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*  Development of Novel Replication-defective Lymphocytic Choriomeningitis Virus Vectors Expressing SIV Antigens
High-density Preculture of PBMCs Restores Defective Sensitivity of Circulating CD8 T Cells to Virus- and Tumor-derived Antigens ... Development of Novel Replication-defective Lymphocytic Choriomeningitis Virus Vectors Expressing SIV Antigens. ... Combination of Epstein-Barr virus nuclear antigen 1, 3 and Lytic Antigen BZLF1 Peptide Pools Allows Fast and Efficient ... Antigen Peptides. Antigen Peptides. Antigen peptides represent specific epitopes for stimulation of T cells in T cell assays ...
  https://www.jpt.com/literature/Development-of-Novel-Replication-defective-Lymphocytic-Choriomeningitis-Virus-Vectors-Expressing-SIV-Antigens/?breadcrumbPath=1847
*  Rubin's 20: Liver & Biliary Flashcards by Languages 247365 | Brainscape
ss RNA (defective RNA virus) expresses core antigen named HDAg (delta antigen) co-infection OR superinfection with Hep B ... Hep B surface ag Hep Be ag - responsible for virus replication Core - Hep Bc-ag and back Once HepB ag, immune ...
  https://www.brainscape.com/flashcards/rubin-s-20-liver-amp-biliary-5291482/packs/7868247
*  Dan Barouch | Harvard Catalyst Profiles | Harvard Catalyst
Development of novel replication-defective lymphocytic choriomeningitis virus vectors expressing SIV antigens. Vaccine. 2017 ... Recruitment of antigen-presenting cells to the site of inoculation and augmentation of human immunodeficiency virus type 1 DNA ... Differential antigen requirements for protection against systemic and intranasal vaccinia virus challenges in mice. J Virol. ... The canarypox virus vector ALVAC induces distinct cytokine responses compared to the vaccinia virus-based vectors MVA and NYVAC ...
  https://connects.catalyst.harvard.edu/Profiles/display/Person/28268
*  The AMEDEO Literature Guide
Intramuscular delivery of replication-defective herpes simplex virus gives antigen expression in muscle syncytia and improved ... Maturation inhibitors facilitate virus assembly and release of HIV-1 capsid P224 mutant.. Virology. 2018;521:44-50.. PubMed ... Equine MX2 is a restriction factor of equine infectious anemia virus (EIAV).. Virology. 2018;523:52-63.. PubMed Text format ... HSV-2 glycoprotein J promotes viral protein expression and virus spread.. Virology. 2018;525:83-95.. PubMed Text format ...
  https://amedeo.com/medicine/hiv/virol.htm
*  Recombinant Varicella-Zoster Virus Vaccines as Platforms for Expression of Foreign Antigens
The replication competent virus amplifies foreign antigen expression-a potential advantage over replication defective vectors. ... C. Y. Pumphrey and W. L. Gray, "The genomes of simian varicella virus and varicella zoster virus are colinear," Virus Research ... "Processing of hepatitis B virus surface antigen expressed by recombinant Oka varicella vaccine virus," Journal of General ... "Recombinant simian varicella viruses expressing respiratory syncytial virus antigens are immunogenic," Journal of General ...
  https://www.hindawi.com/journals/av/2013/219439/
*  Frontiers | Challenges in the Role of Gammaglobulin Replacement Therapy and Vaccination Strategies for Hematological Malignancy...
Defective response to protein antigens, such as tetanus toxoid and influenza virus, is also apparent (47, 48). Interpretation ... Influenza virus vaccination and booster in B-cell chronic lymphocytic leukaemia patients. Eur J Intern Med (2001) 12(5):420-4. ... Chimeric antigen receptor T cells persist and induce sustained remissions in relapsed refractory chronic lymphocytic leukemia. ... Second malignancies in B-cell chronic lymphocytic leukaemia: possible association with human papilloma virus. Br J Haematol ( ...
  https://www.frontiersin.org/articles/10.3389/fimmu.2016.00317/full
*  JCI - Intravaginal immunization with HPV vectors induces tissue-resident CD8+ T cell responses
... several systemic immunization strategies using live viruses, replication-defective viral vectors, or protein antigens and ... Replication-defective viruses as vaccines and vaccine vectors. Virology. 2006;344(1):230-239.. View this article via: PubMed ... Expression of cutaneous lymphocyte-associated antigen by CD8(+) T cells specific for a skin-tropic virus. J Clin Invest. 2002; ... Trafficking of the virus/vector and expression of the antigen in other tissues could lead to subsequent recruitment of ...
