*  Patente US4925787 - Monoclonal anti-idiotypic antibody, method for production thereof, and ... - Google Patentes
... or the hemagglutination method which effects detection of an antigen by the antigen-antibody reaction. The aforementioned ... Use of anti-idiotype antibodies in immunoassays. WO1986001539A1 *. 27 Ago 1985. 13 Mar 1986. The Trustees Of Columbia ... An anti-mouse immunoglobulin antibody labeled with horseradish peroxidase (produced by Amersham & Co., England) was dissolved ... An anti-mouse immunoglobulin antibody labeled with a horseradishperoxidase (produced by Amersham & Company, England and ...
  http://www.google.es/patents/US4925787
*  COMPOSITIONS AND METHODS FOR MODULATING C-REL-DEPENDENT CYTOKINE PRODUCTION - Patent application
... immunologically active portions of immunoglobulin molecules, i.e., molecules that contain an antigen binding site that ... 0078] Antibody fragments that contain the idiotypes of c-Rel can be generated by techniques known in the art. For example, such ... Today, 15(9):406-410 (1994)), such as the binding of CD40 ligand on the T helper cell to the CD40 antigen on the B cell, and ... One example of such an immunomodulatory agent is IL-4. IL-4 enhances antigen-specific activity of TH2 cells at the expense of ...
  http://www.patentsencyclopedia.com/app/20120208203
*  Granulocyte - Wikipedia
... they are professional antigen-presenting cells, they regulate other immune cell functions (e.g., CD4+ T cell, dendritic cell, B ...
  https://en.wikipedia.org/wiki/Granulocytopenia
*  Cellular immunotherapy as a beacon of hope for hematological malignancies
DCs are professional antigen-presenting cells that serve as an essential link between innate and adaptive immune systems. For ... Follicular and indolent B cell lymphomas were also successfully treated with DCs loaded with idiotype or autologous tumor cells ... and killer cell immunoglobulin-like receptors (KIR) [8]. The first NK cell immunotherapy in humans was performed with ... The ideal tumor antigens should be easily available, target specific and should enhance cross-presentation and minimize immune ...
  http://www.bloodresearch.or.kr/journal/view.html?uid=1572&vmd=Full
*  Alternative complement pathway - Wikipedia
This change in shape allows the binding of plasma protein Factor B, which allows Factor D to cleave Factor B into Ba and Bb. Bb remains bound to C3(H2O) to form C3(H2O)Bb. This complex is also known as a fluid-phase C3-convertase. This convertase, the alternative pathway C3-convertase, although only produced in small amounts, can cleave multiple C3 proteins into C3a and C3b. The complex is believed to be unstable until it binds properdin, a serum protein. The addition of properdin forms the complex C3bBbP, a stable compound which can bind an additional C3b to form alternative pathway C5-convertase. The C5-convertase of the alternative pathway consists of (C3b)2BbP (sometimes referred to as C3b2Bb). After the creation of C5 convertase (either as (C3b)2BbP or C4b2a3b from the classical pathway), the complement system follows the same path regardless of the means of activation (alternative, classical, or lectin). C5-convertase cleaves C5 into C5a and C5b. C5b binds sequentially to C6, C7, C8 and ...
  https://en.wikipedia.org/wiki/Alternative_complement_pathway
*  Immunodeficiency - Wikipedia
In the early 1950s Immunoglobulin(Ig) was used by doctors to treat patients with primary immunodeficiency through intramuscular ...
  https://en.wikipedia.org/wiki/Immune_deficiency
*  Polyclonal B cell response - Wikipedia
Steps in production of antibodies by B cells: 1. Antigen is recognized and engulfed by B cell 2. Antigen is processed 3. ... "Organization and Expression of Immunoglobulin Genes (Chapter 5)". Immunology (Fifth ed.). New York. pp. 105-136. ISBN 0-7167- ... Antigen presentation[edit]. Main articles: antigen presentation and major histocompatibility complex. After the processed ... Antigens can be large and complex substances, and any single antibody can only bind to a small, specific area on the antigen. ...
