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*  Immunotherapy of non-Hodgkin's lymphoma with a defined ratio of CD8+ and CD4+ CD19-specific chimeric antigen receptor-modified...
CD19-specific chimeric antigen receptor (CAR)-modified T cells have antitumor activity in B cell malignancies, but factors that ... Immunotherapy of non-Hodgkin's lymphoma with a defined ratio of CD8+ and CD4+ CD19-specific chimeric antigen receptor-modified ... Immunotherapy of non-Hodgkin's lymphoma with a defined ratio of CD8+ and CD4+ CD19-specific chimeric antigen receptor-modified ... Immunotherapy of non-Hodgkin's lymphoma with a defined ratio of CD8+ and CD4+ CD19-specific chimeric antigen receptor-modified ...
  http://stm.sciencemag.org/content/8/355/355ra116
*  In Vitro Expanded Allogeneic Epstein-Barr Virus Specific Cytotoxic T-Lymphocytes (EBV-CTLs) Genetically Targeted to the CD19...
Genetically Targeted to the CD19 Antigen in B-cell Malignancies. This study is currently recruiting participants. See Contacts ...
  https://clinicaltrials.gov/ct2/show/results/NCT01430390
*  Development and Characterization of Three Recombinant Single Chain Antibody Fragments (scFvs) Directed against the CD19 Antigen...
... were properly refolded and bound CD19 antigen in FACS competition assays. These anti-CD19 scFv should be useful in the further ... Antibodies that recognize the CD19 antigen found on normal and malignant B cells, but not on stem cells, have been used to ... Directed against the CD19 Antigen. Bruce E. Bejcek, Duo Wang, Erica Berven, Christopher A. Pennell, Stephen C. Peiper, Sibrand ... Development and Characterization of Three Recombinant Single Chain Antibody Fragments (scFvs) Directed against the CD19 Antigen ...
  http://cancerres.aacrjournals.org/content/55/11/2346.long
*  Administration of Anti-CD19-chimeric-antigen-receptor-transduced T Cells From the Original Transplant Donor to Patients With...
Anti-CD19-chimeric-antigen-receptor- transduced T cell Patients receive T cells genetically engineered to express an anti-CD19 ... Anti-CD19-chimeric-antigen-receptor- transduced T cell Patients receive T cells genetically engineered to express an anti-CD19 ... Anti-CD19-chimeric-antigen-receptor- transduced T cell Patients receive T cells genetically engineered to express an anti-CD19 ... CD19. Chimeric-Antigen-Receptor. Gene Therapy. Adoptive T Cell Therapy. Allogeneic Stem Cell Transplantation. B Cell Cancer. ...
  https://clinicaltrials.gov/ct2/show/NCT01087294?term=stem+cell+transplant&recr=Open&fund=01&rank=10
*  CD19-targeted chimeric antigen receptor T-cell therapy for acute lymphoblastic leukemia | Blood Journal
Two modes of disease recurrence have been seen: CD19 positive and CD19 negative. Relapse of ALL that retains surface CD19 ... CD19-targeted chimeric antigen receptor T-cell therapy for acute lymphoblastic leukemia. Shannon L. Maude, David T. Teachey, ... CD19: an ideal target?. Ideally, an antigen targeted by CAR-modified T cells would be tumor specific. Beyond that, an ideal ... Treating B-cell cancer with T cells expressing anti-CD19 chimeric antigen receptors. Nat Rev Clin Oncol 2013;10(5):267-276. ...
  http://www.bloodjournal.org/content/125/26/4017?sso-checked=true
*  Kite Pharma Announces Patients With Aggressive Non-Hodgkin's Lymphoma Experience Positive Results After Receiving Anti-CD19...
... a cohort of patients demonstrating the potential to treat aggressive non-Hodgkin's lymphoma with an anti-CD19 chimeric antigen ... and Indolent B-cell Malignancies Can Be Effectively Treated with Autologous T Cells Expressing an Anti-CD19 Chimeric Antigen ... Kite's most advanced product candidate, KTE-C19, is an anti-CD19 CAR T cell therapy that involves genetically modifying a ... As seen in other studies, infusion of anti-CD19 CAR T cells was associated with significant, acute toxicities, including fever ...
  http://www.gilead.com/news/press-releases/2014/8/kite-pharma-announces-patients-with-aggressive-nonhodgkins-lymphoma-experience-positive-results-after-receiving-anticd19-chimeric-antigen-receptor-car-t-cells-at-the-national-cancer-institute-nci
*  Evaluation of Ricin A Chain-containing Immunotoxins Directed against CD19 and CD22 Antigens on Normal and Malignant Human B...