  https://www.jci.org/articles/view/63287?key=95b0c2a37738d68fcd61
*  Open Access Papers - Center for Virology and Vaccine Research
Development of novel replication-defective lymphocytic choriomeningitis virus vectors expressing SIV antigens ... The Canarypox Virus Vector ALVAC Induces Distinct Cytokine Responses Compared to the Vaccinia Virus-Based Vectors MVA and NYVAC ... Zika Virus Persistence in the Central Nervous System and Lymph Nodes of Rhesus Monkeys ... Improving Mycobacterium bovis Bacillus Calmette-Gue` rin as a Vaccine Delivery Vector for Viral Antigens by Incorporation of ...
  http://cvvr.hms.harvard.edu/open-access-papers
*  AHDV - Clinical: Hepatitis D Virus Total Antibodies, Serum
... also known as delta hepatitis virus, is a defective RNA virus comprising of a delta antigen and a hepatitis B surface antigen ( ... This virus cannot replicate effectively by itself, and it requires the presence of hepatitis B virus (HBV) to initiate and ... Diagnosis of HDV can be established by detecting HDV antigen, HDV-specific IgM, or HDV-specific total antibodies (combined IgM ... HBsAg) as the core and protein coat of the virus, respectively. ... is a defective RNA virus comprising of a delta antigen and a ...
  https://www.mayomedicallaboratories.com/test-catalog/Clinical+and+Interpretive/9209
*  Patent US6811774 - Defective recombinant adenoviruses expressing cytokines for antitumor treatment - Google Patents
A recombinant nucleic acid used for the production of a defective adenovirus containing an inserted sequence coding for a ... the sequence containing the polyadenylation signal of the gene coding for the early antigens of SV40 virus were placed. The ... c) Transfection of DNA and Isolation of Recombinant Viruses. The Ad-cytokine defective recombinant adenoviruses were obtained ... Hela or Vero cell lines are infected with the defective recombinant viruses obtained. Cells effectively transfected may be ...
  http://www.google.com/patents/US6811774?dq=5,960,411
*  Single-blind, Dose-ranging Study of Novel Swine Influenza Virus Vaccine in Japanese Pediatric Subjects
... of antigen and adjuvant) and schedule (one or two administrations) ... ... Examples of antigens include microorganisms (such as bacteria, fungi, parasites, and viruses) and chemicals. Antibodies may be ... CELL LINES derived from the CV-1 cell line by transformation with a replication origin defective mutant of SV40 VIRUS, which ... Influenza A Virus, H1n1 Subtype. A subtype of INFLUENZA A VIRUS comprised of the surface proteins hemagglutinin 1 and ...
  https://www.bioportfolio.com/resources/trial/71548/Single-blind-Dose-ranging-Study-of-Novel-Swine-Influenza-Virus-Vaccine-in.html
*  Blood group antigens of different types for diagnostic and therapeutic applications - AbSorber AB
... replication defective retroviruses, adenoviruses and adeno-associated viruses), which serve equivalent functions. ... The blood group antigen is an A antigen, a B Antigen or an H antigen. The core saccharide chain type is a type 1, a type 2, a ... Blood group antigens include A antigen, B antigen and H antigen. Core saccharide chain types include type 1, type 2, type 3 and ... Blood group antigens include (A, B, and O (H). The blood group antigens are specific for all the blood group subtypes. By blood ...
  http://www.freepatentsonline.com/7897328.html
*  ORBi: Browsing ORBi
... using reproduction-defective viruses bearing the gene coding for the large T antigen of the leukaemia simian virus (SV40). The ... 7 passages for non-transfected cells), (2) the detection of both the large T transcript and the large T antigen in transformed ...