  https://en.wikipedia.org/wiki/Polyclonal
*  US Patent # 9,750,803. Lipid vesicle compositions and methods of use - Patents.com
Ig-idiotype, p15, gp75, GM2 ganglioside, GD2 ganglioside, human papilloma virus proteins, Smad family of tumor antigens, lmp-1 ... undergo immunoglobulin isotype-switching and somatic hypermutation, and eventually form memory B-cells that can rapidly ... microbial antigens such as bacterial antigens, viral antigens, fungal antigens, parasitic antigens, and mycobacterial antigens ... microbial antigens include bacterial antigens, viral antigens, fungal antigens, parasitic antigens, and mycobacterial antigens ...
  http://patents.com/us-9750803.html
*  PPT - Antibody structure and function PowerPoint presentation | free to download - id: 20efd9-ZWU2N
Most antigens have multiple epitopes (multivalent) Usually carbohydrate or peptide. ... Aggregates formed by interaction of ... antigens. 59. Antigens have multiple epitopes 60. Hemagglutination 61. Coombs test*Direct Add anti-human immunoglobulin ... Antibodies structure, classes and function - define the terms isotype', allotype' and idiotype' ... and toxins; only class of ... Antiserum raised against antigen A reacts also with antigen B. Antigen A and B share epitopes. Antigen A and B have similar ( ...
  http://www.powershow.com/view/20efd9-ZWU2N/Antibody_structure_and_function_powerpoint_ppt_presentation
*  JP2996864B2 - Antibody variable region dna - Google Patents
Modified immunoglobulin molecule incorporating an antigen in a non-CDR loop region ... Anti-idiotype monoclonal antibodies mimicking the HIV gp120 CD4-binding (CD4bs) US10004799B2 (en) 2007-08-27. 2018-06-26. ... C07K16/00-Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies * C07K16/08-Immunoglobulins [IGs], e.g. monoclonal or ... Multivalent and multispecific antigen-binding protein US20040052814A1 (en) 2004-03-18. Fusion proteins for targeted delivery of ...
  https://patents.google.com/patent/JP2996864B2/en
*  Vaccinations and How They Disrupt the Immune System | beingstray.com
HogenEsch H, et al., Effect of vaccination on serum concentrations of total and antigen specific immunoglobulin E in dogs. Am J ... Lymphomas can develop from B cells chronically helped by idiotype specific T cells. Journal of Experimental Medicine 2007; 204 ... Immunoglobulin E antibodies to pollens augmented in dogs by virus vaccines. Am J Vet Res 1981; 44: 440-445.. ... The big moment of epiphany for the author was the reaction that the antigen in vaccines does much to dysregulate the immune ...
  http://beingstray.com/vaccinations-disrupt-immune-system/
*  Zoology Timeline
Upon exposure to a particular antigen, a clone of cells that can make antibody to that antigen is 'selected' and multiplies ... idiotypes), Jerne proposed that regulation of the immune system was mediated by a complex network of antibodies specific for ... By using myeloma tumors (which contain pure immunoglobulin proteins) these investigators were able to work out after many years ... This complex of genes codes for cell surface antigens. These antigens are critically important in various interactions between ...
  http://highered.mheducation.com/sites/0072349034/student_view0/zoology_timeline.html
*  What Is and What Should Always Have Been: Long-Lived Plasma Cells Induced by T Cell-Independent Antigens | The Journal of...
