*  HLA-DR expression on monocytes and systemic inflammation in patients with ruptured abdominal aortic aneurysms | Critical Care |...
This study shows that, in the first days after RAAA repair, patients develop a generalised increase in immunoregulatory cytokines as reflected by elevated levels of IL-6 and IL-10. HLA-DR expression on monocytes is reduced and remains consistently low in non-survivors, while it returns to normal levels in survivors. Early high levels of IL-6 and IL-10 and subsequently reduced HLA-DR were all associated with multiple-organ failure and death.. Several studies have shown that a severe inflammatory response is associated with multiple organ failure and poor outcome in RAAA patients [9, 17, 18]. It is believed that, in RAAA patients, haemorrhagic shock, surgical trauma and ischemia reperfusion injury all contribute to this overwhelming inflammatory response. Blood-transfusions and surgery for sigmoid necrosis may also modulate the inflammatory response [19, 20]. Our study confirms the presence of such an inflammatory response by demonstrating an ...
  https://ccforum.biomedcentral.com/articles/10.1186/cc5017
*  Recombinant gamma interferon induces HLA-DR expression on cultured human keratinocytes. - Semantic Scholar
In normal human epidermis, expression of HLA-DR antigen is restricted to Langerhans cells (LC) and acrosyringial epithelium. However, in diseases such as lichen planus and graft-vs.-host, HLA-DR antigen appears to be expressed by keratinocytes, although the exact source of the HLA-DR is unclear. Two possibilities are that (1) the HLA-DR is shed by neighboring immunocompetent cells, or (2) that the keratinocytes are synthesizing the antigen themselves. Recently, gamma interferon has been shown to induce HLA-DR biosynthesis and expression on human malignant melanoma cells lines and on normal vascular endothelium. We report here that pure recombinant human gamma interferon (100 units/ml) induces HLA-DR ...
  https://www.semanticscholar.org/paper/Recombinant-gamma-interferon-induces-HLA-DR-expres-Basham-Nickoloff/6782a2cea1b780723995cb1e4e2d21823f0a605a
*  Association of Helicobacter pylori with HLA-DR antigen expression in gastritis. | Journal of Clinical Pathology
AIMS: To assess the association between Helicobacter pylori-associated gastritis and HLA-DR antigen (class II antigen) expression. METHODS: Fifty endoscopic gastric biopsy specimens were studied for the presence of H pylori, degree and type of inflammation, and for HLA-DR antigen expression in the epithelium. The cases were chosen to represent different categories: inflamed gastric mucosa with (n = 13) and without (n = 20) H pylori, and non-inflamed mucosa (n = 17). RESULTS: The antigen was aberrantly expressed in the antral mucosal epithelium in 11 of 12 cases (92%) with acute-on-chronic gastritis when H pylori was also present. It was present in the antrum in only seven of 18 H pylori negative cases (39%) with acute-on-chronic/chronic gastritis. One of three cases of acute gastritis and three of seven ...
  http://jcp.bmj.com/content/45/1/30
*  HLA Class II DR - AM26129BT-N | acris-antibodies.com
HLA Class II DR, 0.1 mg. |p|HLA DR antigen is an HLA class II antigen with homology to murine H-2E. HLA-DR is an αβ heterodimer.
  https://www.acris-antibodies.com/antibodies/primary-antibodies/hla-class-ii-dr-am26129bt-n.htm
*  HLA-DR7 + HLA-DR beta - NB100-2706 | acris-antibodies.com
HLA-DR7 + HLA-DR beta, 0.1 mg. Human Leukocyte Antigens are highly polymorphic proteins that are involved in the presentation of antigens to the T cell receptor.
  https://www.acris-antibodies.com/antibodies/primary-antibodies/hla-dr7-hla-dr-beta-nb100-2706.htm
*  Association of HLA-Class II and IgE Serum Levels in Pediatric Asthma
Background: Pediatric bronchial asthma is associated with considerable morbidity. The study was carried out to examine the association of Human Leukocyte Antigen (HLA)- Class II with the disease as we found no similar study on Asian Indian population. Objective: To define the HLA-Class II antigens in Asian Indian pediatric patients with asthma. Methods: A total of 103 children with asthma and 152 controls were analysed for HLA Class II (DRB1, DQB1and DPB1) by PCR-SSP (Sequence Specific Primers) method. Total serum IgE levels were determined by ELISA assay. Results: A positive family history was recorded in 59 patients (57%) and 13 (8.5%) of healthy controls. Serum IgE levels were more than normal range in 72% of the patients and 33% of healthy subjects with mean values of 4877 and 627 IU/ml, respectively. DRB1*04 and DQB1*03 showed ...
