*  Inhibition of HIV-1 progeny virion release by cell-surface CD4 is relieved by expression of the viral Nef protein. | Scholars...
Inhibition of HIV-1 progeny virion release by cell-surface CD4 is relieved by expression of the viral Nef protein.'s profile, ... In contrast, CD4 had no effect on the release of HIV-1 bearing a heterologous envelope protein unable to bind CD4. Nef ... RESULTS: Using human 293T cells expressing high levels of cell-surface CD4 or CD8, we demonstrate that CD4, but not CD8, can ... Inhibition of HIV-1 progeny virion release by cell-surface CD4 is relieved by expression of the viral Nef protein. Journal ...
  https://scholars.duke.edu/display/pub647919
*  CD4 Antigens - CD4 Antigen Summary Report | CureHunter
55-kDa antigens found on HELPER-INDUCER T-LYMPHOCYTES and on a variety of other immune cell types. CD4 antigens are members of ... CD4 antigens also serve as INTERLEUKIN-15 receptors and bind to the HIV receptors, binding directly to the HIV ENVELOPE PROTEIN ... CD4 Antigen; Receptors, CD4; Antigens, CD4; Receptors, Surface CD4; Surface CD4 Receptor; Antigen, CD4; Antigens, T-Cell T4; ... CD4 Antigens (CD4 Antigen). Subscribe to New Research on CD4 Antigens 55-kDa antigens found on HELPER-INDUCER T-LYMPHOCYTES and ...
  http://www.curehunter.com/public/keywordSummaryD015704-CD4-Antigens-CD4-Antigen.do
*  Human antigen-specific CD4⁺ CD25⁺ CD134⁺ CD39⁺ T cells are enriched for regulatory T cells and comprise a substantial...
Human antigen-specific CD4⁺ CD25⁺ CD134⁺ CD39⁺ T cells are enriched for regulatory T cells and comprise a substantial ... Human Ag-specific CD4(+) Txa0cells can be detected by their dual expression of CD134 (OX40) and CD25 after a 44 hours ... We show that surface expression of CD39 on Ag-specific cells consistently identifies a substantial population of CD4(+) CD25 ... Collectively, our data show that Ag-specific CD4(+) CD25(+) CD134(+) CD39(+) Txa0cells are highly enriched for Treg cells, form ...
  https://www.sigmaaldrich.com/catalog/papers/24752698
*  Gereke, M., Jung, S., Buer, J. and Bruder, D. (2009) Alveolar type II epithelial cells present antigen to CD4(1) T cells and...
Alveolar type II epithelial cells present antigen to CD4(1) T cells and induce Foxp3(1) regula-tory T cells. American Journal ... Gereke, M., Jung, S., Buer, J. and Bruder, D. (2009) Alveolar type II epithelial cells present antigen to CD4(1) T cells and ... Human CD4- CD8- Invariant Natural Killer T Cells Promote IgG Secretion from B Cells Stimulated by Cross-Linking of Their ... Innate-like CD4 T cells selected by thymocytes suppress adaptive immune responses against bacterial infections ...
  http://www.scirp.org/reference/ReferencesPapers.aspx?ReferenceID=730672
*  CD4 antigen | Article about CD4 antigen by The Free Dictionary
Although all animals have... Explanation of CD4 antigen ... Find out information about CD4 antigen. see immunity immunity, ... redirected from CD4 antigen). Also found in: Dictionary, Thesaurus, Medical.. Related to CD4 antigen: CD4+ cell antigen:. see ... CD4 antigen , Article about CD4 antigen by The Free Dictionary https://encyclopedia2.thefreedictionary.com/CD4+antigen ... the somatic or O antigens), or from the flagella (the flagellar or H antigens). Other antigens either are excreted by the cell ...
  http://encyclopedia2.thefreedictionary.com/CD4+antigen
*  Acquisition of an additional antigen specificity after mouse CD4 gene transfer into a T helper hybridoma. | JEM
Acquisition of an additional antigen specificity after mouse CD4 gene transfer into a T helper hybridoma.. W G Ballhausen, A B ... These experiments suggest that CD4 may be important in determining the antigen fine specificity and, therefore, may also play a ... Acquisition of an additional antigen specificity after mouse CD4 gene transfer into a T helper hybridoma. ... We have transfected the mouse CD4 gene into a beef insulin (BI)-specific murine T helper hybridoma that lacks CD4 surface ...
