*  HLA A1-B8-DR3-DQ2 - Wikipedia
... its major antigen genes superficially resemble European A1-B8 and it appears to be a homoplastic recombinant from a common DR3- ... There are many genes that lie on either side of HLA-B, TNF alpha is over expressed. Closer to DR3, C4A is null in B8-DR3 ... July 2008). "Autoimmune-associated HLA-B8-DR3 haplotypes in Asian Indians are unique in C4 complement gene copy numbers and HSP ... DR3 is found to correlate with anti-Ro/La antibodies in SLE. HLA-DR3 has been consistently observed at high frequencies in ...
  https://en.wikipedia.org/wiki/HLA_A1-B8-DR3-DQ2
*  HLA DR3-DQ2 - Wikipedia
"HLA gene and haplotype frequencies in Dutch blood donors". Tissue Antigens. 48 (5): 562-74. doi:10.1111/j.1399-0039.1996. ... HLA-DR3-DQ2 is found in HLA A1-B8-DR3-DQ2 haplotype in Northern Europeans (including the British Ilse, Ireland, Iceland). HLA ... C regions of the HLA gene complex in northern and northwestern Europe. The linked haplotype is HLA A1-B8-DR3-DQ2 (AH8.1 in the ... The DR3-DQ2 haplotype is notable because of the very strong linkage between genes that extends into the HLA-A, -B and - ...
  https://en.wikipedia.org/wiki/HLA_DR3-DQ2
*  A30-Cw5-B18-DR3-DQ2 (HLA Haplotype) - Wikipedia
March 2000). "HLA genes in Arabic-speaking Moroccans: close relatedness to Berbers and Iberians". Tissue Antigens. 55 (3): 239- ... there is also the B18-DR3 component and the HLA DR3-DQ2.5. Other haplotypes such as Cw5-B16-DR3 or B8-DR3-DQ2.5 have been ... Müller CR, Ehninger G, Goldmann SF (January 2003). "Gene and haplotype frequencies for the loci hLA-A, hLA-B, and hLA-DR based ... September 2008). "Autoimmune-associated HLA-B8-DR3 haplotypes in Asian Indians are unique in C4 complement gene copy numbers ...
  https://en.wikipedia.org/wiki/A30-Cw5-B18-DR3-DQ2_(HLA_Haplotype)
*  Immunoglobulin D Deficiency: Background, Pathophysiology, Epidemiology
The [HLA-B18, F1C30, DR3] conserved extended haplotype carries a susceptibility gene for IgD deficiency. J Clin Immunol. 2000 ... 9, 10] IgD deficiency is associated with the specific human leukocyte antigens HLA-B18, F1C30, and DR3 in a Spanish Basque ... HLA-B8, SC01, DR3] conserved extended haplotype. Tissue Antigens. 2000 Sep. 56(3):207-16. [Medline]. ... 11] and HLA-B8, SC01, DR3 in white subjects in an American study. [12] A 2008 report noted that depletion of circulating IgD+ ...
  https://emedicine.medscape.com/article/136803-overview
*  Nutritional Intervention to Prevent Diabetes - Full Text View - ClinicalTrials.gov
There is a higher risk of developing T1D with the presence of the human leukocyte antigen (HLA) DR3 or DR4. It is also known ... At birth, or soon after, their babies will be tested for HLA type (to look for the specific gene which confers a higher risk of ... These babies will also be tested for HLA type. Their eligibility will be based on the presence of higher risk genes or the ... If the HLA typing shows that the baby is at higher risk for T1D and no protective genes are present, the baby will then ...
  https://clinicaltrials.gov/ct2/show/NCT00333554?term=diabetes+type+1+AND+
*  HLA-DR3 - Wikipedia
HLA-DR3 is composed of the HLA-DR17 and HLA-DR18 split 'antigens' serotypes. DR3 is a component gene-allele of the AH8.1 ... Type 1 diabetes mellitus is strongly associated with HLA-DR3 or HLA-DR4. Some DR3 also react with HLA-DR17 and/or HLA-DR18. The ... 2007). "Primary sclerosing cholangitis is associated with extended HLA-DR3 and HLA-DR6 haplotypes". Tissue Antigens. 69 (2): ... DR3 is genetically linked to HLA-DR52, DRB3*0202 allele, and HLA-DQ2 (DQ2.5). derived from IMGT/HLA Wiencke K, Karlsen TH, ...
  https://en.wikipedia.org/wiki/HLA-DR3
*  The genetic basis for the association of the 8.1 ancestral haplotype (A1, B8, DR3) with multiple immunopathological diseases -...
