*  Immunotherapy of non-Hodgkin's lymphoma with a defined ratio of CD8+ and CD4+ CD19-specific chimeric antigen receptor-modified...
CD19-specific chimeric antigen receptor (CAR)-modified T cells have antitumor activity in B cell malignancies, but factors that ... Immunotherapy of non-Hodgkin's lymphoma with a defined ratio of CD8+ and CD4+ CD19-specific chimeric antigen receptor-modified ... Immunotherapy of non-Hodgkin's lymphoma with a defined ratio of CD8+ and CD4+ CD19-specific chimeric antigen receptor-modified ... Immunotherapy of non-Hodgkin's lymphoma with a defined ratio of CD8+ and CD4+ CD19-specific chimeric antigen receptor-modified ...
  http://stm.sciencemag.org/content/8/355/355ra116
*  In Vitro Expanded Allogeneic Epstein-Barr Virus Specific Cytotoxic T-Lymphocytes (EBV-CTLs) Genetically Targeted to the CD19...
Genetically Targeted to the CD19 Antigen in B-cell Malignancies. This study is currently recruiting participants. See Contacts ...
  https://clinicaltrials.gov/ct2/show/results/NCT01430390
*  Development and Characterization of Three Recombinant Single Chain Antibody Fragments (scFvs) Directed against the CD19 Antigen...
... were properly refolded and bound CD19 antigen in FACS competition assays. These anti-CD19 scFv should be useful in the further ... Antibodies that recognize the CD19 antigen found on normal and malignant B cells, but not on stem cells, have been used to ... Directed against the CD19 Antigen. Bruce E. Bejcek, Duo Wang, Erica Berven, Christopher A. Pennell, Stephen C. Peiper, Sibrand ... Development and Characterization of Three Recombinant Single Chain Antibody Fragments (scFvs) Directed against the CD19 Antigen ...
  http://cancerres.aacrjournals.org/content/55/11/2346.long
*  Administration of Anti-CD19-chimeric-antigen-receptor-transduced T Cells From the Original Transplant Donor to Patients With...
Anti-CD19-chimeric-antigen-receptor- transduced T cell Patients receive T cells genetically engineered to express an anti-CD19 ... Anti-CD19-chimeric-antigen-receptor- transduced T cell Patients receive T cells genetically engineered to express an anti-CD19 ... Anti-CD19-chimeric-antigen-receptor- transduced T cell Patients receive T cells genetically engineered to express an anti-CD19 ... CD19. Chimeric-Antigen-Receptor. Gene Therapy. Adoptive T Cell Therapy. Allogeneic Stem Cell Transplantation. B Cell Cancer. ...
  https://clinicaltrials.gov/ct2/show/NCT01087294?term=stem+cell+transplant&recr=Open&fund=01&rank=10
*  CD19-targeted chimeric antigen receptor T-cell therapy for acute lymphoblastic leukemia | Blood Journal
Two modes of disease recurrence have been seen: CD19 positive and CD19 negative. Relapse of ALL that retains surface CD19 ... CD19-targeted chimeric antigen receptor T-cell therapy for acute lymphoblastic leukemia. Shannon L. Maude, David T. Teachey, ... CD19: an ideal target?. Ideally, an antigen targeted by CAR-modified T cells would be tumor specific. Beyond that, an ideal ... Treating B-cell cancer with T cells expressing anti-CD19 chimeric antigen receptors. Nat Rev Clin Oncol 2013;10(5):267-276. ...
  http://www.bloodjournal.org/content/125/26/4017?sso-checked=true
*  Kite Pharma Announces Patients With Aggressive Non-Hodgkin's Lymphoma Experience Positive Results After Receiving Anti-CD19...