  http://orbi.ulg.ac.be/browse?type=author&rpp=20&value=Loret%2C+Suzanne
*  Modification of Small Hepatitis Delta Virus Antigen by SUMO Protein
Plasmid PX9-I/II-d1nt, which was used for in vitro transcription of an S-HDAg-encoding defective mutant (d1nt) in which the ... Modification of Small Hepatitis Delta Virus Antigen by SUMO Protein. Chung-Hsin Tseng,1,2 Tai-Shan Cheng,3 Chiung-Yueh Shu,4 ... Virus Res. 81:17-27. [PubMed]. 51. Wong, S. K., and D. W. Lazinski. 2002. Replicating hepatitis delta virus RNA is edited in ... Large hepatitis delta antigen is not a suppressor of hepatitis delta virus RNA synthesis once RNA replication is established. J ...
  http://pubmedcentralcanada.ca/pmcc/articles/PMC2798338/
*  Selection of recombinant MVA by rescue of the essential D4R gene | Virology Journal | Full Text
Recombinant, replicating virus was obtained by re-introduction of the deleted viral gene as a dominant selection marker into ... we assessed marker rescue of the essential viral D4R gene in an engineered deletion mutant that is fully replication defective ... Modified vaccinia virus Ankara (MVA) has become a promising vaccine vector due to its immunogenicity and its proven safety in ... Plaques were immune-stained with antisera directed either to yellow fever virus prME antigen or to vaccinia virus, thereby ...
  https://virologyj.biomedcentral.com/articles/10.1186/1743-422X-8-529
*  Identification of Novel Functions for Hepatitis C Virus Envelope Glycoprotein E1 in Virus Entry and Assembly | Journal of...
3B), which was confirmed in an additional experiment in the presence of a mutant virus defective in virus assembly (Fig. 3C), ... Performance and clinical utility of a novel fully automated quantitative HCV-core antigen assay. J Clin Virol 46:210-215. doi: ... very similar to the level of the control ΔE1E2 virus, which is defective in virus assembly (Fig. 7B). This was not due to the ... Mutagenesis and virus production.The virus used in this study is a modified version of the JFH1 isolate (genotype 2a; GenBank ...
  https://jvi.asm.org/content/91/8/e00048-17
*  Hepatitis Delta Virus: Infection and Disease | Springer for Research & Development
... is a unique defective agent whose infection is inextricably linked to that of hepatitis B virus (HBV) (Rizzetto et al. 1987; ... Bergman KF, Gerin JT (1986) Antigens of hepatitis delta virus in the liver and serum of humans and animals. J Infect Dis 154: ... Hepatitis delta virus (HDV) is a unique defective agent whose infection is inextricably linked to that of hepatitis B virus ( ... Hepatitis Delta Virus HBsAg Carrier NANB Hepatitis Prog Clin Biol Hepatitis Delta Virus Infection These keywords were added by ...
  https://rd.springer.com/chapter/10.1007/978-1-4899-0891-9_4
*  Role of the adenovirus early region 1B tumor antigens in transformation and lytic infection
The 58-kDa mutant virus was not defective when its growth was assayed on human embryonic kidney (HEK) cells. This may indicate ... In lytic infection, the 19-kDa mutant virus was some 30-fold reduced in yield on HeLa cells, whereas the 58-kDa mutant virus ... The 19 and 58-kDa mutant viruses were found to transform BRK cells with 11 and 25% of the efficiency of wild type virus, ... Role of the adenovirus early region 1B tumor antigens in transformation and lytic infection. DSpace/Manakin Repository. ...
  https://dspace.library.uu.nl/handle/1874/13853
*  Treatment of an infant with X-linked severe combined immunodeficiency (SCID-X1) by gene therapy in Australia | The Medical...
Replication-defective: Virus or viral vector that is unable to reproduce itself because a gene or genes critical for ... There was no in-vitro T-cell proliferation response to Candida antigen at 4 months, possibly explained by lack of exposure to ... 9 The vector was derived from a replication-defective Moloney murine leukaemia virus, as previously described.10 The vector- ... Cells were immunostained for expression of CD3 antigen (a cell-surface marker of T cells) plus either CD4 (top) or CD8 (bottom ...
  https://www.mja.com.au/journal/2005/182/9/treatment-infant-x-linked-severe-combined-immunodeficiency-scid-x1-gene-therapy
*  Is Interferon-Based Treatment of Viral Hepatitis C Genotype 3 Infection Still of Value in the Era of Direct-Acting Antivirals?