Several candidate genes in the central MHC have the potential to modulate immune or inflammatory responses in an antigen- ... This review concerns the 8.1 AH (HLA-A1, C7, B8, C4AQ0, C4B1, DR3, DQ2), which is carried by most Caucasians with HLA-B8. It is ... We have mapped susceptibility genes for HIV, IDDM and myasthenia gravis co the central MHC between HLA-B and the tumour ... Here we consider which of the remaining 8.1-associated diseases are more closely associated with HLA-DR3 and/or DQ2. ...
  http://researchrepository.murdoch.edu.au/id/eprint/15013/
*  JCI Insight - Single-cell analysis of glandular T cell receptors in Sjögren's syndrome
9 of whom shared the HLA DR3/DQ2 risk haplotype. TCRα and β sequences were obtained from a median of 91 SG and 107 PB cells per ... The degree of clonal expansion and frequency of cells expressing two productively rearranged α genes were increased in SG ... Knowledge of paired TCRα and β sequences enables further work toward identification of target antigens and development of novel ... CD4+ T cells predominate in salivary gland (SG) inflammatory lesions in Sjögren's syndrome (SS). However, their antigen ...
  https://insight.jci.org/articles/view/85609/pdf
*  JCI Insight - Single-cell analysis of glandular T cell receptors in Sjögren's syndrome
HLA imputation. To confirm the presence of HLA DR3 and DQ2 alleles, classical HLA alleles were imputed from SNP data by the HLA ... our work directly assesses the gene usage of antigen-experienced CD4 T cells, not the sum of all T cells present in SG, which ... although our subjects share the HLA DR3/DQ2 risk haplotype, the HLA restriction of the TCRs reported here remains unknown. ... Unlike in prior reports, the subject cohort in our study was selected for the presence of the HLA DR3/DQ2 risk haplotype as ...
  https://insight.jci.org/articles/view/85609
*  HLA-DR17 - Wikipedia
DR17 is part of the broader antigen group HLA-DR3 and is very similar to the group HLA-DR18. DR17 recognizes the DRB1*0301, * ... These serotypes are the result of gene products from the HLA-DRB3* and HLA DQA1*0501 and HLA DQB1*0201 alleles. DRB1*0301 is ... HLA-DR17 (DR17) is an HLA-DR serotype that recognizes the DRB1*0301 and *0304 gene products. DR17 is found at high frequency in ... 2007). "HLA class I and class II frequencies in patients with sarcoidosis from Croatia: role of HLA-B8, −DRB1*0301, and −DQB1* ...
  https://en.wikipedia.org/wiki/HLA-DR17
*  HLA-DQ6 - Wikipedia
doi:10.1038/sj.gene.6364058. PMID 15014429. Boberg KM, Spurkland A, Rocca G, et al. (August 2001). "The HLA-DR3,DQ2 ... HLA-DQ6 (DQ6) is a human leukocyte antigen serotype within HLA-DQ (DQ) serotype group. The serotype is determined by the ... "Identification by genomic typing of non-DR3 HLA class II genes associated with myasthenia gravis". J Neuroimmunol. 47 (2): 115- ... 1994). "HLA-DQA1, -DQB1 and -DRB1 genotyping in Japanese pemphigus vulgaris patients by the PCR-RFLP method". Tissue Antigens. ...
  https://en.wikipedia.org/wiki/HLA-DQ6
*  HLA A1-B8 haplotype - Wikipedia
April 1990). "A1, Cw7, B8, DR3 HLA antigen combination associated with rapid decline of T-helper lymphocytes in HIV-1 infection ... Müller C, Ehninger G, Goldmann S (2003). "Gene and haplotype frequencies for the loci hLA-A, hLA-B, and hLA-DR based on over ... HLA A1-B8 (Also:HL A1,8; HL A1,A8; HLA A1-Cw7-B8; HLA A*01-B*08, HLA A*0101-B*0801, HLA A*0101-Cw*0701-B*0801; HLA A*01:01-C*07 ... HLA)-DR3 haplotypes depends on genotypic context: association of DPB1 and HLA class I loci among DR3- and DR4-matched Italian ...
  https://en.wikipedia.org/wiki/HLA_A1-B8_haplotype
*  Peyronie's Disease Causes
... most notably HLA-A1, HLA-B7, HLA-B8, HLA-B44, HLA-Cw7, HLA-DR3 and HLA-DQ546), potentially suggesting real genetic predilection ... Several retrospective studies revealed a link between Peyronie's disease and a variety of histocompatibility antigens ( ... with the expression of multiple fibrosis-promoting genes. ...
