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*  Complement System: Pathways, Functions and Regulation - microbeonline
... and Mannose binding Lectin pathway, activated by a plasma lectin that binds to mannose residues on microbes. ... Various plasma and cell membrane proteins regulate complement activation by inhibiting different steps in the cascade. ... Jules Bordet (1895) identified complements as heat-sensitive components in the blood, bearing non-specific antimicrobial ... Lectin pathway (or mannose binding lectin pathway). The early step of complement system varies in different pathways. However, ...
  https://microbeonline.com/complement-system-pathways-functions-regulation/amp/
*  Complement System Made Easy- Immunology- Classical Alternate & Lectin pathway
The mannose-binding lectin pathway can be activated by C3 hydrolysis or antigens without the presence of antibodies (non- ... Over 30 proteins and protein fragments make up the complement system, including serum proteins, serosal proteins, and cell ... Antimicrobial Resistance and Food Safety Video Antimicrobial resistance (AMR) poses a serious health risk to humans and animals ... and attacks the pathogen's plasma membrane. It is part of the innate immune system, which is not adaptable and does not change ...
  https://www.technologynetworks.com/immunology/videos/complement-system-made-easy-immunology-classical-alternate-lectin-pathway-309295
*  Staphylococcus Aureus: Structure and Functions
Bacterial carbohydrate ligand is recognized by mannose binding lectin (MBL) or ficolins and initiates the lectin pathway (LP). ... The plasma C4 and C2 level were not affected by SSL14 treatment, suggesting that the C1q binding is likely to contribute to ... Some host proteins (e.g.fibromodulin) were found to have dual binding capacity for C1q and endogenous complement inhibitors (e. ... 1.4.3.1 Resistance to antimicrobial substances. S. aureus circumvents antimicrobial substances by three main strategies: 1, ...
  https://www.ukessays.com/essays/biology/a-review-of-staphylococcus-aureus-biology-essay.php
*  Expression of complement regulatory proteins CD55, CD59, CD35, and CD46 in rheumatoid arthritis
The lectin pathway begins when mannose-binding lectin, a soluble component of the organism, binds to carbohydrates present on ... The complement system (CS) is composed of receptors and regulators bound to the cell membrane and different plasma proteins ... C3 convertase cleaves the central component of complement, C3, into C3a, an anaphylactic and antimicrobial peptide, and opsonin ... Regulatory soluble proteins are more specific and control either the alternative or the classical or the lectin pathways, ...
  http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0482-50042011000500009&lng=en&nrm=iso&tlng=en
*  IJMS | Free Full-Text | Deleted in Malignant Brain Tumors-1 Protein (DMBT1): A Pattern Recognition Receptor with Multiple...
... surfactant proteins and lactoferrin also bind to DMBT1s through their SRCR domains. The binding motif on the SRCR domains ... All these proteins belong to the scavenger receptor cysteine-rich (SRCR) superfamily of proteins: a superfamily of secreted or ... The SRCR domains play a role in the function of DMBT1s, which is the binding of a broad range of pathogens including cariogenic ... These data demonstrate a role for DMBT1s as pattern recognition molecules containing various peptide and carbohydrate binding ...
  http://www.mdpi.com/1422-0067/11/12/5212/htm
*  ASMscience | Interplay between Myeloid Cells and Humoral Innate Immunity
Human mannose-binding lectin and L-ficolin function as specific pattern recognition proteins in the lectin activation pathway ... The concentration of the C-type lectin, mannan-binding protein, in human plasma increases during an acute phase response. Clin ... The antimicrobial activity of C-reactive protein. Microbes Infect 4:201-205. [PubMed]. ... Mannose binding lectin acute phase activity in patients with severe infection. J Clin Immunol 25:346-352. [PubMed]. ...
