*  Immunotherapy of non-Hodgkin's lymphoma with a defined ratio of CD8+ and CD4+ CD19-specific chimeric antigen receptor-modified...
CD19-specific chimeric antigen receptor (CAR)-modified T cells have antitumor activity in B cell malignancies, but factors that ... Immunotherapy of non-Hodgkin's lymphoma with a defined ratio of CD8+ and CD4+ CD19-specific chimeric antigen receptor-modified ... Immunotherapy of non-Hodgkin's lymphoma with a defined ratio of CD8+ and CD4+ CD19-specific chimeric antigen receptor-modified ... Immunotherapy of non-Hodgkin's lymphoma with a defined ratio of CD8+ and CD4+ CD19-specific chimeric antigen receptor-modified ...
  http://stm.sciencemag.org/content/8/355/355ra116
*  Adoptive cell transfer - Wikipedia
Antigen CD19 appears only on B cells, which go awry in lymphoma and leukemia. Loss of B cells can be countered with ... In 2016, CD19-specific chimeric antigen receptor (CAR)-modified T cells were used to treat patients with relapsed and ... against B cell antigen CD19 was shown to mediate regression of an advanced B cell lymphoma. In 2009, a woman given T cells ... "Acquisition of a CD19-negative myeloid phenotype allows immune escape of MLL-rearranged B-ALL from CD19 CAR-T-cell therapy". ...
  https://en.wikipedia.org/wiki/Adoptive_cell_transfer
*  Blinatumomab - Wikipedia
Blinatumomab specifically targets the CD19 antigen present on B cells. In December 2014 it was approved by the US Food and Drug ... A molecule of blinatumomab combines two binding sites: a CD3 site for T cells and a CD19 site for the target B cells. CD3 is ... CD3 and CD19 are expressed in both pediatric and adult patients, making blinatumomab a potential therapeutic option for both ... "CD19-/CD3-bispecific antibody of the BiTE class is far superior to tandem diabody with respect to redirected tumor cell lysis ...
  https://en.wikipedia.org/wiki/Blinatumomab
*  Bing-Neel syndrome - Wikipedia
With respect to diagnosing BNS, flow cytometry analyzes CSF contents for B-cells expressing the pan antigens CD19 and CD20, ...
  https://en.wikipedia.org/wiki/Bing%E2%80%93Neel_syndrome
*  CD19 - Wikipedia
Mouse CD Antigen Chart Human CD Antigen Chart Human CD19 genome location and CD19 gene details page in the UCSC Genome Browser ... CD19 CD19 molecule". Tedder TF, Isaacs CM (Jul 1989). "Isolation of cDNAs encoding the CD19 antigen of human and mouse B ... B-lymphocyte antigen CD19, also known as CD19 (Cluster of Differentiation 19), is a protein that in humans is encoded by the ... Since 2011, anti-CD19 immunotoxin treatments targeting CD19 have begun to enter trials. Most current experimental anti-CD19 ...
  https://en.wikipedia.org/wiki/CD19
*  B-Cell Prolymphocytic Leukemia - Wikipedia
... b-lymphocyte surface antigens CD19, CD20, CD22, CD79a and FMC7, and weak expression of CD5 and CD23. Due to the similarities ... B-lymphocytes have two responsibilities: Production of antibodies - In response to antigens, B-lymphocytes produce and release ... one of its key identifiers is the absence in expression of the surface antigens CD10, CD11c, CD25, CD103 and cyclin D1 - an ... Interactions between antibodies and antigens allow B-lymphocytes to establish cellular memories, otherwise known as immunities ...
  https://en.wikipedia.org/wiki/B-Cell_Prolymphocytic_Leukemia
*  Acute lymphoblastic leukemia - Wikipedia
In this therapy, mice are immunized with the CD19 antigen and produce anti-CD19 antibodies. Hybridomas developed from mouse ... cytotoxic proteins and proliferation of T cells to kill CD19 B cells. Chimeric antigen receptors (CARs) have been developed as ... Human Antibodies Against Cell Surface Tumor Antigens Selected From Repertoires Displayed on T Cell Chimeric Antigen Receptors ... CD19 is a molecule found on all B-cells and can be used as a means of distinguishing the potentially malignant B-cell ...
  https://en.wikipedia.org/wiki/Acute_lymphoblastic_leukemia
*  Kite Pharma - Wikipedia
... which a patient's T cells are genetically modified to express a chimeric antigen receptor designed to target the antigen CD19, ... which a patient's T cells are genetically modified to express a chimeric antigen receptor designed to target the antigen CD19, ... Anti-CD19 Chimeric Antigen Receptor (CAR) T-Cell Therapy, for Refractory Aggressive Non-Hodgkin's Lymphoma (NHL) ". MarketWatch ... with the NCI for the research and clinical development of a fully human anti-CD19 chimeric antigen receptor (CAR) product ...