  http://jem.rupress.org/content/167/4/1493
*  Lirias: Antigen recognition by autoreactive CD4⁺ thymocytes drives homeostasis of the thymic medulla
Antigen recognition by autoreactive CD4⁺ thymocytes drives homeostasis of the thymic medulla. ... This process exhibits strict dependence on TCR-reactivity with self-antigens expressed by mTECs, as well as engagement of the ... We demonstrate here that conventional SP CD4⁺ thymocytes bearing autoreactive TCRs drive a homeostatic process that fine-tunes ... These interactions induce the expression of lymphotoxin α in autoreactive CD4⁺ thymocytes and RANK in mTECs. Lymphotoxin in ...
  https://lirias.kuleuven.be/handle/123456789/432787
*  Abstract: Caspase-3 on patient antigen-specific CD4<sup>+</sup> T cells diagnose active tuberculosis and monitor treatment...
Caspase-3 on patient antigen-specific CD4+ T cells diagnose active tuberculosis and monitor treatment response ... Methods: Using polychromatic flow cytometry, we evaluated the expression of active caspase-3 on Mtb-specific CD4+ T cells from ... Results: Frequencies of Mtb-specific IFN-g+CD4+ T cells that expressed active caspase-3 were substantially higher in subjects ... Conclusion: We have identified a host blood-based biomarker on Mtb-specific CD4+ T cells that discriminate between ATB and LTBI ...
  https://idsa.confex.com/idsa/2015/webprogram/Paper53409.html
*  Antigen-driven CD4+T cell and HIV-1 dynamics: Residual viral replication under highly active antiretroviral therapy - Oxford...
Antigen-driven CD4+T cell and HIV-1 dynamics: Residual viral replication under highly active antiretroviral therapy ... Antigen-driven CD4+T cell and HIV-1 dynamics: Residual viral replication under highly active antiretroviral therapy ...
  https://www.bdi.ox.ac.uk/publications/634357
*  Epitopes described in Understanding the focused CD4 T cell response to antigen and pathogenic organisms. - Immune Epitope...
Free resource for searching and exporting immune epitopes. Includes more than 95% of all published infectious disease, allergy, autoimmune, and transplant epitope data.
  http://www.iedb.org/pmId/19198764
*  HIV-1 p24 antigen is a significant inverse correlate of CD4 T-cell change in patients with suppressed viremia under long-term...
HIV-1 p24 antigen is a significant inverse correlate of CD4 T-cell change in patients with suppressed viremia under long-term ... Comparison of p24 antigen and HIV-1 RNA concentrations indicate that the p24 antigen detected in these samples is not ... Comparison of p24 antigen and HIV-1 RNA concentrations indicate that the p24 antigen detected in these samples is not ... the level of p24 antigen as expressed by the absorbance/cutoff ratio was a significant inverse correlate of both the CD4 count ...
  http://www.zora.uzh.ch/id/eprint/2140/
*  Identification of a Tumor-specific Shared Antigen Derived From an Eph Receptor and Presented to CD4 T Cells on HLA Class II...
Most of these antigens are presented by HLA class I molecules to CD8 lymphocytes. But tumor-specific CD4 T cells have also been ... We obtained a lytic CD4 T-cell clone that recognized an antigen presented by HLA-DRB1*1101 on the tumor cells of a melanoma ... Identification of a Tumor-specific Shared Antigen Derived From an Eph Receptor and Presented to CD4 T Cells on HLA Class II ... Identification of a Tumor-specific Shared Antigen Derived From an Eph Receptor and Presented to CD4 T Cells on HLA Class II ...
  http://cancerres.aacrjournals.org/content/60/17/4855
*  Analysis of T cell antigen receptor (TCR) expression by human peripheral blood CD4-8- alpha/beta T cells demonstrates...
Analysis of T cell antigen receptor (TCR) expression by human peripheral blood CD4-8- alpha/beta T cells demonstrates ... Analysis of T cell antigen receptor (TCR) expression by human peripheral blood CD4-8- alpha/beta T cells demonstrates ... To investigate whether these cells are selected to recognize particular antigens or antigen-presenting molecules, DN alpha/beta ... recognize a limited spectrum of antigens and suggests that they may use nonpolymorphic antigen-presenting molecules. ...
  http://jem.rupress.org/content/178/1/1?ijkey=3d3c66f3aaa3a1866ed075c5ecb0f54bd1c81b32&keytype2=tf_ipsecsha
*  A Phase I Study of the Safety and Pharmacokinetics of Recombinant Human CD4-Immunoglobulin G (rCD4-IgG) Administered by...
