Loading...
*  Patente US4925787 - Monoclonal anti-idiotypic antibody, method for production thereof, and ... - Google Patentes
... or the hemagglutination method which effects detection of an antigen by the antigen-antibody reaction. The aforementioned ... Use of anti-idiotype antibodies in immunoassays. WO1986001539A1 *. 27 Ago 1985. 13 Mar 1986. The Trustees Of Columbia ... An anti-mouse immunoglobulin antibody labeled with horseradish peroxidase (produced by Amersham & Co., England) was dissolved ... An anti-mouse immunoglobulin antibody labeled with a horseradishperoxidase (produced by Amersham & Company, England and ...
  http://www.google.es/patents/US4925787
*  Active Specific Immunotherapy for Follicular Lymphomas With Tumor-Derived Immunoglobulin Idiotype Antigen Vaccines
The idiotype of the immunoglobulin on a given B cell malignancy (Id) can serve as a clonal marker, and a previous pilot study ... Active Specific Immunotherapy for Follicular Lymphomas With Tumor-Derived Immunoglobulin Idiotype Antigen Vaccines. Trial Phase ... The idiotype of the immunoglobulin on a given B cell malignancy (Id) can serve as a clonal. marker, and a previous pilot study ... against the unique idiotype of the patient's lymphoma and 2) to evaluate the ability of the. Id vaccine to clear the bone ...
  http://www.knowcancer.com/cancer-trials/NCT00001512/
*  Patent US20040009185 - Enhancing the immune response to an antigen by presensitzing with an ... - Google Patents
The antigen may be a tumour associated antigen, pathogenic organism antigen, autoimmune antigen, immunogenic fragment thereof, ... subsequently followed by administration of an inducing agent-antigen mixture. ... USA, 93:7252-7257 (1996)); idiotypic epitopes or antigens, for example, immunoglobulin idiotypes or T cell receptor idiotypes ... Protein antigens include both self antigens, such as tumor antigens and autoimmune antigens as well as non self antigens such ...
  http://www.google.com/patents/US20040009185
*  Vaccination of Follicular Lymphomas With Tumor-Derived Immunoglobulin Idiotype - Full Text View - ClinicalTrials.gov
Antibody to a molecularly-defined antigen confined to a tumour cell surface. Nature. 1975 Apr 24;254(5502):714-6. ... Immunoglobulins. Antibodies. QS 21. Immunoglobulin Idiotypes. Immunologic Factors. Physiological Effects of Drugs. Adjuvants, ... The idiotype of the immunoglobulin on a given B cell malignancy (Id) can serve as a clonal marker, and a previous pilot study ... Vaccination of Follicular Lymphomas With Tumor-Derived Immunoglobulin Idiotype. The safety and scientific validity of this ...
  https://www.clinicaltrials.gov/ct2/show/NCT00001572
*  Regulatory interactions among autologous T cell clones. Human bifunctional T cell clones regulate the activity of an autologous...
T-Lymphocytes, T-Lymphocytes, Helper-Inducer, Clone Cells, Humans, Receptors, Antigen, T-Cell, Immunoglobulin Idiotypes, ...
  https://www.ndorms.ox.ac.uk/publications/482020
*  T-cell clone anti-clone interactions. Effects on suppressor and helper activities. - Nuffield Department of Orthopaedics,...
... indicating that the autoreactive clones recognize their target antigen in conjunction with HLA Class II products. The ability ... Mx9/9 is a CD4 clone bearing an antigen receptor recognized by the Mx9 anti-V beta 8 monoclonal antibody (MoAb). Anti-V beta 8 ... Antigens, Differentiation, T-Lymphocyte, Immunoglobulin Idiotypes, HLA-D Antigens, Autoantigens, Lymphocyte Activation, T- ... Mx9/9 is a CD4 clone bearing an antigen receptor recognized by the Mx9 anti-V beta 8 monoclonal antibody (MoAb). Anti-V beta 8 ...
