*  December 2013 - Undergraduate School of Medicine Blog
A Host Factor That Influences the Neutrophil Response to Murine Hepatitis Virus (MHV) 1 Infection Antiviral Research. Antiviral ... Antiviral Therapy (2012). Rumman, A., O'Loghlen, S., Rutherford, K., Priesman, M., Raboud, J., Wobeser, W. Predictors of ... Climans, S.A., Murphy J.A., Evans G.A., Shamseddin M.K. Renal Failure, Hepatitis, and Myocarditis in a Previously Healthy Man. ...
  http://meds.queensu.ca/ugme-blog/archives/date/2013/12
*  Blockade of Immunosuppressive Cytokines Restores NK Cell Antiviral Function in Chronic Hepatitis B Virus Infection
Distinct organ-dependent mechanisms for the control of murine cytomegalovirus infection by natural killer cells. J Virol. 1997; ... The role of virus-specific CD8(+) cells in liver damage and viral control during persistent hepatitis B virus infection. J Exp ... Blockade of Immunosuppressive Cytokines Restores NK Cell Antiviral Function in Chronic Hepatitis B Virus Infection. Dimitra ... Natural killer cell functional dichotomy in chronic hepatitis B and chronic hepatitis C virus infections. Gastroenterology. ...
  http://pubmedcentralcanada.ca/pmcc/articles/PMC3003000/
*  Emergence of Drug-Resistant Populations of Woodchuck Hepatitis Virus in Woodchucks Treated with the Antiviral Nucleoside...
Seeger C, Baldwin B, Tennant B C. Expression of infectious woodchuck hepatitis virus in murine and avian fibroblasts. J Virol. ... In vitro infection of woodchuck hepatocytes with woodchuck hepatitis virus and ground squirrel hepatitis virus. Virology. 1989; ... Emergence of Drug-Resistant Populations of Woodchuck Hepatitis Virus in Woodchucks Treated with the Antiviral Nucleoside ... Lack of effect of antiviral therapy in nondividing heptocyte cultures on the closed circular DNA of woodchuck hepatitis virus. ...
  http://pubmedcentralcanada.ca/pmcc/articles/PMC89396/?lang=en-ca
*  Binding of the Hepatitis C Virus Envelope Protein E2 to CD81 Inhibits Natural Killer Cell Functions
Characterization of early IL-12, IFN-α/β, and TNF effects on antiviral state and NK cell responses during murine ... Suppression of host immune response by the core protein of hepatitis C virus: possible implications for hepatitis C virus ... Abbreviations used in this paper: HBV, hepatitis B virus; HCV, hepatitis C virus; TM4SF, tetraspan superfamily. ... Hepatitis C virus (HCV)*, a positive-strand RNA virus, is the principal causative agent of parenterally transmitted and ...
  http://pubmedcentralcanada.ca/pmcc/articles/PMC2196015/?lang=en-ca
*  PIs - Universität Ulm
... against chronic Hepatitis B Virus infection). Furthermore we investigate age-related changes in the regulation of murine T cell ... A particular focus is the discovery and characterization of so called "antiviral restriction factors" and their induction by ... while related simian immunodeficiency viruses (SIVs) replicate efficiently in their natural monkey hosts without causing ... and anti-viral immune responses (e.g. ...
  https://www.uni-ulm.de/med/cemma/members/pis/
*  Involvement of ERK pathway in interferon alpha-mediated antiviral activity against hepatitis C virus. - Semantic Scholar
Moreover, induction of a set of antiviral genes by IFN-α was enhanced in HCV-infected Huh7.5.1 cells due to the ERK1/2 ... These results demonstrate that ERK pathway is involved in IFN-α-mediated antiviral activity against HCV. ... is the key component of the therapy for hepatitis C virus (HCV) infection. IFN-α exerts anti-HCV activity by targeting certain ... Control of early Theiler's murine encephalomyelitis virus replication in macrophages by interleukin-6 occurs in conjunction ...