Antigens, CD4. Zidovudine. Carrier Proteins. Additional relevant MeSH terms: HIV Infections. AIDS-Related Complex. Lentivirus ... CD4-IgG is administered by IV bolus on day 16. Samples are drawn beginning 15-30 minutes prior to the injection of CD4-IgG. The ... Patients receive one IV bolus of CD4-IgG on day 1 and samples are drawn beginning 15-30 minutes prior to the CD4-IgG injection ... To determine the safety profile of recombinant human CD4-immunoglobulin G (CD4-IgG) and zidovudine (AZT) combination therapy in ...
  https://clinicaltrials.gov/show/NCT00000976?order=296
*  A Phase I Study of the Safety and Pharmacokinetics of Recombinant Human CD4 Immunoglobulin (rCd4-IgG) Administered by...
Antigens, CD4. AIDS-Related Complex. Carrier Proteins. Additional relevant MeSH terms: HIV Infections. AIDS-Related Complex. ... AMENDED: Includes, as of 891201, an ancillary study entitled 'A Study of Recombinant CD4-Immunoglobulin G (CD4-IgG) Levels in ... Recently, scientists have succeeded in producing highly purified recombinant soluble human CD4. Recombinant CD4 is capable of ... Recently, scientists have succeeded in producing highly purified recombinant soluble human CD4. Recombinant CD4 is capable of ...
  https://clinicaltrials.gov/show/NCT00000675?order=476
*  A Phase I Study of the Safety and Pharmacokinetics of Recombinant CD4 Immunoglobulin G (rCD4-IgG) in HIV-1 Seropositive Women...
Antigens, CD4. AIDS-Related Complex. Immunization, Passive. Additional relevant MeSH terms: HIV Infections. Lentivirus ... A Phase I Study of the Safety and Pharmacokinetics of Recombinant CD4 Immunoglobulin G (rCD4-IgG) in HIV-1 Seropositive Women ... A Phase I Study of the Safety and Pharmacokinetics of Recombinant CD4 Immunoglobulin G (rCD4-IgG) in HIV-1 Seropositive Women ... Part 1: To determine both the safety, tolerance, and pharmacokinetic profile (blood levels) of recombinant CD4 immunoglobulin G ...
  https://clinicaltrials.gov/ct2/show/NCT00000642?term=
*  Assessment of Vaccine-Induced CD4 T Cell Responses to the 119-143 Immunodominant Region of the Tumor-Specific Antigen NY-ESO-1...
Assessment of Vaccine-Induced CD4 T Cell Responses to the 119-143 Immunodominant Region of the Tumor-Specific Antigen NY-ESO-1 ... Assessment of Vaccine-Induced CD4 T Cell Responses to the 119-143 Immunodominant Region of the Tumor-Specific Antigen NY-ESO-1 ... Assessment of Vaccine-Induced CD4 T Cell Responses to the 119-143 Immunodominant Region of the Tumor-Specific Antigen NY-ESO-1 ... Assessment of Vaccine-Induced CD4 T Cell Responses to the 119-143 Immunodominant Region of the Tumor-Specific Antigen NY-ESO-1 ...
  http://clincancerres.aacrjournals.org/content/early/2010/09/03/1078-0432.CCR-10-1485
*  Abstract A017: Method for molecular characterization of antigens, epitopes and T cell receptors for adoptive CD4 immunotherapy ...
Antigen-reactive CD4+ T cells were isolated and expanded. In order to identify the antigen and epitope specificity of each T ... Multifunctional CD4+ T cells are essential to activate, control and maintain immune responses. CD4+ T cells recognize antigen- ... To appropriately employ CD4+ T cells in tumor defense, detailed molecular knowledge regarding the antigens and corresponding ... Subsequently, these pool-loaded APCs were tested with CT-antigen-specific CD4+ T cell clones. In a second step, the single ...
  http://cancerimmunolres.aacrjournals.org/content/4/11_Supplement/A017
*  Correction: First demonstration of antigen induced cytokine expression by CD4-1⁺ lymphocytes in a poikilotherm: Studies in...
