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*  HLA A1-B8-DR3-DQ2 - Wikipedia
... its major antigen genes superficially resemble European A1-B8 and it appears to be a homoplastic recombinant from a common DR3- ... There are many genes that lie on either side of HLA-B, TNF alpha is over expressed. Closer to DR3, C4A is null in B8-DR3 ... B8-DR3[edit]. The region between and including B8 and DR3 bears a number of genes of interest in the study of human disease. ... HLA DR3-DQ2[edit]. DR3-DQ2 is either a known or highly suspect factor in most autoimmune diseases that link to the A1::DQ2 ...
  https://en.wikipedia.org/wiki/HLA_A1-B8-DR3-DQ2
*  HLA DR3-DQ2 - Wikipedia
"HLA gene and haplotype frequencies in Dutch blood donors". Tissue Antigens. 48 (5): 562-74. doi:10.1111/j.1399-0039.1996. ... HLA-DR3-DQ2 is found in HLA A1-B8-DR3-DQ2 haplotype in Northern Europeans (including the British Ilse, Ireland, Iceland). HLA ... C regions of the HLA gene complex in northern and northwestern Europe. The linked haplotype is HLA A1-B8-DR3-DQ2 (AH8.1 in the ... The DR3-DQ2 haplotype is notable because of the very strong linkage between genes that extends into the HLA-A, -B and - ...
  https://en.wikipedia.org/wiki/HLA_DR3-DQ2
*  A30-Cw5-B18-DR3-DQ2 (HLA Haplotype) - Wikipedia
March 2000). "HLA genes in Arabic-speaking Moroccans: close relatedness to Berbers and Iberians". Tissue Antigens. 55 (3): 239- ... there is also the B18-DR3 component and the HLA DR3-DQ2.5. Other haplotypes such as Cw5-B16-DR3 or B8-DR3-DQ2.5 have been ... Müller CR, Ehninger G, Goldmann SF (January 2003). "Gene and haplotype frequencies for the loci hLA-A, hLA-B, and hLA-DR based ... September 2008). "Autoimmune-associated HLA-B8-DR3 haplotypes in Asian Indians are unique in C4 complement gene copy numbers ...
  https://en.wikipedia.org/wiki/A30-Cw5-B18-DR3-DQ2_(HLA_Haplotype)
*  Frontiers | Thyrotropin Receptor Epitope and Human Leukocyte Antigen in Graves' Disease | Endocrinology
Inheritance of HLA genes, especially HLA-DR3, is associated with GD. TSHR-ECD protein is endocytosed into antigen presenting ... especially HLA-DR3, is associated with GD. TSHR-ECD protein is endocytosed into antigen presenting cells (APCs), and processed ... These peptide epitopes bind to HLA-class II molecules, and subsequently the complex of HLA-class II and TSHR-ECD epitope is ... These peptide epitopes bind to HLA-class II molecules, and subsequently the complex of HLA-class II and TSHR-ECD epitope is ...
  https://www.frontiersin.org/articles/10.3389/fendo.2016.00120/full
*  Immunoglobulin D Deficiency: Background, Pathophysiology, Epidemiology
The [HLA-B18, F1C30, DR3] conserved extended haplotype carries a susceptibility gene for IgD deficiency. J Clin Immunol. 2000 ... 9, 10] IgD deficiency is associated with the specific human leukocyte antigens HLA-B18, F1C30, and DR3 in a Spanish Basque ... HLA-B8, SC01, DR3] conserved extended haplotype. Tissue Antigens. 2000 Sep. 56(3):207-16. [Medline]. ... 11] and HLA-B8, SC01, DR3 in white subjects in an American study. [12] A 2008 report noted that depletion of circulating IgD+ ...
  https://emedicine.medscape.com/article/136803-overview
*  HLA-DR3 - Wikipedia
HLA-DR3 is composed of the HLA-DR17 and HLA-DR18 split 'antigens' serotypes. DR3 is a component gene-allele of the AH8.1 ... Type 1 diabetes mellitus is strongly associated with HLA-DR3 or HLA-DR4. Some DR3 also react with HLA-DR17 and/or HLA-DR18. The ... 2007). "Primary sclerosing cholangitis is associated with extended HLA-DR3 and HLA-DR6 haplotypes". Tissue Antigens. 69 (2): ... DR3 is genetically linked to HLA-DR52, DRB3*0202 allele, and HLA-DQ2 (DQ2.5). derived from IMGT/HLA Wiencke K, Karlsen TH, ...
