Defective maturation and function of antigen-presenting cells in type 1 diabetes. Lancet 1995;345:491-492 ... CD40 engagement by T-cell-expressed CD40 ligand reportedly contributes to DCs subsequently upregulating expression of CD80 and ... levels of MHC class I and II as well as CD80 and CD86 expression were significantly higher on iNKT-conditioned DCs from B6.H2g7 ... H2g7 mice drove higher levels of antigen-stimulated AI4 T-cell proliferation and IFNγ production (Fig. 3A and B). Conversely, ...http://diabetes.diabetesjournals.org/content/59/2/423
CD80 Gene - GeneCards | CD80 Protein | CD80 Antibody
CD80 Molecule, including: function, proteins, disorders, pathways, orthologs, and expression. GeneCards - The Human Gene ... cDNA FLJ75225, highly similar to Homo sapiens CD80 antigen (CD28 antigen ligand 1, B7-1 antigen) (CD80), mRNA (A0N0P2_HUMAN) ... GeneCards Summary for CD80 Gene CD80 (CD80 Molecule) is a Protein Coding gene. Diseases associated with CD80 include Vaccinia ... P33681-CD80_HUMAN. Recommended name:. T-lymphocyte activation antigen CD80 Protein Accession:. P33681. Secondary Accessions: * ...http://www.genecards.org/cgi-bin/carddisp.pl?gene=CD80
T lymphocyte co-signaling pathways of the B7-CD28 family.
0/Antigens, CD; 0/Antigens, CD28; 0/Antigens, CD80; 0/Antigens, CD86; 0/Antigens, Differentiation; 0/Antigens, Differentiation ... Antigens, CD. Antigens, CD28 / immunology*. Antigens, CD80 / immunology*. Antigens, CD86 / immunology*. Antigens, ... Antigens, Differentiation, T-Lymphocyte / immunology. Humans. Lymphocyte Activation. Receptors, Immunologic / immunology. ... T-Lymphocyte; 0/BTLA protein, human; 0/Receptors, Immunologic; 0/cytotoxic T-lymphocyte antigen 4; 0/inducible T-cell co- ...http://www.biomedsearch.com/nih/T-lymphocyte-co-signaling-pathways/16212919.html
Primary and Metastatic Uveal Melanoma Cells Genetically Modified to Express HLA-DR and CD80 Present Class II Restricted Tumor...
Conclusions: : Therefore, HLA-DR+/CD80+ uveal melanoma cells activate Th cells to endogenous antigens, and could be used in ... As measured by flow cytometry, HLA-DRB*0101 and CD80 transduced uveal melanoma cells express HLA-DR1 and CD80 on the cell ... restricted tumor antigens is difficult due to the inhibition of Antigen Presenting Cells (APC) within the tumor environment and ... HER2/neu-expressing primary and metastatic uveal melanoma transductants MEL202/DR1/CD80 and OMM2.3/DR1/CD80 were co-cultured as ...http://iovs.arvojournals.org/article.aspx?articleid=2394950
Extract of Oregano, Coffee, Thyme, Clove, and Walnuts Inhibits NF-κB in Monocytes and in Transgenic Reporter Mice | Cancer...
4C, Ccl3), Cd80 antigen (Fig. 4D, CD80), Cd40 antigen (Fig. 4E, CD40), chemokine ligand 10 (Fig. 4G, Cxcl10), chemokine ligand ... Ccl3, chemokine ligand 3; Cd80, CD80 antigen; Cd40, CD40 antigen; Csf1, colony stimulating factor 1 (macrophage); Cxcl10, ... Cd80, Cd40, Il2ra, and Ptprc), growth factor (Csf1), cell adhesion molecule (Vcam1), enzymes (Hmox1 and Nos2), and mitogen ( ...http://cancerpreventionresearch.aacrjournals.org/content/3/5/653.full
CD80_MOUSE. T-lymphocyte activation antigen CD80 (Activation B7-1 antigen) (B7) (CD antigen CD80). Cd80 B7. Mus musculus (Mouse ... CD80_RABIT. T-lymphocyte activation antigen CD80 (Activation B7-1 antigen) (CD antigen CD80). CD80. Oryctolagus cuniculus ( ... T-lymphocyte activation antigen CD80 (Activation B7-1 antigen) (BB1) (CTLA-4 counter-receptor B7.1) (B7) (CD antigen CD80). ... CD80 (B7-1). T-lymphocyte activation antigen cd80 (activation b7-1 antigen). ...http://mordred.bioc.cam.ac.uk/timbal/CD80%20
CD80 transfected human hepatocellular carcinoma cells activate cytotoxic T lymphocytes to target HCC cells with shared tumor...
