Statins and Musculoskeletal Conditions, Arthropathies, and Injuries - American College of Cardiology
Antigens, CD58, Tendon Injuries, Myalgia ...http://www.acc.org/latest-in-cardiology/journal-scans/2013/06/03/16/34/statins-and-musculoskeletal-conditions-arthropathies-and-injuries
CD58 - Wikipedia
CD58, or lymphocyte function-associated antigen 3 (LFA-3), is a cell adhesion molecule expressed on Antigen Presenting Cells ( ... CD58 Antigen at the US National Library of Medicine Medical Subject Headings (MeSH). ... Polymorphisms in the CD58 gene are associated with increased risk for multiple sclerosis. Barbosa JA, Mentzer SJ, Kamarck ME, ... This adhesion occurs as part of the transitory initial encounters between T cells and Antigen Presenting Cells before T cell ...https://en.wikipedia.org/wiki/CD58
LFA3抗体[MEM-63] (FITC)| Abcam中国
CD58 antigen (lymphocyte function associated antigen 3)1 antibody. *CD58 antigen antibody ... This interaction is important in mediating thymocyte interactions with thymic epithelial cells, antigen-independent and - ... dependent interactions of T-lymphocytes with target cells and antigen-presenting cells and the T-lymphocyte rosetting with ...http://www.abcam.cn/lfa3-antibody-mem-63-fitc-ab26006.html
CD2 Antibody (BH1) [DyLight 650] (NBP2-34561C): Novus Biologicals
CD2/CD58 binding can enhance antigen-specific T cell activation. CD2 is a transmembrane glycoprotein that is expressed on ... CD58 is a heavily glycosylated protein with a broad tissue distribution in hematopoietic and other cells, including endothelium ... CD2 interacts through its amino-terminal domain with the extracellular domain of CD58 (also designated CD2 ligand) to mediate ... Interaction between CD2 and its counter receptor LFA3 (CD58) on opposing cells optimizes immune system recognition, thereby ...https://www.novusbio.com/products/cd2-antibody-bh1_nbp2-34561c
Alefacept in Patients With Severe Scalp Alopecia Areata - Full Text View - ClinicalTrials.gov
... lymphocyte function-associated antigen-3 CD58). Induction of a molecular signaling cascade with resultant T-cell activation and ... Activation of T-cells is initiated by interaction of the T-cell receptor with the antigen/major histocompatibility complex on ... Co-stimulatory interactions occur secondarily, including binding of the T-cell CD2 receptor to the antigen-presenting cell ... The cellular infiltrate primarily consists of activated T-lymphocytes and antigen-presenting Langerhans cells. T-lymphocytes ...https://clinicaltrials.gov/show/NCT00167102
WikiGenes - CD2 - CD2 molecule
Amino acid residues required for binding of lymphocyte function-associated antigen 3 (CD58) to its counter-receptor CD2. Osborn ... We now report that CD2 binds to a cell-surface antigen known as lymphocyte function-associated antigen-3 (LFA-3) with high ... Two antigen-independent adhesion pathways used by human cytotoxic T-cell clones. Shaw, S., Luce, G.E., Quinones, R., Gress, R.E ... Interaction between human CD2 and CD58 involves the major beta sheet surface of each of their respective adhesion domains. ...https://www.wikigenes.org/e/gene/e/914.html
Analysis of two-dimensional dissociation constant of laterally mobile cell adhesion molecules. - The Kennedy Institute of...