  https://www.semanticscholar.org/paper/Involvement-of-ERK-pathway-in-interferon-alpha-med-Zhao-Wang/b9e94289db530d1a86742046423afea7200fbd15
*  Lactoferrin - Wikipedia
... human respiratory syncytial virus, murine leukemia viruses and Mayaro virus. The most studied mechanism of antiviral activity ... such as the hepatitis viruses. This mechanism is also confirmed by the antiviral activity of lactoferrin against rotaviruses, ... Lactoferrin also suppresses virus replication after the virus penetrated into the cell. Such an indirect antiviral effect is ... including the herpes simplex virus 1 and 2, cytomegalovirus, HIV, hepatitis C virus, hantaviruses, rotaviruses, poliovirus type ...
  https://en.wikipedia.org/wiki/Lactoferrin
*  GMS | International Conference on SARS - one year after the (first) outbreak | In-vitro activity of S-nitroso-N...
This molecule has been reported to have antiviral effects in a variety of DNA and RNA viruses, including mouse hepatitis virus ... a murine coronavirus. Recently, replication of SARS-CoV was shown to be inhibited by glycyrrhizin, an active compound of ... Antiviral activity was estimated by the inhibition of the SARS-CoV cytopathic effect in Vero E6 cells, determined by a ... This study describes the assessment of the in vitro antiviral potential of nitric oxide (NO) against SARS coronavirus (SARS-CoV ...
  http://www.egms.de/static/de/meetings/sars2004/04sars048.shtml
*  Interleukin-8 Induced Biology in Benign Prostatic Hyperplasia - David Rowley
2012) WFDC1/ps20: a host factor that influences the neutrophil response to murine hepatitis virus (MHV) 1 infection. Antiviral ... We have generated a human xenograft model that overexpresses IL-8 and transgenic mouse lines expressing KC (a murine homolog of ...
  http://grantome.com/grant/NIH/R01-DK083293-03
*  Role of NK in Regulation of anti-viral T cell immunity - Young Hahn
Hepatitis C virus (HCV) infection in humans is remarkably efficient in the establishment of persistent infection by evading ... 2008) Blockade of PD-1/B7-H1 interaction restores effector CD8+ T cell responses in a hepatitis C virus core murine model. J ... 2009) Liver is able to activate naive CD8+ T cells with dysfunctional anti-viral activity in the murine system. PLoS One 4: ... Hepatitis C virus (HCV) infection in humans is remarkably efficient in the establishment of persistent infection by evading ...
  http://grantome.com/grant/NIH/R01-DK063222-07
*  APOBEC3G levels predict rates of progression to AIDS | Retrovirology | Full Text
... hA3G also has antiviral activities against other viruses including SIV, hepatitis B virus (HBV) and murine leukemia virus (MLV ... Turelli P, Mangeat B, Jost S, Vianin S, Trono D: Inhibition of hepatitis B virus replication by APOBEC3G. Science. 2004, 303: ... Doehle BP, Schafer A, Wiegand HL, Bogerd HP, Cullen BR: Differential sensitivity of murine leukemia virus to APOBEC3-mediated ... Genetic association of the antiviral restriction factor TRIM5alpha with human immunodeficiency virus type 1 infection. J Virol ...
  https://retrovirology.biomedcentral.com/articles/10.1186/1742-4690-4-20
*  Basic Science Track - gi
We use both cell-culture based and murine models to study how these viruses have evolved to evade innate antiviral defenses in ... We study the molecular pathogenesis of acute and chronic liver disease due to infections with hepatitis A virus (HAV) and ... how these hepatitis viruses are recognized by host innate immune sensors, and the role of innate immunity in hepatocellular ... hepatitis C virus (HCV). We work at the interface of molecular virology, innate immunity, inflammation, and disease ...
  https://www.med.unc.edu/gi/education/basic-scientist
*  Frontiers | Technical Improvement and Application of Hydrodynamic Gene Delivery in Study of Liver Diseases | Pharmacology
Given its ability to robustly mimic in vivo hepatitis B virus (HBV) production in liver, hydrodynamic gene delivery has become ... Given its ability to robustly mimic in vivo hepatitis B virus (HBV) production in liver, hydrodynamic gene delivery has become ... synthetic small compounds and even viruses in vivo. ... synthetic small compounds and even viruses in vivo. ... 2003). In vivo antiviral efficacy of prenylation inhibitors against hepatitis delta virus. J. Clin. Invest. 112, 407-414. doi: ...