... a cohort of patients demonstrating the potential to treat aggressive non-Hodgkin's lymphoma with an anti-CD19 chimeric antigen ... and Indolent B-cell Malignancies Can Be Effectively Treated with Autologous T Cells Expressing an Anti-CD19 Chimeric Antigen ... Kite's most advanced product candidate, KTE-C19, is an anti-CD19 CAR T cell therapy that involves genetically modifying a ... As seen in other studies, infusion of anti-CD19 CAR T cells was associated with significant, acute toxicities, including fever ...
  http://www.gilead.com/news/press-releases/2014/8/kite-pharma-announces-patients-with-aggressive-nonhodgkins-lymphoma-experience-positive-results-after-receiving-anticd19-chimeric-antigen-receptor-car-t-cells-at-the-national-cancer-institute-nci
*  Evaluation of Ricin A Chain-containing Immunotoxins Directed against CD19 and CD22 Antigens on Normal and Malignant Human B...
In most cases, their sensitivity correlated with the levels of CD19 and CD22 antigens expressed. Neither HD6 nor HD37 IT-As ... Ricin A chain-containing immunotoxins (IT-As) specific for the human B-cell antigens, CD22 and CD19, were constructed using the ... Evaluation of Ricin A Chain-containing Immunotoxins Directed against CD19 and CD22 Antigens on Normal and Malignant Human B- ... Evaluation of Ricin A Chain-containing Immunotoxins Directed against CD19 and CD22 Antigens on Normal and Malignant Human B- ...
  http://cancerres.aacrjournals.org/content/48/9/2610
*  Toward targeting B cell cancers with CD4+ CTLs: identification of a CD19-encoded minor histocompatibility antigen using a novel...
Toward targeting B cell cancers with CD4+ CTLs: identification of a CD19-encoded minor histocompatibility antigen using a novel ... Toward targeting B cell cancers with CD4+ CTLs: identification of a CD19-encoded minor histocompatibility antigen using a novel ...
  http://jem.rupress.org/content/early/2008/11/10/jem.20080713
*  KEGG BRITE: KEGG Orthology (KO) - Camelus ferus (Wild Bactrian camel)
K06465 CD19; B-lymphocyte antigen CD19 K12230 PIK3AP1; phosphoinositide 3-kinase adapter protein 1 K05438 GH; growth hormone ... 102506736 CD19; CD19 molecule 102505471 PIK3AP1; phosphoinositide-3-kinase adaptor protein 1 102518081 GH1; growth hormone 1 ... CD36 antigen K06259 CD36; CD36 antigen K18052 PRKCQ; novel protein kinase C theta type [EC:2.7.11.13] K06068 PRKCD; novel ... CD36 antigen K06259 CD36; CD36 antigen K05459 IGF1; insulin-like growth factor 1 K05087 IGF1R; insulin-like growth factor 1 ...
  http://www.genome.jp/kegg-bin/get_htext?cfr00001+102511249
*  KEGG BRITE: KEGG Orthology (KO) - Equus caballus (horse)
K06465 CD19; B-lymphocyte antigen CD19 K12230 PIK3AP1; phosphoinositide 3-kinase adapter protein 1 K05438 GH; growth hormone ... 100147468 CD19; CD19 molecule 100070796 PIK3AP1; phosphoinositide-3-kinase adaptor protein 1 100034180 GH1; growth hormone 1 ... 100060245 MGEA5; meningioma expressed antigen 5 (hyaluronidase) 100056148 OGT; O-linked N-acetylglucosamine (GlcNAc) ... CD36 antigen K18052 PRKCQ; novel protein kinase C theta type [EC:2.7.11.13] K06068 PRKCD; novel protein kinase C delta type [EC ...
  http://www.genome.jp/kegg-bin/get_htext?ecb00001+100054723
*  A Safety Study of SGN-CD19A for B-Cell Lymphoma - Full Text View - ClinicalTrials.gov
Antigens, CD19. B-Lineage Lymphoblastic Lymphoma. Burkitt Lymphoma. Diffuse Large B-Cell Lymphoma. Mantle Cell Lymphoma. B-Cell ...
  https://clinicaltrials.gov/ct2/show/NCT01786135
*  Mouse Monoclonal anti-CD19 (C19/366) | Biotium
B-lymphocyte antigen CD19; B-lymphocyte surface antigen B4; CVID3; Leu-12; Lymphocyte Surface Antigen; T-cell surface antigen ... Isolation of cDNAs encoding the CD19 antigen of human and mouse B-lymphocytes. A new member of the immunoglobulin superfamily. ... Mouse Monoclonal anti-CD19 (C19/366) CD19 is a transmembrane glycoprotein that contains two extracellular immunoglobulin-like ... CD19 is a transmembrane glycoprotein that contains two extracellular immunoglobulin-like domains. CD19 is present in both ...