In most cases, their sensitivity correlated with the levels of CD19 and CD22 antigens expressed. Neither HD6 nor HD37 IT-As ... Ricin A chain-containing immunotoxins (IT-As) specific for the human B-cell antigens, CD22 and CD19, were constructed using the ... Evaluation of Ricin A Chain-containing Immunotoxins Directed against CD19 and CD22 Antigens on Normal and Malignant Human B- ... Evaluation of Ricin A Chain-containing Immunotoxins Directed against CD19 and CD22 Antigens on Normal and Malignant Human B- ...
  http://cancerres.aacrjournals.org/content/48/9/2610
*  Pleural cavity cytokine release syndrome in CD19-directed chimeric antigen receptor-modified T cell therapy, Medicine | 10.1097...
"Pleural cavity cytokine release syndrome in CD19-directed chimeric antigen receptor-modified T cell therapy, Medicine" on ... T cells expressing CD19 chimeric antigen receptors for acute lymphoblastic leukaemia in children and young adults: a phase 1 ... Pleural cavity cytokine release syndrome in CD19-directed chimeric antigen receptor-modified T cell therapy. Ding, Lijuan; Hu, ... Pleural cavity cytokine release syndrome in CD19-directed chimeric antigen receptor-modified T... Ding, Lijuan; Hu, Yongxian; ...
  https://www.deepdyve.com/lp/wolters_kluwer/pleural-cavity-cytokine-release-syndrome-in-cd19-directed-chimeric-fJqlafcZ6W
*  Toward targeting B cell cancers with CD4+ CTLs: identification of a CD19-encoded minor histocompatibility antigen using a novel...
Toward targeting B cell cancers with CD4+ CTLs: identification of a CD19-encoded minor histocompatibility antigen using a novel ... Toward targeting B cell cancers with CD4+ CTLs: identification of a CD19-encoded minor histocompatibility antigen using a novel ...
  http://jem.rupress.org/content/early/2008/11/10/jem.20080713
*  KEGG BRITE: KEGG Orthology (KO) - Camelus ferus (Wild Bactrian camel)
K06465 CD19; B-lymphocyte antigen CD19 K12230 PIK3AP1; phosphoinositide 3-kinase adapter protein 1 K05438 GH; growth hormone ... 102506736 CD19; CD19 molecule 102505471 PIK3AP1; phosphoinositide-3-kinase adaptor protein 1 102518081 GH1; growth hormone 1 ... CD36 antigen K06259 CD36; CD36 antigen K18052 PRKCQ; novel protein kinase C theta type [EC:2.7.11.13] K06068 PRKCD; novel ... CD36 antigen K06259 CD36; CD36 antigen K05459 IGF1; insulin-like growth factor 1 K05087 IGF1R; insulin-like growth factor 1 ...
  http://www.genome.jp/kegg-bin/get_htext?cfr00001+102511249
*  KEGG BRITE: KEGG Orthology (KO) - Equus caballus (horse)
K06465 CD19; B-lymphocyte antigen CD19 K12230 PIK3AP1; phosphoinositide 3-kinase adapter protein 1 K05438 GH; growth hormone ... 100147468 CD19; CD19 molecule 100070796 PIK3AP1; phosphoinositide-3-kinase adaptor protein 1 100034180 GH1; growth hormone 1 ... 100060245 MGEA5; meningioma expressed antigen 5 (hyaluronidase) 100056148 OGT; O-linked N-acetylglucosamine (GlcNAc) ... CD36 antigen K18052 PRKCQ; novel protein kinase C theta type [EC:2.7.11.13] K06068 PRKCD; novel protein kinase C delta type [EC ...
  http://www.genome.jp/kegg-bin/get_htext?ecb00001+100054723
*  Blinatumomab - DrugBank
CD19. Uniprot ID. P15391. Uniprot Name. B-lymphocyte antigen CD19. Molecular Weight. 61127.985 Da. ... Assembles with the antigen receptor of B-lymphocytes in order to decrease the threshold for antigen receptor-dependent ... Blinatumomab is a bispecific CD19-directed CD3 T-cell engager that binds to CD19 expressed on the surface of cells of B-lineage ... B Acute Lymphoblastic Leukemia / B Acute Lymphoblastic Leukemia With t(9;22)(q34.1;q11.2); BCR-ABL1 / CD19-Positive Neoplastic ...