... human hepatocellular carcinoma cells activate cytotoxic T lymphocytes to target HCC cells with shared tumor antigens ... CD80 transfected human hepatocellular carcinoma cells activate cytotoxic T lymphocytes to target HCC cells with shared tumor ...http://cell-lines.toku-e.com/Reference_194.html
Role of Oxidative Stress in Estrogen-related Bone Loss Discovered by Boffins
... that processes and presents antigen material on the surface of other immune cells D to up-regulate the immune antigen CD80. ... CD80 is a 'co-stimulatory' molecule that is part of the CD80/CD28 pathway required for activation of T lymphocytes. When this ... They found that reactive oxygen stimulates dendritic cells D a type of 'antigen-presenting cell' ... which prevents the activation of T cells by blocking the binding of CD80 to CD28. Because CTLA4-Ig did not directly affect ...http://www.medindia.net/news/Role-of-Oxidative-Stress-in-Estrogen-related-Bone-Loss-Discovered-by-Boffins-26269-1.htm
Increased expression of TLRs in mDCs and pDCs of dengue | Open-i
Methodology/principal findings: We evaluated the expression levels of TLR2, 3, 4 and 9 and the co-stimulatory molecules CD80 ... Furthermore, the expression of CD80 and CD86 was altered in mDCs and CD86 in pDCs of severe dengue cases. We show that ... Methodology/principal findings: We evaluated the expression levels of TLR2, 3, 4 and 9 and the co-stimulatory molecules CD80 ... Furthermore, the expression of CD80 and CD86 was altered in mDCs and CD86 in pDCs of severe dengue cases. We show that ...https://openi.nlm.nih.gov/detailedresult.php?img=PMC3585035_pntd.0002060.g003&req=4
Strong increase of protective serum cytokines after inj | Open-i
Antigens, CD274. *Antigens, CD80/metabolism. *Antigens, Surface/metabolism. *Apoptosis Regulatory Proteins/metabolism ...https://openi.nlm.nih.gov/detailedresult.php?img=PMC2875405_pone.0010800.g005&req=4
Only TCR-CD28-stimulated DP thymocytes die in respons | Open-i
Antigen Presentation. *Antigens, CD/genetics. *Antigens, CD80/physiology. *Antigens, CD95/genetics/physiology ... by TCR signals in the absence of simultaneous costimulatory signals and is mediated by subsequent interaction with antigen- ... by TCR signals in the absence of simultaneous costimulatory signals and is mediated by subsequent interaction with antigen- ... strategies that are differentially implemented during development depending on whether immature thymocytes encounter antigen in ...https://openi.nlm.nih.gov/detailedresult.php?img=PMC2199155_JEM.971308f3d&req=4
Estimating the kon and koff for sCD80 binding CTLA-4 Ig | Open-i
... on antigen-presenting cells (APC) and modulate T cell antigen recognition. Preliminary reports have suggested that CD80 binds ... on antigen-presenting cells (APC) and modulate T cell antigen recognition. Preliminary reports have suggested that CD80 binds ... CD80 (B7-1) binds both CD28 and CTLA-4 with a low affinity and very fast kinetics. ... In the present study, we use surface plasmon resonance to measure the affinity and kinetics of CD80 binding to CD28 and CTLA-4 ...https://openi.nlm.nih.gov/detailedresult.php?img=PMC2196039_JEM.vandermerwe4&req=4
Induction of IFN-γ- and TNF-α-secreting CD8+ T cell s | Open-i