Both CD2 and CD58 are laterally mobile in their respective membranes. Adhesion is indicated by accumulation of CD2 and CD58 in ... We derive a new binding equation, B/F=[(Ntxf)/(KdxScell)]-[(Bxp)/Kd], where B and F are bound and free CD58 density in the ... We use this analysis to determine that the 2D Kd for CD2-CD58 is 5.4-7.6 molecules/microm2. 2D Kd analysis provides a general ... to study the interaction of CD2-expressing T cells with glass-supported planar bilayers containing fluorescently labeled CD58, ...https://www.kennedy.ox.ac.uk/publications/482603
Mouse Monoclonal anti-CD2 (HuLy-m1) | Biotium
CD2/CD58 binding can enhance antigen-specific T cell activation. CD2 is a transmembrane glycoprotein that is expressed on ... Activation of human T lymphocytes via the CD2 antigen results in tyrosine phosphorylation of T cell antigen receptor zeta- ... T-cell surface antigen CD2; T-cell surface antigen T11/Leu-5; T11 ... CD58 is a heavily glycosylated protein with a broad tissue ... CD2 interacts through its amino-terminal domain with the extracellular domain of CD58 (also designated CD2 ligand) to mediate ...https://biotium.com/product/monoclonal-anti-cd2-huly-m1/
Albert Edge | Harvard Catalyst Profiles | Harvard Catalyst
... identification of a porcine antigen homologous to CD58. Transplantation. 2004 Apr 27; 77(8):1288-94. PMID: 15114100. ... antagonistic antibody AL-57 that preferentially binds the high-affinity form of lymphocyte function-associated antigen-1. J ...https://connects.catalyst.harvard.edu/profiles/display/Person/60563
A model for CD2/CD58-mediated adhesion strengthening. - The Kennedy Institute of Rheumatology
Mobile CD2 and CD58 can diffuse freely on both the cell and substrate. Their binding in the contact area is controlled by first ... In this paper, we present a theoretical model that simulates the accumulation of CD2 and CD58 in the contact area of a Jurkat T ... Yet how low affinity adhesion molecules such as CD2 and CD58 can produce stable cell adhesion is still not completely ... The contact area grows linearly with the total number of CD2/CD58 bonds. Cellular deformation and cytoskeleton involvement were ...https://www.kennedy.ox.ac.uk/publications/482622
Expression of intercellular adhesion molecule-1 and lymphocyte function-associated antigen-3 on human thyroid epithelial cells...
Since the initiation of a specific immune response also involves antigen-receptor independent interactions between accessory ... and lymphocyte function-associated antigen-3 (LFA-3) with CD2, it was of interest to determine whether TEC can express the ... adhesion molecules (ICAM-1 and LFA-3) which augment the efficiency of antigen presentation. Cultured TEC were studied for their ... molecules, such as lymphocyte function-associated antigen-1 (LFA-1) with intercellular adhesion molecule-1 (ICAM-1) ...https://www.kennedy.ox.ac.uk/publications/481745
... leukocyte function-associated antigen-1/β2-integrin) complex; and CD58 (leukocyte function-associated antigen-3), which ... In this assay, antigen is added to PBMCs that must take up and present the antigen to T cells. Although the simplest antigen to ... Among the many tumor antigens described, the model antigen, carcinoembryonic antigen (CEA), is of particular interest because ... Induction of protective host immunity to carcinoembryonic antigen (CEA) a self-antigen in CEA transgenic mice, by immunizing ...http://clincancerres.aacrjournals.org/content/11/8/3017
List of MeSH codes (D23) - Wikipedia
... antigens, cd56 MeSH D23.050.301.264.035.157 --- antigens, cd57 MeSH D23.050.301.264.035.158 --- antigens, cd58 MeSH D23.050. ... antigens, cd56 MeSH D22.214.171.124.157 --- antigens, cd57 MeSH D126.96.36.199.158 --- antigens, cd58 MeSH D188.8.131.52.159 ... hla-a antigens MeSH D23.050.301.500.450.370.372 --- hla-a1 antigen MeSH D23.050.301.500.450.370.374 --- hla-a2 antigen MeSH ... hla-b antigens MeSH D23.050.301.500.450.380.383 --- hla-b7 antigen MeSH D23.050.301.500.450.380.385 --- hla-b8 antigen MeSH ...https://en.wikipedia.org/wiki/List_of_MeSH_codes_(D23)
Alefacept in Patients With Relapsed/Refractory Aplastic Anemia - Full Text View - ClinicalTrials.gov
LFA3/CD58) and the Fc portion of human IgG1. It prevents co-stimulatory signals between antigen presenting cells and memory T ... Alefacept is a human recombinant dimeric fusion protein composed of the terminal portion of leukocyte functioning antigen-3 ( ...https://clinicaltrials.gov/show/NCT01267643%A0
Human antibodies derived from immunized xenomice - Abgenix, Inc.