  https://www.news-medical.net/health/Peyronies-Disease-Causes.aspx
*  Patent WO1989004875A2 - Characterization and detection of sequences associated with autoimmune diseases - Google Patents
DNA sequences and corresponding amino acid sequences from the HLA class II beta region of the human genome that are associated ... Molecular analyses of the HLA genes herein has resulted in further subdivision of the HLA DR3, DR4 and DRw6 serological types ... Hla-dr antigen gene, its nucleotide sequence and its use. EP0527199A1 *. 1 May 1991. 17 Feb 1993. Univ Leland Stanford Junior. ... HLA class II DR-beta genes have been isolated from HLA- typed IDDM patients and HLA-matched controls and have been sequenced, ...
  http://www.google.com.au/patents/WO1989004875A2?cl=en
*  HLA typing is not predictive of proliferative diabetic retinopathy in patients with younger onset type 2 diabetes mellitus |...
The frequencies of HLA-A, B, and Cw antigens in the control group, the non-DR group, and the PDR group are shown in table 2, ... The type 2 diabetic patients in this study showed a typical HLA pattern. Other research has reported that DR3, DR4, and Cw4 ... 10 Type 2 diabetes is not autoimmune and has less association or linkage with genes in the HLA region than type 1. ... Human leucocyte antigen (HLA) status has a significant role in immune responses and immunological tolerance and is a factor in ...
  http://bjo.bmj.com/content/88/2/303
*  HLA-DQ2 - Wikipedia
This haplotype, HLA A1-B8-DR3-DQ2, is associated with diseases in which HLA-DQ2 has suspect involvement. Direct involvement of ... doi:10.1038/sj.gene.6364061. PMID 15014431. Karell K, Louka AS, Moodie SJ, et al. (April 2003). "HLA types in celiac disease ... high-resolution and large sample typing of HLA DR-DQ haplotypes in a sample of European Americans". Tissue Antigens. 62 (4): ... HLA-DR3 plays a prominent role in autoimmune diabetes. However, DQ2 presence with DR3 decreases the age of onset and the ...
  https://en.wikipedia.org/wiki/HLA-DQ2
*  HLA-B8 - Wikipedia
B8 is a component gene-allele of the AH8.1 haplotype in Northern and Western Europeans. Genes between B8 and DR3 on this ... HLA-B8, previously known as HL-A8 was one of the first identified of the HLA antigens. It coined the "Super B8" haplotype, also ... HLA-B8 (B8) is an HLA-B serotype. The serotype identifies the HLA-B*08 gene products. (For terminology help see: HLA-serotype ... 2005). "Nomenclature for factors of the HLA system, 2004". Tissue Antigens. 65 (4): 301-69. doi:10.1111/j.1399-0039.2005.00379. ...
  https://en.wikipedia.org/wiki/HLA-B8
*  JCI Insight - Targeting CLEC9A delivers antigen to human CD141+ DC for CD4+ and CD8+T cell recognition
Ag presentation to CD8+ and CD4+ T cells. DCs from HLA-A*0201+ or HLA-DR3+ donors were incubated for 2 hours in the presence of ... Plasmids encoding heavy and light chains in pcDNA3.1+ were generated by gene synthesis of codon-optimized variable region ... containing the CMV pp65 HLA-DR3-restricted epitope AGI and HLA-A*0201-restricted epitope NLV and a FLAG tag DYKDDDDK to ... We confirmed that soluble pp65 Ag could be equally processed and that the AGI epitope was presented by HLA-DR3-restricted CD141 ...
  https://insight.jci.org/articles/view/87102?mc_cid=cbef8d27d0&mc_eid=c74be96a2e
*  Descriptive epidemiology of IDDM in Hokkaido, Japan: the Childhood IDDM Hokkaido Registry. - Semantic Scholar
Relationship of Type 1 Diabetes with Human Leukocyte Antigen (HLA) Class II Antigens Except for DR3 and DR4. *Masahito Katahira ... The Relationship Between Human Leukocyte Antigen Class II Genes and Type 1 Diabetes, Autoimmune Thyroid Diseases, and ... PD-1 gene haplotype is associated with the development of type 1 diabetes mellitus in Japanese children. *Ronghua Ni, Kenji ...