Antigens, CD/biosynthesis. *Antigens, CD80/biosynthesis. *Cross-Priming/immunology. *Female. *Humans. *Immunoglobulins/ ... leading to the subsequent presentation of bacterial antigens and triggering the induction of memory T cells, mostly CD3(+)CD8 ... leading to the subsequent presentation of bacterial antigens and triggering the induction of memory T cells, mostly CD3(+)CD8 ... leading to the subsequent presentation of bacterial antigens and triggering the induction of memory T cells, mostly CD3(+)CD8 ...https://openi.nlm.nih.gov/detailedresult.php?img=PMC2691582_pone.0005879.g009&req=4
B7-DC costimulates PD1−/− CD4+ T cells. (a) Purifie | Open-i
Antigens, CD/physiology*. *Antigens, CD80/physiology*. *Antigens, Surface/physiology*. *CD4-Positive T-Lymphocytes/immunology* ... Cooperative B7-1/2 (CD80/CD86) and B7-DC costimulation of CD4+ T cells independent of the PD-1 receptor. ... Cooperative B7-1/2 (CD80/CD86) and B7-DC costimulation of CD4+ T cells independent of the PD-1 receptor. ...https://openi.nlm.nih.gov/detailedresult.php?img=PMC2196092_20030242f4&req=4
Percentage of TFH and expression of CXCR5 and PD-1 duri | Open-i
Antigens, CD80/metabolism. *Antigens, CD86/metabolism. *Female. *Fingolimod Hydrochloride. *Follow-Up Studies ... Methods: Using flow cytometry, B and T cell subtypes, and their expression of antigen presentation, costimulation and migration ... Methods: Using flow cytometry, B and T cell subtypes, and their expression of antigen presentation, costimulation and migration ... Furthermore, expression of surface molecules involved in antigen presentation and costimulation during fingolimod treatment are ...https://openi.nlm.nih.gov/detailedresult.php?img=PMC4215872_pone.0111115.g004&req=4
Phagocyted bacteria are not the immunogen by themselves | Open-i
Antigens, Bacterial/immunology. *Antigens, CD80/immunology. *Bone Marrow Cells/immunology. *Cell Differentiation ... Serum samples were collected at day 14 and serum titers of antigen specific Ig isotypes were determined by ELISA. The data show ... Serum samples were collected at day 14 and serum titers of antigen specific Ig isotypes were determined by ELISA. The data show ... or perhaps were serving as nonspecific and passive carriers of antigen. Thus, BMDCs were first pulsed with S. pneumoniae type ...https://openi.nlm.nih.gov/detailedresult.php?img=PMC2196017_011432f4&req=4
Anti-CD80 Mouse Monoclonal Antibody (PE (Phycoerythrin)) [clone: 2D10.4] | VWR
Antigen: CD80. Clonality: Monoclonal. Clone: 2D10.4. Conjugation: PE (Phycoerythrin). Epitope: Host: Mouse. Isotype: IgG1 kappa ... Both CD80 and CD86 are expressed on activated B cells and antigen-presenting cells. These ligands trigger CD28 signaling in ... The 2D10.4 antibody reacts with human CD80, also known as B7-1, a 55 kDa type I transmembrane protein ligand for CD152 (CTLA-4 ... Antigen Synonyms. Cluster of Differentiation 80, Cd28l, Ly-53, Ly53, B71, MIC17, TSA1. ...https://us.vwr.com/store/product/16757075/anti-cd80-mouse-monoclonal-antibody-pe-phycoerythrin-clone-2d10-4
Anti-CD80 Mouse Monoclonal Antibody [clone: 1G1] | VWR
Antigen: CD80. Clonality: Monoclonal. Clone: 1G1. Conjugation: Unconjugated. Epitope: Host: Mouse. Isotype: Reactivity:. ... Antigen Synonyms. Cluster of Differentiation 80, Ly53, MIC17, Cd28l, Ly-53, B71, TSA1. ...https://us.vwr.com/store/product/16494954/anti-cd80-mouse-monoclonal-antibody-clone-1g1
Intrinsic Differences in Donor CD4 T Cell IL-2 Production Influence Severity of Parent-into-F1 Murine Lupus by Skewing the...