  https://en.wikipedia.org/wiki/HLA-DR3
*  Nutritional Intervention to Prevent Diabetes - Full Text View - ClinicalTrials.gov
There is a higher risk of developing T1D with the presence of the human leukocyte antigen (HLA) DR3 or DR4. It is also known ... At birth, or soon after, their babies will be tested for HLA type (to look for the specific gene which confers a higher risk of ... These babies will also be tested for HLA type. Their eligibility will be based on the presence of higher risk genes or the ... If the HLA typing shows that the baby is at higher risk for T1D and no protective genes are present, the baby will then ...
  https://clinicaltrials.gov/ct2/show/NCT00333554?term=diabetes+type+1+AND+
*  Innate Immune Activity Is Detected Prior to Seroconversion in Children With HLA-Conferred Type 1 Diabetes Susceptibility |...
Susceptibility to T1D is inherited, with the human leukocyte antigen (HLA) class II haplotypes encoding DR3-DQ2 (DRB1*03-DQA1* ... 250 kb around the gene coordinates of each differentially regulated gene. A linear model was fit for genotype-gene expression, ... The genes regulating IRF5 or -7 are presented on the left, and the downstream target genes of IRF5 or -7 on the right. Solid ... In addition, ,40 non-HLA genes with more modest effect on disease risk, such as INS, cytotoxic T-lymphocyte-associated protein ...
  http://diabetes.diabetesjournals.org/content/63/7/2402
*  Pediatric Sjogren Syndrome: Practice Essentials, Background, Etiology
The association of Sjögren syndrome with human leukocyte antigen (HLA)-B8, HLA-Dw3, HLA-DR3, and the DQA1*0501 allele supports ... An active area of research involves genetic polymorphisms of cytokine genes, including IL10 and TNFA. [7] Associations with ... 14, 15] Additional cytokine and chemokine gene polymorphisms continue to be focus of several ongoing studies. ...
  https://emedicine.medscape.com/article/1008536-overview
*  Association of −1087 IL10 and −308 TNFA Gene Polymorphisms with Serological Markers of Coeliac Disease | SpringerLink
A genetically determined high setting of TNF-alpha influences immunologic parameters of HLA-B8,DR3 positive subjects: ... A possible gene dosage effect of DQB1*0201. Tissue Antigens 41:173-177, 1993Google Scholar ... We analyzed the association between serological markers of CD and the −1087 IL10 and −308 TNFA gene polymorphisms in Swedish ... Nilsen EM, Lundin KE, Krajci P, Scott H, Sollid LM, Brandtzaeg P: Gluten specific, HLA-DQ restricted T cells from coeliac ...
  https://link.springer.com/article/10.1023%2FA%3A1024588800754
*  HLA complex - definition of HLA complex by The Free Dictionary
HLA complex synonyms, HLA complex pronunciation, HLA complex translation, English dictionary definition of HLA complex. adj. 1 ... The major genetic determinants are the DR3 and DR4 alleles (or variants) of a group of genes called the HLA complex.. Diabetes ... Related to HLA complex: HLA system, Human lymphocyte antigen. com·plex. (kəm-plĕks′, kŏm′plĕks′). adj.. 1. a. Consisting of ... The HLA complex, located on chromosome 6, comprises the most polymorphic genes in humans [1] and plays a pivotal role in ...
  https://www.thefreedictionary.com/HLA+complex
*  Autoimmune Hepatitis: Practice Essentials, Background, Pathophysiology
... they include autoantibodies against liver-specific and non-liver-specific antigens and increased immunoglobulin G (IgG) levels. ... C4A gene deletions are associated with the development of autoimmune hepatitis in younger patients. [10] HLA-DR3-positive ... Aberrant display of human leukocyte antigen (HLA) class II on the surface of hepatocytes facilitates the exposure of normal ... HLA status affects treatment outcome. As an example, HLA DR3-positive patients are more likely to have active disease and are ...
  https://emedicine.medscape.com/article/172356-overview
*  The genetic basis for the association of the 8.1 ancestral haplotype (A1, B8, DR3) with multiple immunopathological diseases -...