  https://www.semanticscholar.org/paper/Descriptive-epidemiology-of-IDDM-in-Hokkaido%2C-Japa-Matsuura-Fukuda/fa1a261eb7629c50b5be71a9ab512b5cb92b96e3
*  Sjögren syndrome - Wikipedia
Studies on the polymorphisms of human leukocyte antigen (HLA)-DR and HLA-DQ gene regions in SS patients show differential ... and DR3 genes.[22] HLA class II alleles are associated with the presence of specific subsets of autoantibodies, rather than ... Patients of different ethnic origin carry different HLA susceptibility alleles, of which, HLA-DR and HLA-DQ are involved in the ... HLA-DQ2 and HLA-B8 are generally found in Caucasian patients, while HLA-DR5 is related to Greek and Israeli patients.[59] ...
  https://en.m.wikipedia.org/wiki/Sj%C3%B6gren%27s_syndrome
*  Influence of Secondary Antiphospholipid Syndrome and Secondary Sjögren's Syndrome on Patient's Quality of Life with Systemie...
... including antigens HLA class II DR2, DR3 [8], but many other genes outside of this system) [4,9-14], hormones, [15-17] ( ... An important role in its development are genetic factors (including HLA DR2, HLA-DR3, HLA-B7, HLA DQ) and environmental (viral ... Castaño-Rodríguez N, Diaz-Gallo LM, Pineda-Tamayo R, Rojas-Villarraga A, Anaya JM (2008) Meta-analysis of HLA-DRB1 and HLA-DQB1 ... Genes Immun 10(5): 373-379.. *Suarez-Gestal M, Calaza M, Endreffy E, Pullmann R, Ordi-Ros J, et al. (2009) Replication of ...
  http://googlescholar.medcraveonline.com/scholars/article_fulltext/4919
*  Autoimmune Thyroid Disorders
... with certain HLA alleles such as DR3. There is linkage to certain alleles of the gene for CTLA-4. The thyroglobulin gene has ... In order for HLA class II antigen expression and presentation of antigens to be realized, there must be a local insult to ... Y. Tomer and T. F. Davies, "Searching for the autoimmune thyroid disease susceptibility genes: from gene mapping to gene ... Among the major AITD susceptibility genes that have been identified and characterized is the HLA-DR gene locus, as well as non- ...
  https://www.hindawi.com/journals/isrn/2013/509764/
*  HLA Genes, Islet Autoantibodies and Residual C-Peptide at the Clinical Onset of Type 1 Diabetes Mellitus...
HLA antigens and other risk factors in the development of retinopathy in type 1 diabetes. Br J Ophthalmol. 1982;66:280-285. [ ... HLA-DR3 and DR4 and their relation to the incidence and progression of diabetic retinopathy. Ophthalmology. 2002;109:275-281. [ ... Tissue Antigens. 1993;41:55-56. [PubMed]. 58. Olerup O, Zetterquist H. HLA-DR typing by PCR amplification with sequence- ... The HLA gene complex has been repeatedly studied for its association with DR for the past 30 years with both negative [29], [30 ...
  http://pubmedcentralcanada.ca/pmcc/articles/PMC3055880/?lang=en-ca
*  Hashimoto's | Pearltrees
... associated with HLA-DR3 gene inheritance enlarged thyroid (goiterous form) through HLA-DR5 inheritance These genes are common ... This inadvertently causes a cross-reaction with our "self" antigens, i.e., our own cells. ... This is only partially true - genes are not our destiny! Is Hashimoto's Hypothyroidism Genetic? And What To Do About Genes. ... Many people have asked me if Hashimoto's is genetic, and if so, is there anything we can do about our genes? ...
  http://www.pearltrees.com/wizard1807/hashimoto/id15920776
*  Human leukocyte antigen - Wikipedia
HLA-C. Minor genes are HLA-E, HLA-F and HLA-G. β2-microglobulin binds with major and minor gene subunits to produce a ... A*01:01 ; C*07:01 ; B*08:01 ; DRB1*03:01 ; DQA1*05:01 ; DQB1*02:01 (By serotyping A1-Cw7-B8-DR3-DQ2) ... "Frequencies of HLA-A, HLA-B, HLA-DR, and HLA-DQ phenotypes in the United Arab Emirates population". Tissue Antigens. 66 (2): ... The HLA gene complex resides on a 3 Mbp stretch within chromosome 6p21. HLA genes are highly polymorphic, which means that they ...
  https://en.wikipedia.org/wiki/Human_leucocyte_antigen