*  Novel Analysis of Clonal Diversification in Blood B Cell and Bone Marrow Plasma Cell Clones in Immunoglobulin Light Chain...
Immunoglobulin light chain amyloidosis (AL) is characterized by a limited clonal expansion of plasma cells and amyloid ... Jain R, Roncella S, Hashimoto S, Carbone A, Francia di Celle P, Foa R, Ferrarini M, Chiorazzi N: A potential role for antigen ... Razzeca KJ, Pillemer E, Weissman IL, Rouse RV: In situ identification of idiotype-positive cells participating in the immune ... Immunoglobulin light chain amyloidosis (AL) is characterized by a limited clonal expansion of plasma cells and amyloid ...
  https://link.springer.com/article/10.1007%2Fs10875-006-9056-9
*  Patente US4925787 - Monoclonal anti-idiotypic antibody, method for production thereof, and ... - Google Patentes
... or the hemagglutination method which effects detection of an antigen by the antigen-antibody reaction. The aforementioned ... Use of anti-idiotype antibodies in immunoassays. WO1986001539A1 *. 27 Ago 1985. 13 Mar 1986. The Trustees Of Columbia ... An anti-mouse immunoglobulin antibody labeled with horseradish peroxidase (produced by Amersham & Co., England) was dissolved ... An anti-mouse immunoglobulin antibody labeled with a horseradishperoxidase (produced by Amersham & Company, England and ...
  http://www.google.es/patents/US4925787
*  Patent US20040009185 - Enhancing the immune response to an antigen by presensitzing with an ... - Google Patents
The antigen may be a tumour associated antigen, pathogenic organism antigen, autoimmune antigen, immunogenic fragment thereof, ... subsequently followed by administration of an inducing agent-antigen mixture. ... USA, 93:7252-7257 (1996)); idiotypic epitopes or antigens, for example, immunoglobulin idiotypes or T cell receptor idiotypes ... Protein antigens include both self antigens, such as tumor antigens and autoimmune antigens as well as non self antigens such ...
  http://www.google.com/patents/US20040009185
*  Regulatory interactions among autologous T cell clones. Human bifunctional T cell clones regulate the activity of an autologous...
T-Lymphocytes, T-Lymphocytes, Helper-Inducer, Clone Cells, Humans, Receptors, Antigen, T-Cell, Immunoglobulin Idiotypes, ...
  https://www.ndorms.ox.ac.uk/publications/482020
*  James Swartz | Stanford Medicine Profiles
The unique immunoglobulin idiotype expressed on the surface of B lymphoma cells can be used as an effective antigen in tumor- ... The unique immunoglobulin (Ig) idiotype on the surface of each B-cell lymphoma represents an ideal tumor-specific antigen for ... Novel Anti-CD19/Idiotype Bispecific Diabody Vaccine for B-Cell Lymphoma 51st Annual Meeting and Exposition of the American- ... Clinical studies of idiotype (Id) vaccination in patients with lymphoma have established a correlation between the induced anti ...
  https://med.stanford.edu/profiles/james-swartz
*  Shoshana Levy | Stanford Medicine Profiles
The unique immunoglobulin idiotype expressed on the surface of B lymphoma cells can be used as an effective antigen in tumor- ... The unique immunoglobulin (Ig) idiotype on the surface of each B-cell lymphoma represents an ideal tumor-specific antigen for ... The rescued immunoglobulins were then tested for their ability to bind the HCV-E2 envelope glycoprotein, an antigen that was ... The variable immunoglobulin (Ig) domains contain hypervariable regions that are involved in the formation of the antigen ...
  https://med.stanford.edu/profiles/shoshana-levy?tab=teaching
*  Plus it
5, 6, 7, 8 ). Furthermore, immunoglobulin idiotype vaccination in myeloma and non-Hodgkin lymphoma can induce immune responses ... Shinohara N., Watanabe M., Sachs D. H., Hozumi N. Killing of antigen-reactive B cells by class II-restricted, soluble antigen- ... Induction of immune responses in patients with B-cell lymphoma against the surface-immunoglobulin idiotype expressed by their ... an alternative source of highly efficient antigen presenting cells to generate autologous antigen-specific T cells for adoptive ...
