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*  Dendritic cell - Wikipedia
Every helper T-cell is specific to one particular antigen. Only professional antigen-presenting cells (macrophages, B ... Histiocyte Macrophage List of human clusters of differentiation for a list of CD molecules (such as CD80 and CD86) Steinman, R ... Their main function is to process antigen material and present it on the cell surface to the T cells of the immune system. They ... Here they act as antigen-presenting cells: they activate helper T-cells and killer T-cells as well as B-cells by presenting ...
  https://en.wikipedia.org/wiki/Dendritic_cell
*  Primary immunodeficiency - Wikipedia
This is carried out by using donor-derived antigen-presenting cells. These new methods have reduced culture time to 10-12 days ... CD80 (B cells). Tests for T cell function: skin tests for delayed-type hypersensitivity, cell responses to mitogens and ... recurrent infections and failure of the development of antibodies on exposure to antigens. The 1999 criteria also distinguish ... selective immunoglobulin A deficiency Specific antibody deficiency to specific antigens with normal B cell and normal Ig ...
  https://en.wikipedia.org/wiki/Primary_immunodeficiency
*  Heligmosomoides polygyrus - Wikipedia
In addition costimulatory signals via CD80 and CD86 has also be shown important in mounting a Th2 immune response and producing ... Furthermore, a cocktail of H. polygyrus excretory-secretory antigens can be collected, and administered to mice in the presence ...
  https://en.wikipedia.org/wiki/Heligmosomoides_polygyrus
*  PD-L1 - Wikipedia
Interestingly, PD-L1 also has an appreciable affinity for the costimulatory molecule CD80 (B7-1), but not CD86 (B7-2). CD80's ... Normally the immune system reacts to foreign antigens that are associated with exogenous or endogenous Danger signals, which ... monocytogenes antigen-specific CD8 T cells (but not CD4 T cells). This evidence suggests that PD-L1 acts as a positive ... The related molecule PD-L2 has no such affinity for CD80 or CD86, but shares PD-1 as a receptor (with a stronger Kd of 140nM). ...
  https://en.wikipedia.org/wiki/PD-L1
*  Immunoglobulin V-set domain - Wikipedia
CD80, and CD86; in myelin membrane adhesion molecules; in junctional adhesion molecules (JAM); in tyrosine-protein kinase ... IPR003596 T-cell surface antigen CD2 InterPro: IPR013285 ACAM; ACAN; ADAMTSL1; AGC1; AMICA1; BCAM; BCAN; BGP; BGPc; BT3.3; ... CD80; CD83; CD86; CD8A; CD8B; CD8B1; CD96; CEACAM1; CEACAM16; CEACAM19; CEACAM21; CEACAM3; CEACAM4; CEACAM5; CEACAM6; CEACAM7; ...
  https://en.wikipedia.org/wiki/Immunoglobulin_V-set_domain
*  Artificial antigen presenting cells - Wikipedia
... this is done by co-stimulatory molecules such as the proteins CD80 (B7.1) or CD86 (B7.2), although other additional co- ... As specific cancer antigens have been discovered, these antigens can be loaded to aAPCs to successfully stimulate and expand ... It is the specific antigen or epitope that is loaded into the MHC determines the antigen-specificity. The peptide-loaded MHC ... Antigen presenting cells are the sentinels of the immune system and patrol the body for pathogens. When they encounter foreign ...
  https://en.wikipedia.org/wiki/Artificial_antigen_presenting_cells
*  Co-stimulation - Wikipedia
Co-stimulation is required in addition to the antigen-specific signal from their antigen receptors. T cells require two signals ... One of the best characterized co-stimulatory molecules expressed by T cells is CD28, which interacts with CD80 (B7.1) and CD86 ... B cell binds antigens with its BCR (a membrane-bound antibody), which transfers intracellular signals to the B cell as well as ... This additional binding makes the B cells 100- to 10,000-fold more sensitive to antigen. CR2 on mature B cells forms a complex ...
  https://en.wikipedia.org/wiki/Co-stimulation
*  Abatacept - Wikipedia
One of those signals is the major histocompatibility complex (MHC), combined with the antigen, and the other signal is the CD80 ... In order for T cells to be activated and attack an antigen, that antigen must be presented to the T cell by an antigen- ... Abatacept prevents antigen-presenting cells (APCs) from delivering the co-stimulatory signal. This prevents the T cells from ... the APC must bind the antigen to a major histocompatibility complex (MHC) molecule, bring that complex to its surface, and ...
  https://en.wikipedia.org/wiki/Abatacept
*  Induced stem cells - Wikipedia
DC-like antigen-presenting cells obtained from human induced pluripotent stem cells can serve as a source for vaccination ... Cd80, Ctsl, Pax1). mesenchymal stem/stromal cells (MSCs) are under investigation for applications in cardiac, renal, neural, ... Thus, the ability to generate platelet products ex vivo and platelet products lacking HLA antigens in serum-free media would ... A potentially efficient approach for generating antigen-specific CTLs is to revert mature immune T cells into iPSCs, which ...