The majority of "natural" immunoglobulin-secreting cells are short-lived and the progeny of cycling lymphocytes. Eur. J. ... Long-lasting thymus-independent immune responses to anti-idiotype lipopolysaccharide conjugates require continuous B cell ... A role for antigen in the maintenance of immunological memory. Nat. Rev. Immunol. 2: 60-65. ... Distinction of the memory B cell response to cognate antigen versus bystander inflammatory signals. J. Exp. Med. 206: 2013-2025 ...
  http://www.jimmunol.org/content/190/12/5913
*  IMP321 - Wikipedia
The investigators for this work used influenza matrix protein antigen and the tumor antigens Melan-A/MART-1 and survivin when ... had successfully produced a soluble fusion protein of LAG3 and immunoglobulin around 1995 and had initially envisaged its use ... therapeutic composition and anti-idiotype antibody", published 1995-12-2, assigned to Institut Gustave Roussy, INSERM, Merck ... Subjects who got IMP321 had higher levels of HBsAg antibody in their blood as well as higher levels of antigen-specific T cells ...
  https://en.wikipedia.org/wiki/IMP321
*  Epitope : Wikis (The Full Wiki)
Somatic hypermutation · V(D)J recombination · Junctional diversity · Immunoglobulin class switching · MHC/HLA ... T cell epitopes are presented on the surface of an antigen-presenting cell, where they are bound to MHC molecules. T cell ... Idiotype. ... Antigens can bind in pockets or grooves, or on extended ... Antigens can bind in pockets or grooves, or on extended surfaces in the binding sites of antibodies (Janeway Immunobiology ...
  http://www.thefullwiki.org/Epitope
*  Major histocompatibility complex : Wikis (The Full Wiki)
lymphocyte navs: cells/physio, immunodeficiency/immunoproliferative immunoglobulin/neoplasia, proc. Surface antigens. Major ... Idiotype. ... Human leukocyte antigen. MHC class I. HLA-A • HLA-B • HLA-C • ... They achieve this by displaying fragmented pieces of antigens on the host cell's surface. These antigens may be self or nonself ... Main article: Human leukocyte antigen. The best-known genes in the MHC region are the subset that encodes antigen-presenting ...
  http://www.thefullwiki.org/Major_histocompatibility_complex
*  Patent WO1989004875A2 - Characterization and detection of sequences associated with autoimmune diseases - Google Patents
Human leukocyte antigen typing. EP0472399A2 *. 20 Aug 1991. 26 Feb 1992. Mitsui Petrochemical Industries, Ltd.. HLA-DR antigen ... The term "monoclonal antibodies" as used herein refers to an immunoglobulin composition produced by a clonal population (or ... or anti-idiotype antibodies could then be used to prevent or reverse an immune response against epitopes presented by the ... For example, the antigen-binding ability of the antibodies may be evaluated in vitro by immunoblots, ELISAs and antigen ...
  http://www.google.com.au/patents/WO1989004875A2?cl=en
*  PRODUCTION OF ANTI-SELF ANTIBODIES FROM ANTIBODY SEGMENT REPERTOIRES AND DISPLAYED ON PHAGE - Patent application
Human Anti-Idiotypes [0098]Anti-idiotype antibodies (antibodies directed against the antigen combining sites formed by the ... immunoglobulins and immunoglobulin homologs in this application includes members of the immunoglobulin superfamily and homologs ... 0118]A self antigen is an antigen or epitope which is capable of binding to an antigen binding site formed by antibody variable ... member has an antigen binding site with binding specificity for an antigen which is a self antigen of a species of mammal, the ...
  http://www.patentsencyclopedia.com/app/20090325815
*  Plus it
Dippold W. G., Lloyd K. O., Li L. T., Ikeda H., Oettgen H. F., Old L. J. Cell surface antigens of human malignant melanoma: ... cloning and relation to adhesion molecules of the immunoglobulin gene superfamily. Science (Washington DC), 247: 1219-1222, ... Antibody responses in melanoma patients immunized with an anti-idiotype antibody mimicking disialoganglioside GD2. Clin. Cancer ... Boland L. M., Dingledine R. Expression of sensory neuron antigens by a dorsal root ganglion cell line, F-11. Brain Res. Dev. ...