  http://clincancerres.aacrjournals.org/content/10/3/1047
*  US4680174A - Induction of immune response by immunization with encapsulated antigen-producing cells - Google Patents
The capsules are injected into an experimental animal where antigen passing through the pores of the capsule membrane induces ... lymphocytes to produce antibodies complementary to the antigen. The antibody may be harvested from the circulatory system of ... substance are encapsulated within capsule membranes having pores of dimensions sufficient to permit efflux of the antigens ... The distinguishing immunoglobulin region (idiotype) of each lymphoma clone is substantially unique and can distinguish tumor ...
  https://patents.google.com/patent/US4680174A/en
*  In vitro Stimulation with WT1 Peptide-Loaded Epstein-Barr Virus-Positive B Cells Elicits High Frequencies of WT1 Peptide...
... and immunoglobulin idiotypes specific to leukemic clones (6 , 7) , the protein products of fusion genes resulting from leukemia ... 5D⇓ , T4). These results, thus, demonstrate a requirement for the coexpression of the specific antigen and the T-cell- ... To prepare peptide-loaded antigen-presenting cells (APCs), we incubated 1 to 2 × 106 cells/mL CAMs or EBV-BLCLs from the same ... Berger CL, Longley J, Hanlon D, Girardi M, Edelson R. The clonotypic T cell receptor is a source of tumor-associated antigens ...
  http://clincancerres.aacrjournals.org/content/10/21/7207.long
*  US8119117B2 - Adenoviral expression vector comprising a CD40L fusion protein adapted to elicit cellular immunity -...
Further provided are methods of generating an immune response against cancer expressing a tumor antigen in an individual by ... Also provided are methods of generating an immune response against cells expressing a tumor antigen by administering an ... the polypeptide comprising a secretory signal sequence upstream of a tumor antigen upstream of CD40 ligand, which is missing ... Provided are adenoviral vectors for generating an immune response to antigen. The vectors comprise a transcription unit ...
  https://patents.google.com/patent/US8119117?oq=6004266
*  Rescue fusion hybridization - Wikipedia
This cell then secretes the unique idiotype, or immunoglobulin antigen characteristic of the individual tumor, which is ...
  https://en.wikipedia.org/wiki/Rescue_fusion_hybridization
*  Adoptive cell transfer - Wikipedia
Multiple other B cell antigens are being studied as targets, including CD22, CD23, ROR-1 and the immunoglobulin light-chain ... idiotype expressed by the individual cancer. CARs targeting either CD33 or CD123 have been studied as a therapy for patients ... Antigen CD19 appears only on B cells, which go awry in lymphoma and leukemia. Loss of B cells can be countered with ... Cancer-testes antigen MAGE-A3 is not known to be expressed in any normal tissues. However, targeting an HLA-A*0201-restricted ...
  https://en.wikipedia.org/wiki/Adoptive_cell_transfer
*  VIRAL ADJUVANTS - Patent application
... the idiotype of the antibody, a malignant B cell antigen receptor, a malignant B cell immunoglobulin idiotype, a variable ... HSV antigens) mumps antigen, measles antigen, rubella antigen, diptheria toxin or other diptheria antigen, pertussis antigen, ... squamous cell carcinoma antigen (SCCA), ovarian cancer antigen (OCA), pancreas cancer associated antigen (PaA), mutant K-ras ... The use of adjuvants, or compounds co-administered with antigen which augment antigen-specific immune responses, have proven to ...
