple Conformation- ...
  http://www.100md.com/index/other/byinfono/022/513.htm
*  Production of Type I IFN Sensitizes Macrophages to Cell Death Induced by Listeria monocytogenes | The Journal of Immunology
66) suggested a sensitizing effect of type I IFN to apoptosis through regulation of a Fas-associated death domain protein ... In case of some viruses, type I IFNs also promote programmed death of infected cells (13). Protein kinase R (PKR), an enzyme ... Possible involvement of double-stranded RNA-activated protein kinase in cell death by influenza virus infection. J. Virol. 70: ... The mechanism of cell death in Listeria monocytogenes-infected murine macrophages is distinct from apoptosis. Infect. Immun. 65 ...
  http://www.jimmunol.org/content/169/11/6522
*  Plus it
C, Curcumin; CIAP, cleavage inhibitor of apoptosis; FADD, Fas-associated protein with death domain; FLIP, FLICE-like inhibitory ... conformational change in the receptors allows Fas-associated death domain (FADD) binding and recruits the death-induced ... Curcumin was shown to upregulate extrinsic apoptosis pathway signals via the Fas pathway. In TNF-related-apoptosis-inducing ... protein kinase C; PLC, phospholipase C; XIAP, X-linked inhibitor of apoptosis protein; VEGF, vascular endothelial growth factor ...
  http://cancerpreventionresearch.aacrjournals.org/content/6/5/387
*  Caspase-14, an apoptotic protease, nucleic acids encoding and methods of use - Patent # 6432628 - PatentGenius
... a Novel Death Domain-Containing Protein Interacts with the Death Doamin of Fas and Initiates Apoptosis," Cell 81: 505-512, 1995 ... "A Novel Protein That Interacts with the Death Domain of Fas/APO1 Contains a Sequence Motif Related to the Death Domain," J. ... Nagata and Golstein, "The Fas Death Factor," Science 267: 1449-1456, 1995... Nagata, "Apoptosis by Death Factor," Cell 88: 355- ... Kischkel et al., "Cytotoxicity-dependent APO-1 (Fas/CD95)-associated proteins form a death-inducing signaling complex (DISC) ...
  http://www.patentgenius.com/patent/6432628.html
*  Overview of Eukaryotic In Vitro Translation and Expression Systems - Current Protocols
FADD, a novel death domain‐containing protein, interacts with the death domain of Fas and initiates apoptosis. Cell 81:505‐512 ... Bik, a novel death‐inducing protein, shares a distinct sequence motif with Bcl‐2 family proteins and interacts with viral and ... Proteinprotein interaction between the transcriptional repressor E4BP4 and the TBP‐binding protein Dr1. Nucl. Acid Res. 24: ... Synthesizing proteins in vitro by transcription and translation of cloned genes. In Current Protocols in Molecular Biology (F.A ...
  http://www.currentprotocols.com/WileyCDA/CPUnit/refId-cb1101.html?quicktabs_cp=abstract
*  Nonapoptotic functions of Fas/CD95 in the immune response, Febs Journal | 10.1111/febs.14292 | DeepDyve
"Nonapoptotic functions of Fas/CD95 in the immune response, Febs Journal" on DeepDyve, the largest online rental service for ... FADD, a novel death domain‐containing protein, interacts with the death domain of fas and initiates apoptosis ... A novel protein that interacts with the death domain of Fas/APO1 contains a sequence motif related to the death domain ... Signal transduction mediated by Bid, a pro‐death Bcl‐2 family proteins, connects the death receptor and mitochondria apoptosis ...
  https://www.deepdyve.com/lp/wiley/nonapoptotic-functions-of-fas-cd95-in-the-immune-response-2MTbOcdod1
*  Histone Deacetylase Inhibitors Modulate the Sensitivity of Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand-Resistant...
FADD, a novel death domain-containing protein, interacts with the death domain of Fas and initiates apoptosis. Cell 1995; 81: ... Fas, TNFR-1, TRAIL-R1, and TRAIL-R2) share a homophilic protein/protein intracellular domain, the death domain ( 41, 42), which ... the death domain of FADD binds to the death domain of TRAIL-R1 or TRAIL-R2. The death effector domain of FADD, in turn, ... Itoh N, Nagata S. A novel protein domain required for apoptosis. Mutational analysis of human Fas antigen. J Biol Chem 1993; ...
  http://cancerres.aacrjournals.org/content/66/1/499
*  anti-FADD antibody | Rabbit Fas Associating Death Domain Containing Protein (FADD) Polyclonal Antibody-NP 034305.1
Rabbit Fas Associating Death Domain Containing Protein (FADD) Polyclonal Antibody-NP_034305.1 (MBS2004183) product datasheet at ... FADD: an adaptor molecule that mediates apoptosis. Recruited through its C-terminal death domain by Fas-receptor, tumor ... UniProt Protein Name FAS-associated death domain protein UniProt Synonym Protein Names FAS-associating death domain-containing ... NCBI Protein Information FAS-associated death domain protein ... Protein Family Fas-associated death domain protein UniProt Gene ...
