*  Plus it
Molecular characterization of human Ro/SS-A antigen. Amino terminal sequence of the protein moiety of human Ro/SS-A antigen and ... Purification and biotinylation of human immunoglobulins. Antibody purification from human serum and immunoglobulin ... for whom a tumor-specific idiotype T-cell response was assessed (6). ... Strategies for antigen loading of dendritic cells to enhance the antitumor immune response. Cancer Res 2002;62:1884-9. ...
  http://cancerres.aacrjournals.org/content/70/22/9062
*  USE AND TARGETING OF CD98 LIGHT-CHAIN PROTEINS IN THERAPIES FOR THYROID HORMONE DISORDERS - Patent application
Such neutralizing anti-idiotypes or Fab fragments of such anti-idiotypes can be used in therapeutic regimens to neutralize TH ... 0020]Amino acid transporter, 4F2 antigen (also known as CD98 antigen), is a heterodimeric protein composed of two subunits, a ... 77-96). Such antibodies may be of any immunoglobulin class including IgG, IgM, IgE, IgA, IgD and any subclass thereof. The ... 0114]Antibodies to 4F2hc or CD98lc can, in turn, be utilized to generate anti-idiotype antibodies that "mimic" 4F2hc or CD98lc ...
  http://www.patentsencyclopedia.com/app/20090081212
*  Kinetics of B Cell Receptor Signaling in Human B Cell Subsets Mapped by Phosphospecific Flow Cytometry | The Journal of...
The initiation of antigen-induced B cell antigen receptor signaling viewed in living cells by fluorescence resonance energy ... In vivo ablation of surface immunoglobulin on mature B cells by inducible gene targeting results in rapid cell death. Cell 90: ... idiotype, developmental stage, oncogene expression, and other biomarkers in a flow cytometry analysis of BCR signaling kinetics ... A role for Bruton's tyrosine kinase in B cell antigen receptor-mediated activation of phospholipase C-γ 2. J. Exp. Med. 184: 31 ...
  http://www.jimmunol.org/content/177/3/1581.full
*  CULTURES, PRODUCTS AND METHODS USING UMBILICAL CORD MATRIX CELLS - Patent application
Cd19 specific chimeric antigen receptor and uses thereof. 2016-05-26. Sickled erythrocytes and progenitors target cytotoxics to ... immunoglobulin gene control region, which is active in lymphoid cells (Grosschedl et al., 1984, Cell 3S:647-658; Adams et al., ... polypeptides corresponding to the idiotype of neutralizing antibodies for GM-CSF, TNF, IL-1, IL-2, or other inflammatory ... Immunocytochemical detection of a single antigen was performed on one set of sections by known methods and the adjacent sets ...
  http://www.patentsencyclopedia.com/app/20100284978
*  T cell receptor Alpha + Beta| T cell receptor Alpha + Beta Antibody | Anti-T cell receptor Alpha + Beta
T cell antigen receptor betapolypeptide antibody;T cell antigen receptor beta polypeptide T cell receptor beta cluster antibody ... The receptors on T cells consist of immunoglobulin like integral membrane glycoproteins containing 2 polypeptide subunits alpha ... The concentration of antibodies used depends on each antibody, the amount of antigen and the detection method used. Generally, ... FLJ22602 antibody;MGC117436 antibody;MGC22624 antibody;MGC23964antibody;MGC71411 antibody;T cell antigen receptor alpha ...
  http://www.immuquest.com/sub-cellular-markers-c39/plasma-membranes-c191/tcr-alpha-tcr-beta-antibody-kj1298-p1035
*  Patent US5861164 - Vaccination against diseases resulting from pathogenic responses by specific ... - Google Patents
The recognition of antigen by the immune system rapidly mobilizes immune mechanisms to destroy that antigen, thus preserving ... Yanagi et al., A human T cell specific cDNA clone encodes a protein having extenstive homology to immunoglobulin chains. Nature ... Protection from experimental allergic encephalomyelitis conferred by a monoclonal antibody directed against a shared idiotype ... T cells owe their antigen specificity to the T cell receptor (TCR) which is expressed on the cell surface. The TCR is a ...