3 hepatitis C virus (HCV) in Poland at the beginning of the inte... ... INFLAMMATION of the LIVER in humans caused by HEPATITIS DELTA VIRUS, a defective RNA virus that can only infect HEPATITIS B ... For its viral coating, hepatitis delta virus requires the HEPATITIS B SURFACE ANTIGENS produced by these patients. Hepatitis D ... Hepatitis C virus (HCV) infection is a global health problem, which may lead to chronic hepatitis, cirrhosis, hepatic ...
  https://www.bioportfolio.com/resources/pmarticle/1966666/Is-Interferon-Based-Treatment-of-Viral-Hepatitis-C-Genotype-3-Infection-Still.html
*  Adenovirus-mediated Prodrug Gene Therapy for Carcinoembryonic Antigen-producing Human Gastric Carcinoma Cells in Vitro | Cancer...
We analyzed the ability of a recombinant replication-defective adenovirus vector with the carcinoembryonic antigen (CEA) ... promoter to transfer the thymidine kinase gene of herpes simplex virus (HSVtk) into gastric cancer cells to confer sensitivity ... Adenovirus-mediated Prodrug Gene Therapy for Carcinoembryonic Antigen-producing Human Gastric Carcinoma Cells in Vitro. Torao ... Adenovirus-mediated Prodrug Gene Therapy for Carcinoembryonic Antigen-producing Human Gastric Carcinoma Cells in Vitro ...
  http://cancerres.aacrjournals.org/content/56/6/1341
*  Discovery of endogenous viruses | Philosophical Transactions of the Royal Society B: Biological Sciences
I first came across an endogenous factor which functionally complemented env-defective Rous sarcoma virus (RSV) during my ... avian leukosis virus (ALV). However, the specificity of this test was confounded by the presence of a cross-reacting antigen in ... Marek's disease virus [65] and the related turkey virus. REV has also been found in the genome of fowlpox virus [66], a virus ... 1972 Xenotropic viruses: murine leukemia viruses associated with NIH Swiss, NZB, and other mouse strains . Science 182, 1151- ...
  http://rstb.royalsocietypublishing.org/content/368/1626/20120494
*  T Cell Reactivity against Mycolyl Transferase Antigen 85 of M. tuberculosis in HIV-TB Coinfected Subjects and in AIDS Patients...
H. McShane, A. A. Pathan, C. R. Sander et al., "Recombinant modified vaccinia virus Ankara expressing antigen 85A boosts BCG- ... A defective immune system, caused by iatrogenic immunosuppression, poverty-related malnutrition, stress, ageing, and genetic ... L. Y. Armitige, C. Jagannath, A. R. Wanger, and S. J. Norris, "Disruption of the genes encoding antigen 85A and antigen 85B of ... disease were completely unreactive to all antigens tested (PPD: ; Ag85: ; PWM ) (Figures 2(a), 2(b), and 2(c), resp.). ...
  https://www.hindawi.com/journals/jir/2011/640309/
*  MeSH Semantic Type: Cell [T025]
In AIDS, they are induced when the envelope glycoprotein of the HIV virus binds to the CD4 antigen of uninfected neighboring T4 ... CELL LINES derived from the CV-1 cell line by transformation with a replication origin defective mutant of SV40 VIRUS, which ... and highly susceptible to transformation by SV40 VIRUS and murine sarcoma virus (SARCOMA VIRUSES, MURINE). ... Instead, they hold antigen in the form of immune complexes on their surfaces for long periods and can present antigen to B- ...
  http://www.slicksurface.com/medical-thesaurus/semantic-type/cell.htm
*  Reproduction of Papovaviruses | SpringerLink
... simian virus 40 (SV40), which is a vacuolating virus of monkeys (Sweet and Hilleman, 1960), and the papilloma... ... The principal members of the papova group are polyoma virus (Stewart et al., 1957), ... Uchida, S., Yoshiike, K., Watanabe, S., and Furano, A., 1968, Antigen-forming defective viruses of simian virus 40, Virology 34 ... simian virus 40 (SV40), which is a vacuolating virus of monkeys (Sweet and Hilleman, 1960), and the papilloma viruses (Melnick ...
  https://link.springer.com/chapter/10.1007/978-1-4684-2703-5_2