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*  Frontiers | Differential Roles of PML Isoforms | Oncology
Finally, the key players involved in the degradation of the PML isoforms in response to As2O3 or other inducers are discussed. ... The functions of the PML isoforms and their differential roles in antiviral defense also are reviewed. Finally, the key players ... The functions of the PML isoforms and their differential roles in antiviral defense also are reviewed. ... They share the same N-terminal region containing the RBCC/TRIM motif but differ in their C-terminal sequences. Recent studies ...
  https://www.frontiersin.org/articles/10.3389/fonc.2013.00125/full
*  Protocols and Video Articles Authored by Yi-Wen Chen (Translated to Norwegian)
The consensus motif of the six proteins, which form the committee of BD-A versus HC, is [KE]DIL[AG]L[LV]I[NL][IC][SVKH]G[LV][VN ... May, 2002 , Pubmed ID: 12036489 Viral infection triggers a cascade of interferon response genes, but the mechanisms that prime ... Among candidate cellular mediators of the antiviral response are the double-stranded RNA (dsRNA)-binding proteins. Here we show ... and cysteine-rich angiogenic inducer 61). These data provide the first characterization of the transcriptional response of ...
  https://www.jove.com/author/Yi-Wen_Chen?language=Norwegian
*  JoVE | Peer Reviewed Scientific Video Journal - Methods and Protocols
... and then enables activation of an antiviral interferon response. While methods to measure antiviral host gene expression are ... In many cases membrane-spanning proteins have evolved highly sophisticated mechanisms of action.1-3 One way in which membrane ... Here, we describe two methods to monitor RIG-I and PKR stimulation upon infection with an established interferon inducer, the ... Molecular BIology, Issue 59, Calmodulin, calcium, IQ-motif, affinity chromatography, pull-down, Ca2+/Calmodulin-dependent ...
  https://www.jove.com/visualize/abstract/23342057/ack1-activation-and-regulation-by-allostery
*  Autophagy - Wikipedia
The generated PtdIns(3)P is used as a docking point for proteins harboring a PtdIns(3)P binding motif. WIPI2, a PtdIns(3)P ... leading to induction of interferon and other antiviral cytokines. A subset of viruses and bacteria subvert the autophagic ... One of the mechanisms of programmed cell death (PCD) is associated with the appearance of autophagosomes and depends on ... Deter, RL; De Duve, C (1967). "Influence of glucagon, an inducer of cellular autophagy, on some physical properties of rat ...
  https://en.wikipedia.org/wiki/Autophagy
*  Related Articles
In contrast, β-IFN decreased cell viability in Panc3.27 cells suggesting intact anti-viral mechanisms. VSV treated xenografts ... After having identified defects in the signalling cascade of type I interferon induction, responsible for attenuated antiviral ... RNA binding motif 5 (RBM5) is a tumor suppressor gene, which inhibits tumor cells' growth and enhances chemosensitivity through ... FAST proteins may therefore provide a multi-pronged approach to improving oncolytic virotherapy via syncytium formation and ...
  http://pubmedcentralcanada.ca/pmcc/mlt?mltid=3548661&idtype=acc&term=author%3A
*  JoVE | Peer Reviewed Scientific Video Journal - Methods and Protocols
... and then enables activation of an antiviral interferon response. While methods to measure antiviral host gene expression are ... Here, we describe two methods to monitor RIG-I and PKR stimulation upon infection with an established interferon inducer, the ... However, whole animal studies alone cannot be used to decipher the cellular and neural circuit mechanisms of SD. Instead, in ... This interaction was enhanced in the presence of the TBK1 adaptor proteins, NAP1 (NF-?B activating kinase-associated protein-1 ...
  https://www.jove.com/visualize/abstract/23675467/trim11-negatively-regulates-ifn-production-antiviral-activity
*  Frontiers | The Molecular Mechanism of Natural Killer Cells Function and Its Importance in Cancer Immunotherapy | Immunology
NK cells express several activating and inhibitory receptors that recognize the altered expression of proteins on target cells ... NK cells express several activating and inhibitory receptors that recognize the altered expression of proteins on target cells ... interferon-γ; ITAM, immunoreceptor tyrosine-based activation motif; ITIM, immunoreceptor tyrosine-based inhibitory motif; MCA, ... Several mechanisms have been proposed to explain NK cell education, one of the models being disarming model. According to this ...