  http://www.patentsencyclopedia.com/app/20110064772
*  Vaccine abstracts
Clinical Outcome of Lymphoma Patients After Idiotype Vaccination Is Correlated With Humoral Immune Response and Immunoglobulin ... Vaccination of patients with B-cell lymphoma using autologous antigen-pulsed dendritic cells. Nat Med. 1996 Jan;2(1):52-8. PMID ... Idiotype vaccination following ABMT can stimulate specific anti-idiotype immune responses in patients with B-cell lymphoma. ... Idiotype vaccines for non-Hodgkin's lymphoma induce polyclonal immune responses that cover mutated tumor idiotypes: comparison ...
  http://lymphomation.org/vaccines-abstracts.htm
*  CHAPTER 104 PLASMA CELL NEOPLASMS: GENERAL CONSIDERATIONS | Free Medical Textbook
Features Surface Markers Zonal Electrophoresis Immunoelectrophoresis and Immunofixation Electrophoresis Immunoglobulin… ... immunoglobulin idiotypes, and surface antigens as all malignant plasma cells.52 As such, these neoplasms may be composed of ... Measurements of immunoglobulin light chains in urine, however, do not always correlate with the rate of immunoglobulin light- ... QUANTITATIVE IMMUNOGLOBULIN ASSAYS. Immunoglobulins in serum, urine, or CSF usually are measured by nephelometry. This ...
  https://medtextfree.wordpress.com/2012/01/23/chapter-104-plasma-cell-neoplasms-general-considerations/
*  ADENOVIRAL VECTOR VACCINE - Patent application
TSAs not induced by viruses can be idiotypes of the immunoglobulin on B cell antigens (TAA) are more common than TSA. [0029] ... 0007] In one embodiment, the tumor antigen is a human tumor antigen. In another embodiment, the human tumor antigen is the E7 ... 0013] In one embodiment, the tumor antigen is a human tumor antigen. In another embodiment, the human tumor antigen is the E7 ... 0017] In one embodiment, the tumor antigen is a human tumor antigen. In another embodiment, the human tumor antigen is the E7 ...
  http://www.patentsencyclopedia.com/app/20120276148
*  Idiotype - Wikipedia
The variable region of antigen receptors of T cells (TCRs) and B cells (immunoglobulins) contain complementarity determining ... Immunoglobulins or TCRs with a shared idiotope are the same idiotype. Antibody idiotype is determined by: Gene rearrangement ... In immunology, an idiotype is a shared characteristic between a group of immunoglobulin or T cell receptor (TCR) molecules ... The term "idiotype" is sometimes used to describe the collection of multiple idiotopes, and therefore overall antigen binding ...
  https://en.wikipedia.org/wiki/Idiotype
*  The Limiting Dilution Approach to the Analysis of the Idiotypic Repertoire | SpringerLink
The role of idiotype and the MHC in suppressor T cell pathways, in: Immunoglobulin Idiotypes: ICN-UCLA Symposia on Molecular ... Expression of anti-H-2kidiotypes on antibodies induced by antiidiotype or H-2k antigen,J. Exp. Med. 154:1305-1318.PubMed ... Idiotype-anti-idiotype network. II. Activation of silent clones by treatment at birth with idiotypes is associated with the ... Jerne, N. K., 1982, in:Idiotypes: Antigens on the Inside(I. Westen-Schnurr, ed.), Editiones Roche, Basel, pp. 12-15.Google ...
  https://link.springer.com/chapter/10.1007/978-1-4684-4739-2_11
*  Idiotypes in Medicine: Autoimmunity, Infection and Cancer - 1st Edition
Purchase Idiotypes in Medicine: Autoimmunity, Infection and Cancer - 1st Edition. Print Book & E-Book. ISBN 9780444828071, ... Anti-Idiotype to Bluetongue Virus VP7 Antigen: Potential Diagnostic Reagent and Vaccine (E.-M. Zhou and M. Lin). An Idiotype ... Anti-idiotypes to Autoantibodies in Therapeutic Preparations of Normal Polyspecific Human IgG (Intravenous Immunoglobulin, IVIg ... Modulation of the immune response to simian virus 40 large tumor antigen via idiotype-anti-idiotype interactions (M.H. Shearer ...