Several candidate genes in the central MHC have the potential to modulate immune or inflammatory responses in an antigen- ... This review concerns the 8.1 AH (HLA-A1, C7, B8, C4AQ0, C4B1, DR3, DQ2), which is carried by most Caucasians with HLA-B8. It is ... We have mapped susceptibility genes for HIV, IDDM and myasthenia gravis co the central MHC between HLA-B and the tumour ... Here we consider which of the remaining 8.1-associated diseases are more closely associated with HLA-DR3 and/or DQ2. ...
  http://researchrepository.murdoch.edu.au/id/eprint/15013/
*  JCI Insight - Single-cell analysis of glandular T cell receptors in Sjögren's syndrome
9 of whom shared the HLA DR3/DQ2 risk haplotype. TCRα and β sequences were obtained from a median of 91 SG and 107 PB cells per ... The degree of clonal expansion and frequency of cells expressing two productively rearranged α genes were increased in SG ... Knowledge of paired TCRα and β sequences enables further work toward identification of target antigens and development of novel ... CD4+ T cells predominate in salivary gland (SG) inflammatory lesions in Sjögren's syndrome (SS). However, their antigen ...
  https://insight.jci.org/articles/view/85609/pdf
*  JCI Insight - Single-cell analysis of glandular T cell receptors in Sjögren's syndrome
HLA imputation. To confirm the presence of HLA DR3 and DQ2 alleles, classical HLA alleles were imputed from SNP data by the HLA ... our work directly assesses the gene usage of antigen-experienced CD4 T cells, not the sum of all T cells present in SG, which ... although our subjects share the HLA DR3/DQ2 risk haplotype, the HLA restriction of the TCRs reported here remains unknown. ... Unlike in prior reports, the subject cohort in our study was selected for the presence of the HLA DR3/DQ2 risk haplotype as ...
  https://insight.jci.org/articles/view/85609
*  Pediatric Primary Sclerosing Cholangitis: Background, Pathophysiology, Etiology
An increased frequency of HLA-B8 and HLA-DR3 is observed in patients with primary sclerosing cholangitis. HLA-B8 is also ... The close association between primary sclerosing cholangitis and various human leukocyte antigen (HLA) haplotypes is well ... In addition, other gene polymorphisms have been suggested in the immunopathogenesis of primary sclerosing cholangitis, ... and abnormal expression of human leukocyte antigen (HLA) on biliary epithelial cells all support an immune-mediated process. ...
  https://emedicine.medscape.com/article/931355-overview
*  HLA-DR17 - Wikipedia
DR17 is part of the broader antigen group HLA-DR3 and is very similar to the group HLA-DR18. DR17 recognizes the DRB1*0301, * ... These serotypes are the result of gene products from the HLA-DRB3* and HLA DQA1*0501 and HLA DQB1*0201 alleles. DRB1*0301 is ... HLA-DR17 (DR17) is an HLA-DR serotype that recognizes the DRB1*0301 and *0304 gene products. DR17 is found at high frequency in ... 2007). "HLA class I and class II frequencies in patients with sarcoidosis from Croatia: role of HLA-B8, −DRB1*0301, and −DQB1* ...
  https://en.wikipedia.org/wiki/HLA-DR17
*  HLA-DQ6 - Wikipedia
doi:10.1038/sj.gene.6364058. PMID 15014429. Boberg KM, Spurkland A, Rocca G, et al. (August 2001). "The HLA-DR3,DQ2 ... HLA-DQ6 (DQ6) is a human leukocyte antigen serotype within HLA-DQ (DQ) serotype group. The serotype is determined by the ... "Identification by genomic typing of non-DR3 HLA class II genes associated with myasthenia gravis". J Neuroimmunol. 47 (2): 115- ... 1994). "HLA-DQA1, -DQB1 and -DRB1 genotyping in Japanese pemphigus vulgaris patients by the PCR-RFLP method". Tissue Antigens. ...