  https://www.ndorms.ox.ac.uk/publications/481768
*  James Swartz | Stanford Medicine Profiles
The unique immunoglobulin idiotype expressed on the surface of B lymphoma cells can be used as an effective antigen in tumor- ... The unique immunoglobulin (Ig) idiotype on the surface of each B-cell lymphoma represents an ideal tumor-specific antigen for ... Novel Anti-CD19/Idiotype Bispecific Diabody Vaccine for B-Cell Lymphoma 51st Annual Meeting and Exposition of the American- ... Clinical studies of idiotype (Id) vaccination in patients with lymphoma have established a correlation between the induced anti ...
  https://med.stanford.edu/profiles/james-swartz
*  Shoshana Levy | Stanford Medicine Profiles
The unique immunoglobulin idiotype expressed on the surface of B lymphoma cells can be used as an effective antigen in tumor- ... The unique immunoglobulin (Ig) idiotype on the surface of each B-cell lymphoma represents an ideal tumor-specific antigen for ... The rescued immunoglobulins were then tested for their ability to bind the HCV-E2 envelope glycoprotein, an antigen that was ... The variable immunoglobulin (Ig) domains contain hypervariable regions that are involved in the formation of the antigen ...
  https://med.stanford.edu/profiles/shoshana-levy?tab=teaching
*  US4680174A - Induction of immune response by immunization with encapsulated antigen-producing cells - Google Patents
The capsules are injected into an experimental animal where antigen passing through the pores of the capsule membrane induces ... lymphocytes to produce antibodies complementary to the antigen. The antibody may be harvested from the circulatory system of ... substance are encapsulated within capsule membranes having pores of dimensions sufficient to permit efflux of the antigens ... The distinguishing immunoglobulin region (idiotype) of each lymphoma clone is substantially unique and can distinguish tumor ...
  https://patents.google.com/patent/US4680174A/en
*  Plus it
5, 6, 7, 8 ). Furthermore, immunoglobulin idiotype vaccination in myeloma and non-Hodgkin lymphoma can induce immune responses ... Shinohara N., Watanabe M., Sachs D. H., Hozumi N. Killing of antigen-reactive B cells by class II-restricted, soluble antigen- ... Induction of immune responses in patients with B-cell lymphoma against the surface-immunoglobulin idiotype expressed by their ... an alternative source of highly efficient antigen presenting cells to generate autologous antigen-specific T cells for adoptive ...
  http://clincancerres.aacrjournals.org/content/10/3/1047
*  In vitro Stimulation with WT1 Peptide-Loaded Epstein-Barr Virus-Positive B Cells Elicits High Frequencies of WT1 Peptide...
... and immunoglobulin idiotypes specific to leukemic clones (6 , 7) , the protein products of fusion genes resulting from leukemia ... 5D⇓ , T4). These results, thus, demonstrate a requirement for the coexpression of the specific antigen and the T-cell- ... To prepare peptide-loaded antigen-presenting cells (APCs), we incubated 1 to 2 × 106 cells/mL CAMs or EBV-BLCLs from the same ... Berger CL, Longley J, Hanlon D, Girardi M, Edelson R. The clonotypic T cell receptor is a source of tumor-associated antigens ...
  http://clincancerres.aacrjournals.org/content/10/21/7207.long
*  Plus it
The clonotypic idiotype of malignant B cells was the first tumor-specific antigen identified as capable of eliciting a T cell- ... Recognition of immunoglobulin idiotypes by thymus-derived lymphocytes. Proc Natl Acad Sci U S A 1975; 72: 2357-60. ... Ia antigen-bearing B cell tumor lines can present protein antigen and alloantigen in a major histocompatibility complex- ... Cross-presentation of tumor antigens by bone marrow-derived antigen-presenting cells is the dominant mechanism in the induction ...
  http://cancerres.aacrjournals.org/content/68/13/5439
*  US8119117B2 - Adenoviral expression vector comprising a CD40L fusion protein adapted to elicit cellular immunity -...