  https://www.elsevier.com/books/idiotypes-in-medicine-autoimmunity-infection-and-cancer/kennedy/978-0-444-82807-1
*  Isotype (immunology) - Wikipedia
Idiotype Stavnezer, Janet (1996). "Immunoglobulin Class Switching". Current Opinion in Immunology. 8: 199-205. doi:10.1016/ ... they are rarely highly mutated and have broad antigen reactivity thus providing an early response to a wide range of antigens ... In immunology, the immunoglobulin (Ig) isotype (class) is encoded by the constant region segments of the immunoglobulin gene ... Immunoglobulin Isotypes at the US National Library of Medicine Medical Subject Headings (MeSH) Overview at University of South ...
  https://en.wikipedia.org/wiki/Isotype_(immunology)
*  Idiotype dictionary definition | idiotype defined
... of idiotopes contained within the variable region of a particular immunoglobulin molecule and making up the molecule's antigen ... idiotype. id·i·o·type. noun. The complete set of idiotopes contained within the variable region of a particular immunoglobulin ... plural idiotypes). *(immunology) A characteristic shared by a group of immunoglobulin or T cell receptor molecules, based on ... How would you define idiotype? Add your definition here.. Please enable JavaScript to view the comments powered by Disqus.. ...
  http://www.yourdictionary.com/idiotype
*  Systemic Lupus Erythematosus | SpringerLink
Isenberg DA, Collins C: Detection of cross-reactive anti-DNA antibody idiotypes on renal tissue-bound immunoglobulins from ... Madaio MP, Carlson J, Cataldo J, et al.: Murine monoclonal anti-DNA antibodies bind directly to glomerular antigens and form ... Koffler D, Agnello V, Carr I, et al.: Variable patterns of immunoglobulin and complement deposition in the kidneys of patients ... Blaese M, Grayson J, Steinberg AD: Increased immunoglobulin-secreting cells in the blood of patients with active systemic lupus ...
  https://link.springer.com/chapter/10.1007/978-1-4757-6632-5_28
*  Immunoglobulins devoid of light chains - Vrije, Universiteit Brussel
... provided an isolated immunoglobulin comprising two heavy polypeptide chains sufficient for the formation of a complete antigen ... binding site or several antigen binding sites, wherein the immun ... Such anti-idiotypes can be produced against human or animal ... The invention also relates to anti-idiotypes capable of recognizing idiotypes of heavy-chain immunoglobulins. ... The immunoglobulins of the type described here-above can comprise type G immunoglobulins and especially immunoglobulins which ...
  http://www.freepatentsonline.com/5759808.html
*  02.09.09(c): Antibody-Based Clinical Tests - English
8. Idiotypes. Serological term--antigenicdeterminant unique to a given immunoglobulin.Used to describe the ... which occurs at theposition where antibody and antigen concentration areabout equal.Since immunoglobulins have many VH and VL ... 4. 1. Antigenic determinants used to describe parts of immunoglobulins: isotypes and idiotypes.2. Immunological tests: ... antigen] [antibody] = 10-6 to 10-10constant [antigen:antibody complex]Avidity is used to describe the interaction ofmultivalent ...
  https://www.slideshare.net/openmichigan/020909m1-immunoantibody-basedclinicaltests
*  Physicochemical and biological characterization of 1E10 Anti-Idiotype vaccine | BMC Biotechnology | Full Text
Anti-idiotype vaccination represents an innovative approach to target tumor-associated antigen-expressing cells. This approach ... which postulates that due to the huge potentiality for diversity of the immunoglobulin variable regions, the idiotype ... mAb-1E10 induced an idiotype-positive antigen-negative (Id+Ag-) Ab3 response in syngeneic, allogeneic and xenogeneic models, ... mAb-1E10 [8] is an IgG1 anti-idiotype (Ab2) mAb obtained by immunizing Balb/c mice with mAb-P3 (Ab1) [9] coupled to keyhole ...
  https://bmcbiotechnol.biomedcentral.com/articles/10.1186/1472-6750-11-112