Fully human antibodies against a specific antigen can be prepared by administering the antigen to a transgenic animal which has ... Campath antigen), CD56, CD58, CD69, CD72, CTLA-4, LFA-1 and TCR ... tumor antigens, such as her2-neu, mucin, CEA and endosialin; ... histocompatibility antigens, such as MHC class I or II, the Lewis Y antigens, Slex, Sley, Slea, and Selb; ... Fully human antibodies against a specific antigen can be prepared by administering the antigen to a transgenic animal which has ...http://www.freepatentsonline.com/6150584.html
Low affinity interaction of human or rat T cell adhesion molecule CD2 with its ligand aligns adhering membranes to achieve high...
Fluorescently labeled glycosylphosphatidylinositol-anchored CD48 and CD58 were prepared and incorporated into supported ... In solution, the interaction of human CD2 with its ligand CD58 is of low affinity (500 mM-1) and the interaction of rat CD2 ... CD58, Antigens, CD, Antigens, CD2, Membranes, Artificial, Ligands, Cell Adhesion, Kinetics, Surface Properties, CD48 Antigen ... In solution, the interaction of human CD2 with its ligand CD58 is of low affinity (500 mM-1) and the interaction of rat CD2 ...https://www.ndorms.ox.ac.uk/publications/31210
SMART: IG domain annotation
CRYSTAL STRUCTURE OF THE CD2-BINDING DOMAIN OF CD58 (LYMPHOCYTE FUNCTION-ASSOCIATED ANTIGEN 3) AT 1.8-A RESOLUTION. ... Structure of New Antigen Receptor variable domain from sharks. 1ves. Structure of New Antigen Receptor variable domain from ... Structure of new antigen receptor variable domain from sharks. 2ywz. Structure of new antigen receptor variable domain from ... Structure of new antigen receptor variable domain from sharks. 2cqv. Solution structure of the eighth Ig-like domain of human ...http://smart.embl.de/smart/do_annotation.pl?DOMAIN=IG&START=94&END=176&E_VALUE=5.75e-4&TYPE=SMART&BLAST=GPATLIFEGDTLVLHCRAWQDWPLTQVIFYREGSALGPPGPKSEFSITMVQKSDGGHYHCSGIFRSPGPGSREAASPVAITVQ
Mechanisms of Cellular Avidity Regulation in CD2-CD58-Mediated T Cell Adhesion. - The Kennedy Institute of Rheumatology
... and the 2D affinity of CD2 for CD58 increased by 2.5-fold. The combination of T cell activation and CD2 ligation to CD58 ... Subsequently, T cell activation causes the CD58-bound CD2 to be recognized and immobilized at sites of cell-cell contact, ... Although the affinity of the molecular interaction between CD2 and its counter-receptor, CD58, is relatively low when measured ... To understand the mechanisms responsible for regulating the avidity of the CD2-CD58 interaction, we measured the number, ...https://www.kennedy.ox.ac.uk/publications/482601
Generation of xenogeneic antibodies - ABGENIX, INC.
CD58), TGF-β, various snake venum antigens, and Rh factor. 8. A method for producing a modified non-human animal, said animal ... 0066] Antigens associated with tumors include lymphoma antigens such as CD19, CD20 and CD22; antigens associated with non-small ... 0072] Transplantation antigens, such as T cell and other immune cell antigens such as CD4, CD7, CD8 (α and β), CD28, CTLA-4, T ... 0258] transplantation antigens, such as T cell and other immune cell antigens such as CD4, CD7, CD8 (α and β), CD28, CTLA-4, T ...http://www.freepatentsonline.com/y2004/0010810.html
Low affinity interaction of human or rat T cell adhesion molecule CD2 with its ligand aligns adhering membranes to achieve high...