  https://biotium.com/product/monoclonal-anti-cd19-cvid3366/
*  CD19 polyclonal antibody - (PAB19567) - Products - Abnova
Synthetic protein corresponding to human CD19. (PAB19567) - Products - Abnova ... Rabbit polyclonal antibody raised against synthetic protein of CD19. ... yet sensitive manner to the various antigens is achieved with the use of low-affinity antigen receptors. This gene encodes a ... Lymphocytes proliferate and differentiate in response to various concentrations of different antigens. The ability of the B ...
  http://www.abnova.com/products/products_detail.asp?catalog_id=PAB19567
*  CD19 recombinant monoclonal antibody, clone FMC63 - (RAB00074) - Products - Abnova
Recombinant mouse monoclonal antibody raised against human CD19. Original antibody is raised against human prolymphocytic ... yet sensitive manner to the various antigens is achieved with the use of low-affinity antigen receptors. This gene encodes a ... Lymphocytes proliferate and differentiate in response to various concentrations of different antigens. The ability of the B ... cell surface molecule which assembles with the antigen receptor of B lymphocytes in order to decrease the threshold for antigen ...
  http://www.abnova.com/products/products_detail.asp?catalog_id=RAB00074
*  Why is chimeric antigen receptor better than just injecting anti-CD19 antibodies? Since our natural killer cells can kill the...
It stands to reason that anti-CD19 antibodies would target B cell, which ~ exclusively and specifically express the CD19 ... In turn, anti-CD19 antibody-bound B cells are the target of Natural killer cell-mediated Antibody-dependent cell-mediated ... Why is chimeric antigen receptor better than just injecting anti-CD19 antibodies? Since our natural killer cells can kill the ... Comments Off on Why is chimeric antigen receptor better than just injecting anti-CD19 antibodies? Since our natural killer ...
  https://tirumalaikamala.wordpress.com/2016/12/28/why-is-chimeric-antigen-receptor-better-than-just-injecting-anti-cd19-antibodies-since-our-natural-killer-cells-can-kill-the-cells-attached-with-antibodies-via-antibody-dependent-cell-mediated-cytoto/
*  Hairy Cell Leukemia Treatment (PDQ )
In addition to the B-cell antigens CD19, CD20, and CD22, the cells coexpress CD11c, CD25, and CD103. The BRAF-V600E mutation is ...
  https://www.meb.uni-bonn.de/cancer.gov/CDR0000062926.html
*  Frontiers | DNA damage response and evasion from immunosurveillance in CLL: new options for NK cell-based immunotherapies |...
These constructs target different tumor antigens (CD33, CD123, and CD19) and are currently tested for effectiveness (Singer et ... T cells with specificity for the common B cell antigens CD19, CD20, and CD23 were generated (Riches and Gribben, 2013). Initial ... 2007). Human leukocyte antigen-B-associated transcript 3 is released from tumor cells and engages the NKp30 receptor on natural ... Professional antigen presenting cells (APCs) such as dendritic cells (DCs) phagocytose components of dying tumor cells and ...
  https://www.frontiersin.org/articles/10.3389/fgene.2015.00011/full
*  A Dose-Escalation Study of SAR3419, an Anti-CD19 Antibody Maytansinoid Conjugate, Administered by Intravenous Infusion Once...