  https://en.wikipedia.org/wiki/Kite_Pharma
*  MALT lymphoma - Wikipedia
B-cell-associated antigens such as CD19, CD20, CD22, and CD79a are usually expressed. In contrast to small lymphocytic lymphoma ...
  https://en.wikipedia.org/wiki/MALT_lymphoma
*  David G. Maloney - Wikipedia
Turtle, C., Riddell, S. & Maloney, D. (2016). CD19-Targeted chimeric antigen receptor-modified T-cell immunotherapy for B-cell ... Immunotherapy of non-Hodgkin's lymphoma with a defined ratio of CD8+ and CD4+ CD19-specific chimeric antigen receptor-modified ... doi:10.1002/cpt.392 Turtle, C. J., & Maloney, D. G. (2016). Clinical trials of CD19-targeted CAR-modified T cell therapy; a ... Maloney leads an early-phase clinical trial for patients with certain advanced, treatment-resistant CD19-positive B-cell ...
  https://en.wikipedia.org/wiki/David_G._Maloney
*  List of MeSH codes (D23) - Wikipedia
... antigens, cd15 MeSH D23.050.301.264.035.118 --- antigens, cd18 MeSH D23.050.301.264.035.119 --- antigens, cd19 MeSH D23.050. ... antigens, cd5 MeSH D23.050.301.264.051.119 --- antigens, cd19 MeSH D23.050.301.264.051.120 --- antigens, cd20 MeSH D23.050. ... antigens, cd15 MeSH D23.101.100.110.118 --- antigens, cd18 MeSH D23.101.100.110.119 --- antigens, cd19 MeSH D23.101.100.110.120 ... antigens, cd5 MeSH D23.101.100.150.119 --- antigens, cd19 MeSH D23.101.100.150.120 --- antigens, cd20 MeSH D23.101.100.150.140 ...
  https://en.wikipedia.org/wiki/List_of_MeSH_codes_(D23)
*  Juno Therapeutics - Wikipedia
The trials will assess combinations of MEDI4736 and one of Juno's CD19 directed chimeric antigen receptor T cell candidates. In ... In December 2014 the company signed an agreement with Opus Bio, Inc for a chimeric antigen receptor (CAR-T) cell product ... "A Pediatric and Young Adult Trial of Genetically Modified T Cells Directed Against CD19 for Relapsed/Refractory CD19+ Leukemia ... fully human binding domain targeting B-cell maturation antigen. In January 2018, Celgene announced it would acquire Juno for $9 ...
  https://en.wikipedia.org/wiki/Juno_Therapeutics
*  AstraZeneca - Wikipedia
The trials will assess combinations of MEDI4736 and one of Juno Therapeutics' CD19 directed chimeric antigen receptor T-cell ...
  https://en.wikipedia.org/wiki/AstraZeneca
*  Induced stem cells - Wikipedia
Another method combines iPSC and chimeric antigen receptor (CAR) technologies to generate human T cells targeted to CD19, an ... DC-like antigen-presenting cells obtained from human induced pluripotent stem cells can serve as a source for vaccination ... Thus, the ability to generate platelet products ex vivo and platelet products lacking HLA antigens in serum-free media would ... A potentially efficient approach for generating antigen-specific CTLs is to revert mature immune T cells into iPSCs, which ...
  https://en.wikipedia.org/wiki/Induced_stem_cells
*  Tumor antigens recognized by T lymphocytes - Wikipedia
... observed in leukemic patients infused with T cells genetically engineered to carry an artificial receptor that recognizes CD19 ... In some patients, the majority of the tumor-specific T cells recognize mutated antigens. The contribution of these antigens to ... The carcinoma cells still harbour the viral genes and antigens. As expected T cell responses against antigens encoded by genes ... Cancer therapy targeted at tumor antigens can involve the direct use of these antigens in vaccines, but also the adoptive ...
  https://en.wikipedia.org/wiki/Tumor_antigens_recognized_by_T_lymphocytes
*  LYN - Wikipedia
In these cells, a small amount of LYN is associated with cell surface receptor proteins, including the B cell antigen receptor ... BCR), CD40, or CD19. The abbreviation Lyn is derived from Lck/Yes novel tyrosine kinase, Lck and Yes also being members of the ... Brown VK, Ogle EW, Burkhardt AL, Rowley RB, Bolen JB, Justement LB (Jun 1994). "Multiple components of the B cell antigen ... Yamamoto T, Yamanashi Y, Toyoshima K (Apr 1993). "Association of Src-family kinase Lyn with B-cell antigen receptor". ...
  https://en.wikipedia.org/wiki/LYN
*  Acute biphenotypic leukaemia - Wikipedia
The presence of specific T-lymphoid antigens, cytoplasmic CD3 (cCD3), MPO and CD 19 became the most important standard for ...