  http://www.google.com/patents/US5861164?dq=6,232,546
*  HER-2 BINDING ANTAGONISTS - Patent application
Such neutralizing anti-idiotypes or Fab fragments of such anti-idiotypes can be used in cancer therapeutic regimens. [0052] ... 0043] The p68HER-2 ECDIIIa variant 3 (see TABLE 1, below) glycosylated polypeptide was expressed and used as an antigen for ... 77-96, 1985). Such antibodies may be of any immunoglobulin class including IgG, IgM, IgE, IgA, IgD and any subclass thereof. ... 39. A diagnostic kit comprising: (a) a monoclonal antibody or antigen-binding fragment thereof that specifically binds to an ...
  http://www.patentsencyclopedia.com/app/20120045755
*  Antibody-induced arthritis: disease mechanisms and genes involved at the effector phase of arthritis | Arthritis Research &...
... and some other self-antigens appear. Of these, a pathogenic effect of the anti-CII and anti-G6PI antibodies is well ... Antigen-presenting cell-derived cytokines, TNF-α and IL-1β, have been proved to be important for arthritis induction and ... Immunoglobulins mediate pro- and anti-inflammatory activities through the engagement of their Fc fragment with distinct FcγRs. ... Mo JA, Scheynius A, Nilsson S, Holmdahl R: Germline-encoded IgG antibodies bind mouse cartilage in vivo: epitope- and idiotype- ...
  https://arthritis-research.biomedcentral.com/articles/10.1186/ar2089
*  Antigen - Wikipedia
While antigens are the "target" of antibodies, immunoglobulin-binding proteins "attack" antibodies. . ... Different antibody idiotypes, each have distinctly formed complementarity determining regions. ... Antigens can be classified according to their source.. Exogenous antigens[edit]. Exogenous antigens are antigens that have ... Tumor antigens[edit]. Tumor antigens are those antigens that are presented by MHC class I or MHC class II molecules on the ...
  https://en.wikipedia.org/wiki/Antigen
*  Plasma cell - Wikipedia
... continued exposure to antigen through those low levels of immunoglobulin is important, as it partly determines the cell's ... Surface antigens[edit]. Terminally differentiated plasma cells express relatively few surface antigens, and do not express ... Another important surface antigen is CD319 (SLAMF7). This antigen is expressed at high levels on normal human plasma cells. It ... After leaving the bone marrow, the B cell acts as an antigen presenting cell (APC) and internalizes offending antigens, which ...
  https://en.wikipedia.org/wiki/Plasma_cells
*  Chronic inflammatory demyelinating polyneuropathy (CIDP): change of serum IgG dimer levels during treatment with intravenous...
Polyvalent immunoglobulin (Ig) G form idiotypic/anti-idiotypic antibody pairs in serum and IVIg preparations. We determined IgG ... Intravenous immunoglobulin (IVIg) is an effective treatment in chronic inflammatory demyelinating polyneuropathy (CIDP). In ... Anti-idiotypes against anti-neutrophil cytoplasmic antigen autoantibodies in normal human polyspecific IgG for therapeutic use ... Immunoglobulin G dimer: an idiotype-anti-idiotype complex. Mol Immunol. 1988;25:41-8.View ArticlePubMedGoogle Scholar. ...
  https://jneuroinflammation.biomedcentral.com/articles/10.1186/s12974-015-0361-1
*  Humoral immunity - Wikipedia
Each immunoglobulin class differs in its biological properties and has evolved to deal with different antigens.[12] Antibodies ... Antibody-antigen reaction[edit]. Now these antibodies will encounter antigens and bind with them. This will either interfere ... Formation (1900), antigen-antibody binding. hypothesis (1938), produced by B cells (1948),. structure (1972), immunoglobulin ... When a B cell encounters an antigen, it is bound to the receptor and taken inside by endocytosis. The antigen is processed and ...