  https://www.frontiersin.org/articles/10.3389/fimmu.2017.01124/full
*  Protocols and Video Articles Authored by Deepali Singh (Translated to Japanese)
The bait is a HIV-1 RNA motif immobilized on a solid support, typically magnetic or Sepharose beads. The prey is pre-formed ... Mar, 2010 , Pubmed ID: 20007598 Retroviruses rely on host RNA-binding proteins to modulate various steps in their replication. ... and ROS with parallel reduction in the expression of interferon-gamma (IFN-γ), TNF-α, and interleukin-1β (IL-1β) in rat PMNs. ... γ was found to be the most potent inducer. Moreover, AP ameliorated cytokine-induced free radical generation and restored XO ...
  https://www.jove.com/author/Deepali_Singh?language=Japanese
*  Frontiers | Dying to Be Noticed: Epigenetic Regulation of Immunogenic Cell Death for Cancer Immunotherapy | Immunology
Mechanisms of tumor evasion from the immune response. Cancer Chemother Biol Response Modif (2003) 21:351-64. doi:10.1016/S0921- ... Heat-shock proteins, molecular chaperones, and the stress response: evolutionary and ecological physiology. Annu Rev Physiol ( ... Trinchieri G. Type I interferon: friend or foe? J Exp Med (2010) 207(10):2053-63. doi:10.1084/jem.20101664 ... C-C motif) ligand 2 (CCL2) by dying cancer cells and subsequent recruitment of innate immune cells such as neutrophils and DCs ...
  https://www.frontiersin.org/articles/10.3389/fimmu.2018.00654/full
*  An Overview of the Immune Evasion Strategies Adopted by Different Viruses with Special Reference to Classical Swine Fever Virus...
The key role of both type I (α and β) and type II (γ) IFNs as one of the first anti-viral defense mechanisms is indicated by ... L Binding, and inhibition of interferon gamma induction by human poxvirus-encoded proteins. Proc. Natl. Acad. Sci., ... This RNA-polymerase contains a GDD (Glycine-D-aspartate-D-aspartate) active site motif, otherwise known as the motif c [108]. ... Apoptosis, or programmed cell death, can be triggered by a variety of inducers, including ligands of the TNF family, ...
  https://www.intechopen.com/books/viral-replication/an-overview-of-the-immune-evasion-strategies-adopted-by-different-viruses-with-special-reference-to-/
*  Interferon - wikidoc
Interferon can cause increased p53 activity in virus infected cells. It acts as an inducer and causes increased production of ... However, mechanisms of such action of interferon are not well understood; it is thought that doses must be larger by several ... The H5N1 influenza virus, also known as bird flu, has been shown to have resistance to interferon and other anti-viral ... Interferons (IFNs) are natural proteins produced by the cells of the immune system of most vertebrates in response to ...
  https://www.wikidoc.org/index.php/Interferon
*  Protocols and Video Articles Authored by Eva Wagner
One of these proteins, Rny (YmdA), which has so far not been functionally characterized, is required for the processing of the ... In contrast, antiviral T cell levels remained low in patients without VZV disease. Our results demonstrate that VZV-specific T ... The results suggest that ILR may begin after a single inducer presentation, and increases over at least 2 to 3 min as the ... In temporal lobe epilepsy (TLE), HS is a key factor for pharmacoresistance, even though the mechanisms are not quite understood ...
  https://www.jove.com/author/Eva_Wagner
*  JoVE | Peer Reviewed Scientific Video Journal - Methods and Protocols
... and then enables activation of an antiviral interferon response. While methods to measure antiviral host gene expression are ... Here, we describe two methods to monitor RIG-I and PKR stimulation upon infection with an established interferon inducer, the ... Reversible posttranslational modifications of proteins with ubiquitin or ubiquitin-like proteins (Ubls) are widely used to ... The data showed that SENP8 only cleaved the peptide bond beyond the di-glycine motif of CrNEDD8 and His-RUB1 was subsequently ...