  https://en.wikipedia.org/wiki/Acute_biphenotypic_leukaemia
*  CD79B - Wikipedia
... induced tyrosine phosphorylation of CD19 requires a CD19 domain that mediates association with components of the B cell antigen ... It is associated with agammaglobulinemia-6. The B lymphocyte antigen receptor is a multimeric complex that includes the antigen ... Müller B, Cooper L, Terhorst C (1995). "Interplay between the human TCR/CD3 epsilon and the B-cell antigen receptor associated ... 1994). "CD5 is associated with the human B cell antigen receptor complex". Eur. J. Immunol. 24 (4): 812-6. doi:10.1002/eji. ...
  https://en.wikipedia.org/wiki/CD79B
*  Complement receptor 2 - Wikipedia
CD19 and CD81(=TAPA-1). The CR2-CD19-CD81 complex is often called the B cell coreceptor complex, because CR2 binds to antigens ... Complement receptor 2 has been shown to interact with CD19. Epstein-Barr virus (EBV) binds to B cells at CR2 during infection ... Horváth G, Serru V, Clay D, Billard M, Boucheix C, Rubinstein E (November 1998). "CD19 is linked to the integrin-associated ... Philadelphia: Saunders, ISBN 0-7216-0008-5 Bradbury LE, Kansas GS, Levy S, Evans RL, Tedder TF (November 1992). "The CD19/CD21 ...
  https://en.wikipedia.org/wiki/Complement_receptor_2
*  Plasma cell - Wikipedia
Another important surface antigen is CD319 (SLAMF7). This antigen is expressed at high levels on normal human plasma cells. It ... such as CD19 and CD20. Instead, plasma cells are identified through flow cytometry by their additional expression of CD138, ... After leaving the bone marrow, the B cell acts as an antigen presenting cell (APC) and internalizes offending antigens, which ... Pieces of the antigen (which are now known as antigenic peptides) are loaded onto MHC II molecules, and presented on its ...
  https://en.wikipedia.org/wiki/Plasma_cell
*  Chimeric antigen receptor - Wikipedia
The first two FDA approved CAR-T therapies were targeted at CD19 (found on many types of lymphoma cells). The approved ... A spacer region links the antigen binding domain to the transmembrane domain. It should be flexible enough to allow the antigen ... Bridgeman, JS; Hawkins RE; Bagley S; Blaylock M; Holland M; Gilham DE (2010). "The Optimal Antigen Response of Chimeric Antigen ... A list of tumors antigens and CARs in in vitro and in vivo trials A list of tumors antigens and CARs in in vitro and in vivo ...
  https://en.wikipedia.org/wiki/Chimeric_antigen_receptor
*  Co-stimulation - Wikipedia
Co-stimulation is required in addition to the antigen-specific signal from their antigen receptors. T cells require two signals ... CR2 on mature B cells forms a complex with CD19 and CD81. This complex is called the B cell coreceptor complex for such ... B cell binds antigens with its BCR (a membrane-bound antibody), which transfers intracellular signals to the B cell as well as ... The latter case induces recognition by antigen-specific Th2 cells, leading to activation of the B cell through binding of TCR ...
  https://en.wikipedia.org/wiki/Co-stimulation
*  Fuat Oduncu - Wikipedia
A recombinant triplebody with specificity for CD19 and HLA-DR mediates preferential binding to antigen double-positive cells by ... These molecules present antibody-derivatives and small molecules which specifically bind to the surface antigens of cancer ... A Novel CD19-directed recombinant bispecific antibody derivative with enhanced immune effector functions for human leukemic ... A dual-targeting triplebody mediates preferential redirected lysis of antigen double-positive over single-positive leukemic ...
  https://en.wikipedia.org/wiki/Fuat_Oduncu
*  Biochemical cascade - Wikipedia
CD28/CD19) play an important role because they can improve the antigen/receptor binding and initiate parallel cascade events, ... These receptors, that recognize the antigen soluble (B cells) or linked to a molecule on Antigen Presenting Cells (T cells), ... The antigen receptor and signal protein form a stable complex, named BCR or TCR, in B or T cells, respectively. The family Src ... Therefore, Lyn and Lck, in lymphocytes B and T, respectively, phosphorylate ITAMs after the antigen recognition and the ...
  https://en.wikipedia.org/wiki/Biochemical_cascade
*  Cancer immunotherapy - Wikipedia
Dendritic cells are antigen presenting cells (APCs) in the mammalian immune system. In cancer treatment they aid cancer antigen ... This treatment cleans CD19 positive cells from the body (including the disease). Antibodies are a key component of the adaptive ... Cancer vaccine Antigen 5T4 Chimeric antigen receptor Coley's Toxins Combinatorial ablation and immunotherapy Cryoimmunotherapy ... Antigens can be added to the antibody and can induce the dendritic cells to mature and provide immunity to the tumor. Dendritic ...
  https://en.wikipedia.org/wiki/Cancer_immunotherapy