Further provided are methods of generating an immune response against cancer expressing a tumor antigen in an individual by ... Also provided are methods of generating an immune response against cells expressing a tumor antigen by administering an ... the polypeptide comprising a secretory signal sequence upstream of a tumor antigen upstream of CD40 ligand, which is missing ... Provided are adenoviral vectors for generating an immune response to antigen. The vectors comprise a transcription unit ...
  https://patents.google.com/patent/US8119117?oq=6004266
*  Rescue fusion hybridization - Wikipedia
This cell then secretes the unique idiotype, or immunoglobulin antigen characteristic of the individual tumor, which is ...
  https://en.wikipedia.org/wiki/Rescue_fusion_hybridization
*  Adoptive cell transfer - Wikipedia
Multiple other B cell antigens are being studied as targets, including CD22, CD23, ROR-1 and the immunoglobulin light-chain ... idiotype expressed by the individual cancer. CARs targeting either CD33 or CD123 have been studied as a therapy for patients ... Antigen CD19 appears only on B cells, which go awry in lymphoma and leukemia. Loss of B cells can be countered with ... Cancer-testes antigen MAGE-A3 is not known to be expressed in any normal tissues. However, targeting an HLA-A*0201-restricted ...
  https://en.wikipedia.org/wiki/Adoptive_cell_transfer
*  VIRAL ADJUVANTS - Patent application
... the idiotype of the antibody, a malignant B cell antigen receptor, a malignant B cell immunoglobulin idiotype, a variable ... HSV antigens) mumps antigen, measles antigen, rubella antigen, diptheria toxin or other diptheria antigen, pertussis antigen, ... squamous cell carcinoma antigen (SCCA), ovarian cancer antigen (OCA), pancreas cancer associated antigen (PaA), mutant K-ras ... The use of adjuvants, or compounds co-administered with antigen which augment antigen-specific immune responses, have proven to ...
  http://www.patentsencyclopedia.com/app/20110064772
*  CHAPTER 104 PLASMA CELL NEOPLASMS: GENERAL CONSIDERATIONS | Free Medical Textbook
Features Surface Markers Zonal Electrophoresis Immunoelectrophoresis and Immunofixation Electrophoresis Immunoglobulin… ... immunoglobulin idiotypes, and surface antigens as all malignant plasma cells.52 As such, these neoplasms may be composed of ... Measurements of immunoglobulin light chains in urine, however, do not always correlate with the rate of immunoglobulin light- ... QUANTITATIVE IMMUNOGLOBULIN ASSAYS. Immunoglobulins in serum, urine, or CSF usually are measured by nephelometry. This ...
  https://medtextfree.wordpress.com/2012/01/23/chapter-104-plasma-cell-neoplasms-general-considerations/
*  Vaccine abstracts
Clinical Outcome of Lymphoma Patients After Idiotype Vaccination Is Correlated With Humoral Immune Response and Immunoglobulin ... Vaccination of patients with B-cell lymphoma using autologous antigen-pulsed dendritic cells. Nat Med. 1996 Jan;2(1):52-8. PMID ... Idiotype vaccination following ABMT can stimulate specific anti-idiotype immune responses in patients with B-cell lymphoma. ... Idiotype vaccines for non-Hodgkin's lymphoma induce polyclonal immune responses that cover mutated tumor idiotypes: comparison ...
  http://lymphomation.org/vaccines-abstracts.htm
*  ADENOVIRAL VECTOR VACCINE - Patent application
TSAs not induced by viruses can be idiotypes of the immunoglobulin on B cell antigens (TAA) are more common than TSA. [0029] ... 0007] In one embodiment, the tumor antigen is a human tumor antigen. In another embodiment, the human tumor antigen is the E7 ... 0013] In one embodiment, the tumor antigen is a human tumor antigen. In another embodiment, the human tumor antigen is the E7 ... 0017] In one embodiment, the tumor antigen is a human tumor antigen. In another embodiment, the human tumor antigen is the E7 ...