  https://en.wikipedia.org/wiki/Humoral_immune_response
*  Complement Receptors | Springer for Research & Development
Mechanism of inhibition of immunoglobulin G-mediated phagocytosis by monoclonal antibodies that recognize the Mac-1 antigen, J ... with an antibody to anti-factor H idiotype, J. Exp. Med. 155: 1400-1411.PubMedCrossRefGoogle Scholar ... Malhotra, V., Hogg, N., and Sim, R. B., 1986, Ligand binding by the p 150,95 antigen of U937 monocytic cells: Properties in ... Campbell, R. D., Dodds, A. W., and Porter, R. R., 1980, The binding of human complement component C4 to antibody-antigen ...
  https://rd.springer.com/chapter/10.1007/978-1-4757-9534-9_9
*  Anti-Lebanon Mountains | Article about Anti-Lebanon Mountains by The Free Dictionary
anti-idiotype antibody. *anti-immunoglobulin antibody. *anti-impotence drug. *anti-infective vitamin ... Anti-Latent Nuclear Antigen-1. *Anti-lawfulness. *Anti-lawfulness. *Anti-lawfulness. *Anti-Lebanon ...
  http://encyclopedia2.thefreedictionary.com/Anti-Lebanon+Mountains
*  Anti-hero | Article about anti-hero by The Free Dictionary
anti-idiotype antibody. *anti-immunoglobulin antibody. *anti-impotence drug. *anti-infective vitamin ... Anti-High Molecular Weight Antigen. *Anti-Hist. *Anti-histamine. *Anti-histamine. *Anti-histamine ...
  https://encyclopedia2.thefreedictionary.com/anti-hero
*  Antiguans | Article about Antiguans by The Free Dictionary
anti-idiotype antibody. *anti-immunoglobulin antibody. *anti-impotence drug. *anti-infective vitamin ...
  http://encyclopedia2.thefreedictionary.com/Antiguans
*  METHODS OF MODULATING BINDING OF SON OF SEVENLESS TO PHOSPHATIDIC ACID AND IDENTIFYING COMPOUNDS THAT MODULATE SUCH BINDING...
The antigens can be injected at a total volume of 100 μl per site at six different sites. Each injected material will contain ... 0048] It is also possible to use the anti-idiotype technology to produce monoclonal antibodies that mimic an epitope. As used ... immunoglobulin-secreting cell line. The resulting fused cells, or hybridomas, are cultured, and the resulting colonies screened ... Following the last antigen boost, the animals are sacrificed and spleen cells removed. [0046] Fusion with mammalian myeloma ...
  http://www.patentsencyclopedia.com/app/20120301895
*  Chang Yi Wang - Wikipedia
Immunoglobulin M antibody to hepatitis C virus core antigen: Correlations with viral replication, histological activity, and ... Idiotype-like molecules on cells of a human T-cell leukemia. J Exp Med 1983; 158:1000. 54. Welte K, Platzer EW, Wang, CY, ... Human lymphocyte bearing 1a-like antigens [now termed HLA-DK or class 1 MHC antigen]: Absence in patients with infantile ... An antigen characteristic of hairy cell leukemia cells is expressed on certain activated B cells. J immunol 1984; 133:1635. 48 ...
  https://en.wikipedia.org/wiki/Chang_Yi_Wang
*  Kudos - helping increase the reach and impact of research
Antigen-Induced Increases in Pulmonary Mast Cell Progenitor Numbers Depend on IL-9 and CD1d-Restricted NKT Cells. Published in: ... A cross-reactive idiotype on anti-collagen antibodies in collagen-induced arthritis: Identification and relevance to disease. ... Chronic treatment with rabbit anti-mouse mu-chain antibody alters the characteristic immunoglobulin heavy-chain restriction of ... CHANGES IN ANTIGEN-PRESENTING CELL FUNCTION IN THE SPLEEN AND LYMPH NODES OF ULTRAVIOLET-IRRADIATED MICE. Published in: ...