  http://www.asmscience.org/content/journal/microbiolspec/10.1128/microbiolspec.MCHD-0051-2016
*  Most recent papers with the keyword SP-D | Read by QxMD
Mannose-binding lectins Surfactant protein D (SP-D), cyanovirin-N (CV-N) and human mannose-binding lectin (hMBL) also induce ... Surfactant proteins in different glandular structures of the oral cavity display antimicrobial activity for protection of ... the relationship between the plasma Nrf2 level and the extent of systemic inflammation associated with COPD status remains ... is an oligometric C type lectin that promotes phagocytosis by binding to carbohydrates on microbial surfaces. SP-D can also ...
  https://www.readbyqxmd.com/keyword/70831
*  Complement Deficiencies
A second set of initiating proteins, the ficolins, interact with acetylated sugars and proceed as in the mannose-binding lectin ... Complement, a part of the innate immune system, is composed of more than 30 plasma- and cell membrane-bound proteins that ... Patients who have recurrent infections may benefit from antimicrobial prophylaxis. Patients should also receive all routine ... The lectin pathway is initiated by the binding of mannose-binding lectin to certain sugars, which are often present on the cell ...
  http://www.psychiatryadvisor.com/pediatrics/complement-deficiencies/article/624480/
*  Humoral immunity - Wikipedia
... and the mannose-binding lectin pathway. The classical complement pathway typically requires antibodies for activation and is a ... It is derived from many small blood plasma proteins that work together to disrupt the target cell's plasma membrane leading to ... complement proteins, and certain antimicrobial peptides. Humoral immunity is so named because it involves substances found in ... The proteins account for 5% of the serum globulin fraction. Most of these proteins circulate as zymogens, which are inactive ...
  https://en.wikipedia.org/wiki/Humoral_immunity
*  Evolving Immunity
In mammals, the lectin pathway is initiated by the binding of a protein called MBP (mannose-binding protein) to a mannose- ... In fact, complement proteins are believed to comprise a higher percentage of blood plasma proteins than any other group of ... 1)It begins first with an innate membrane-bound receptor that can induce the transcription and release of antimicrobial ... The ancient lectin pathway need not contain proteins as complex as the MBP/MASP complex. Those may have appeared later, before ...
  http://www.talkdesign.org/faqs/Evolving_Immunity1.2.html
*  Osteichthyes: Immune Systems of Teleosts (Actinopterygii) | SpringerLink
Vitved L, Holmskov U, Koch C, Teisner B, Hansen S, Salomonsen J, Skjødt K (2000) The homologue of mannose-binding lectin in the ... Zhang XJ, Wang P, Zhang N, Chen DD, Nie P, Li JL, Zhang YA (2017b) B cell functions can be modulated by antimicrobial peptides ... de Souza KB, Jutfelt F, Kling P, Förlin L, Sturve J (2014) Effects of increased CO2 on fish gill and plasma proteome. PLoS One ... Howe K, Schiffer PH, Zielinski J et al (2016) Structure and evolutionary history of a large family of NLR proteins in the ...
  https://link.springer.com/chapter/10.1007%2F978-3-319-76768-0_19
*  JoVE | Peer Reviewed Scientific Video Journal - Methods and Protocols
Mannose-binding lectin (MBL) is a key soluble effector of the innate immune system that recognizes pathogen-specific surface ... plasma was depleted of the fourteen most abundant proteins using a multiple affinity removal system (MARS-14; Agilent). ... In addition to mucins, mucus layers also contain antimicrobial peptides, cytokines, and immunoglobulins5-9. The mucus layer is ... This blocking procedure makes the GBPs and lectins bind only to the glycans of captured proteins. After this chemically ...
  https://www.jove.com/visualize/abstract/23573288/lectin-dependent-enhancement-ebola-virus-infection-via-soluble
*  Molecular Mechanisms of Microbial Pathogenesis
... mannose-binding lectins), in lung (surfactant proteins A and D), and most likely in other tissues as well and bind to ... A plasma protein, LPS-binding protein (LBP), transfers LPS to membrane-bound CD14 on myeloid cells and promotes binding of LPS ... Mucous secretions, saliva, and tears contain antibacterial factors such as lysozyme and antimicrobial peptides as well as ... Many strains of Escherichia coli isolated from urinary tract infections express mannose- binding type 1 pili, whose binding to ...