Enhancement of suboptimal CD8 cytotoxic T cell effector function in vivo using antigen-specific CD80 defective T cells. J. ... Allogeneic MHC antigen requirements for lupus-like autoantibody production and nephritis in murine graft-vs-host disease. J. ... Fas expression on antigen-specific T cells has costimulatory, helper, and down-regulatory functions in vivo for cytotoxic T ... Genetic and structural evidence for antigen selection of anti-DNA antibodies. Annu. Rev. Immunol. 12: 487-520. ...http://www.jimmunol.org/content/195/7/2985
Patent US7884085 - Delivery of AS-oligonucleotide microspheres to induce dendritic cell ... - Google Patents
The oligonucleotides are targeted to bind to primary transcripts CD40, CD80, CD86 and their combinations. ... Microspheres containing the antisense oligonucleotides of interest down-regulate surface cell antigens CD40, CD80 and CD86, ... CD80-AS:. 5′-G*GG* AA*A G*CC* AG*G A*AT*. Seq ID 2. ... CD80-AS:. 5′-G*GG* AA*A G*CC* AG*G A*AT*. Seq ID 2. ... These antigen presenting dendritic cells function as triggers of the immune response through the activation of T-cells, ...http://www.google.com/patents/US7884085?dq=5,666,293
Tumor cyclooxygenase 2-dependent suppression of dendritic cell function. - PubMed - NCBI
MHC class II antigen, CD80, and CD86 as well as a reduction in the transporter-associated proteins, transporter associated with ... serve as professional antigen-presenting cells and are pivotal in the host immune response to tumor antigens. To define the ... Functional analyses indicated that TSN causes a decrement in DC capacity to (a) process and present antigens, (b) induce ... Whereas TSN DCs showed a significant reduction in cell surface expression of CD11c, DEC-205, MHC class I antigen, ...https://www.ncbi.nlm.nih.gov/pubmed/12631593
Association of Neisseria gonorrhoeae OpaCEA with Dendritic Cells Suppresses Their Ability to Elicit an HIV-1-Specific T Cell...
In each case, the maturing DCs showed a similar pattern of upregulating their expression of the surface antigens, CD80, CD86, ... Immature DCs are highly efficient in antigen capture and processing, whereas mature DCs are specialized in antigen presentation ... After 7 days of culture, more than 50% of the cells were CD1ahigh, MHC class II+, CD80low, and CD14-, which represents an ... 2005) Carcinoembryonic antigen (CEA) inhibits NK killing via interaction with CEA-related cell adhesion molecule 1. J Immunol ...http://pubmedcentralcanada.ca/pmcc/articles/PMC3570455/?lang=en-ca
Frontiers | B and T Cell Phenotypic Profiles of African HIV-Infected and HIV-Exposed Uninfected Infants: Associations with...
... which inhibits expression of the activation markers CD80 and CD86 on antigen presenting cells; CD39 and CD73, ectoenzymes that ... Gamma interferon production in response to Mycobacterium bovis BCG and Mycobacterium tuberculosis antigens in infants born to ... B cell and antigen presenting cell function, Tregs also play an important role in tolerance and allograft retention (40, 41). ... to postimmunization in vaccinees compared to placebo-recipients for all RV5 antigens in PHEU, and for G1, G3, G4, and P1 in ...https://www.frontiersin.org/articles/10.3389/fimmu.2017.02002/full
Preventing Intolerance: The Induction of Nonresponsiveness to Dietary and Microbial Antigens in the Intestinal Mucosa | The...
Role of CD80 and CD86 interactions with CD28 and CTLA-4. It is known that low levels of costimulatory molecule (CD80 and CD86) ... Selective enhancement of B cell antigen receptor-mediated antigen presentation by treatment with transforming growth factor-β. ... A bone marrow-derived APC in the gut-associated lymphoid tissue captures oral antigens and presents them to both CD4+ and CD8+ ... B7.2 (CD86) but not B7.1 (CD80) costimulation is required for the induction of low dose oral tolerance. J. Immunol. 163:2284. ...http://www.jimmunol.org/content/174/7/3851
CD80 polyclonal antibody - (PAB18734) - Products - Abnova
A synthetic peptide corresponding to amino acids at internal region of human CD80. (PAB18734) - Products - Abnova ... Goat polyclonal antibody raised against synthetic peptide of CD80. ... B-lymphocyte activation antigen B7,CD80 antigen,CD80 antigen (CD28 antigen ligand 1, B7-1 antigen),costimulatory factor CD80, ... CD80 polyclonal antibody (Cat # PAB18734) (1 ug/mL) staining of human lymph node lysate (35 ug protein in RIPA buffer). Primary ...http://www.abnova.com/products/products_detail.asp?catalog_id=PAB18734
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