CD19 is the earliest differentiation antigen of the B lineage and is ubiquitously expressed on all types of B lymphocytes ... CD19 antigen in leukemia and lymphoma diagnosis and immunotherapy. Leuk Lymphoma 1995;18:385-97. ... CD19, the earliest differentiation antigen of the B cell lineage, bears three extracellular immunoglobulin-like domains and an ... SAR3419: An anti-CD19-Maytansinoid Immunoconjugate for the treatment of B-cell malignancies. Clin Cancer Res 2011 17:6448-6458 ...
  http://clincancerres.aacrjournals.org/content/20/1/213
*  Anti-CD19 antibody (Phycoerythrin) [CB19] | Abcam
Anti-CD19 antibody conjugated to Phycoerythrin [CB19] validated for Flow Cyt and tested in Human. Referenced in 3 publications ... Assembles with the antigen receptor of B lymphocytes in order to decrease the threshold for antigen receptor-dependent ... CD3 and NKG2a positive population were negative for CD19 staining.All CD20 positive cells also stained positive for CD19. ... The CD19/CD21 signal transducing complex of human B lymphocytes includes the target of antiproliferative antibody-1 and Leu-13 ...
  http://www.abcam.com/cd19-antibody-cb19-phycoerythrin-ab1168.html
*  Search of: Farber's Disease - List Results - ClinicalTrials.gov
T-Lymphocytes Genetically Targeted to the B-Cell Specific Antigen CD19 in Pediatric and Young Adult Patients With Relapsed B- ... The secondary objective is to correlate the clinical and prostate-specific antigen (PSA) response with baseline serum ...
  https://clinicaltrials.gov/ct2/results?term=Farber
*  B23 Influence of mycoplasma arginini on inflammatory response and energy metabolism in human cells with and without HTT gene...
However, Antigen CD19 presentation and the EBV copy number in both contaminated cell lines were reduced more effectively than ... Monitoring of the M. arginini, EBV copies and CD19 antigen were measured by qPCR and flow cytometry, respectively. ...
  http://jnnp.bmj.com/content/87/Suppl_1/A17.1
*  Blinatumomab antibody molecule, artwork - Stock Image C029/1339 - Science Photo Library
A molecule of blinatumomab combines two binding sites: a CD3 site for T cells and a CD19 site for the target B cells. CD3 is ... specifically targets the CD19 antigen present on B cells. Blinatumomab enables a patient's T cells to recognize malignant B ... specifically targets the CD19 antigen present on B cells. Blinatumomab enables a patient's T cells to recognize malignant B ... Keywords: activating, activity, acute, adult, antibodies, antibody, antigen, artwork, bi-specific, bites, blinatumomab, cancer ...
  http://www.sciencephoto.com/media/723003/view
*  BRAF V600E mutation in hairy cell leukemia: from bench to bedside | Blood Journal
2 The HCL cells are positive for the B-cell-associated antigens CD19, CD20, and CD22 and typically coexpress the CD103, CD25, ...
  http://www.bloodjournal.org/content/128/15/1918?sso-checked=true
*  Anti-CD19 (FMC-63) h(t2B4-CD3ζ) CAR, pCDCAR1 vector - Creative Biolabs
Creative Biolabs provides Anti-CD19 (FMC-63) h(t2B4-CD3ζ) CAR, pCDCAR1 product for Biopharmaceutical research,preclinical and ... CD19; CD19 molecule; B4; CVID3; B-lymphocyte antigen CD19; differentiation antigen CD19; T cell surface antigen Leu-12; B- ... The vector of anti-CD19 chimeric antigen receptor (CAR) is constructed for the engineering of NK cells to target human CD19. ... Lenti-CD19 CAR (scFv-CD28-CD27-CD3ζ, 47G4) Viral Particle. VP-CAR-LC633 Lenti-CD19 CAR (scFv-41BB-CD3ζ, 104882) Viral Particle ...
  https://www.creative-biolabs.com/car-t/cd19-fmc-63-h-t2b4-cd3%CE%B6-car-1471.htm
*  Plasma cell - Wikipedia
Surface antigens[edit]. Terminally differentiated plasma cells express relatively few surface antigens, and do not express ... common pan-B cell markers, such as CD19 and CD20. Instead, plasma cells are identified through flow cytometry by their ... Another important surface antigen is CD319 (SLAMF7). This antigen is expressed at high levels on normal human plasma cells. It ... After leaving the bone marrow, the B cell acts as an antigen presenting cell (APC) and internalizes offending antigens, which ...
  https://en.wikipedia.org/wiki/Plasma_cells