  http://www.gkhub.info/molecular-mechanisms-of-microbial-pathogenesis.html
*  Natural Antibodies Bridge Innate and Adaptive Immunity | The Journal of Immunology
mannose-binding lectin. MZ. marginal zone. PRR. pattern recognition receptor. SLE. systemic lupus erythematosus. TI. T cell- ... development of safer and more effective immunomodulators and antimicrobial therapies in conjunction with partner proteins ( ... These plasma cells produce IgD that is highly specific to respiratory commensals and pathogens (18). IgD also was shown to be ... Mannose-binding lectin engagement with late apoptotic and necrotic cells. Eur. J. Immunol. 33: 2853-2863. ...
  http://www.jimmunol.org/content/194/1/13.long
*  Integral Options Cafe: Towards a Liquid Self: How Time, Geography, and Life Experiences Reshape the Biological Identity
This enhanced activity is due to the high affinity that IgG-G0 has with mannose-binding lectin that activates complement ... good examples of these are heat shock proteins (HSPs). HSPs are highly conserved proteins during evolution. Besides being ... The gut-associated lymphoid tissue (GALT) contains a number of plasma cells and lymphocytes exceeding the number found in the ... First, certain probiotics can exclude or inhibit pathogens (through competition/cooperation for nutrients, antimicrobial ...
  http://integral-options.blogspot.com/2014/10/towards-liquid-self-how-time-geography.html
*  David A. Stevens | Stanford Medicine Profiles
Collectins and fungal pathogens: roles of surfactant proteins and mannose binding lectin in host resistance MEDICAL MYCOLOGY ... Mycologic catastrophe. Antimicrobial agents and chemotherapy Stevens, D. A. 2013; 57 (6): 2904-? View details for DOI 10.1128/ ... After a single oral VCZ dose of 20 or 40 mg/kg, plasma concentrations peaked 2 h postdose (5.8 and 6.9 microg/ml) and remained ... We review the structure of the lung surfactant proteins (SP) SP-A and SP-D, and the serum collectins, mannose binding lectins; ...
  https://med.stanford.edu/profiles/david-stevens
*  j.fsi.2018.08.031
Enhancement of complement activation and opsonophagocytosis by complexes of mannose-binding lectin with mannose-binding lectin- ... the alternative complement pathway comprises plasma proteins, 349 which represent the major humoral defense mechanism against ... which produces various bacteriostatic substances as 85 probiotics including antimicrobial proteins, lipopeptides, antibiotics, ... Mansour MH, Abdul-Salam F. Characterization of fucose-binding lectins in rock- and mud-dwelling snails inhabiting Kuwait Bay. ...
  https://www.docme.ru/doc/4200610/j.fsi.2018.08.031
*  Microbiology immune system, antibiotics, immunity Flashcards - Cram.com
lectins are proteins that bind to carbs.) 1) Mannose binding lectin binds to mannose which is found in bacterial cell walls. ... Found in plasma, lymph, mucus secretion. B cells are part of humoral immunity and produce antibodies. Mainly effective against ... A series of proteins that are produced by the liver. They are used as a cascade and can trigger the proteins to aid in ... Other complement proteins are attrachted to the surface of microbial cells, and when this happens C3 is activated into C3a, ...
  http://www.cram.com/flashcards/microbiology-immune-system-antibiotics-immunity-416927
*  Frontiers | Characterization of Ixodes ricinus Fibrinogen-Related Proteins (Ixoderins) Discloses Their Function in the Tick...