  http://cancerres.aacrjournals.org/content/60/23/6670
*  Document 993
Fas antigen is the major target molecule for CD4+ T cell-mediated cytotoxicity. J. Immunol. 152:1127. 33 Hanabuchi, S., M. ... Bispecific anti-idiotype/anti-CD3 antibody therapy of murine B cell lymphoma. J. Immunol. 147:4035. 3. Demanet, C.. J. ... Binding of human immunoglobulin to human tissues after immunotherapy with anticolorectal carcinoma monoclonal antibody. Inr. J ... Role of T-cell subsets in the bispecitic antibody (anti-idiotype X anti-CD3) treatment of the BCLl lymphoma. Cancer Res. 54: ...
  http://spotidoc.com/doc/993/
*  SOLUBLE TREPONEMA PALLIDUM PROTEIN TP0453, TP0453-TP0326 FUSION PROTEIN, AND USE IN SYPHILIS DIAGNOSIS - Patent application
... antigens; and the like); lipoidal antigens; tuberculosis (TB) antigens (such as the T-cell antigen ESAT-6 and the CFP10 antigen ... See, e.g., Coligan et al., sections 2.7.1-2.7.12 and sections 2.9.1-2.9.3; Barnes et al., Purification of Immunoglobulin G (IgG ... 0228] It is also possible to use the anti-idiotype technology to produce monoclonal antibodies which mimic an epitope. For ... antigens; Candidiasis antigens; Hepatitis antigens (such as Hepatitis A, B or C antigens); Herpes simplex for 2 antigens; HPV ( ...
  http://www.patentsencyclopedia.com/app/20140186861
*  US Patent # 9,365,636. Human cytomegalovirus neutralizing antibodies and use thereof - Patents.com
An antibody, or an antigen binding fragment thereof, expressed from the above cell lines as well as antibodies, and antigen ... Methods for obtaining and sequencing immunoglobulin genes from B cells are well known in the art (e.g. see reference 37). The ... Third communication: correspondence of the idiotype activity and virus neutralization activity of the new monoclonal antibody, ... Antibodies and antigen binding fragments thereof, with the same amino acid sequence as those expressed from the aforementioned ...
  http://patents.com/us-9365636.html
*  Application # 2017/0143726. ADENOSINE RECEPTOR AGONISTS AND ANTAGONISTS TO MODULATE T CELL RESPONSES - Patents.com
For example, an idiotype antigen may be incorporated into the Listeria that will result in an anti-idiotype immune response to ... LFA-1 binds the immunoglobulin superfamily ligands ICAM-1, -2, -3. Blocking .beta.-2 integrin is a very effective way of ... For instance, the antigen may comprise a fragment of a tumor-associated antigen, a variant of a tumor-associated antigen, or a ... 0136] The antigen can be a protein or peptide. In certain embodiments, the antigen is exogenous. The antigen can, for example, ...
  http://patents.com/us-20170143726.html
*  US5830995A - Fanphiregulins: a family of heparin-binding epithelial cell growth factors - Google Patents
C07K16/00-Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies * C07K16/18-Immunoglobulins [IGs], e.g. monoclonal or ... Soluble MHC artificial antigen presenting cells US20060034865A1 (en) * 2001-01-16. 2006-02-16. Hildebrand William H. Soluble ... Antibody fragments which contain the idiotype of the molecule can be generated by known techniques. For example, such fragments ... Soluble MHC artificial antigen presenting cells US20020197672A1 (en) * 2000-10-10. 2002-12-26. Hildebrand William H.. ...
  https://patents.google.com/patent/US5830995A/en
*  18 ??? ??? - ?? ????????? ??????
Membrane- destined immunoglobulins (Ig), including IgM and IgD, on the superficies of herald B-cells feign as receptors for ... In putting together, vaccina- tion with anti-idiotype ACA-125, an analogue of CA-125, resulted in CA-125-specific antibodies ... unreduced antigens. Awareness or consciousness (as the ability of dirt to be reported when conscious) has been proposed earlier ...
  http://www.mir-krolikov.ru/forums/index.php?showtopic=210&pid=22929&st=20