  https://www.mybiosource.com/prods/Antibody/Polyclonal/Fas-Associating-Death-Domain-Containing-Protein-FADD/FADD/datasheet.php?products_id=2004183
*  Plus it
DISC, death-inducing signaling complex; FADD, Fas-associated protein with death domain; IAP, inhibitor of apoptosis. ... down-regulation of the death signaling molecule Fas-associated protein with death domain and caspase-8 has been shown in ... it is not surprising that altered expression of these proteins in cancerous cells often allows them to resist apoptosis. Fas ... leading to apoptotic cell death. Engagement of the surface Fas, TRAIL, or TNF death receptors by their secreted or cell surface ...
  http://clincancerres.aacrjournals.org/content/14/14/4385
*  E6 - Protein E6 - Human papillomavirus type 16 - E6 gene & protein
Fas-associated death domain-containing protein (FADD) and procaspase 8, are degraded by E6/E6AP causing inhibition of apoptosis ... Acts mainly as an oncoprotein by stimulating the destruction of many host cell key regulatory proteins. E6 associates with host ... UBE3A/E6-AP ubiquitin-protein ligase, and inactivates tumor suppressors TP53 and TP73 by targeting them to the 26S proteasome ... Fas-associated death domain-containing protein (FADD) and procaspase 8, are degraded by E6/E6AP causing inhibition of apoptosis ...
  https://www.uniprot.org/uniprot/P03126
*  Pathogenic Mechanisms in Type 1 Diabetes: The Islet is Both Target and Driver of Disease
... expression of dominant-negative Fas-associated death domain protein in beta cells protects against Fas ligand-induced apoptosis ... BH3-interacting domain death agonist, CTL - cytotoxic T lymphocyte, dnFADD - dominant-negative Fas-associated death domain, ... Fas-associated death domain; GAD65 - glutamic acid decarboxylase 65; GFAP - glial fibrillary acidic protein; HLA - human ... 5.3 The Fas/FasL pathway is a minor effector of beta-cell destruction. Ligation of the Fas (CD95) death receptor by FasL on ...
  http://www.soc-bdr.org/content/rds/archive/9/4_winter/chapter_i_pathogenesis/pathogenic_mechanisms_in_t1d/?showfulltext=1
*  Phosphorylation of FADD is critical for sensitivity to anticancer drug-induced apoptosis : Carcinogenesis
Fas-associated death domain-containing protein; PBS, phosphate-buffered saline; β-gal, β-galactosidase ... Keywords: MEKK, MEK kinase; MKK, MAP kinase kinase; MAP, mitogen-activated protein; JNK, c-jun NH2-terminal kinase; FADD, ... Here we have investigated the contribution of this phosphorylation to apoptosis induced by anticancer drugs in two human ... Here we have investigated the contribution of this phosphorylation to apoptosis induced by anticancer drugs in two human ...
  http://oxfordindex.oup.com/view/10.1093/carcin/bgh130
*  Sindbis virus induces apoptosis through a caspase-dependent, CrmA-sensitive pathway. - Semantic Scholar
The specificity of CrmA indicates that the Sindbis virus-induced death pathway is similar to that induced by Fas or tumor ... inhibited Sindbis virus-induced cell death, suggesting that cellular caspases facilitate apoptosis induced by Sindbis virus. ... To study the role of caspases in virus-induced apoptosis, we determined the effects of specific caspase inhibitors on Sindbis ... cells and of neurons in mouse brains leads to programmed cell death exhibiting the classical characteristics of apoptosis. ...
  https://www.semanticscholar.org/paper/Sindbis-virus-induces-apoptosis-through-a-pathway.-Nava-Ros%C3%A9n/c2eb607b659f44b25893e5f957476e35fa3524ad
*  Proapoptotic Chemotherapeutic Drugs Induce Noncanonical Processing and Release of IL-1β via Caspase-8 in Dendritic Cells | The...
cellular inhibitor of apoptosis protein. DC. dendritic cell. Dox. doxorubicin. FADD. Fas-associated death domain protein. IAP. ... Anti-caspase-1 (p10) rabbit polyclonal (sc-514), anti-actin goat polyclonal (sc-1615), anti-Fas-associated death domain protein ... inhibitor of apoptosis protein. Nec-1. necrostatin-1. P2X7R. P2X7 receptor. PARP. poly-ADP-ribosyltransferase. qPCR. ... Cellular inhibitors of apoptosis proteins cIAP1 and cIAP2 are required for efficient caspase-1 activation by the inflammasome. ...
  http://www.jimmunol.org/content/191/9/4789.long