  https://www.drugbank.ca/drugs/DB09052
*  A Safety Study of SGN-CD19A for B-Cell Lymphoma - Full Text View - ClinicalTrials.gov
Antigens, CD19. B-Lineage Lymphoblastic Lymphoma. Burkitt Lymphoma. Diffuse Large B-Cell Lymphoma. Mantle Cell Lymphoma. B-Cell ...
  https://clinicaltrials.gov/ct2/show/NCT01786135
*  Mouse Monoclonal anti-CD19 (C19/366) | Biotium
B-lymphocyte antigen CD19; B-lymphocyte surface antigen B4; CVID3; Leu-12; Lymphocyte Surface Antigen; T-cell surface antigen ... Isolation of cDNAs encoding the CD19 antigen of human and mouse B-lymphocytes. A new member of the immunoglobulin superfamily. ... Mouse Monoclonal anti-CD19 (C19/366) CD19 is a transmembrane glycoprotein that contains two extracellular immunoglobulin-like ... CD19 is a transmembrane glycoprotein that contains two extracellular immunoglobulin-like domains. CD19 is present in both ...
  https://biotium.com/product/monoclonal-anti-cd19-cvid3366/
*  JCI Insight - Identification of human plasma cells with a lamprey monoclonal antibody
... can be distinguished by differential expression of the CD19 and CD138 cell-surface antigens: population "A" (CD19+/CD138-); ... CD19+/IgD+/CD27+), transitional B cells (CD19+/IgD+/CD27-/CD10+/CD24+), non-B/T cells (CD19-/CD3-), T cells (CD19-/CD3+), and ... CD19+/IgD+/CD38+); germinal center B cells (CD19+/IgD-/CD38+); non-B/T cells (CD19-/CD3-); and T cells (CD19-/CD3+). Shown is a ... CD19+/CD138-); population "B" (CD19+/CD138+); population "C" (CD19-/CD138-); and population "D" (CD19-/CD138+). The various ...
  https://insight.jci.org/articles/view/84738
*  Blood and Lymph Unit 3 Flashcards by Kristen Stahl | Brainscape
... often express antigens only seen in mature T cells (CD99, 1a). -B lymphoblasts express B lineage antigens: CD19, 22, 79a. do ... Cross reaction of foreign antigen with self: foreign+self antigen. would be good if we could identify antigens that start rxn. ... Often by the time symptoms show up, triggering antigen is long gone. Coupling Self antigen with Foreign Antigen "carrier": have ... worms shed antigen that diffuse to mast cells. -Mast cells' FceR are loaded then with anti-helminth IgE. -antigen cross links ...
  https://www.brainscape.com/flashcards/blood-and-lymph-unit-3-4806757/packs/6999439
*  CD19 polyclonal antibody - (PAB19567) - Products - Abnova
Synthetic protein corresponding to human CD19. (PAB19567) - Products - Abnova ... Rabbit polyclonal antibody raised against synthetic protein of CD19. ... yet sensitive manner to the various antigens is achieved with the use of low-affinity antigen receptors. This gene encodes a ... Lymphocytes proliferate and differentiate in response to various concentrations of different antigens. The ability of the B ...
  http://www.abnova.com/products/products_detail.asp?catalog_id=PAB19567
*  CD19 recombinant monoclonal antibody, clone FMC63 - (RAB00074) - Products - Abnova
Recombinant mouse monoclonal antibody raised against human CD19. Original antibody is raised against human prolymphocytic ... yet sensitive manner to the various antigens is achieved with the use of low-affinity antigen receptors. This gene encodes a ... Lymphocytes proliferate and differentiate in response to various concentrations of different antigens. The ability of the B ... cell surface molecule which assembles with the antigen receptor of B lymphocytes in order to decrease the threshold for antigen ...
  http://www.abnova.com/products/products_detail.asp?catalog_id=RAB00074
*  Anti-CD19 antibody (PE-DyLight™ 594) [4G7] | Abcam
Anti-CD19 antibody conjugated to PE-DyLight™ 594 [4G7] validated for Flow Cyt and tested in Human. Immunogen corresponding to ... Assembles with the antigen receptor of B lymphocytes in order to decrease the threshold for antigen receptor-dependent ... Anti-CD19 antibody [4G7] (PE-DyLight™ 594). See all CD19 primary antibodies. ... Defects in CD19 are the cause of immunodeficiency common variable type 3 (CVID3) [MIM:613493]; also called antibody deficiency ...