  https://en.wikipedia.org/wiki/HLA-DQ6
*  HLA A1-B8 haplotype - Wikipedia
April 1990). "A1, Cw7, B8, DR3 HLA antigen combination associated with rapid decline of T-helper lymphocytes in HIV-1 infection ... Müller C, Ehninger G, Goldmann S (2003). "Gene and haplotype frequencies for the loci hLA-A, hLA-B, and hLA-DR based on over ... HLA A1-B8 (Also:HL A1,8; HL A1,A8; HLA A1-Cw7-B8; HLA A*01-B*08, HLA A*0101-B*0801, HLA A*0101-Cw*0701-B*0801; HLA A*01:01-C*07 ... HLA)-DR3 haplotypes depends on genotypic context: association of DPB1 and HLA class I loci among DR3- and DR4-matched Italian ...
  https://en.wikipedia.org/wiki/HLA_A1-B8_haplotype
*  HLA-DQ2 - Wikipedia
This haplotype, HLA A1-B8-DR3-DQ2, is associated with diseases in which HLA-DQ2 has suspect involvement. Direct involvement of ... doi:10.1038/sj.gene.6364061. PMID 15014431. Karell K, Louka AS, Moodie SJ, et al. (April 2003). "HLA types in celiac disease ... high-resolution and large sample typing of HLA DR-DQ haplotypes in a sample of European Americans". Tissue Antigens. 62 (4): ... HLA-DR3 plays a prominent role in autoimmune diabetes. However, DQ2 presence with DR3 decreases the age of onset and the ...
  https://en.wikipedia.org/wiki/HLA-DQ2
*  HLA-B8 - Wikipedia
B8 is a component gene-allele of the AH8.1 haplotype in Northern and Western Europeans. Genes between B8 and DR3 on this ... HLA-B8, previously known as HL-A8 was one of the first identified of the HLA antigens. It coined the "Super B8" haplotype, also ... HLA-B8 (B8) is an HLA-B serotype. The serotype identifies the HLA-B*08 gene products. (For terminology help see: HLA-serotype ... 2005). "Nomenclature for factors of the HLA system, 2004". Tissue Antigens. 65 (4): 301-69. doi:10.1111/j.1399-0039.2005.00379. ...
  https://en.wikipedia.org/wiki/HLA-B8
*  Peyronie's Disease Causes
... most notably HLA-A1, HLA-B7, HLA-B8, HLA-B44, HLA-Cw7, HLA-DR3 and HLA-DQ546), potentially suggesting real genetic predilection ... Several retrospective studies revealed a link between Peyronie's disease and a variety of histocompatibility antigens ( ... with the expression of multiple fibrosis-promoting genes. ...
  https://www.news-medical.net/health/Peyronies-Disease-Causes.aspx
*  Patent WO1989004875A2 - Characterization and detection of sequences associated with autoimmune diseases - Google Patents
DNA sequences and corresponding amino acid sequences from the HLA class II beta region of the human genome that are associated ... Molecular analyses of the HLA genes herein has resulted in further subdivision of the HLA DR3, DR4 and DRw6 serological types ... Hla-dr antigen gene, its nucleotide sequence and its use. EP0527199A1 *. 1 May 1991. 17 Feb 1993. Univ Leland Stanford Junior. ... HLA class II DR-beta genes have been isolated from HLA- typed IDDM patients and HLA-matched controls and have been sequenced, ...
  http://www.google.com.au/patents/WO1989004875A2?cl=en
*  HLA typing is not predictive of proliferative diabetic retinopathy in patients with younger onset type 2 diabetes mellitus |...
The frequencies of HLA-A, B, and Cw antigens in the control group, the non-DR group, and the PDR group are shown in table 2, ... The type 2 diabetic patients in this study showed a typical HLA pattern. Other research has reported that DR3, DR4, and Cw4 ... 10 Type 2 diabetes is not autoimmune and has less association or linkage with genes in the HLA region than type 1. ... Human leucocyte antigen (HLA) status has a significant role in immune responses and immunological tolerance and is a factor in ...
  http://bjo.bmj.com/content/88/2/303