  https://www.jove.com/visualize/abstract/22110750/the-molecular-determinants-nedd8-specific-recognition-human
*  Gene regulation and suppression of type I interferon signaling by STAT3 in diffuse large B cell lymphoma | PNAS
De novo motif discovery from STAT3 ChIP-seq peaks shows identical sequence logs to the known STAT consensus motif (15). (D) ... 2015) Mechanisms of action of lenalidomide in B-cell non-Hodgkin lymphoma. J Clin Oncol 33:2803-2811. ... 2017) A novel anti-viral role for STAT3 in IFN-α signalling responses. Cell Mol Life Sci 74:1755-1764. ... C) Immunoblot analysis of the indicated proteins in TMD8, OCI-Ly10, and the control cell line SUDHL7 after 2 d of knockdown of ...
  http://www.pnas.org/content/115/3/E498
*  Toll-like receptor 8 functions as a negative regulator of neurite outgrowth and inducer of neuronal apoptosis | JCB
Active Motif) according to the manufacture's protocols. In brief, 5 μg nuclear proteins were incubated in a 96-well plate ... Virus infection switches TLR-3-positive human neurons to become strong producers of beta interferon. J. Virol. 79:12893-12904. ... Human TLR7 or TLR8 independently confer responsiveness to the antiviral compound R-848. Nat. Immunol. 3:499. ... mechanisms. R-848 was recently shown to activate caspase 1 in macrophages through cyropyrin/Nalp3 in a MAPK/NF-κB/TLR7- ...
  http://jcb.rupress.org/content/175/2/209
*  JoVE | Peer Reviewed Scientific Video Journal - Methods and Protocols
... and then enables activation of an antiviral interferon response. While methods to measure antiviral host gene expression are ... The kindlins are ~75 kDa multidomain proteins and bind to an NPxY motif and upstream T/S cluster of the integrin β-subunit ... Here, we describe two methods to monitor RIG-I and PKR stimulation upon infection with an established interferon inducer, the ... Furthermore, these fidelity variants can be useful tools in characterizing mechanisms of virus adaptation and evolution4-7. ...
  https://www.jove.com/visualize/abstract/21390296/synthetic-protocells-interact-with-viral-nanomachinery-inactivate
*  Most recent papers with the keyword Multiple sclerosis and hepatitis B immunization | Read by QxMD
Interferon beta (IFNβ) is a cytokine that is naturally produced by the immune system in response to biological and chemical ... The antiviral TRIM22 protein has been shown to inhibit the replication of a number of viruses, including HIV-1, hepatitis B, ... Tripartite motif protein 22 (TRIM22) is an evolutionarily ancient protein that plays an integral role in the host innate immune ... The biological activities underpin the mechanisms by which the protein is used to treat various diseases such as hepatitis C ...
  https://www.readbyqxmd.com/keyword/26397
*  Interferon Regulatory Factor (Irf)-1 and Irf-2 Regulate Interferon γ-Dependent Cyclooxygenase 2 Expression | JEM
1998) Analysis of interferon-regulated proteins binding the interferon-alpha-stimulated response element. Methods. 15:167-174, ... LPS (28)(29)(30)(31)(32) and IL-1α (33)(34) are two powerful inducers of Cox-2 expression in several cell types. We sought to ... 1993) Mechanisms of suppression of macrophage nitric oxide release by transforming growth factor beta. J. Exp. Med. 178:605-613 ... Although the consensus sequence for IRF-1/IRF-2 binding motif, (G/C)(A)AAA (N)2-3AAA(G/C)(T/C) (6)(9), did not precisely match ...
  http://jem.rupress.org/content/191/12/2131
*  JoVE | Peer Reviewed Scientific Video Journal - Methods and Protocols
... and then enables activation of an antiviral interferon response. While methods to measure antiviral host gene expression are ... The kindlins are ~75 kDa multidomain proteins and bind to an NPxY motif and upstream T/S cluster of the integrin β-subunit ... Here, we describe two methods to monitor RIG-I and PKR stimulation upon infection with an established interferon inducer, the ... Understanding the mechanisms underlying Salmonella-host interactions are important to elucidate the molecular pathogenesis of ...
