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*  Antigens, CD40 - Medical Dictionary online-medical-dictionary.org
Mutations of the Gene for CD40 Antigen result in Hyper-IgM Immunodeficiency Syndrome, Type 3. Signaling of the receptor occurs ... Antigens, CD40. A member of the Tumor Necrosis Factor Receptor superfamily with specificity for CD40 Ligand. It is found on ... Evidence suggests that CD40-dependent activation of B-Cells is important for Generation of Memory B-Cells within the Germinal ...
  http://www.online-medical-dictionary.org/definitions-a/antigens-cd40.html
*  Cd40-Cd40 Ligand Interactions in Vivo Regulate Migration of Antigen-Bearing Dendritic Cells from the Skin to Draining Lymph...
1996) Chemical carcinogens and antigens induce immune suppression via Langerhans' cell depletion. Immunology 88:134-139, pmid: ... and CD40 ligand −/− (c) mice. To reconstitute CD40 signaling in wild-type (d) and CD40 ligand −/− (e) mice, anti-murine CD40 (d ... Thus, CD40-CD40 ligand interactions in vivo regulate the migration of antigen-bearing DCs from the skin to DLNs via TNF-α ... Cd40-Cd40 Ligand Interactions in Vivo Regulate Migration of Antigen-Bearing Dendritic Cells from the Skin to Draining Lymph ...
  http://jem.rupress.org/content/191/11/2011
*  CD40 Gene - GeneCards | TNR5 Protein | TNR5 Antibody
CD40 Molecule, including: function, proteins, disorders, pathways, orthologs, and expression. GeneCards - The Human Gene ... Suggested Antigen Peptide Sequences for CD40 Gene. GenScript: Design optimal peptide antigens:. *CD40 protein (Q6P2H9_HUMAN) ... GeneCards Summary for CD40 Gene CD40 (CD40 Molecule) is a Protein Coding gene. Diseases associated with CD40 include ... No data available for DME Specific Peptides for CD40 Gene Domains & Families for CD40 Gene Gene Families for CD40 Gene. HGNC:. ...
  http://www.genecards.org/cgi-bin/carddisp.pl?gene=CD40&rf=/home/genecards/current/website/carddisp.pl&bioalma_dis=93
*  CD40-activated human B cells: an alternative source of highly efficient antigen presenting cells to generate autologous antigen...
Dendritic cells pulsed with protein antigens in vitro can prime antigen-specific, MHC-restricted T cells in situ. J Exp Med. ... CD40-activated human B cells: an alternative source of highly efficient antigen presenting cells to generate autologous antigen ... Banchereau J, Bazan F, Blanchard D, Brière F, Galizzi JP, van Kooten C, Liu YJ, Rousset F, Saeland S. The CD40 antigen and its ... Rock KL, Rothstein L, Gamble S, Fleischacker C. Characterization of antigen-presenting cells that present exogenous antigens in ...
  http://pubmedcentralcanada.ca/pmcc/articles/PMC508480/?lang=en-ca
*  Patent US6391637 - Use of CD40 ligand, a cytokine that binds CD40, to stimulate hybridoma cells - Google Patents
... this invention provides isolated human and murine CD40-L polypeptides that bind to the extracellular binding region of a CD40 ... Also disclosed are methods of simulating hybridoma cells to increase monoclonal antibody production by administering a CD40 ... vectors and transformed host cells useful in providing CD40-L polypeptides. More particularly, ... B cell antigen CD40 (Stamenkovic et al., EMBO J. 8:1403, 1989), T cell antigen OX40 (Mallett et al., EMBO J. 9:1063, 1990), ...
  http://www.google.com.au/patents/US6391637
*  Frontiers | Cytokine-Mediated Regulation of Plasma Cell Generation: IL-21 Takes Center Stage | Immunology
Indeed, efficient production of antigen (Ag)-specific Ab underlies the success of most currently available vaccines. The mature ... Indeed, efficient production of antigen (Ag)-specific Ab underlies the success of most currently available vaccines. The mature ... The CD40 antigen and its ligand. Annu Rev Immunol (1994) 12: 881-922. ... Antibody responses to protein, polysaccharide, and phi X174 antigens in the hyperimmunoglobulinemia E (hyper-IgE) syndrome. J ...
  https://www.frontiersin.org/articles/10.3389/fimmu.2014.00065/full
*  A Monoclonal Antibody Reactive with a 40-kDa Molecule on Fetal Thymocytes and Tumor Cells Blocks Proliferation and Stimulates...