  https://en.wikipedia.org/wiki/Induced_stem_cells
*  Immune tolerance - Wikipedia
Interaction with B7 on T cells Downregulation of CD80/CD86 costimultory molecules on antigen presenting cells upon interaction ... tumor antigens, alloantigens, and self-antigens in inflamed tissue. Immune recognition of non-self-antigens typically ... Self-antigens are present due to endogenous expression, importation of antigen from peripheral sites via circulating blood, and ... Upon exposure to a foreign antigen, either the antigen is eliminated by the standard immune response (resistance), or the ...
  https://en.wikipedia.org/wiki/Immune_tolerance
*  VTCN1 - Wikipedia
These proteins are expressed on the surface of antigen-presenting cells and interact with ligands (e.g., CD28; MIM 186760) on T ... B7H4 belongs to the B7 family (see CD80; MIM 112203) of costimulatory proteins. ...
  https://en.wikipedia.org/wiki/VTCN1
*  CD80 - Wikipedia
... and T cell costimulatory activity of the murine homologue of the human B lymphocyte activation antigen B7". The Journal of ... Human CD80 genome location and CD80 gene details page in the UCSC Genome Browser. Weitzmann MN, Pacifici R (April 2006). " ... Lanier LL, O'Fallon S, Somoza C, Phillips JH, Linsley PS, Okumura K, Ito D, Azuma M (January 1995). "CD80 (B7) and CD86 (B70) ... Cluster of differentiation 80 (also CD80 and B7-1) is a protein found on dendritic cells, activated B cells and monocytes that ...
  https://en.wikipedia.org/wiki/CD80
*  CTLA-4 - Wikipedia
It acts as an "off" switch when bound to CD80 or CD86 on the surface of antigen-presenting cells. The CTLA-4 protein is encoded ... on antigen-presenting cells. CTLA-4 binds CD80 and CD86 with greater affinity and avidity than CD28 thus enabling it to ... CTLA4 is homologous to the T-cell co-stimulatory protein, CD28, and both molecules bind to CD80 and CD86, also called B7-1 and ... CTLA-4 can also affect signalling indirectly via competing with CD28 for CD80/86 binding. CTLA-4 can also bind PI3K, although ...
  https://en.wikipedia.org/wiki/CTLA-4
*  B7 (protein) - Wikipedia
There are two major types of B7 proteins: B7-1 or CD80, and B7-2 or CD86. However, it is not known if they differ significantly ... This is also called "Signal 1" and its main purpose is to guarantee antigen specificity of the T cell activation. However, MHC ... B7 is a type of peripheral membrane protein found on activated antigen presenting cells (APC) that, when paired with either a ...
  https://en.wikipedia.org/wiki/B7_(protein)
*  Gamma delta T cell - Wikipedia
The antigens recognized by non-Vδ2 T cells expanded in the above infectious contexts have not been characterized, but the fact ... CD80, CD86) and adhesion receptors (CD11a, CD18, CD54). Thus activated Vγ9Vδ2 T cells behave like APCs (γδ T-APC) and present ... It is still not clear whether these non-peptidic antigens bind directly to the Vγ9/Vδ2 TCR or if a presenting element exists. ... However, none of the known antigen-presenting molecules like MHC class I and II or CD1 are required for γδ T cell activation ...
  https://en.wikipedia.org/wiki/Gamma_delta_T_cell
*  Cancer immunotherapy - Wikipedia
... the T-cell receptor binding to an antigen-MHC complex and T-cell surface receptor CD28 binding to CD80 or CD86 proteins. CTLA4 ... Dendritic cells are antigen presenting cells (APCs) in the mammalian immune system. In cancer treatment they aid cancer antigen ... Cancer vaccine Antigen 5T4 Chimeric antigen receptor Coley's Toxins Combinatorial ablation and immunotherapy Cryoimmunotherapy ... Antigens can be added to the antibody and can induce the dendritic cells to mature and provide immunity to the tumor. Dendritic ...
  https://en.wikipedia.org/wiki/Cancer_immunotherapy
*  Seth Lederman - Wikipedia
"5c8 Antigen". Google Patents. Google. Retrieved 21 December 2011. "Methods of inhibiting an autoimmune response in a human ... cell-B cell-activating molecule/CD40-L molecules induce normal B cells or chronic lymphocytic leukemia B cells to express CD80 ... Review Articles Lederman S; Yellin MJ; Covey LR; Cleary AM; Callard R; Chess L (June 1993). "Non-antigen signals for B-cell ... U.S. Patent #6,455,044 B1 (Issued September 24, 2002) "5c8 Antigen", Lederman, S., M.J. Yellin, and L. Chess. U.S. Patent # ...