  http://iji.sums.ac.ir/article_16762.html
*  HLA-DR3 - Wikipedia
HLA-DR3 is composed of the HLA-DR17 and HLA-DR18 split 'antigens' serotypes. DR3 is a component gene-allele of the AH8.1 haplotype in Northern and Western Europeans. Genes between B8 and DR3 on this haplotype are frequently associated with autoimmune disease. Type 1 diabetes mellitus is strongly associated with HLA-DR3 or HLA-DR4. Some DR3 also react with HLA-DR17 and/or HLA-DR18. The DRB1*0304 primarily reacts with DR3. The serotypes of *0305, *0306, *0308 to *0331 are unknown. HLA-DR3 is associated with early-age onset myasthenia gravis, Hashimoto's thyroiditis (along with DR5), primary ...
  https://en.wikipedia.org/wiki/HLA-DR3
*  Sensors | Free Full-Text | Human NK Cell Up-regulation of CD69, HLA-DR, Interferon γ Secretion and Cytotoxic Activity by...
Human plasmacytoid dendritic cells secrete high levels of IFNa and are thus implicated in the activation of NK cells. Activated NK cells are characterised by the up-regulation of CD69 and MHC class II DR expression, secretion of IFN g and enhanced cytotoxicity. We show that pDC mediate these processes by different mechanisms, some of which overlap. Human NK cells were analysed after co-culture with immature or CpG-matured blood pDC or with supernatant from these cells. Maximal CD69 expression by NK cells was mediated by supernatant from mature pDC and did not require pDC contact. Up-regulation was due in part to IFNa but also to factors in IFNa negative supernatant from immature DC. HLA-DR expression was independent of secreted molecules but required contact with immature or mature DC. Enhanced NK cytotoxicity, measured by killing of K562 targets and expression of CD107a, was mediated by multiple factors including type I IFN, supernatant ...
  http://mdpi.com/1424-8220/9/1/386
*  Downregulation of Blood Monocyte HLA-DR in ICU Patients Is Also Present in Bone Marrow Cells - pdf descargar
Downregulation of Blood Monocyte HLA-DR in ICU Patients Is Also Present in Bone Marrow Cells. . Biblioteca virtual para leer y descargar libros, documentos, trabajos y tesis universitarias en PDF. Material universiario, documentación y tareas realizadas por universitarios en nuestra biblioteca. Para descargar gratis y para leer online.
  http://libros.duhnnae.com/2017/jun9/149859799350-Downregulation-of-Blood-Monocyte-HLA-DR-in-ICU-Patients-Is-Also-Present-in-Bone-Marrow-Cells.php
*  Additional pages Product Categories - Healthmatics | Page 68
Encoded by multiple HLA-DRA and HLA-DRB genes in a complex variable 5 cM region of MHC between HLA-B and -D, HLA-DR Antigens are Class II histocompatibility transmembrane glycoprotein heterodimers of alpha (heavy, 35-kD) and beta (light, 27-kD) chains. Located predominantly on B cells and macrophages, HLA-DR antigens function in antigen presentation to regulatory T cells in the immune response and in self/nonself discrimination. Invariant alpha and polymorphic beta chains have glycosylated N-termini, hydrophobic membrane regions, and hydrophilic C-termini. The heterodimer consists of 4 extracellular domains; invariant alpha-1, polymorphic N-terminal beta-1, and conserved Ig-like alpha-2 and beta-2. Alpha-1 ...
  http://healthmatics.info/products-page/additional-pages/page/68/
*  HLA-DR - Wikipedia
HLA-DR is an MHC class II cell surface receptor encoded by the human leukocyte antigen complex on chromosome 6 region 6p21.31. The complex of HLA-DR (Human Leukocyte Antigen - antigen D Related) and its ligand, a peptide of 9 amino acids in length or longer, constitutes a ligand for the T-cell receptor (TCR). HLA (human leukocyte antigens) were originally defined as cell surface antigens that mediate graft-versus-host disease. Identification of these antigens has led to greater success and longevity in organ transplant. Antigens most responsible for graft loss are HLA-DR (first six months), HLA-B (first two years), and HLA-A ...