The CD40 antigen and its ligand. Annu. Rev. Immunol. 12: 881. OpenUrlCrossRefPubMed ... Presentation of exogenous antigens by macrophages: analysis of major histocompatibility complex class I and II presentation. ... Antigen recognition by H-2-restricted T cells. I. Cell-free antigen. J. Exp. Med. 158: 303. ... Antigen presentation by Ia+ B cell hybridomas to H-2-restricted T cell hybridomas. Proc. Natl. Acad. Sci. USA 79: 3604. ...
  http://www.jimmunol.org/content/163/3/1306
*  Patent US7884085 - Delivery of AS-oligonucleotide microspheres to induce dendritic cell ... - Google Patents
The oligonucleotides are targeted to bind to primary transcripts CD40, CD80, CD86 and their combinations. ... Dendritic cells appear to take up the oligonucleotide microspheres and suppress the expression of surface cell antigens CD40, ... These antigen presenting dendritic cells function as triggers of the immune response through the activation of T-cells, ... Microspheres containing the antisense oligonucleotides of interest down-regulate surface cell antigens CD40, CD80 and CD86, ...
  http://www.google.com/patents/US7884085?dq=5,666,293
*  Cell-Surface Proteomics Identifies Lineage-Specific Markers of Embryo-Derived Stem Cells
Cdcp1 and Cd40 antigen for TS cells; Pdgfrα, Dpp4, and Robo2 for XEN cells; Cd40 antigen and Cd47 antigen for EpiSC (Figures ​( ... and disease-specific antigens accessible from the vasculature. Nat. Protoc. 2006;1:192-199. [PubMed] ... and Cd81 antigen for ES cells; Notch3, Cd40 antigen, Cdh10, Sirpa, Cd47 antigen, and Cdh2 for EpiSC (Figures 3A and 3B). ... Cd40 is also a protein marker of EpiSC, and consistent with this, we detected cell-surface expression of Cd40 in EPI at E5.5 ( ...
  http://pubmedcentralcanada.ca/pmcc/articles/PMC3405530/?lang=en-ca
*  T b cell activating molecule Dictionary Definition and More from Dictionary.net
Membrane glycoprotein and differentiation antigen expressed on the surface of T- cells. It binds to CD40; ( ANTIGENS, CD40) on ...
  http://www.dictionary.net/t%20b%20cell%20activating%20molecule
*  Dartmouth Digital Library Program
The role of CD40 in cutaneous and regional immune responses. * CD antigens. ; Immune response -- Regulation. ; T cells -- ... Modulation antigen presentaton by Fcγ receptor-targeting and glucocorticoids. * Antigen presenting cells. ; Major ...
  http://libarchive.dartmouth.edu/cdm/search/searchterm/containing
*  Sustained signaling through the B-cell receptor induces Mcl-1 and promotes survival of chronic lymphocytic leukemia B cells |...
Triggering of CD40 antigen inhibits fludarabine-induced apoptosis in B chronic lymphocytic leukemia cells. Blood. 1998;92: 990- ... Thus, CLL B cells with unmutated VH genes may predominantly display specificity for T-independent foreign antigens or membrane- ... Inhibition of the MEK/ERK signaling pathway blocks a subset of B cell responses to antigen. J Immunol. 2001;166: 3855-3864. ... The PI3K/Akt, NF-κB, and ERK pathways can be activated in CLL B cells by a number of stimuli, including CD154 (CD40 ligand), ...