  https://www.frontiersin.org/articles/10.3389/fphar.2017.00591/full
*  JoVE | Peer Reviewed Scientific Video Journal - Methods and Protocols
Chronic hepatitis B virus (HBV) infection is caused by inadequate anti-viral immunity. Activation of plasmacytoid dendritic ... Murine γHV68 is a natural pathogen of murine rodents. γHV68 infection of mice provides a tractable small animal model to ... Infectious Diseases, Issue 88, Hepatitis C Virus, HCV, Tumor-virus, Hepatitis C, Cirrhosis, Liver Cancer, Hepatocellular ... Hepatitis C virus (HCV) is a hepatotropic virus with a host-range restricted to humans and chimpanzees. Although HCV RNA ...
  https://www.jove.com/visualize/abstract/21246041/hepatitis-b-virus-lacks-immune-activating-capacity-but-actively
*  An antiviral for enveloped viruses
Omsk hemorrhagic fever virus, Russian spring-summer encephalitis virus, yellow fever virus, hepatitis C virus, West Nile virus ... murine leukemia virus); rhabdoviruses (vesicular stomatitis virus); and poxviruses (cowpox virus, vaccinia virus). The compound ... Virus Res. 2009 Apr;141(1):47-54. Epub 2009 Jan 20.. [3] Therapeutic action of meliacine, a plant-derived antiviral, on HSV- ... influenza A virus; arenaviruses (Junin), bunyaviruses (Rift Valley fever virus, LaCrosse virus); flaviviruses ( ...
  http://www.virology.ws/2010/02/18/an-antiviral-for-enveloped-viruses/
*  Reciprocal Relationship between Myeloid-Derived Suppressor Cells and T Cells | The Journal of Immunology
In a Theiler's murine encephalomyelitis virus mouse model of multiple sclerosis, the depletion of M-MDSCs increased the virus- ... Patients with chronic hepatitis C virus showed a significant correlation between the MDSC levels, disease progression, and the ... response of patients to antiviral therapy. MDSCs suppressed T cell function in an Arg1-dependent manner (32). HIV and SIV ... In individuals who received hepatitis B virus vaccine, GM-CSF augmented the preservation of peripheral blood MDSCs, which could ...
  http://www.jimmunol.org/content/191/1/17
*  'peanut agglutinin' Protocols and Video...
... to Monitor the Cellular Uptake of Human Lactoferrin and its Associated Antiviral Activity Against the Hepatitis C Virus', ' ... Isolation of Primary Murine Retinal Ganglion Cells (RGCs) by Flow Cytometry', 'Place and Response Learning in the Open-field ... Adapting Human Videofluoroscopic Swallow Study Methods to Detect and Characterize Dysphagia in Murine Disease Models', ' ... A Miniaturized Glycan Microarray Assay for Assessing Avidity and Specificity of Influenza A Virus Hemagglutinins', 'Isolation ...
  https://www.jove.com/keyword/peanut+agglutinin
*  The AMEDEO Literature Guide
... hepatitis B virus reactivation and subsequent hepatitis in patients with chronic hepatitis C receiving direct-acting antiviral ... Development of a recombinant murine tumor model using hepatoma cells expressing hepatitis C virus (HCV) non-structural antigens ... Prophylactic antiviral therapy for the prevention of mother-to-child transmission of hepatitis B virus can be stopped at ... Treatment with direct-acting antiviral agents of hepatitis C virus infection in injecting drug users: a prospective study.. J ...
  http://amedeo.com/medicine/hep/jvirhepa.htm
*  JoVE | Peer Reviewed Scientific Video Journal - Methods and Protocols
Here we show that mouse AKAP7 rapidly degrades 2-5A with kinetics similar to that of murine coronavirus (mouse hepatitis virus ... Viral 2',5'-phosphodiesterases (2',5'-PDEs) help disparate RNA viruses evade the antiviral activity of interferon (IFN) by ... Murine AKAP7 has a 2',5'-phosphodiesterase domain that can complement an inactive murine coronavirus ns2 gene. ... allowing diverse RNA viruses to antagonize the RNase L pathway. Importance: Early virus-host interactions determine whether an ...