  https://www.abcam.com/cd19-antibody-4g7-pe-dylight-594-ab178449.html
*  https://www.cancer.gov/types/leukemia/hp/cll-treatment-pdq
CLL lymphocytes coexpress the B-cell antigens CD19 and CD20 along with the T-cell antigen CD5.[33] This coexpression only ... Autologous T cells were modified by a lentiviral vector to incorporate antigen receptor specificity for the B-cell antigen CD19 ... Porter DL, Levine BL, Kalos M, et al.: Chimeric antigen receptor-modified T cells in chronic lymphoid leukemia. N Engl J Med ... clinical trials are testing the concept of T cells directed at specific antigen targets with engineered chimeric-antigen ...
  https://www.cancer.gov/types/leukemia/hp/cll-treatment-pdq
*  CD40L-Tri upregulates expression of costimulatory molec | Open-i
Antigen-Presenting Cells/drug effects/immunology. *Antigens, CD19/analysis. *Antigens, Viral/immunology ... Bottom Line: Consistent with these results, CD40L-Tri-activated B cells could effectively stimulate antigen-specific T ... Bottom Line: Consistent with these results, CD40L-Tri-activated B cells could effectively stimulate antigen-specific T ... our studies demonstrate the potent immune-stimulatory effects of CD40L-Tri on B cells that enable their expansion of antigen- ...
  https://openi.nlm.nih.gov/detailedresult.php?img=PMC3569584_262_2012_1331_Fig2_HTML&req=4
*  CD40L-Tri-activated CLL cells effectively elicit patien | Open-i
Antigen-Presenting Cells/drug effects/immunology. *Antigens, CD19/analysis. *Antigens, Viral/immunology ... Bottom Line: Consistent with these results, CD40L-Tri-activated B cells could effectively stimulate antigen-specific T ... Bottom Line: Consistent with these results, CD40L-Tri-activated B cells could effectively stimulate antigen-specific T ... our studies demonstrate the potent immune-stimulatory effects of CD40L-Tri on B cells that enable their expansion of antigen- ...
  https://openi.nlm.nih.gov/detailedresult.php?img=PMC3569584_262_2012_1331_Fig4_HTML&req=4
*  Why is chimeric antigen receptor better than just injecting anti-CD19 antibodies? Since our natural killer cells can kill the...
It stands to reason that anti-CD19 antibodies would target B cell, which ~ exclusively and specifically express the CD19 ... In turn, anti-CD19 antibody-bound B cells are the target of Natural killer cell-mediated Antibody-dependent cell-mediated ... Why is chimeric antigen receptor better than just injecting anti-CD19 antibodies? Since our natural killer cells can kill the ... Comments Off on Why is chimeric antigen receptor better than just injecting anti-CD19 antibodies? Since our natural killer ...
  https://tirumalaikamala.wordpress.com/2016/12/28/why-is-chimeric-antigen-receptor-better-than-just-injecting-anti-cd19-antibodies-since-our-natural-killer-cells-can-kill-the-cells-attached-with-antibodies-via-antibody-dependent-cell-mediated-cytoto/
*  Anti-CD19 antibody [6D5] (PE/Cy5®) (ab25508) | Abcam
Rat monoclonal CD19 antibody [6D5] conjugated to PE/Cy5®. Validated in IP, FuncS, Flow Cyt and tested in Mouse. Cited in 3 ... Assembles with the antigen receptor of B lymphocytes in order to decrease the threshold for antigen receptor-dependent ... Defects in CD19 are the cause of immunodeficiency common variable type 3 (CVID3) [MIM:613493]; also called antibody deficiency ... Self-renewal of B-1 lymphocytes is dependent on CD19.. Eur J Immunol 26:238-42 (1996). Read more (PubMed: 8566073) » ...
  https://www.abcam.com/cd19-antibody-6d5-pecy5-ab25508.html
*  Plasma cell - Wikipedia
Surface antigens[edit]. Terminally differentiated plasma cells express relatively few surface antigens, and do not express ... common pan-B cell markers, such as CD19 and CD20. Instead, plasma cells are identified through flow cytometry by their ... Another important surface antigen is CD319 (SLAMF7). This antigen is expressed at high levels on normal human plasma cells. It ... After leaving the bone marrow, the B cell acts as an antigen presenting cell (APC) and internalizes offending antigens, which ...
  https://en.wikipedia.org/wiki/Plasma_cells