Lectins, sugar-binding proteins, can distinguish between self and non-self oligosaccharide motifs on pathogen surfaces. ... Although tick hemolymph possesses strong lectin activity, and several lectins have already been isolated and characterized, ... Although tick hemolymph possesses strong lectin activity, and several lectins have already been isolated and characterized, ... sugar-binding proteins, can distinguish between self and non-self oligosaccharide motifs on pathogen surfaces. ...
  https://www.frontiersin.org/articles/10.3389/fcimb.2017.00509/full
*  General principles of immune response Flashcards by Eleanor Price | Brainscape
e.g. Mannose-binding Lectin. Recognition of microbial complex carbohydrates. Bind via Carbohydrate-Recognition Domains (CRDs). ... Produced by plasma cells from class-switched B cells under the control of IL-4 and CD40L - CD40 interaction. Extremely low ... Produce anti-microbial peptides. - tissue specific epithelia produce mediators of local innate immunity, e.g. lung epithelial ... Nickel acts as hapten with epidermal proteins. Antigen presentation by APC. Keratinocytes may present to CTL precursors. ...
  https://www.brainscape.com/flashcards/general-principles-of-immune-response-4258090/packs/6300991
*  The 'immunologic advantage' of HIV-exposed seronegative indi... : AIDS
Mannose-binding lectin (MBL) is a component of the soluble innate immune complement system and can bind HIV as well as surface ... proteins are the most important of these antiviral proteins. In particular, APOBEC3G shows a broad antiviral activity capable ... Plasma stromal cell-derived factor (SDF)-1 levels, SDF1-3′A genotype, and expression of CXCR4 on T lymphocytes: their impact on ... Antimicrobial polypeptides are key anti-HIV-1 effector molecules of cervicovaginal host defense. Am J Reprod Immunol 2008; 59: ...
  https://journals.lww.com/aidsonline/fulltext/2009/01140/the__immunologic_advantage__of_hiv_exposed.2.aspx
*  Pentraxin 3(PTX 3): An Endogenous Modulator of the Inflammatory Response
PTX3 interacts also with components of the lectin pathway. The mannose binding lectin (MBL) binds PTX3 via its collagen-like ... fasting plasma glucose, and (v) plasma IL-6 levels and negatively with (i) HDL cholesterol and (ii) adiponectin, PTX3 displays ... The classical short pentraxins C-reactive protein (CRP) and serum amyloid P component (SAP) are acute-phase proteins in humans ... Localization of PTX3 in neutrophil extracellular traps contributes to the generation of an antimicrobial microenvironment which ...
  https://www.hindawi.com/journals/mi/2012/920517/
*  Chemical Defenses- Online Textbook Chapters - Alyvea.com
Mannose-binding lectin. Activates complement cascade. The Complement System. The complement system is a group of plasma protein ... Acute-phase Proteins. The acute-phase proteins are another class of antimicrobial mediators. Acute-phase proteins are primarily ... The lectin activation pathway is similar to the classical pathway, but it is triggered by the binding of mannose-binding lectin ... Cytokines stimulate the production of acute-phase proteins such as C-reactive protein and mannose-binding lectin in the liver. ...
  http://www.alyvea.com/micro/chemical-defenses.php
*  Protocols and Video Articles Authored by Sonia S. Hassan
A Role for Mannose-binding Lectin, a Component of the Innate Immune System in Pre-eclampsia American Journal of Reproductive ... activation of plasma proteins involved in acute inflammatory response' and 'positive regulation of cholesterol esterification ... which has antimicrobial and anti-angiogenic properties. The purpose of this study was to: (1) determine whether CXCL13 is ... Mannose-binding lectin (MBL) is a pattern-recognition receptor that activates complement and modulates inflammation. ...
  https://www.jove.com/author/Sonia+S._Hassan
*  Antievolution.org - Antievolution.org Discussion Board -Topic::immune system evolution
The Mannose-binding lectin-associated serine proteases (MASPs) have been the subject of intensive research particularly over ... Lectins and associated MASP/C1r/C1s-like proteins have been found in invertebrates, while factor D, the defining component of ... systemic antimicrobial response, the Toll pathway. Despite the fact that gain-of-function mutations in the Toll. receptor gene ... In addition to modulating plasma. coagulation mechanisms, inflammatory mediators appear to increase platelet reactivity. In ...
  http://www.antievolution.org/cgi-bin/ikonboard/ikonboard.cgi?s=5bcfd125cc8722c6