  https://www.growkudos.com/profiles/46599
*  JCI Insight - Welcome
... was determined using a multiplex infectious-antigen array (MIAA), which screens for reactivity to purified antigens or lysates ... Irgm1-/- mice have increased local production in the lung of TECP15-idiotype IgA, a natural antibody with dual reactivity ... However, the association between infection and the immunoglobulin-secreting (Ig-secreting) B proliferative disorders remains ... EBV was the most frequent target (15.6%), with 36 of 38 mc IgGs recognizing EBV nuclear antigen-1 (EBNA-1). MM patients with ...
  https://insight.jci.org/tags/13?content=articles&page=3
*  Adaptive immune system - Wikipedia
... anti-idiotypes' (antigen receptors that react with the idiotype as if it were a foreign antigen). This theory, which builds on ... which are proteins also known as immunoglobulins. Antibodies travel through the bloodstream and bind to the foreign antigen ... Exogenous antigens are usually displayed on MHC class II molecules, which activate CD4+T helper cells. Endogenous antigens are ... A critical difference between B cells and T cells is how each cell "sees" an antigen. T cells recognize their cognate antigen ...
  https://en.wikipedia.org/wiki/Adaptive_immune_system
*  US Patent for Anti-HCV monoclonal antibody as a medicament for the therapeutic treatment and prevention of HCV infections...
... type of full-length immunoglobulin or immunoglobulin fragment fused to specific full-length immunoglobulins or immunoglobulin ... The anti-idiotype antibody of the invention can be obtained by conventional methods for obtaining anti-idiotype antibodies, ... A recombinant human Fab (c33-3) specific for a non-structural HCV antigen (NS3) was included as a negative control in each ... A further object of the invention is an anti-idiotype antibody capable of specifically binding to the idiotype of the antibody ...
  https://patents.justia.com/patent/8623363
*  Antibody targeting: Theoretical considerations | SpringerLink
Haskell, C.M., Buchegger, F., Schreyer, M., Carrel, S., and Mach, J.P. (1983) Monoclonal antibodies to carcinoembryonic antigen ... Efficacy of whole immunoglobulin and its F(ab′)2 fragments. Cancer Res. 45:3378-3387.PubMedGoogle Scholar ... A clinical trial of anti-idiotype therapy for B cell malignancy. Blood 65:1349-1363.PubMedGoogle Scholar ... A.M. (1981) Localization of human breast-carcinoma xenografts using antibodies to carcinoembryonic antigen. Br. J. Cancer 43: ...
  https://link.springer.com/chapter/10.1007/978-1-4613-1497-4_2
*  Ipilimumab and Sargramostim in Treating Patients With Metastatic Prostate Cancer - Full Text View - ClinicalTrials.gov
Patients with nonmeasurable disease must have a positive bone scan and a prostate-specific antigen (PSA) level of at least 5 ng ... Anti-idiotype antibody (human anti-human antibodies [HAHA]) development [ Time Frame: Baseline, before each ipilimumab infusion ... Quantitate T-cell response to antigens in patients with relevant HLA allele using HLA*0201 tetramers. (Cohort Expansion) VII. ... Determine the prostate-specific antigen and/or objective responses in patients treated with this regimen. (Phase I) IV. ...
  https://clinicaltrials.gov/ct2/show/NCT00064129
*  Patente US4925787 - Monoclonal anti-idiotypic antibody, method for production thereof, and ... - Google Patentes
... or the hemagglutination method which effects detection of an antigen by the antigen-antibody reaction. The aforementioned ... Use of anti-idiotype antibodies in immunoassays. WO1986001539A1 *. 27 Ago 1985. 13 Mar 1986. The Trustees Of Columbia ... An anti-mouse immunoglobulin antibody labeled with horseradish peroxidase (produced by Amersham & Co., England) was dissolved ... An anti-mouse immunoglobulin antibody labeled with a horseradishperoxidase (produced by Amersham & Company, England and ...
  http://www.google.es/patents/US4925787