  https://en.wikipedia.org/wiki/HLA-DR
*  anti-HLA-DR beta antibody [TDR 31.1] | GeneTex
HLA-DR beta antibody [TDR 31.1] for ELISA, FACS, RIA. Anti-HLA-DR beta mAb (GTX40182) is tested in Human samples. 100% Ab-Assurance.
  http://www.genetex.com/HLA-DR-beta-antibody-TDR-311-GTX40182.html
*  Expression of HLA-DR structure and a membrane-specific antigen by a granulocytopoietic line of acute leukemic blast cells]. -...
Blast cells from peripheral blood of 32 patients with acute leukemia were tested for their ability to react with a monoclonal antibody (D1.B6) specific for HLA-DR surface antigen. In order to evaluate the degree of leukemic cell differentiation a monoclonal antibody (R1.B19) specific for the granulocytopoietic lineage was also employed. The results demonstrated that a considerable proportion of blast cell populations expressed the HLA-DR antigen, while only a small fraction of cells expressed the myeloid antigen.
  https://www.semanticscholar.org/paper/Expression-of-HLA-DR-structure-and-a-membrane-spe-Palumbo-Giovinazzo/1980940489b3e7a4aab7184db2eddf1acb67f6ee
*  Clinical Immunology Society
ALPS panel uses antibodies against CD3, CD4, CD8, CD45, alpha beta TCR, CD25, CD27, HLA-DR, CD19, CD5, CD27, and B220 to create a panel that quantifies double negative T cells, CD27+ B cells, and CD25 and HLA-DR expression on T cells to rank the likelihood of ALPS. Test Code: ALPS Panel by Flow. ...
  https://www.clinimmsoc.org/links/comprehensive-directory/test-directory/disease-specific-flow-cytometry-tests-or-panels
*  Anti-Ovine MHC Class II DR antibody [37.68] (ab34007)
Mouse monoclonal Ovine MHC Class II DR antibody [37.68] validated for IP, IHC, Flow Cyt and tested in Human, Shp, Goat and Cow. Immunogen corresponding to…
  http://www.abcam.com/ovine-mhc-class-ii-dr-antibody-3768-ab34007.html
*  Plus it
Cell lines. Colon cancer cell line HT29, rectal cancer cell lines SW837 and SW1463, and Ramos B-cell line were all cultured in Iscove's modified Dulbecco's medium (Cambrex) supplemented with glutamine, penicillin/streptomycin, and 8% heat-inactivated FCS, at 37°C. Where indicated, exponentially growing cells were treated with 100 units/mL human recombinant IFNγ for the indicated time periods.. Visualization of HLA-DR on surface of cell lines. For these experiments, IFNγ-treated or untreated growing cells were harvested, washed, and resuspended in PBS supplemented with 0.5% bovine serum albumin and 0.05% sodium azide (PBA). Cells were incubated with a monoclonal FITC-labeled anti-HLA-DR antibody at 1:50 (BD Biosciences) for 30 min at 4°C. PBA alone was used as negative control. Antibody binding was detected with the use of a FACSCalibur (BD Biosciences). Propidium iodide was added to allow exclusion of dead cells.. Promoter-specific reverse ...
  http://clincancerres.aacrjournals.org/content/14/4/1073
*  HLA-DR7 - Wikipedia
HLA-DR7 (DR7) is a HLA-DR serotype that recognizes the DRB1*0701 to *0705 gene products. The serological reaction of DR7 is excellent for *0701. The serology of *0703 to *0705 to *0709, and *0711 to *0714 serotypes is unknown. DRB1*0710N is a null allele. DRB1*0702 nomenclature has been deleted. DR7 is positively associated with psoriasis vulgaris. DRB1*07 is linked to T. cruzi infection with cardiomyopathy (also called Chaga's cardiomyopathy). DR7:DQA1*0201:DQB1*0202 is associated with Graves' disease. DR7-DQ2/DR5-DQ7 phenotype (transhaplotype encoded isoform DQα5β2) is the primary risk DQ isoform in celiac disease. DR7-DQ2/DR5-DQ7 (/DR11-DQ7 or /DR12-DQ7) is a clarifying identifier for the at risk ...