  http://www.patentsencyclopedia.com/app/20120276148
*  Idiotype - Wikipedia
The variable region of antigen receptors of T cells (TCRs) and B cells (immunoglobulins) contain complementarity determining ... Immunoglobulins or TCRs with a shared idiotope are the same idiotype. Antibody idiotype is determined by: Gene rearrangement ... In immunology, an idiotype is a shared characteristic between a group of immunoglobulin or T cell receptor (TCR) molecules ... The term "idiotype" is sometimes used to describe the collection of multiple idiotopes, and therefore overall antigen binding ...
  https://en.wikipedia.org/wiki/Idiotype
*  Urmia University of Medical Sciences Digital Library: T cell antigen receptor usage, phenotype and cytokine production in human...
In B-cell malignancies the immunoglobulin idiotype may serve as an autoantigen, being recognized by T cells that may have the ... for antigen allows a highly specific antigen recognition. Determination of TCR usage and characterization of T cell subsets in ... The correlation with antigen exposure implicates the expanded I cells in the pathogeneses of these diseases. ... This finding therefore suggests the existence of a specific vasculitis-associated antigen. A phenotypic analysis of T cell ...
  http://dl.umsu.ac.ir/handle/10616/44123
*  Untitled Document
... idiotypes reflect variation in the antigen-binding sites of the immunoglobulin. The antigenic epitope within the antigen- ... Isotypes, allotypes and idiotypes. Immunoglobulins can be characterised by their own ability to act as antigens: isotypes are ... IMMUNOGLOBULIN EXPRESSION. B cell surface expression. Binding of antigen to surface IgD is an early event in the B lympho cell ... IMMUNOGLOBULIN GENES. The genetic system for antibodies have to generate a diversity for antigen binding and a limited choice ...
  http://verdec.com/vu/evolutie/opdrachten/samenvattingen/immunsamen.htm
*  Idiotypes in Medicine: Autoimmunity, Infection and Cancer - 1st Edition
Purchase Idiotypes in Medicine: Autoimmunity, Infection and Cancer - 1st Edition. Print Book & E-Book. ISBN 9780444828071, ... Anti-Idiotype to Bluetongue Virus VP7 Antigen: Potential Diagnostic Reagent and Vaccine (E.-M. Zhou and M. Lin). An Idiotype ... Anti-idiotypes to Autoantibodies in Therapeutic Preparations of Normal Polyspecific Human IgG (Intravenous Immunoglobulin, IVIg ... Modulation of the immune response to simian virus 40 large tumor antigen via idiotype-anti-idiotype interactions (M.H. Shearer ...
  https://www.elsevier.com/books/idiotypes-in-medicine-autoimmunity-infection-and-cancer/kennedy/978-0-444-82807-1
*  The Limiting Dilution Approach to the Analysis of the Idiotypic Repertoire | SpringerLink
The role of idiotype and the MHC in suppressor T cell pathways, in: Immunoglobulin Idiotypes: ICN-UCLA Symposia on Molecular ... Expression of anti-H-2kidiotypes on antibodies induced by antiidiotype or H-2k antigen,J. Exp. Med. 154:1305-1318.PubMed ... Idiotype-anti-idiotype network. II. Activation of silent clones by treatment at birth with idiotypes is associated with the ... Jerne, N. K., 1982, in:Idiotypes: Antigens on the Inside(I. Westen-Schnurr, ed.), Editiones Roche, Basel, pp. 12-15.Google ...
  https://link.springer.com/chapter/10.1007/978-1-4684-4739-2_11
*  Isotype (immunology) - Wikipedia
Idiotype Stavnezer, Janet (1996). "Immunoglobulin Class Switching". Current Opinion in Immunology. 8: 199-205. doi:10.1016/ ... they are rarely highly mutated and have broad antigen reactivity thus providing an early response to a wide range of antigens ... In immunology, the immunoglobulin (Ig) isotype (class) is encoded by the constant region segments of the immunoglobulin gene ... Immunoglobulin Isotypes at the US National Library of Medicine Medical Subject Headings (MeSH) Overview at University of South ...
  https://en.wikipedia.org/wiki/Isotype_(immunology)