  http://www.bloodjournal.org/content/105/12/4820?ijkey=503813b13f31f01e9776d8b6c4d3f5ea8ba3c48e&keytype2=tf_ipsecsha&sso-checked=true
*  TIDCs may express diverse phenotypes but are immature i | Open-i
Antigens, CD40/immunology. *CD8-Positive T-Lymphocytes/immunology. *Female. *Immunity, Active/immunology ... Bottom Line: Deficient antitumor immunity could be related to a lack of tumor-associated antigen (TAA) presentation by tumor- ... Bottom Line: Deficient antitumor immunity could be related to a lack of tumor-associated antigen (TAA) presentation by tumor- ... CD40, and CD86 molecules of TIDCs to that of lymph node DCs or immature BM-DCs (Figs. 1 B and 2 A). We observed that TIDCs had ...
  https://openi.nlm.nih.gov/detailedresult.php?img=PMC2196048_20020732f1&req=4
*  Characterization of ASKP1240, a Fully Human Antibody Targeting Human CD40 With Potent Immunosuppressive Effects
The recovery of free CD40 receptor also delayed in a dose-dependent manner (Figure 5B). The CD40 antigen was almost completely ... Modulation of CD40 antigens on B cell lines analyzed by flow cytometry. Ramos cells were incubated with FITC-labeled ASKP1240 ( ... The CD40 molecule is mainly expressed on antigen-presenting cells such as macrophages, and dendritic cells (DCs) as well as on ... Although free CD40 antigen started to increase from around 5 days after the administration in 1. mg/kg group, it is expected ...
  http://pubmedcentralcanada.ca/pmcc/articles/PMC4225473/
*  T helper cell - Wikipedia
It binds to CD40 on antigen-presenting cells (APC), which leads to many effects depending on the target cell type. CD154 acts ... but unprocessed antigens do not interact with T cells and are not involved in their activation. The antigens that bind to MHC ... Roles of T cell-B-cell-activating molecule (5c8 antigen) and CD40 in contact-dependent help". Journal of Immunology. 149 (12): ... For example, when an antigen-presenting cell expresses an antigen on MHC class II, a CD4+ cell will aid those cells through a ...
  https://en.wikipedia.org/wiki/T_helper_cell
*  CD154 - Wikipedia
It binds to CD40 on antigen-presenting cells (APC), which leads to many effects depending on the target cell type. In total ... B cells can present antigens to a specialized group of helper T cells called TFH cells. If an activated TFH cell recognizes the ... "CD40-CD40 ligand". Journal of Leukocyte Biology. 67 (1): 2-17. PMID 10647992. Schattner EJ (May 2000). "CD40 ligand in CLL ... Roles of T cell-B-cell-activating molecule (5c8 antigen) and CD40 in contact-dependent help". Journal of Immunology. 149 (12): ...
  https://en.wikipedia.org/wiki/CD154
*  List of MeSH codes (D23) - Wikipedia
... antigens, cd36 MeSH D23.050.301.264.035.138 --- antigens, cd38 MeSH D23.050.301.264.035.140 --- antigens, cd40 MeSH D23.050. ... hla-a antigens MeSH D23.050.301.500.450.370.372 --- hla-a1 antigen MeSH D23.050.301.500.450.370.374 --- hla-a2 antigen MeSH ... antigens, cd19 MeSH D23.050.301.264.051.120 --- antigens, cd20 MeSH D23.050.301.264.051.140 --- antigens, cd40 MeSH D23.050. ... antigens, cd36 MeSH D23.101.100.110.138 --- antigens, cd38 MeSH D23.101.100.110.140 --- antigens, cd40 MeSH D23.101.100.110.143 ...
  https://en.wikipedia.org/wiki/List_of_MeSH_codes_(D23)
*  CD40 (protein) - Wikipedia
The expression of CD40 is diverse. CD40 is constitutively expressed by antigen presenting cells, including dendritic cells, B ... The B cell can present antigens to helper T cells. If an activated T cell recognizes the peptide presented by the B cell, the ... "CD40-CD40 ligand". Journal of Leukocyte Biology. 67 (1): 2-17. PMID 10647992. Schattner EJ (May 2000). "CD40 ligand in CLL ... Banchereau J, Bazan F, Blanchard D, Brière F, Galizzi JP, van Kooten C, Liu YJ, Rousset F, Saeland S (1994). "The CD40 antigen ...