Correction of the article "First demonstration of antigen induced cytokine expression by CD4-1⁺ lymphocytes in a poikilotherm: ... Correction: First demonstration of antigen induced cytokine expression by CD4-1⁺ lymphocytes in a poikilotherm: Studies in ... First demonstration of antigen induced cytokine expression by CD4-1⁺ lymphocytes in a poikilotherm: Studies in zebrafish (Danio ...
  https://researchcommons.waikato.ac.nz/handle/10289/11005
*  Virology Lecture | T Cell | T Helper Cell
Killing of CD4 cells 3. Cytotoxic T cell-mediated lysis . Killing of CD4+ cells 4. Binding of free Gp120 to CD4 antigen makes ... HIV gp120 binds to macrophage CD4 antigen Virus is opsonized by anti gp120 antibodies which bind to macrophage Fc receptors - ... Mature Th cells are believed to always express the surface protein CD4. T cells expressing CD4 are also known as CD4+ T cells ... Dendritic cells present antigen and virus to CD4 cells • Epitope variation allows more and more HIV to escape from immune ...
  https://www.scribd.com/presentation/23995943/Virology-Lecture
*  anti-CD4 antibody [MAB0810] | GeneTex
CD4 antigen) for Blocking, Depletion, Stimulation. Anti-CD4 mAb (GTX52398) is tested in Mouse samples. 100% Ab-Assurance. ... CD4 antigen Antibody , L3T4 Antibody , Ly-4 Antibody , Cd4 Antibody. Specificity. The antibody was selected for its ability to ...
  http://www.genetex.com/CD4-antibody-MAB0810-GTX52398.html
*  Real-time immune cell interactions in target tissue during autoimmune-induced damage and graft tolerance | JEM
Direct contact between antigen-specific CD4+ Teff cells and their target cells. CD4+ T cells are categorized into several ... For CD4+ BDC2.5 T cell analyses, the CD4+ Teff cells (n = 5 mice, 110 cells; mean ± SEM) and CD4+ BDC2.5 Treg cells (n = 5 mice ... cognate interaction with CD4+ T cells. To study tissue destruction by antigen-specific CD4+ Teff cells, pancreatic islets ... Antigen-specific CD4+ BDC2.5 Teff and Treg cells were purified from transgenic mice on the NOD genetic background that carries ...
  http://jem.rupress.org/content/early/2014/02/18/jem.20130785
*  Radiation Oncology/Sarcoma/Overview - Wikibooks, open books for an open world
High grade lymphoma: CD45 (leukocyte common antigen), CD4, nuclear TdT. *Mesothelioma: WT1, pancytokeratin ... Follicular dendritic cell sarcoma: Follicular dendritic cells that present antigens to B-cells in a lymph node. Surgery primary ...
  https://en.wikibooks.org/wiki/Radiation_Oncology/Soft_tissue_sarcoma
*  GK1.5 ATCC ® TIB-207™ Rattus norvegicus (B cell); Mus muscul
immunoglobulin; monoclonal antibody; against mouse helper, inducer T cells (L3T4 antigen, CD4) ... immunoglobulin; monoclonal antibody; against mouse helper, inducer T cells (L3T4 antigen, CD4) ... Evidence implicating L3T4 class II MHC antigen reactivity; monoclonal antibody GK1.5 (anti-L3T4a) blocks class II MHC antigen- ... Evidence implicating L3T4 class II MHC antigen reactivity; monoclonal antibody GK1.5 (anti-L3T4a) blocks class II MHC antigen- ...
  https://www.atcc.org/en/Products/Cells_and_Microorganisms/By_Tissue/Spleen/TIB-207.aspx
*  Chimeric antigen receptor-modified T cells derived from defined CD8(+) and CD4(+) subsets confer superior antitumor reactivity...
Chimeric antigen receptor-modified T cells derived from defined CD8(+) and CD4(+) subsets confer superior antitumor reactivity ... Adoptive T-cell therapy with gene-modified T-cells expressing a tumor-reactive T-cell receptor (TCR) or chimeric antigen ... In all reported trials, patients have received T-cell products comprised of random compositions of CD4(+) and CD8(+) naïve and ... Combining the most potent CD4(+) and CD8(+) CAR-expressing subsets resulted in synergistic antitumor effects in vivo. We show ...
  https://sharedresources.fredhutch.org/publications/papers/chimeric-antigen-receptor-modified-t-cells-derived-defined-cd8-and-cd4-subsets-c