  https://www.jove.com/visualize/abstract/22348050/genome-wide-identification-immune-response-analysis-serine-protease
*  NFKB2 nuclear factor kappa B subunit 2 [Homo sapiens (human)] - Gene - NCBI
TNF related weak inducer of apoptosis (TWEAK) Signaling Pathway, organism-specific biosystemTNF related weak inducer of ... ANK; ANK repeat [structural motif]. cl08275. Location:6 → 179. RHD-n; N-terminal sub-domain of the Rel homology domain (RHD). ... See identical proteins and their annotated locations for XP_011538132.1 Conserved Domains (7) summary. cd08798. Location:629 → ... Title: Interferon-β 1a Modulates Expression of RAGE but Not S100A12 and Nuclear Factor-κB in Multiple Sclerosis Patients. ...
  https://www.ncbi.nlm.nih.gov/gene?cmd=Retrieve&dopt=Graphics&list_uids=4791
*  Irf1 - Interferon regulatory factor 1 - Mus musculus (Mouse) - Irf1 gene & protein
... target genes and can act as a transcriptional activator and repressor regulating target genes by binding to an interferon- ... proteins_section' target='_top'>More...,/a>,/p>Similar proteinsi. *100% Identity ... "IFN regulatory factor-1 bypasses IFN-mediated antiviral effects through viperin gene induction.". Stirnweiss A., Ksienzyk A., ... p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually ...
  https://www.uniprot.org/uniprot/P15314
*  heat shock proteins | Leaders in Pharmaceutical Business Intelligence (LPBI) Group
CCL2, C-C motif chemokine ligand 2; CXCL11, C-X-C motif chemokine ligand 11; DR, death receptor 5; IFN, interferon; IL, ... recent studies in anti-viral immunity indicate that several interferon-inducible genes and Toll-like receptor-3 expression are ... stress-denatured proteins. Both mechanisms may contribute to pathological processes such as oncogenesis (mutant p53) and ... It has been suggested that many of the HSPs have the property of damage associated molecular patterns (DAMPs), inducers of ...
  https://pharmaceuticalintelligence.com/tag/heat-shock-proteins/
*  Molecular Basis of DNA Recognition in the Immune System | The Journal of Immunology
Orchestrating the interferon antiviral response through the mitochondrial antiviral signaling (MAVS) adapter. Curr. Opin. ... 72) using a cDNA library to screen for cellular interacting proteins of HIV-1 RNA; it was shown to bind RNA, as well as DNA ... Human TLR9 confers responsiveness to bacterial DNA via species-specific CpG motif recognition. Proc. Natl. Acad. Sci. USA 98: ... A better understanding of the molecular mechanisms by which cells generate inflammation in response to DNA may provide new ...
  http://www.jimmunol.org/content/190/5/1911
*  Identification of NAP1, a Regulatory Subunit of IκB Kinase-Related Kinases That Potentiates NF-κB Signaling
Triggering the interferon antiviral response through an IKK-related pathway. Science 300:1148-1151. [PubMed] ... TANK, a co-inducer with TRAF2 of TNF- and CD 40L-mediated NF-κB activation. Genes Dev. 10:963-973. [PubMed] ... Production of recombinant proteins. The plasmid pGEX-NAP1 was generated by ligation of the EcoRI-XhoI fragment of pcDNA3.1Myc/ ... Although some of the molecular mechanisms of TNF-α signal transduction are relatively well understood, control of the balance ...
  http://pubmedcentralcanada.ca/pmcc/articles/PMC207563/?lang=en-ca
*  Frontiers | Interplay between Inflammation and Cellular Stress Triggered by Flaviviridae Viruses | Microbiology
Simultaneously, the synthesis of virus RNA and proteins are distinguished in different compartments such as mitochondria, ER ... which are recognized by cellular mechanisms evolved to prevent virus infection, resulting in inflammation and stress responses ... Simultaneously, the synthesis of virus RNA and proteins are distinguished in different compartments such as mitochondria, ER ... which are recognized by cellular mechanisms evolved to prevent virus infection, resulting in inflammation and stress responses ...
  https://www.frontiersin.org/articles/10.3389/fmicb.2016.01233/full