  https://en.wikipedia.org/wiki/HLA-DR7
*  HLA-DRB1*1302 - HLA-DR beta1 - Homo sapiens (Human) - HLA-DRB1*1302 gene & protein
p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.,/p> ,p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.,/p> ,p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).,/p> ,p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x,sup>64,/sup> + x,sup>4,/sup> + x,sup>3,/sup> + x + 1. The algorithm is described in the ISO 3309 standard. ,/p> ,p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.,br /> ,strong>Cyclic redundancy and other checksums,/strong>,br /> ,a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993),/a>),/p> Checksum:i ...
  http://www.uniprot.org/uniprot/O19663
*  HLA-DRB1*1402 - HLA-DR beta1 - Homo sapiens (Human) - HLA-DRB1*1402 gene & protein
p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.,/p> ,p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.,/p> ,p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).,/p> ,p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x,sup>64,/sup> + x,sup>4,/sup> + x,sup>3,/sup> + x + 1. The algorithm is described in the ISO 3309 standard. ,/p> ,p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.,br /> ,strong>Cyclic redundancy and other checksums,/strong>,br /> ,a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993),/a>),/p> Checksum:i ...
  http://www.uniprot.org/uniprot/O19665
*  Plus it
The families of 41 probands with type I (insulin-dependent) diabetes mellitus (IDDM) were typed for HLAA, HLA-B, and HLA-DR antigens in addition to the complement polymorphisms C2, C4A, C4B, and Bf. All of these loci are encoded on the short arm of human chromosome 6 in a narrow region. Alleles at HLA-B (8, 15, 18, and 40), HLA-DR (3 and 4), and Bf (F1) have been associated with increased relative risk (RR) for IDDM, while HLA-B7 and HLA-DR2 have been associated with decreased RR for IDDM. This study confirms those significant risks in addition to confirming increased risk for the null (silent) allele for C4A (C4AQ0) and a rare C4B variant (C4B2.9). The significantly associated antigens (alleles) and risks were: HLA-B8 (RR = 3.1), ...
  http://diabetes.diabetesjournals.org/content/34/5/504
*  alpha-Chains, HLA-DR - Medical Dictionary online-medical-dictionary.org
Transmembrane Proteins that form the alpha subunits of the HLA-DR Antigens. They are also referred to as the HLA-DR heavy chains ...
  http://www.online-medical-dictionary.org/definitions-a/alpha-chains-hla-dr.html
*  HLA-DR抗体[EPR3692]|Abcam中国|Anti-HLA-DR抗体[EPR3692]
HLA-DR兔单克隆抗体[EPR3692](ab92511)可与人样本反应并经WB, IP, IHC, ICC, Flow Cyt实验严格验证,被2篇文献引用并得到1个独立的用户反馈。所有产品均提供质保服务,中国75%以上现货。
  http://www.abcam.cn/hla-dr-antibody-epr3692-ab92511.html
*  HLA-DR Mouse anti-Human, PerCP-Cy5.5, Clone: LN3, eBioscience™ 25 tests; PerCP-Cy5.5 HLA-DR Mouse anti-Human, PerCP-Cy5.5,...
HLA-DR Mouse anti-Human, PerCP-Cy5.5, Clone: LN3, eBioscience™ 25 tests; PerCP-Cy5.5 HLA-DR Mouse anti-Human, PerCP-Cy5.5, Clone: LN3, eBioscience™ Primary...
  https://www.fishersci.co.uk/shop/products/hla-dr-mouse-anti-human-percp-cy5-5-clone-ln3-ebioscience/15559046
*  Anti-HLA-DR 抗体 (ab118347) | アブカム
ウサギ・ポリクローナル抗体 ab118347 交差種: Hu 適用: WB,IP…HLA-DR抗体一覧…画像、プロトコール、文献などWeb上の情報が満載のアブカムの Antibody 製品。国内在庫と品質保証制度も充実。
  http://www.abcam.co.jp/hla-dr-antibody-ab118347.html