Fluorescently labeled glycosylphosphatidylinositol-anchored CD48 and CD58 were prepared and incorporated into supported ... In solution, the interaction of human CD2 with its ligand CD58 is of low affinity (500 mM-1) and the interaction of rat CD2 ... Animals, Antigens, CD, Antigens, CD2, Antigens, CD58, CD48 Antigen, Cell Adhesion, Cell Membrane, Fluorescein-5-isothiocyanate ... In solution, the interaction of human CD2 with its ligand CD58 is of low affinity (500 mM-1) and the interaction of rat CD2 ...https://www.kennedy.ox.ac.uk/publications/31210
Human cell-adhesion molecule CD2 binds CD58 (LFA-3) with a very low affinity and an extremely fast dissociation rate but does...
... which mediates transient adhesion of T cells to antigen-presenting cells and target cells. Reported ligands for human CD2 ... recombinant form of human CD2 with soluble forms of CD58, CD48, and CD59. Binding of CD2 to CD58 was readily detected but we ... In contrast to previous reports we found that human CD2 bound CD58 with a very low affinity (Kd 9-22 microM) and dissociated ... for human CD2 binding CD58 which suggested that the weak binding of rat CD2 to CD48 may not represent a typical CAM interaction ...https://www.neuroscience.ox.ac.uk/publications/9145
US20060137603A1 - Methods and apparatus for rapid crystallization of biomolecules - Google Patents
CD58, CD69, CD72, CTLA4, LFA-1 and TCR histocompatibility antigens, such as MHC class I or II antigens, the Lewis Y antigens, ... Also included are tumor antigens, such as her2-neu, mucin, CEA and endosialin. Allergens, such as house dust mite antigen, lol ... Also included are glycoprotein tumor-associated antigens, for example, carcinoembryonic antigen (CEA), human mucins, her-2/neu ... Two-dimensional crystallization technique for imaging macromolecules, with application to antigen-antibody-complement complexes ...https://patents.google.com/patent/US20060137603A1/en
Blog | Discovery of Brain-Penetrant, Irreversible Kynurenine Aminotransferase II Inhibitors | Page 2
CD2 antigen also functions as the receptor for the CD58 antigen(LFA-3)  High sodium potentiates pro-inflammatory results of ... Normal B lymphocytes, monocytes or granulocytes do not express surface CD2 antigen, neither do common ALL cells. CD2 antigen ... It is a human NK cell associated antigen. CD16 is a low affinity receptor for IgG which functions in phagocytosis and ADCC ... Normal B lymphocytes, monocytes or granulocytes do not express surface CD2 antigen, Mouse monoclonal to CD2.This recognizes a ...http://researchreport-digital.com/category/blog/page/2/
Motility and ultrastructure of large granular lymphocytes on lipid bilayers reconstituted with adhesion receptors LFA-1, ICAM-1...
CD58, Cell Adhesion Molecules, Intercellular Adhesion Molecule-1, Antigens, CD, Antibodies, Monoclonal, Antigens, Surface, ... Lymphocytes, Killer Cells, Natural, Cell Membrane, Golgi Apparatus, Humans, Lipid Bilayers, Membrane Glycoproteins, Antigens, ...https://www.ndorms.ox.ac.uk/publications/482699
The CD2 ligand LFA-3 activates T cells but depends on the expression and function of the antigen receptor. - Nuffield...
CD58, Receptors, Immunologic, Receptors, Antigen, T-Cell, Antigens, CD2, Antigens, Differentiation, T-Lymphocyte, Adjuvants, ... The CD2 ligand LFA-3 activates T cells but depends on the expression and function of the antigen receptor. Share Share Share ... The CD2 ligand LFA-3 activates T cells but depends on the expression and function of the antigen receptor. ... T-Lymphocytes, Cell Line, Humans, Calcium, Membrane Glycoproteins, Antigens, ...https://www.ndorms.ox.ac.uk/publications/482711