  https://en.wikipedia.org/wiki/CD40_(protein)
*  Lipid raft - Wikipedia
... endocytosis of antigen bound to the BCR and its routing to late endosomes to facilitate loading of antigen-derived peptides ... Their functions include signaling by BCR, modulation of that signaling by co-receptors, signaling by CD40, ... Then oligomeric antigens bind to receptor-bound IgE to crosslink two or more of these receptors. This crosslinking then ... T cell antigen receptor signalling, B cell antigen receptor signalling, EGF receptor signalling, insulin receptor signalling ...
  https://en.wikipedia.org/wiki/Lipid_raft
*  Adenoviridae - Wikipedia
... genetically engineered adenovirus vector targeted to CD40 mediates transduction of canine dendritic cells and promotes antigen- ... Adenovirus dodecahedron can qualify as a potent delivery platform for foreign antigens to human myeloid dendritic cells (MDC), ...
  https://en.wikipedia.org/wiki/Adenoviridae
*  Waldenström's macroglobulinemia - Wikipedia
Bone marrow tumour cells express the following antigen targets CD20 (98.3%), CD22 (88.3%), CD40 (83.3%), CD52 (77.4%), IgM ( ... "Expression of serotherapy target antigens in Waldenstrom's macroglobulinemia: therapeutic applications and considerations". ... The following signalling pathways have been implicated: CD154/CD40 Akt ubiquitination, p53 activation, cytochrome c release NF- ...
  https://en.wikipedia.org/wiki/Waldenstr%C3%B6m's_macroglobulinemia
*  Immunogenic cell death - Wikipedia
... surface receptors like CD91 and CD40 and also facilitate crosspresentation of antigens derived from tumour cells on MHC class I ... On the cell surface they have an immunostimulatory effect, based on their interaction with number of antigen-presenting cell ( ... and its release to the extracellular space seems to be required for the optimal release and presentation of tumour antigens to ...
  https://en.wikipedia.org/wiki/Immunogenic_cell_death
*  Antigen-presenting cell - Wikipedia
Professional antigen-presenting cells, including macrophages, B cells and dendritic cells, present foreign antigens to helper T ... This occurs through the interaction of co-stimulatory molecules including B7 and CD40 on the dendritic cell, with CD28 and CD40 ... Professional APCs specialize in presenting antigen to T cells. They are very efficient at internalizing antigens, either by ... An antigen-presenting cell (APC) or accessory cell is a cell that displays antigen complexed with major histocompatibility ...
  https://en.wikipedia.org/wiki/Antigen-presenting_cell
*  Macrophage - Wikipedia
Eventually, the antigen presentation results in the production of antibodies that attach to the antigens of pathogens, making ... T cells that express the T cell receptor which recognizes the antigen-MHCII complex (with co-stimulatory factors- CD40 and ... the antigen is endocytosed and processed. The processed antigen is then presented in MHCII on the surface of the B-cell. ... The antigen presentation on the surface of infected macrophages (in the context of MHC class II) in a lymph node stimulates TH1 ...
  https://en.wikipedia.org/wiki/Macrophage
*  Follicular B helper T cells - Wikipedia
... which binds and stimulates the B cell surface receptor CD40. TFH cell-dependent paracrine activation of B cell CD40 results in ... Follicular B helper T cells (also known as just follicular helper T cells or TFH), are antigen-experienced CD4+ T cells found ... Therefore, in the absence of TFH cells, similar to B cell activation by T-cell independent antigens, a quick burst of low ... May 2009). "T follicular helper cells differentiate from Th2 cells in response to helminth antigens". J Exp Med. 206 (5): 991-9 ...
  https://en.wikipedia.org/wiki/Follicular_B_helper_T_cells