  https://www.jove.com/visualize?author=Rong-Guang%20Zhang%20
*  Too Much of a Good Thing? Tim-3 and TCR Signaling in T Cell Exhaustion | The Journal of Immunology
hepatitis C virus. mTORC1. mTOR complex 1. SH2. Src homology 2. TB. tuberculosis. Treg. regulatory T cell. WT. wild-type.. ... An elegant study by Behar and colleagues (31) revealed a novel and unexpected function for Tim-3 in a murine model of TB. Thus ... a large body of evidence now supports a net negative impact of Tim-3 expression on T cell-dependent antiviral immune responses. ... Negative immune regulator Tim-3 is overexpressed on T cells in hepatitis C virus infection and its blockade rescues ...
  http://www.jimmunol.org/content/193/4/1525
*  Natural killer cells act as rheostats modulating anti-viral T cells
Pichinde virus. MCMV. murine cytomegalovirus. VV. vaccinia virus. MHV. mouse hepatitis virus. HCV. hepatitis C virus. pI:C. ... Anti-viral T cells are thought to regulate whether hepatitis C virus (HCV) and HIV infections result in viral control, ... Natural killer cell depletion enhances virus synthesis and virus-induced hepatitis in vivo. J Immunol. 1983;131:1531-1538. [ ... While direct NK cell-mediated lysis of virus-infected cells may contribute to anti-viral defense during some virus infections, ...
  http://pubmedcentralcanada.ca/pmcc/articles/PMC3539796/?lang=en-ca
*  Innovations in Antiviral Development and the Detection of Virus Infections | Springer for Research & Development
... there are only seven compounds licensed for use as antiviral agents, in the USA ... THE ERA OF ANTIVIRALS Introduction Although there are more than one hundred medically useful antibiotics and fungicides, ... Delta Virus as a Vector for the Delivery of Biologically-Active RNAs: Possibly a Ribozyme Specific for Chronic Hepatitis B ... Effect of Herpes Simplex Virus Type 1 Infection on Cytokine Gene Expression in Activated Murine Peritoneal Macrophages ...
  https://rd.springer.com/book/10.1007%2F978-1-4615-3462-4
*  Alternative splicing takes control of cytokine signaling
Unlike the tightly linked IFNL3, IFNL4 is genetically associated with hepatitis C virus persistence. Thus, we examined whether ... The murine homolog of IL-22BPi2 has been characterized as an antagonist of IL-22 while the physiological relevance of IL-22BPi1 ... In the case of IFNλ4, alternative splicing suppresses protein expression and secretion to prevent its antiviral activity. ... exhibits antiviral activity without blocking other IFN signaling. Even so, little of this active cytokine is made as ...
  https://digital.lib.washington.edu/researchworks/handle/1773/37154
*  ADVANCED VIRAL RESEARCH CORP Company Profile
Factors improving the utility of anti-viral therapy for chronic hepatitis B: a nationwide multi-center study in Japan. ... of research outcomes is emphasized in research promotion to eradicate hepatitis B virus according to the Basic Act on Hepatitis ... and V-raf murine sarcoma b-viral oncogene homolog B1 (BRAF)-mutated color... ... Third Party Anti-Viral Cytotoxic T-Cells. The purpose of this study is to demonstrate that viral specific T-cells (a type of ...
  https://www.bioportfolio.com/corporate/company/20443/Advanced-Viral-Research-Corp.html
*  Frontiers | Efficacy of a Virus-Like Nanoparticle As Treatment for a Chronic Viral Infection Is Hindered by IRAK1 Regulation...
Thus we identified a possible pitfall in the use of virus-like particles for the systemic treatment of chronic viral infections ... We have recently demonstrated that the papaya mosaic virus-like (PapMV) nanoparticle can be used as a prophylactic vaccine ... We have recently demonstrated that the papaya mosaic virus-like (PapMV) nanoparticle can be used as a prophylactic vaccine ... PapMV of inducing robust IFN-I production as treatment for the chronic viral infection model lymphocytic choriomeningitis virus ...
  https://www.frontiersin.org/articles/10.3389/fimmu.2017.01885/full