  https://en.wikipedia.org/wiki/Seth_Lederman
*  HLA-DOB - Wikipedia
HLA class II histocompatibility antigen, DO beta chain is a protein that in humans is encoded by the HLA-DOB gene. HLA-DOB ... 1995). "HIV gp120 inhibits T cell activation by interfering with expression of costimulatory molecules CD40 ligand and CD80 ( ... 1992). "DNA sequence analysis of 66 kb of the human MHC class II region encoding a cluster of genes for antigen processing". J ... 1994). "HLA class II antigens and the HIV envelope glycoprotein gp120 bind to the same face of CD4". J. Immunol. 152 (9): 4475- ...
  https://en.wikipedia.org/wiki/HLA-DOB
*  HLA-DMB - Wikipedia
HLA class II histocompatibility antigen, DM beta chain is a protein that in humans is encoded by the HLA-DMB gene. HLA-DMB ... 1995). "HIV gp120 inhibits T cell activation by interfering with expression of costimulatory molecules CD40 ligand and CD80 ( ... 1994). "HLA class II antigens and the HIV envelope glycoprotein gp120 bind to the same face of CD4". J. Immunol. 152 (9): 4475- ... Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain ...
  https://en.wikipedia.org/wiki/HLA-DMB
*  HLA-DQB2 - Wikipedia
HLA class II histocompatibility antigen, DX beta chain is a protein that in humans is encoded by the HLA-DQB2 gene. ... 1995). "HIV gp120 inhibits T cell activation by interfering with expression of costimulatory molecules CD40 ligand and CD80 ( ... 1994). "HLA class II antigens and the HIV envelope glycoprotein gp120 bind to the same face of CD4". J. Immunol. 152 (9): 4475- ... 1998). "Identification of a new DQB1*0613 allele in a family". Tissue Antigens. 50 (6): 685-7. doi:10.1111/j.1399-0039.1997. ...
  https://en.wikipedia.org/wiki/HLA-DQB2
*  HLA-DOA - Wikipedia
HLA class II histocompatibility antigen, DO alpha chain is a protein that in humans is encoded by the HLA-DOA gene. HLA-DOA ... 1995). "HIV gp120 inhibits T cell activation by interfering with expression of costimulatory molecules CD40 ligand and CD80 ( ... 1994). "HLA class II antigens and the HIV envelope glycoprotein gp120 bind to the same face of CD4". J. Immunol. 152 (9): 4475- ... 1991). "Interaction of CD4 with HLA class II antigens and HIV gp120". Immunogenetics. 34 (2): 121-8. doi:10.1007/BF00211424. ...
  https://en.wikipedia.org/wiki/HLA-DOA
*  HLA-DQA2 - Wikipedia
Also known as HLA-DXA or DAAP-381D23.2, it is part of the human leucocyte antigen system. The protein encoded by this gene is ... 1995). "HIV gp120 inhibits T cell activation by interfering with expression of costimulatory molecules CD40 ligand and CD80 ( ... HLA class II histocompatibility antigen, DQ(6) alpha chain is a protein that in humans is encoded by the HLA-DQA2 gene. ... 1994). "HLA class II antigens and the HIV envelope glycoprotein gp120 bind to the same face of CD4". J. Immunol. 152 (9): 4475- ...
  https://en.wikipedia.org/wiki/HLA-DQA2
*  IRF8 - Wikipedia
"ICSBP/IRF-8 differentially regulates antigen uptake during dendritic-cell development and affects antigen presentation to CD4+ ... They expressed very low levels of costimulatory molecules (intercellular adhesion molecule ICAM1, CD40, CD80, CD86) and of the ...
  https://en.wikipedia.org/wiki/IRF8
*  CD48 - Wikipedia
CD48 antigen (Cluster of Differentiation 48) also known as B-lymphocyte activation marker (BLAST-1) or signaling lymphocytic ... CD48 and CD2 molecular coupling together with other interaction pairs of CD28 and CD80, TCR and peptide-MHC and LFA-1 and ICAM- ... Smith GM, Biggs J, Norris B, Anderson-Stewart P, Ward R (1998). "Detection of a soluble form of the leukocyte surface antigen ... Killeen N, Moessner R, Arvieux J, Willis A, Williams AF (October 1988). "The MRC OX-45 antigen of rat leukocytes and ...
  https://en.wikipedia.org/wiki/CD48
*  Single-chain variable fragment - Wikipedia
All of these formats can be composed from variable fragments with specificity for two different antigens, in which case they ... and purification of monospecific and bispecific recombinant antibody fragments derived from antibodies that block the CD80/CD86 ... These molecules were created to facilitate phage display, where it is highly convenient to express the antigen-binding domain ... ScFvs have many uses, e.g., flow cytometry, immunohistochemistry, and as antigen-binding domains of artificial T cell receptors ...
  https://en.wikipedia.org/wiki/Single-chain_variable_fragment